LOCUS       NM_001182961            2994 bp    mRNA    linear   PLN 30-JUN-2025
DEFINITION  Saccharomyces cerevisiae S288C Nma111p (NMA111), partial mRNA.
ACCESSION   NM_001182961
VERSION     NM_001182961.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K.,
            Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R.,
            Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P.,
            Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F.,
            Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A.,
            Hani,J. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
            and its evolutionary implications
  JOURNAL   Nature 387 (6632 SUPPL), 93-98 (1997)
   PUBMED   9169873
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 2994)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (30-JUN-2025) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2994)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2994)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 2994)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 2994)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001146).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XIV"
     gene            <1..>2994
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /db_xref="GeneID:855600"
     CDS             1..2994
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:14657274|PMID:14562095]"
                     /experiment="EXISTENCE:direct assay:GO:0008236 serine-type
                     peptidase activity [PMID:18946088]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004252
                     serine-type endopeptidase activity [PMID:29861160]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid
                     metabolic process [PMID:16470384]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006915
                     apoptotic process
                     [PMID:16608876|PMID:14657274|PMID:16470384]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein
                     catabolic process [PMID:18946088]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0033554
                     cellular response to stress [PMID:29861160]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0034605
                     cellular response to heat [PMID:18946088]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0120174
                     stress-induced homeostatically regulated protein
                     degradation pathway [PMID:29861160]"
                     /experiment="EXISTENCE:physical interaction:GO:0006629
                     lipid metabolic process [PMID:16470384]"
                     /note="Serine protease and general molecular chaperone;
                     cleaves Roq1p, which modifies the substrate specificity of
                     the Ubr1p Ub-ligase, promoting the stress-induced
                     homeostatically-regulated protein degradation (SHRED) of
                     misfolded and native ER-membrane and cytosolic proteins;
                     chaperone activity involved in the heat stress response;
                     promotes apoptosis through proteolysis of Bir1p; role in
                     lipid homeostasis; mammalian Omi/HtrA2 serine protease
                     family member"
                     /codon_start=1
                     /product="Nma111p"
                     /protein_id="NP_014276.1"
                     /db_xref="GeneID:855600"
                     /db_xref="SGD:S000005067"
                     /translation="

MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYTDHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHAITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDNKETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDTTGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSADILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVKYDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIPRYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIMDCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNIVDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGISATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPTAELKRDNITHKWIEKEFTGNSQSEK"

     misc_feature    <124..273
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="Family of unknown function (DUF5923); Region:
                     DUF5923; pfam19343"
                     /db_xref="CDD:466049"
     misc_feature    304..1170
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="Periplasmic serine protease, S1-C subfamily,
                     contain C-terminal PDZ domain [Posttranslational
                     modification, protein turnover, chaperones]; Region: DegQ;
                     COG0265"
                     /db_xref="CDD:440035"
     misc_feature    895..1161
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="circularly permuted first PDZ domain (PDZ1) of
                     Saccharomyces cerevisiae pro-apoptotic serine protease
                     Nma111p and related domains; Region: cpPDZ1_ScNma111-like;
                     cd06786"
                     /db_xref="CDD:467625"
     misc_feature    order(901..924,973..975,982..984,1072..1077,1084..1086)
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467625"
     misc_feature    1174..1407
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="PDZ-like domain; Region: PDZ_1; pfam12812"
                     /db_xref="CDD:372324"
     misc_feature    1714..2595
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="Periplasmic serine protease, S1-C subfamily,
                     contain C-terminal PDZ domain [Posttranslational
                     modification, protein turnover, chaperones]; Region: DegQ;
                     COG0265"
                     /db_xref="CDD:440035"
     misc_feature    2314..2586
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="circularly permuted third PDZ domain (PDZ3) of
                     Saccharomyces cerevisiae pro-apoptotic serine protease
                     Nma111p and related domains; Region: cpPDZ3_ScNma111-like;
                     cd10827"
                     /db_xref="CDD:467627"
     misc_feature    order(2320..2343,2386..2388,2395..2397,2488..2493,
                     2500..2502)
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467627"
     misc_feature    2611..2850
                     /gene="NMA111"
                     /locus_tag="YNL123W"
                     /gene_synonym="YNM3"
                     /note="second and fourth PDZ domains (PDZ2 and 4) of
                     Saccharomyces cerevisiae pro-apoptotic serine protease
                     Nma111p and related domains; Region: PDZ2-4_Nma111p-like;
                     cd06719"
                     /db_xref="CDD:467617"
ORIGIN      

atgaccatatcgttgagcaatataaagaaaagagaccattctaaaatttccgatggaacttctggtgaatcatcgcttgtaaaaaggaaacagttggaaagcgccaccggagatcaagaggaagaatatacagaccatgaaatcattatagagccgttgcactttgctaataataataacactgtactcacagattcagaaaattatctaagatggcaaaataccatctccaacgttgttaaatcagtggtttccattcatttttcacaagttgcgccattcgattgcgattctgctttggtatctgaagctaccggatttgtcgtggatgctaaattaggtataattctgaccaataggcacgtcgttggtcctggtccgttcgtaggctacgtagttttcgataatcatgaagaatgcgatgttataccaatttacagagatcctgttcatgattttgggttcctcaaattcgatccgaaaaacataaaatattctaagatcaaagcgttaacgctaaaaccaagtttggctaaggtcggctcagaaattagagttgtcggtaatgatgccggtgagaaattaagtatcctagcaggttttattagtagaattgacaggaacgctccagaatatggtgagctgacatacaatgacttcaatacagaatatattcaagctgctgcatctgcttctggcggttcaagtggttctccagtcgtaaatatagatgggtatgctgtggctttacaggcaggtggctctacagaggcatctactgatttttttttaccgttagatagaattcttagagcgttaatttgcatccaaaccaacaaacctatcacacgtggtacgattcaagttcaatggctgctgaagccttatgacgagtgtagaagattaggtttaacttcagagagagaaagtgaggctcgtgctaaatttcccgaaaatatcggactgttggtagcagaaaccgttttaagagaaggcccaggctatgataaaattaaagaaggtgatactctaatttcaataaacggtgaaaccatatcttctttcatgcaagtggataaaattcaagatgaaaatgttgggaaggaaatccaattggttattcaaaggggcggtgtcgaatgtactgtcacctgcactgttggtgatttacatgctatcacccctcatcgttatgtagaggtttgtggtgcgacttttcatgaattatcatatcaaatggcaaggttttatgcgctacctgtcaggggtgtatttttaagtagtgcatcagggtctttcaactttgattcaaaagaaagagtgggttggattgtggattctatagacaataaggaaacccccgacttagatacatttattgaaattatgaaaactattccagatcgtaagcgcgttactgtacgataccaccatctaacagatcagcattctccacttgttacttctatttacattgaccgtcattggtgcaatgaattcagagtttacacaaggaacgatacaactggtatttgggattacaaaaatgttgctgatccacttccagccgatgcgttgaaacctcgttcggccaaaattattcctattcctgttaataatgaaaaagttgcaaaattgtcatcatcgttatgtacagtggctacaatggcagcagttccattggattcactttctgctgatattttaaaaacatcaggcttaatcattgatgctgaaaaaggttatgtcctagtgtccagaagggtagttccacatgattgtcttgatacttttgtcaccattgcagattcccttgtagttccagccacagtagaatttctccatccaactcacaacttcgctattgttaaatatgatccagagttagtaaaggctccactaatcactcccaagctatctaccaccagaatgaaacgtggtgataagcttcagtttataggttttacccagaatgatagaattgttacttcagagaccactgtcaccgatatttcctctgtaagtattccaagtaatttaattccgaggtaccgtgccactaatttagaagctatatctatcgactgcaacgttagcaccagatgtaattccggtattttgacagataatgatggtacagtaagaggtttatggcttccatttttaggcgaaagattagaaaataaagaaaaggtttatttgatgggattagatataatggactgtagggaagttatagatatcttaaaaaatggcggtaaaccaagagtaagtatagttgatgctgggttcggttcaatttccgttctgcaagccagaattagaggtgtgcccgaagaatggatcatgcgtatggaacatgaatcaaataacaggctacagtttatcactgtttctagagtttcttatacagaagacaagattcatttagagaccggtgacgtcattttatctgtgaacggaaaattagtcactgaaatgaatgatttgaatggagttgtaagctcagctgatggtattttgccatcagccatgttagattttaaagttgttcgtgatggtaatattgttgatttgaaaattaaaaccgtggaagttcaggaaaccgaccgttttgtaatatttgcaggtagtatcttacaaaagccgcatcatgctgttttgcaagctatggttgatgttccaaagggtgtctactgtacattcaggggagaatcgtcaccggcgctccagtacggtatatctgccacaaacttcataactcatgtcaatgaaattgaaacacctgatctagatacatttttgaaagttgtcaaaacaatccctgataatagttattgtaaaatgaggttaatgactttcgacaatgtgcccttcgctatttcactgaaaacgaattatcattacttccctactgcagaattgaagagggacaacatcacgcacaaatggattgaaaaggaatttaccggcaacagccaaagtgaaaaatag

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