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Previous release (v1)
2025-08-18 20:04:06, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_001437548 4576 bp mRNA linear PRI 04-APR-2025
DEFINITION Homo sapiens semaphorin 5B (SEMA5B), transcript variant 7, mRNA.
ACCESSION NM_001437548 XM_047448353 XM_054346925
VERSION NM_001437548.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4576)
AUTHORS Maki-Nevala,S., Sarhadi,V.K., Knuuttila,A., Scheinin,I.,
Ellonen,P., Lagstrom,S., Ronty,M., Kettunen,E.,
Husgafvel-Pursiainen,K., Wolff,H. and Knuutila,S.
TITLE Driver Gene and Novel Mutations in Asbestos-Exposed Lung
Adenocarcinoma and Malignant Mesothelioma Detected by Exome
Sequencing
JOURNAL Lung 194 (1), 125-135 (2016)
PUBMED 26463840
REMARK GeneRIF: SEMA5B could possibly serve as a candidate gene for
alterations associated with asbestos exposure.
REFERENCE 2 (bases 1 to 4576)
AUTHORS Wu,C., Hu,Z., He,Z., Jia,W., Wang,F., Zhou,Y., Liu,Z., Zhan,Q.,
Liu,Y., Yu,D., Zhai,K., Chang,J., Qiao,Y., Jin,G., Liu,Z., Shen,Y.,
Guo,C., Fu,J., Miao,X., Tan,W., Shen,H., Ke,Y., Zeng,Y., Wu,T. and
Lin,D.
TITLE Genome-wide association study identifies three new susceptibility
loci for esophageal squamous-cell carcinoma in Chinese populations
JOURNAL Nat Genet 43 (7), 679-684 (2011)
PUBMED 21642993
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4576)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 4 (bases 1 to 4576)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am J Hum Genet 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4576)
AUTHORS O'Connor,T.P., Cockburn,K., Wang,W., Tapia,L., Currie,E. and
Bamji,S.X.
TITLE Semaphorin 5B mediates synapse elimination in hippocampal neurons
JOURNAL Neural Dev 4, 18 (2009)
PUBMED 19463192
REMARK GeneRIF: Sema5B regulates the development and maintenance of
synapse size and number in hippocampal neurons.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4576)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE 7 (bases 1 to 4576)
AUTHORS Adams,R.H., Betz,H. and Puschel,A.W.
TITLE A novel class of murine semaphorins with homology to thrombospondin
is differentially expressed during early embryogenesis
JOURNAL Mech Dev 57 (1), 33-45 (1996)
PUBMED 8817451
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC083797.16 and AC078794.13.
On or before Apr 4, 2025 this sequence version replaced
XM_047448353.1, XM_054346925.1.
Summary: This gene encodes a member of the semaphorin protein
family which regulates axon growth during development of the
nervous system. The encoded protein has a characteristic Sema
domain near the N-terminus, through which semaphorins bind to
plexin, and five thrombospondin type 1 repeats in the C-terminal
region of the protein. The protein product may be cleaved and exist
as a secreted molecule (PMID: 19463192). Multiple transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jan 2012].
##Evidence-Data-START##
Transcript exon combination :: SRR14372080.2199607.1,
SRR18074969.3222164.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-300 AC083797.16 147427-147726
301-504 AC078794.13 3032-3235
505-604 AC078794.13 8206-8305
605-650 AC078794.13 12271-12316
651-713 AC078794.13 22683-22745
714-812 AC078794.13 23126-23224
813-1026 AC078794.13 23738-23951
1027-1312 AC078794.13 25064-25349
1313-1448 AC078794.13 27989-28124
1449-1656 AC078794.13 29294-29501
1657-1864 AC078794.13 29619-29826
1865-1982 AC078794.13 35851-35968
1983-2164 AC078794.13 36120-36301
2165-2308 AC078794.13 37740-37883
2309-2453 AC078794.13 38060-38204
2454-2679 AC078794.13 38317-38542
2680-2898 AC078794.13 38680-38898
2899-3069 AC078794.13 39399-39569
3070-3219 AC078794.13 39672-39821
3220-3264 AC078794.13 40206-40250
3265-3470 AC078794.13 40696-40901
3471-4576 AC078794.13 41440-42545
FEATURES Location/Qualifiers
source 1..4576
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21.1"
gene 1..4576
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="semaphorin 5B"
/db_xref="GeneID:54437"
/db_xref="HGNC:HGNC:10737"
/db_xref="MIM:609298"
exon 1..300
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 301..504
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
CDS 351..3629
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="isoform 5 precursor is encoded by transcript
variant 7; sema domain, seven thrombospondin repeats (type
1 and type 1-like), transmembrane domain (TM) and short
cytoplasmic domain, (semaphorin) 5B"
/codon_start=1
/product="semaphorin-5B isoform 5 precursor"
/protein_id="NP_001424477.1"
/db_xref="GeneID:54437"
/db_xref="HGNC:HGNC:10737"
/db_xref="MIM:609298"
/translation="
MVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEASPGQRCFPNS"
sig_peptide 351..428
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
exon 505..604
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 605..650
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 651..713
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 714..812
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 813..1026
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1027..1312
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1313..1448
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1449..1656
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1657..1864
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1865..1982
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1983..2164
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2165..2308
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2309..2453
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2454..2679
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2680..2898
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2899..3069
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3070..3219
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3220..3264
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3265..3470
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3471..4576
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
regulatory 4557..4562
/regulatory_class="polyA_signal_sequence"
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="hexamer: ATTAAA"
polyA_site 4576
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="major polyA site"
ORIGIN
ctccctgctctctccgagcgccgggtcgggagctagttggagcgcgggggttggtgccagagcccagctccgccgagccgggcgggtcggcagcgcatccagcggctgctgggagcccgagcgcagcgggcgcgggcccgggtggggactgcaccggagcgctgagagctggaggccgttcctgcgcggccgccccattcccagaccggccgccagcccatctggttagctcccgccgctccgcgccgcccgggagtcgggagccgcggggaaccgggcacctgcacccgcctctgggaggtcttctcccctgtctgcctcccggagctaggactgcagaggggcctatcatggtgcttgcaggccccctggctgtctcgctgttgctgcccagcctcacactgctggtgtcccacctctccagctcccaggatgtctccagtgagcccagcagtgagcagcagctgtgcgcccttagcaagcaccccaccgtggcctttgaagacctgcagccgtgggtctctaacttcacctaccctggagcccgggatttctcccagctggctttggacccctccgggaaccagctcatcgtgggagccaggaactacctcttcagactcagccttgccaatgtctctcttcttcaggccacagagtgggcctccagtgaggacacgcgccgctcctgccaaagcaaagggaagactgaggaggagtgtcagaactacgtgcgagtcctgatcgtcgccggccggaaggtgttcatgtgtggaaccaatgccttttcccccatgtgcaccagcagacaggtggggaacctcagccggactattgagaagatcaatggtgtggcccgctgcccctatgacccacgccacaactccacagctgtcatctcctcccagggggagctctatgcagccacggtcatcgacttctcaggtcgggaccctgccatctaccgcagcctgggcagtgggccaccgcttcgcactgcccaatataactccaagtggcttaatgagccaaacttcgtggcagcctatgatattgggctgtttgcatacttcttcctgcgggagaacgcagtggagcacgactgtggacgcaccgtgtactctcgcgtggcccgcgtgtgcaagaatgacgtggggggccgattcctgctggaggacacatggaccacattcatgaaggcccggctcaactgctcccgcccgggcgaggtccccttctactataacgagctgcagagtgccttccacttgccggagcaggacctcatctatggagttttcacaaccaacgtaaacagcatcgcggcttctgctgtctgcgccttcaacctcagtgctatctcccaggctttcaatggcccatttcgctaccaggagaaccccagggctgcctggctccccatagccaaccccatccccaatttccagtgtggcaccctgcctgagaccggtcccaacgagaacctgacggagcgcagcctgcaggacgcgcagcgcctcttcctgatgagcgaggccgtgcagccggtgacacccgagccctgtgtcacccaggacagcgtgcgcttctcacacctcgtggtggacctggtgcaggctaaagacacgctctaccatgtactctacattggcaccgagtcgggcaccatcctgaaggcgctgtccacggcgagccgcagcctccacggctgctacctggaggagctgcacgtgctgccccccgggcgccgcgagcccctgcgcagcctgcgcatcctgcacagcgcccgcgcgctcttcgtggggctgagagacggcgtcctgcgggtcccactggagaggtgcgccgcctaccgcagccagggggcatgcctgggggcccgggacccgtactgtggctgggacgggaagcagcaacgttgcagcacactcgaggacagctccaacatgagcctctggacccagaacatcaccgcctgtcctgtgcggaatgtgacacgggatgggggcttcggcccatggtcaccatggcaaccatgtgagcacttggatggggacaactcaggctcttgcctgtgtcgagctcgatcctgtgattcccctcgaccccgctgtgggggccttgactgcctggggccagccatccacatcgccaactgctccaggaatggggcgtggaccccgtggtcatcgtgggcgctgtgcagcacgtcctgtggcatcggcttccaggtccgccagcgaagttgcagcaaccctgctccccgccacgggggccgcatctgcgtgggcaagagccgggaggaacggttctgtaatgagaacacgccttgcccggtgcccatcttctgggcttcctggggctcctggagcaagtgcagcagcaactgtggagggggcatgcagtcgcggcgtcgggcctgcgagaacggcaactcctgcctgggctgcggcgagttcaagacgtgcaaccccgagggctgccccgaagtgcggcgcaacaccccctggacgccgtggctgcccgtgaacgtgacgcagggcggggcacggcaggagcagcggttccgcttcacctgccgcgcgccccttgcagacccgcacggcctgcagttcggcaggagaaggaccgagacgaggacctgtcccgcggacggctccggctcctgcgacaccgacgccctggtggaggtcctcctgcgcagcgggagcacctccccgcacacggtgagcgggggctgggccgcctggggcccgtggtcgtcctgctcccgggactgcgagctgggcttccgcgtccgcaagagaacgtgcactaacccggagccccgcaacgggggcctgccctgcgtgggcgatgctgccgagtaccaggactgcaacccccaggcttgcccagttcggggtgcttggtcctgctggacctcatggtctccatgctcagcttcctgtggtgggggtcactatcaacgcacccgttcctgcaccagccccgcaccctccccaggtgaggacatctgtctcgggctgcacacggaggaggcactatgtgccacacaggcctgcccagaaggctggtcgccctggtctgagtggagtaagtgcactgacgacggagcccagagccgaagccggcactgtgaggagctcctcccagggtccagcgcctgtgctggaaacagcagccagagccgcccctgcccctacagcgagattcccgtcatcctgccagcctccagcatggaggaggccaccgactgtgcagggttcaatctcatccacttggtggccacgggcatctcctgcttcttgggctctgggctcctgaccctagcagtgtacctgtcttgccagcactgccagcgtcagtcccaggagtccacactggtccatcctgccacccccaaccatttgcactacaagggcggaggcaccccgaagaatgaaaagtacacacccatggaattcaagaccctgaacaagaataacttgatccctgatgacagagccaacttctacccattgcagcagaccaatgtgtacacgactacttactacccaagccccctgaacaaacacagcttccggcccgaggcctcacctggacaacggtgcttccccaacagctgataccgccgtcctggggacttgggcttcttgccttcataaggcacagagcagatggagatgggacagtggagccagtttggttttctccctctgcactaggccaagaacttgctgccttgcctgtggggggtcccatccggcttcagagagctctggctggcattgaccatgggggaaagggctggtttcaggctgacatatggccgcaggtccagttcagcccaggtctctcatggttatcttccaacccactgtcacgctgacactatgctgccatgcctgggctgtggacctactgggcatttgaggaattggagaatggagatggcaagagggcaggcttttaagtttgggttggagacaacttcctgtggcccccacaagctgagtctggccttctccagctggccccaaaaaaggcctttgctacatcctgattatctctgaaagtaatcaatcaagtggctccagtagctctggattttctgccagggctgggccattgtggtgctgccccagtatgacatgggaccaaggccagcgcaggttatccacctctgcctggaagtctatactctacccagggcatccctctggtcagaggcagtgagtactgggaactggaggctgacctgtgcttagaagtcctttaatctgggctggtacaggcctcagccttgccctcaatgcacgaaaggtggcccaggagagaggatcaatgccataggaggcagaagtctggcctctgtgcctctatggagactatcttccagttgctgctcaacagagttgttggctgagacctgcttgggagtctctgctggcccttcatctgttcaggaacacacacacacacacactcacacacgcacacacaatcacaatttgctacagcaacaaaaaagacattgggctgtggcattattaattaaagatgatatccagtc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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