LOCUS       XM_021467292            7710 bp    mRNA    linear   VRT 15-JUN-2017
DEFINITION  PREDICTED: Danio rerio CDC42 binding protein kinase alpha
            (DMPK-like) a (cdc42bpaa), mRNA.
ACCESSION   XM_021467292
VERSION     XM_021467292.1
DBLINK      BioProject: PRJNA13922
KEYWORDS    RefSeq; corrected model.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_007128.7) and transcript sequence (GDQH01012544.1) annotated
            using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Danio rerio Annotation Release 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            assembly gap :: added 118 transcript bases to patch genome assembly
                            gap
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               BX248131.6         89727-89904         c
            179-270             BX248131.6         59869-59960         c
            271-354             BX248131.6         47681-47764         c
            355-450             BX248131.6         47182-47277         c
            451-599             BX248131.6         37700-37848         c
            600-693             BX248131.6         5017-5110           c
            694-894             FO818681.2         28480-28680
            895-1143            FO818681.2         29506-29754
            1144-1223           FO818681.2         30127-30206
            1224-1384           FO818681.2         31426-31586
            1385-1507           FO818681.2         34182-34304
            1508-1641           FO818681.2         36549-36682
            1642-1884           FO818681.2         37758-38000
            1885-1995           FO818681.2         38232-38342
            1996-2243           FO818681.2         40733-40980
            2244-2325           FO818681.2         41460-41541
            2326-2429           FO818681.2         50559-50662
            2430-2535           FO818681.2         53107-53212
            2536-2684           FO818681.2         53673-53821
            2685-2776           FO818681.2         55749-55840
            2777-2853           FO818681.2         56289-56365
            2854-2892           FO818681.2         56648-56686
            2893-3012           FO818681.2         59827-59946
            3013-3015           FO818681.2         60542-60544
            3016-3121           FO818681.2         61736-61841
            3122-3258           FO818681.2         61932-62068
            3259-3398           FO818681.2         66158-66297
            3399-3480           FO818681.2         66380-66461
            3481-3700           FO818681.2         68946-69165
            3701-3763           FO818681.2         71252-71314
            3764-4363           FO818681.2         74184-74783
            4364-4461           FO818681.2         77858-77955
            4462-4546           FO818681.2         78104-78188
            4547-4670           FO818681.2         82042-82165
            4671-4788           FO818681.2         84535-84652
            4789-4906           GDQH01012544.1     2971-3088           c
            4907-5067           FO818681.2         89201-89361
            5068-5142           FO818681.2         92259-92333
            5143-7710           CU462878.9         99694-102261        c
FEATURES             Location/Qualifiers
     source          1..7710
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="17"
     gene            1..7710
                     /gene="cdc42bpaa"
                     /note="The sequence of the model RefSeq transcript was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: added 118 bases not found in
                     genome assembly; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 4 Proteins, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments"
                     /db_xref="GeneID:567912"
                     /db_xref="ZFIN:ZDB-GENE-120727-12"
     CDS             1..5274
                     /gene="cdc42bpaa"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: added 118 bases not found in
                     genome assembly"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK alpha"
                     /protein_id="XP_021322967.1"
                     /db_xref="GeneID:567912"
                     /db_xref="ZFIN:ZDB-GENE-120727-12"
                     /translation="

MSGEVRLKKLEKLILDGPVQANGQCFSVESLLDVLICIYDECTNSPLRREKNVAEFLEWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKSSDKVFAMKILNKWEMLKRAETACFREERDVLVNGDSQWITTLHYAFQDDNFLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIDSVHQLHYVHRDIKPDNILIDVNGHIRLADFGSCLKLTEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQMTDVSENAKDLIRRLICCREHRLGQNGIEDFKQHPFFSGIDWQNIRNCDAPYIPEVSSPSDTSNFDVDDDCLKNTETMPPPSHTAFSGHHLPFVGFTYTSNCTLSDRGCLRESAAPAQMDVCVQRGLEDSLATEAYERRIRRLEQEKLELGRKLQESTKAVQALQYSSSDGPVSSNREFEIRGLKEEIEMLKKQIADTGQVEQQLEQAISARSDMEDSSKQIRSLEKQLKSTKQERDDLQKRLQESSDKQKVQGKELKEADSQRKMAMQEFAEVSEKVTELRSLKQRLTRQLRDKEEELDSLNQKVEALRLDVRKAERAKKEMEVQAEEWSAEAQKEKKLRERSEQFSRQLEEELDSIKQKHVGRSPSTGSSEQNQELSKLRADLEKKTVHFKEELSRIEQQHANELKSLKKELKESEGQQLSLKKEIMMLKDKLDKSRRESHSERDELEFERVLLSEENKKLSSELDKLSCSNKQLEEKIRVLADEKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLKNASLGARATDMPWKVRRLAKLDMSARLELQSALDAEIKAKQTIQDELNKVKASHMATECKLEESEKQNQDLQAEIQRLKQETDNLRMSKGVKHQDSQNSFLAFLNAPTSALDQFDRSTASGPAGKGRRIDSIDNFSLSNTPSREEDGRSQATSHSRSPSTTSDVESHEQPKAHQFVVKTFNTPTKCNQCTSLMVGIIRQGCTCEVCNFSCHVTCADKAPAVCPIPPDQTKGPLGIDPQKGIGTAYEGHVKVPKPLGVKKGWQRAIAVVCDFKLFLYDLPEGKAAQPGVVVNQVIDMRDEEFSVSPVLASDVIHANRKDIPCIFRVTASQLCASSNKKCSILILADSDQERTKWVGLLKELHRLLKKSKLKERFVYVPKEAYDCALPLIKTTQSAAIIDHERIALGNEEGLYVIHVTKDEIIKVGDNKKVHQIELIPSEQLIAVISGRNGHVRLYPMTALDDRDVESYKIAETKGCQTLLSGTIRHGSLTCLFVAMKKPDKVIVYELNKSKARHRKLREILVPGSVQWMGLQGEKLCVGFQSGFLRYSLQGDGGTSSLLHPDDHTLGFIEQLGLDSLCAVEISSKELLLCFSSIGIYVDYQGRRSRQQELMWPATPTACRYNAPYLSVYSENAVDVFDVNTMEWIQTIPLKKVHPLNSDGSLNLLGLETVRLIYFKNKTAEGDELVVPETSDNSRKQMVRSTASKRRFSFRIPEEERVLQRREMLRDPEIRNKLISNPTNFNHVVHMGPGDGIQILKELPMNMRSQESRGVLGASVSIPSISRTRPEPGRSMSASSGLGTRSSSQNGSALRQDFSVGNYGSTKRQMTSPSDGSLSSGGGMDCGGDAPLSQFDREWPGVSPTEKTPDLKRALRTLLSKLKDSESPRHSTASNSSNLSSPPSPSSPHKSKTQSLERGEHLGWGT"

     misc_feature    10..1236
                     /gene="cdc42bpaa"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl21453"
                     /db_xref="CDD:451246"
     misc_feature    order(247..258,265..267,271..273,310..312,316..318,
                     412..414,460..471,601..603,613..618,622..624,652..657)
                     /gene="cdc42bpaa"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270870"
     misc_feature    <1297..>2775
                     /gene="cdc42bpaa"
                     /note="DNA repair exonuclease SbcCD ATPase subunit
                     [Replication, recombination and repair]; Region: SbcC;
                     COG0419"
                     /db_xref="CDD:223496"
     misc_feature    1582..1818
                     /gene="cdc42bpaa"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; Region: KELK; pfam15796"
                     /db_xref="CDD:434944"
     misc_feature    3019..3198
                     /gene="cdc42bpaa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase alpha (MRCK alpha) and similar proteins; Region:
                     C1_MRCKalpha; cd20864"
                     /db_xref="CDD:410414"
     misc_feature    order(3040..3060,3082..3096,3103..3105)
                     /gene="cdc42bpaa"
                     /note="putative DAG/PE binding site [chemical binding];
                     other site"
                     /db_xref="CDD:410414"
     misc_feature    3202..3609
                     /gene="cdc42bpaa"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; Region: PH_MRCK;
                     cd01243"
                     /db_xref="CDD:269949"
     misc_feature    3700..4479
                     /gene="cdc42bpaa"
                     /note="CNH domain; Region: CNH; pfam00780"
                     /db_xref="CDD:425867"
ORIGIN      

atgtctggggaagtgcgtttgaaaaagctggaaaaactgatcctggatggtcctgtccaggctaatggacagtgttttagtgtggaaagtcttctggatgttctcatctgcatttatgatgagtgcaccaactccccactgagaagagagaaaaatgttgctgagtttttggaatgggccaaaccgttcacctctaaagtgaaacagatgcgattgcacaaggaggacttcgagatactgaaggtcattggtcgaggagctttcggcgaggtagcagttgtaaaggtgaaaagttcagacaaggtgtttgccatgaagatcctcaacaagtgggagatgctgaaacgagcagagacagcatgttttcgggaggaacgggatgtgctggtgaacggggacagtcagtggatcaccacactacactacgcttttcaggatgacaacttcctgtacctggtgatggattactatgtgggcggtgacctcttgactctcctcagcaagtttgaggatcgtttaccagaggacatggcccgcttctacctggcggagatggttctggccatcgattctgtgcatcagctccattacgtccacagagacattaagccagataacatcctcatagatgtgaacggacatattcgactcgcagatttcggctcctgtctgaaactcacggaggatggaacggtgcagtcgtctgttgctgtgggcacgccagactacatctctcctgagatcctgcaggccatggaggatgggaaagggaaatatggccctgaatgtgactggtggtcactgggtgtttgcatgtatgaaatgctctatggggaaactcctttctatgctgagtccctggtggaaacctatggcaagattatgaaccacaaggaacggttccagtttcctgctcaaatgacggacgtgtctgaaaatgccaaagatctgatccgcagactcatctgctgcagagagcacaggctagggcagaacggcatcgaggacttcaaacaacaccccttcttctctggcattgactggcagaacatccgcaactgtgacgccccctacatccctgaagtcagcagcccgtctgacacatcaaactttgacgtggacgacgactgcctcaagaacacggagacgatgccacctccttcccacaccgctttttcaggacaccatctcccatttgttggattcacctacaccagcaactgtacactctctgatcggggttgcctgcgtgagtctgcggctccagcacagatggatgtttgtgttcagcgcggcctggaggacagtctggccactgaggcgtacgagaggaggattcgccgtctggagcaggagaaactggagctcggtcgcaagctacaagagtccacaaaagcggtacaggctctgcagtattccagctcggatgggcctgtttcctccaacagagagtttgagatccgcggactgaaggaggagatagaaatgctaaaaaaacagattgcagatacaggacaggtggagcagcagctggaacaagccatttctgcacgcagtgatatggaggactcctccaaacagatccggtctctggaaaaacagctcaagagcacaaagcaggagagagatgacctgcagaagcgtctgcaggagtcctcagacaagcagaaagttcaggggaaggagctgaaggaggccgacagtcagaggaaaatggccatgcaggagtttgcggaggtgagcgagaaagtgacggagctgaggtcactcaaacagcgtctgacccgacagctacgggacaaagaggaggagctggattcactcaatcagaaggtggaggcgcttcggctggatgtgcgcaaagcagagagagccaagaaagagatggaggtccaggctgaagagtggtctgctgaggctcagaaagagaagaagttgagggagcgcagcgagcagttcagcagacagctggaagaagagctggacagcatcaagcagaagcatgtgggccgctctccaagcacggggtcgtctgagcagaaccaagagcttagtaaactacgagcagacctggaaaagaagacggtgcacttcaaagaagagctttcccgcatagaacagcaacatgccaatgaactgaagagcctgaagaaggaactgaaagagtcagagggacagcagctcagcttgaagaaagagatcatgatgcttaaagacaagctggacaagtcccgcagagagagtcatagcgaacgagacgagcttgagtttgagcgagtgctgctgtctgaagaaaacaagaaactgtccagtgaactcgacaagttgagctgcagtaacaaacagctggaggagaagattagagtactggctgatgagaaagagagcgtggctcactgggaggcccaaatcacagaaatcattcagtgggtcagtgatgagaaagatgctcgaggatatctgcaggctttggccactaagatgacagaggaactggaaggcctgaagaatgccagtttgggtgcacgtgccactgacatgccatggaaggtgagacgtctggccaaactggatatgtctgcccgtctggaactgcagtctgcactggatgctgagattaaagccaaacaaaccatccaggatgagctcaacaaagtcaaggcatcccatatggctactgagtgcaaactggaggagtcggaaaagcaaaaccaggacctgcaggcagagatccagaggctgaaacaagaaacggacaatctgcgcatgtctaaaggtgtcaagcaccaagactcccagaattccttcctggcattcctcaatgctccaacctcagctctggatcagtttgatcgctccactgccagtgggccggctggtaaaggcagacgtattgattccattgataacttcagcctctccaacacaccgtcacgggaggaagatggaagatcccaggcgacgtcccactctcgctcgccctctaccactagcgacgtggagtctcatgagcagccaaaagcccatcagtttgtggtgaaaaccttcaacacacctactaaatgtaaccagtgtacgtctctgatggtggggatcatccgtcagggctgcacgtgtgaagtctgtaacttctcctgtcatgtgacgtgtgcggataaagctcccgctgtgtgcccgatcccaccagatcaaaccaaaggaccgctcggcatcgaccctcagaagggcatcggcacagcatatgagggccacgtaaaggtgcccaaacctttaggcgtgaaaaagggatggcagagggccattgctgtggtctgtgacttcaaactcttcttatatgatctcccggaaggcaaagctgctcagcctggtgtcgtggtgaaccaggtcattgacatgagggatgaggaattttctgttagccctgttttggcgtcagatgtcattcatgcaaacaggaaggatattccctgtatcttcagagtgacagcatcacagctctgcgcctccagcaataaaaaatgctccattttgatcctggccgacagcgatcaggaaagaacaaagtgggtcggccttttgaaggagctgcaccggctcttgaagaaaagcaaactgaaagaacgctttgtttacgtccctaaagaagcatatgactgcgcactgcctctcatcaaaaccacacagtctgctgctattatagatcatgagaggattgctctgggaaacgaggaggggttatacgttattcatgttaccaaagatgaaattatcaaagtaggggacaacaaaaaggttcatcaaatcgaactgatcccatcagagcagttgattgctgtgatatccggccgaaatggccacgtgcgcttatacccaatgacggcactggatgatcgcgatgtcgaatcctacaagatagccgaaaccaaaggctgccaaactctcctttctggcacaattagacacggatctctcacctgtctctttgtggccatgaagaaacccgacaaggtgatcgtctacgagctcaacaaaagcaaagcgcgtcatcggaagctgcgggaaatcctggtcccgggaagcgtgcagtggatggggctccagggcgagaagctttgcgttggttttcagtctgggtttttgcgctacagtcttcagggcgatggaggcaccagcagcctcctccatcctgatgatcacacgctgggcttcattgagcagctcgggcttgactctctgtgtgctgtggagatctccagtaaagagctgctcttgtgttttagcagtataggcatatatgtggactatcaaggcagacggtcacgacagcaggagctgatgtggccggcgacaccaactgcatgtcgttataatgcaccttatctgtcagtgtacagtgagaatgcggtagatgtatttgatgtcaacactatggagtggattcaaacaattcctttgaaaaaggtccatccactgaactctgatggctctctaaacctgctggggctggagactgtacggctcatctacttcaagaacaagacagcagagggagatgagctggtggtgccagagacatctgacaacagtcgcaaacagatggtgcgcagtacggcgagcaaacgccgcttttctttccgcataccggaggaggagagagttctgcagaggagggagatgctgagagacccagaaataaggaataagttgatttcaaacccaactaacttcaaccatgtggttcatatgggtccgggagatgggatccagatcctgaaagaactgccaatgaacatgcgctctcaggagagccgcggtgttctgggagcatctgtcagcatcccctccatcagcaggaccaggcctgaaccaggccgatctatgagcgccagtagcggccttggcacacgctcctcctctcaaaacggcagcgcactgagacaggacttttctgtcggcaactatggttccaccaaacggcagatgacatcaccatctgatggctctctgtcatccggagggggcatggactgcggtggtgatgcccccctctcccagttcgacagagagtggccgggagtttcacccacagagaagacccctgatctgaaaagggctttaaggaccctgcttagtaagctaaaggattcagagtctccacgtcactccacagcctccaacagctcaaacctgagcagccccccaagcccttcatccccacacaagagcaagacccaatctctggagcgcggcgagcacctcggctggggcacatgagcaactctgaccagaaatcaccaaaaaatcaagacgtccagccatcctctggctccttctctgctaccaacagagtcacacatttaaccaagaccaagagccgactccttataaatcatattcccaaacatggcgctgggggccaggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgagagtgactgagtgagtgtgtttgcgtgtattagtgtgcatatgcataacacgtgtgattgcgataaacacgcatattactgtgcaccttacatcccttcaccactgatactgtgttggatggagaaacagaccactgagtgtagctgatccaccaggtgtgtgttgcgggtggagaaaaagacaaatataaagctttaacgtgagtttatcagtgtgcctgattttacgtatgtattcagaagtcttaatggaccccgtgggaatgttactttaaatgcataacacaaaaaaattacagtcgttaagaatcgtgggaactttgaacttaaacctaatatggaaacgctattattaagttgcgccctgataagatatagcgccccctgtctgtggcactactgtataactctgtagcctctaccctccagtgccatgcagaccttcacattcagaggtcaagaagagattgtgagttcaataatgtaaatagagttttagtagagtataatatattatggaatcgttaaacactattttgttgatgataaataagtatggctttttaagagagagatttctttcctttggatttttttttttcgtggcaaggttattgtcggtttaaggattactttgtcaagatgctttttttgtttcgttatttccactgaaattgctcagattaagattaggaaagggaacactacgcaaacttgtggggcgtcatttgtgaaacacaatattaattttgtttgtgtgtgtaaatcattcgtaaggcgttcttatctaaatttattcattgtactgcatatgacattagctcggaatgaagtcgttcttaaaatttagagctgtggcaaacaacattattcgagaaatcatttctgagatttttaaaatgcatcgtcattttctcctgaatggattctgagcttaggtttttcattcattcattcccttcggcttagttcctttattaaacaggggtttgggatgggatgggactgacccatcatgccacccagcttaggtttttatttttttattgaaggaaaagaaaaccttcacacataaaaacagtaaacattgcagtttccttctttctatttttgttttatcctaagatctgaacatcccaaggcagcttaacacaataattagggtcaaatacaatgatatcattgaaaatacaatgtaatctatattcagtctaactgctcacaacgtctacattaaacctaaaataatcattaataaagttgggaaaggtttaagcaaattacaggagtgtttatagtgagctgagtttacacaaatcttgtaaacttacatgacacaagctttctttctcatgagcatttccgtgtacgtaatttttttttgttgcctagaacgccatctgctgttataaagctaatcgcagaattgatttaaaaatagaattttacaaatatttcaatctatttctctaattatttttgccacagctttaatgaagaccatcatgtgcaaattgtcttgggcaaattttccttgggctcagtccctttataaatcaggggccgccacagtcgaatgaacctccaacttatccagaattttttttacacagtggatgtcacccgaaatcacgacattgcaaaaaaaaactattatagaaaatatttgaacagctcaagtaaaattgtaataaaataaatactgtaaaatcttatatatattgtcataacaaaagcaagatttgcaaggtcgtagtaaattattgtaaaaagtacctgtgtaagttttctgcataattgaagtttcacaaactaatttcaaaataaatttaattcggctgctctctcatcagtaatcatccgcaagccaatcagattattccaaactcactataaatatcccgtctagcattactcccttatctttgtttttgaagaatcccccatcttacctatctccttcttttcatcctttaccaaggggatctcttgagaactaccagatcttgtaccccccttatatgctcatcaaccaggcgggaaccctgggctcaattatttctgagttcagggttctctcttgggacagcatgccaaacctgctatcattatcaagcaatacctttcaagagtgtagactcttgaaattgttatgataaacaaacatttgtgatcgatgttcttattgtcgtgaaattggtccgaaattcatttgtcgttaaacaaattttcataaaattacaaaattcctaaaaaaa

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