LOCUS       XM_017358485            3160 bp    mRNA    linear   VRT 15-JUN-2017
DEFINITION  PREDICTED: Danio rerio mitogen-activated protein kinase 8b
            (mapk8b), transcript variant X1, mRNA.
ACCESSION   XM_017358485
VERSION     XM_017358485.2
DBLINK      BioProject: PRJNA13922
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_007123.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 15, 2017 this sequence version replaced XM_017358485.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Danio rerio Annotation Release 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="12"
     gene            1..3160
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="mitogen-activated protein kinase 8b; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 EST, 45 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 36 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
     CDS             224..1510
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8 isoform X1"
                     /protein_id="XP_017213974.1"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
                     /translation="

MNRNKREKEYYSIDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDHVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWSIGCIMAEMVRGSVLFPGTDHIDQWNKVIEQLGTPSQEFMMKLNQSVRTYVENRPRYAGYSFEKLFPDVLFPADSDHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEVEAPPPAITDKQLDEREHSVEEWKELIYKEVLEWEERTKNGVIRGQPASLGAAVSSDSHEPSTSSSSINDVSSMSTEVTLTSDTDSSQETSNGALHCCR"

     misc_feature    296..1303
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850"
                     /db_xref="CDD:270840"
     misc_feature    order(317..337,341..343,380..382,386..388,437..439,
                     479..481,545..565,569..574,674..676,680..682,686..691,
                     695..697,725..730,737..739,770..772,776..787,791..793,
                     902..904)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="active site"
                     /db_xref="CDD:270840"
     misc_feature    order(317..337,341..343,380..382,386..388,479..481,
                     545..565,695..697,725..727)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(437..439,569..571,674..676,680..682,737..739,
                     770..772,776..787,791..793,902..904)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(557..559,575..577,602..604,611..613,698..712,
                     1190..1195,1199..1201,1208..1210)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(725..757,767..793)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; mapk8; zgc:112379"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270840"
ORIGIN      

accgtgacgtagtacgcaagtgtccgcagctcaagtaaaggcctgccagtggacggaaacgcagtgcttgtgtcttgtgtggaaagacaaatacaacaacccgctgagaagaccccagtgtttttatgattctacacttgaattgtctgttcatcttttaggaggatttttgaaggtgaagctcttcttgaatgcccaggatacagtcagtacggttttcatcatgaacaggaataagcgcgagaaagaatattacagcatagatgtaggagattcaacgttcaccgttttgaagcgctatcagaatttaagaccaatcgggtccggagcacaaggcatcgtctgctcagcgtatgaccacgtcctcgatcgaaatgtggcaattaagaaactcagccgaccctttcaaaaccaaactcatgccaaacgggcctacagagaactggtcctgatgaaatgcgtcaaccacaaaaatataattggcttactaaacgtgttcacaccacagaagacacttgaagagttccaggatgtttatctggtgatggagctgatggatgcaaacctgtgtcaggtgattcagatggagctggaccacgagaggctgtcctacctgctctatcagatgctctgcggcattaaacacctgcacgctgctggcatcatacacagggatctgaaacccagtaatatagtagtgaaatcggactgcacgctgaagatcctggatttcggtctggcccgaacggctgcaaccggcctcctcatgactccttatgtcgtgacacgctattatcgggccccagaggtcatcctgggcatgggttatcaagctaacgttgatgtctggtctattggctgcatcatggctgaaatggtcagaggtagtgtgttgtttcctggcacagaccatattgaccagtggaataaagtgatcgagcagctgggcacgccgtcacaggagttcatgatgaagctgaatcagtctgtgaggacgtatgtggagaaccggcctcggtatgcgggatacagctttgagaagctcttcccagacgtgctcttccccgcagactcggaccacaacaaactcaaggcgagtcaggcacgagacttgttatccaaaatgctggtaatagatgcatccaagcggatctctgtagacgaggcgcttcagcacccctacatcaacgtttggtacgacccatcagaagtggaggcgccgccaccagcgatcacggataaacagctcgatgagagagaacactcagtggaagagtggaaagagctcatatacaaggaagtgctggaatgggaggagcgaacaaaaaatggagtgatcagaggacagccggcctcgctaggtgcagcagtgagcagtgactcccatgagccctcgacgtcgtcctcctccataaacgatgtgtcgtccatgtccaccgaggtcacgctgacctcagacaccgacagcagtcaggagacgtccaacggagcgctgcactgctgcagatgaccatccttcttcaacctccgtcaccctctgaaatccttcatcaccttccattgtcttctgtcatgattcttcatcctccaaaatgcttcatcaccttccaaaatcatctattgttctctgtcatggttcttcatcctccaaaatcctcccattggccttttaaaatcctccatcctcccctgtcaccttccaaaatcctctagccccctcaaatatgctctgttaccctctaaaatcctccatccttctttgtttaccatccaaaatcctcaatcgccctccaaattcctccattctcctcagttaccttccaaaatcctccattgtcttcattcaccctccaaaatcctccactaccccgtaaatcctccattaccctccaaaatccctcattgtgtttgtcaggattcttcatcctctgtcgccctccaaaatccttcattttcctccaaaatcctctgtcaccggcaaaatcctcctacattatccttcaaaatccttaattgccctccattttcctccagagtcctctgtcacctccaaaatctcttcattcacccttcaaaatactcagttgccctctaaaatcctctattttcctctagaatcctctgtcacctcccaaatcctcctcaatcgccctccaaaatcctctatcaccctctaaaatcctccatcacccttcaaaattctccatcacgctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcctccataacccttcaaaatctcccattaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcaccctccaaaattctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccattaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccattaccttccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccataacccttcaaaatctcccatcaccctccaaaatcatatatcaccctccaaaatcctccattaccctccaaaattctccatcatcctccaaaattctccatcatcctccaacattctccattaccctccaaaattctccatcaccctccagaatcgtccatcaccctccaaaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaatcctcaaactttcaagctcttgtcaattcaaaagtgtaagagtggcggggatagtttttttgagggcatctcaaaggcttttacaccaaaccagcattactttcactgctttcctgtttttattttgaactttgcatcaaattgaagctactgctacgtcgtcttgccattcggaagtggaatgattcaagtttatttgtaaagataaatggtgaatatat

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