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Previous release (v1)
2025-08-18 20:02:35, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_001438721 5057 bp mRNA linear PRI 22-APR-2025
DEFINITION Homo sapiens ring finger protein 157 (RNF157), transcript variant
3, mRNA.
ACCESSION NM_001438721 XM_047435286 XM_054314936
VERSION NM_001438721.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5057)
AUTHORS Dogan,T., Gnad,F., Chan,J., Phu,L., Young,A., Chen,M.J., Doll,S.,
Stokes,M.P., Belvin,M., Friedman,L.S., Kirkpatrick,D.S.,
Hoeflich,K.P. and Hatzivassiliou,G.
TITLE Role of the E3 ubiquitin ligase RNF157 as a novel downstream
effector linking PI3K and MAPK signaling pathways to the cell cycle
JOURNAL J Biol Chem 292 (35), 14311-14324 (2017)
PUBMED 28655764
REMARK GeneRIF: Data suggest that RNF157 plays role as downstream effector
of both PI3K signaling and MAPK signaling in melanoma cell line;
regulation of RNF157 expression is cell-cycle-dependent in melanoma
cell line; both CDH1 and CDK2 are involved in modulation of RNF157
stability during melanoma cell proliferation. (PI3K =
phosphatidylinositol 3-kinase; CDH1 = E-cadherin; CDK2 =
cyclin-dependent kinase 2)
REFERENCE 2 (bases 1 to 5057)
AUTHORS Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
Schreiber,S. and Nebel,A.
TITLE Investigation of genetic susceptibility factors for human longevity
- a targeted nonsynonymous SNP study
JOURNAL Mutat Res 694 (1-2), 13-19 (2010)
PUBMED 20800603
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 5057)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 4 (bases 1 to 5057)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am J Hum Genet 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC015801.25 and AC018665.9.
On or before Apr 22, 2025 this sequence version replaced
XM_047435286.1, XM_054314936.1.
##Evidence-Data-START##
Transcript exon combination :: SRR14038194.1117120.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-341 AC015801.25 64155-64495
342-460 AC015801.25 92166-92284
461-549 AC018665.9 13283-13371
550-696 AC018665.9 19276-19422
697-814 AC018665.9 19947-20064
815-881 AC018665.9 20546-20612
882-925 AC018665.9 21528-21571
926-973 AC018665.9 22278-22325
974-1045 AC018665.9 24450-24521
1046-1205 AC018665.9 25071-25230
1206-1318 AC018665.9 25426-25538
1319-1557 AC018665.9 27500-27738
1558-1666 AC018665.9 28572-28680
1667-1778 AC018665.9 30752-30863
1779-1951 AC018665.9 31339-31511
1952-2017 AC018665.9 31756-31821
2018-2066 AC018665.9 32745-32793
2067-2177 AC018665.9 34608-34718
2178-5057 AC018665.9 41720-44599
FEATURES Location/Qualifiers
source 1..5057
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q25.1"
gene 1..5057
/gene="RNF157"
/note="ring finger protein 157"
/db_xref="GeneID:114804"
/db_xref="HGNC:HGNC:29402"
/db_xref="MIM:621044"
exon 1..341
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
CDS 254..2296
/gene="RNF157"
/EC_number="2.3.2.27"
/note="isoform 3 is encoded by transcript variant 3;
RING-type E3 ubiquitin transferase RNF157; E3 ubiquitin
ligase RNF157"
/codon_start=1
/product="E3 ubiquitin ligase RNF157 isoform 3"
/protein_id="NP_001425650.1"
/db_xref="GeneID:114804"
/db_xref="HGNC:HGNC:29402"
/db_xref="MIM:621044"
/translation="
MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETRPCVWGPLAV"
misc_feature 1238..1249
/gene="RNF157"
/note="propagated from UniProtKB/Swiss-Prot (Q96PX1.3);
Region: D-box 1. /evidence=ECO:0000303|PubMed:28655764"
misc_feature 1268..1339
/gene="RNF157"
/note="propagated from UniProtKB/Swiss-Prot (Q96PX1.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2204..2293
/gene="RNF157"
/note="propagated from UniProtKB/Swiss-Prot (Q96PX1.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2222..2233
/gene="RNF157"
/note="propagated from UniProtKB/Swiss-Prot (Q96PX1.3);
Region: D-box 2. /evidence=ECO:0000303|PubMed:28655764"
misc_feature 2234..2236
/gene="RNF157"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:28655764; propagated from
UniProtKB/Swiss-Prot (Q96PX1.3); phosphorylation site"
misc_feature 2237..2239
/gene="RNF157"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:28655764; propagated from
UniProtKB/Swiss-Prot (Q96PX1.3); phosphorylation site"
misc_feature 2240..2242
/gene="RNF157"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:28655764; propagated from
UniProtKB/Swiss-Prot (Q96PX1.3); phosphorylation site"
misc_feature 2243..2245
/gene="RNF157"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:28655764; propagated from
UniProtKB/Swiss-Prot (Q96PX1.3); phosphorylation site"
exon 342..460
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 461..549
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 550..696
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 697..814
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 815..881
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 882..925
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 926..973
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 974..1045
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1046..1205
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1206..1318
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1319..1557
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1558..1666
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1667..1778
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1779..1951
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 1952..2017
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 2018..2066
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 2067..2177
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
exon 2178..5057
/gene="RNF157"
/inference="alignment:Splign:2.1.0"
regulatory 5036..5041
/regulatory_class="polyA_signal_sequence"
/gene="RNF157"
/note="hexamer: AATAAA"
polyA_site 5057
/gene="RNF157"
/note="major polyA site"
ORIGIN
acgcggcctgaggcggcggcggcgcccccggcccagacccgcagcccccttggcagaggcgccgccgcggtgcccggcggaggatggtgcgcggcgcgccgggggctccccgccgccagagccgcagcgccgcagcggagccggccgcggcgggcagtcggcccccgcaccgggcgcggggcgggcggccgcggtgaagcgcggagggcggcgcgggcaccggggccgggccggggctgcagccgcagcggccatgggggccctgacgagccggcagcacgcgggcgtggaggaggtggacatcccgtctaattccgtgtaccgctacccgcccaagtccggaagctattttgccagccacttcattatgggaggagagaagtttgactcaactcatcctgaaggttacctgtttggagagaacagcgatctgaactttctggggaacagaccagttgtgtttccttacgccgccccacctccccaagaacccgtgaagactctgagaagcctggtcaatatccgaaaggacacactgaggctcgtcaaatgtgctgaggaagtgaagagccctggagaagaggccagtaaagctaaagtccactacaatgttgagttcacctttgacacagatgctcgggtagccatcaccatctattaccaggccacggaagagttccagaatggtattgccagctacattcccaaagacaacagcctccagtcggagactgtgcagtacaagcgaggagtgtgtcagcagttctgcctgccctcccacaccgtggatccctccgagtgggccgaagaggagcttggctttgatttagaccgagaagtttaccctctagtggtacatgccgtggtggatgaaggagacgagtattttggccattgccatgtactgctgggtacttttgagaagcacacagatggaactttctgtgtcaagcccctcaaacagaaacaagtagtagacggggtcagctacctccttcaggagatctatggaattgaaaacaagtacaacacacaagattctaaggtggctgaagacgaagtgagtgataacagtgccgagtgtgtggtgtgtctctcggatgtccgggacaccttgattctgccctgtcgccacctctgcctctgtaacacctgtgcagacacgctgcgctaccaggccaacaactgccccatctgccgactgcccttccgggcactgcttcagatccgagccatgaggaaaaaattgggccccttgtccccaaccagctttaaccccatcatctcatcccagacatctgactctgaagagcatccatcctcagagaatattccaccaggctatgaagtagtatctcttctggaggccctcaacgggcccctcaccccgtccccagcagttcctccacttcacgtgcttggagatggccacctctcaggaatgctcccttcatatggcagtgatggccacctgccccccgtcaggacgatctcgcctcttgaccgcctgtctgacagcagcagtcagggactcaaactcaaaaagagtctctccaaatccacttcccaaaactcttccgtgctgcatgaagaggaagatgagcattcctgcagcgagtcggagacacagctctctcagagaccgtcggttcagcatctcggagaggaatgtggtgtgactccagaaagtgagaatctcaccttgtcgtcatctggagctattgaccagtcgtcttgcacagggacgcctctgtcatccactatttcctccccagaaggccctgccagcagcagcttggcccagtctgtcatgtccatggcatcctcccagatcagcactgacaccgtctcctccatgtctggctcctacatcgcccctggcactgaagaggagggagaggctctctcttccccccagcctgccagcagggccccctcagaagaaggagaggggctgccagcggagtctccagacagcaactttgctggcctcccagctggagagcaggatgcagagggaaatgatgttatagaggaagaggatggatcacccacgcaggaaggtggccagaggacgtgcgcatttctaggtatggagtgtgacaataacaatgactttgacatcgcaagcgtgaaagcactggacaataagctgtgctctgaggtctgcttacctggtgcctggcaggctgatgacaatgccgtcagtcggaatgcccagcgccggcgcttgtcatccagcagcctggaggactctgagacgaggccctgtgtgtggggccctttggctgtctgagccccagcctctgcacttgggctcccctcctgccctgcattccatccatcctcactcagctgctgcctactgggcatcctcagcaagatgctggagactttttaccctcctgtgacagctgttacaacctgtaaccacaatccctcacctctcagagggaactggaaccctcctttctccgtgtgacctaaagccactcaatgaactgcagctcacgagaccttttgcagggactctggaatgtcctcacggtatattgatgttcaggtggagctggggtccatgggctaatttcttacacatcttttttctccttagggggtagaacaagaaggcttagagtttggcagctttgttacaaacatccctctggcatttcctggtctctggcacatcataaccaattggaaacctgcagtttggggtagggctggaggatcgctcctgtggaaagggagagccatactgcacggacgtagcgtttccctctacaagcactaggagcacctttctcaaggacaagaaatggtagcaaccaaaaggttggttgaaggaaacaatccttccttctggtggcagagccagtcttctgggcctcacatgcctgtgcggttaagaaggagctcttggccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggcgggtggatcatgagatcaggagatcgagaccatcctggctaacacggcgaaaccccgtctctactaaaaatacaaaaaattagctgggcatggttgcaggcgcctgtagtcccagctacttgggaggctgaggcaggagaatggcctgaacccgggaggcggagcttgcagtgagccgagatcgcgccaatgcactccagcctgggcgacagagaaaaaaaaaaaaaaagaaggagcccttgaatctgagaatcccccagttaagatgatttcccttaaggagcatttctcctgatcaggtgcattcagggaggcctgcaactccatcctaaggtgacatttcaagaaacacatgtgttgaccacctctgtgtgccaagcactgggtgaggagtggtcgtatattaccataattcatcctcactcaattgggaggtggcattcttgtccctgttgcccccatctctacccccttttgttaatggttgagagaaatgtggaccagtgattctcagtttggtgcccaggtccccaaaggaagtgatggagagccttgagctaagttcaggcagcagcatgtggccagcagcagtgtgctgggagcagaggttggaatcagggctcagggccttcacttcaagggccctccccagctactcgggaggctgaggcaggagaatcgcttgaactcaggaggtggaggttgcggtgagccaagatcgtgccactgcactccagcctgggctacaagattgaaaagatcgaaactctgtctcaaacaaaaaaaaaaaaattcaaggctgtttccaaggcagcctcaaaaagagcctggtgcccagggggtccttcgtttctgtgtggctgcagaggccaggagtgcagtgactgtctcactgcctagtggttgtggctcacatcctgccctgatggagaggggggcctgtcgtccaaccctctctgaaaaactgcagtagactttaccatttcaggccccacctaatgttctttccttccttccccctacattcttcccgcccctttcatagttaagatgcataagctgagcaataaccccacttcctgatttccctgaaatatgagcccagaagcagcaggtgacagggagcttcccttaccctggggtggtggcacacagaccacctcctgtcctgtcccctgcaggtagtattcacagtgtggtgttacctgggaggagggaggaaggagctgagatgaaggagattcaggtaaacagtagccacagtggccaggacccccttcctgaggatccctgtccttcctcgcagcaggtgcttagtcctctcctagggagaagcacggaaagattcctcaaggcctcagtcccatgtccaaggcatacctaggttagaaatgtcctttacttgtttctcagttactatttctcctcttcctccctccccctgccttctcttggctgtcatttagctctctggcccacagaaatactccatccaaggagctggtcctcagtcagcctgatgaggacaggtcagtggccaacccttttgccccagtccttcatctggagacagtcacatagtcacgtcaacagttcacccaaagagaagaggtggggcctggcttctcccacagggcacagcctaactatggagacccagggctccttcctgctgcactaggcctgtgctctccctattgccttcaggtggtgtgatcccggcttcctcacagagcccttttttccttctgcccagctccatcccaccagagtttctacccccgctgaggcatctcctgggcacagaccaccacactctaagccggctggcctgggagttagggtcctgcccacctcacctgggagttggggtcctgcccacctggagtttagcacgctggtcgctcactttgctttggtctgcacacctggtgtgtgcatgtgtatactgcttgtgccatctgtgtacccctctccctggagtacacttgtggtcacactacagtggggacatcaagaatgcaatatttatggattgctgcatgattcttaaaaatgaataaaactgtttacaagggaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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