LOCUS       NM_001037774            2285 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus claudin 8 (Cldn8), mRNA.
ACCESSION   NM_001037774 XM_221709
VERSION     NM_001037774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Molina-Jijon E, Rodriguez-Munoz R, Gonzalez-Ramirez R,
            Namorado-Tonix C, Pedraza-Chaverri J and Reyes JL.
  TITLE     Aldosterone signaling regulates the over-expression of claudin-4
            and -8 at the distal nephron from type 1 diabetic rats
  JOURNAL   PLoS One 12 (5), e0177362 (2017)
   PUBMED   28493961
  REMARK    GeneRIF: the participation of aldosterone (ALD), and the effect of
            spironolactone (SPL), a mineralocorticoid receptor antagonist, on
            the expressions of claudin-2, -4, -5 and -8, and occludin in
            glomeruli, proximal and distal tubules isolated from diabetic rats,
            was evaluated.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima
            T, Yamashita T and Sawada N.
  TITLE     Differential expression and subcellular localization of claudin-7,
            -8, -12, -13, and -15 along the mouse intestine
  JOURNAL   J Histochem Cytochem 54 (8), 933-944 (2006)
   PUBMED   16651389
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem
            P, Lehrach H, Yaspo ML and Janitz M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Ohta H, Adachi H and Inaba M.
  TITLE     Developmental changes in the expression of tight junction protein
            claudins in murine metanephroi and embryonic kidneys
  JOURNAL   J Vet Med Sci 68 (2), 149-155 (2006)
   PUBMED   16520537
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Morita K, Furuse M, Fujimoto K and Tsukita S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099804.1.
            
            On Dec 16, 2005 this sequence version replaced XM_221709.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC099804.1, DN932765.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2285
                     /gene="Cldn8"
                     /note="claudin 8"
                     /db_xref="GeneID:304124"
                     /db_xref="RGD:1308575"
     exon            1..2250
                     /gene="Cldn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..680
                     /gene="Cldn8"
                     /codon_start=1
                     /product="claudin-8"
                     /protein_id="NP_001032863.1"
                     /db_xref="GeneID:304124"
                     /db_xref="RGD:1308575"
                     /translation="

MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFENRWEGLWMNCMRHANIRMQCKVYDSLLALSPDLQASRGLMCAASVLSFLAFMTAILGMKCTRCTGEDENVKSRILLTAGIIFFITGLVVLIPVSWVANAIIRDFYNPLVDVAQKRELGEALYIGWTTALVLIAGGALFCCVFCCTERSNSYKYSVPSHRTTQRSFHAEKRSPSIYSKSQYV"

     misc_feature    15..548
                     /gene="Cldn8"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
ORIGIN      

ccatggcaacctacgctcttcaaatggctgccctggtgcttggtggtgttggcatggtgggcacagtggctgtgacgatcatgcctcagtggagagtgtctgccttcatcgaaagtaacattgtcgtgtttgagaaccgctgggaaggtttgtggatgaactgcatgaggcatgccaacatcagaatgcagtgtaaggtctatgactccctgctggctcttagtccagacctccaggcatccagaggactgatgtgtgctgcgtccgtcctgtccttcttggctttcatgacagccatcctcggaatgaagtgcaccaggtgcaccggggaggacgagaacgtgaagagccgcatcttgctgacggctggaatcatcttcttcatcaccggcttggttgtgctcatccctgtcagctgggttgccaatgccatcatcagagacttctacaacccgctggtggatgtggcccaaaagcgcgagcttggtgaagccctctacataggctggaccacggcgctggtgctgatcgctggaggagcactgttctgttgcgtgttttgctgtactgaaaggagtaacagttacaagtactcggtaccatcccatcgcaccactcagaggagtttccacgccgaaaagagatccccgagcatatactccaaaagtcagtatgtgtagctgtgtgtgtatattttagctgtagctataaagcgaagctttataaatcactgaaccagccactattttatagaaatggaacccacagtgtttccatttacctttcttaactgcctcgtactcattacaggaaatacgcagcgtctatgattccataaatgattttagcagaatgaggtattatgcacactgcttcaattgttccagaaagcatagccatttgttttctaaaatggttcacgcggttcttcttttatcagtcactctaagacgacccatcgaaagactgttggtttaagctgcgatttctctgtgtcatggcattatacaagtaatgcgagtggcagttatagctcacacaaatagagacaggcttatgtggttctatttaaagtgaaatgccaatccatcaggctgaataaacagaactcagctattgcatttcaggggacctggggataaaaggaaagaaggctgatattaattgcctaaaaacagcttaaggattagtgcactctatttatagcaaaggttaaaatgaaggctttcatcattagtgtaagggaaactgaatggctttctgatcgcctgctttgcagcctccaggagttaaaaatcctgtcacctttatcctttatccacgtgccttttttttttctgattgtgttccttagtatcttttaaagtttaaagcagatattgtaacaaaatattttttttcttcagactacgtttgtaaggctgggctaacaagagagataaagcagtggtcttagaaaaattaacgttttcagaaaaatgactttaccttagcctttctctttagagaagaatgtattgtttttaaaatgaagtcacatcatataaaaggggccgttcaagtgctatttgtgcatacctttttgggaatttttctgtataaataagagaggaaaaagaatattttgtcatttacttaccccaaagaggtacaatccctccaaatccaaaaacttgtcctctttcaactcttgtcattcaatcaaagttgtcatttctgttctgttggaggtgatttcctctttttctatgtctttgctaagttttattaaagtgtggtatcactgtgtgtttcctcctaatttgagacaactattaaggtaataccaaatttcatatatatgacttttatattggtaaattgtatcttttataacaatatagcatttcttacatttacattctttttcattactttgcacaagtgtttaaaacttggcattgacaatttatgtttgaacatagatttcgtgttcattttttctggtgcggtgtaggatttaaatcaatttactttataatgacctgactcatgcattaatatttgattaatatattaataatactaagttctacttaggtccagtgaaatgtgtttgctgtaaatattgtgtatgtaatcatatttttaaaagttgtccatatgtatttcaacttctgagaattcgtttgaattaaaaacaaagctgaatgatttgggagtatgcaccatatttatgtgaagtatattattaaaactttgcaatactaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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