LOCUS       XM_009294368            9864 bp    mRNA    linear   VRT 15-JUN-2017
DEFINITION  PREDICTED: Danio rerio argonaute RISC catalytic component 2 (ago2),
            transcript variant X1, mRNA.
ACCESSION   XM_009294368
VERSION     XM_009294368.3
DBLINK      BioProject: PRJNA13922
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_007130.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 15, 2017 this sequence version replaced XM_009294368.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Danio rerio Annotation Release 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9864
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="19"
     gene            1..9864
                     /gene="ago2"
                     /note="argonaute RISC catalytic component 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 22 ESTs, 5 Proteins, and 99% coverage of the annotated
                     genomic feature by RNAseq alignments, including 29 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:570630"
                     /db_xref="ZFIN:ZDB-GENE-110606-6"
     CDS             366..3062
                     /gene="ago2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X1"
                     /protein_id="XP_009292643.1"
                     /db_xref="GeneID:570630"
                     /db_xref="ZFIN:ZDB-GENE-110606-6"
                     /translation="

MYPIGAAGATELFQGRPSSGSDVSAPASPPAPQEYVFKPPQRPDFGTMGRTIKLQANFFEMEIPKLEVYHYEIDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVYDGRKNLYTAMPLPIGRDKVELEVTIPGEGKDRSFKVAIKWMSCVSLQALHEALSGRLPNIPFETIQALDVVMRHLPSMRYTPVGRSFFTPSEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTIECTVAQYFKDKYKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQDEISKLMRSANFNTDPYVREFGVMVRDDMTEVNGRVLQAPSILYGGRVRISSAQLSIWLNPCLIWSCLWLFQNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTELLLKAFTDQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFKHLKYTYQGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQVKNVQKTTPQTLSNLCLKINVKLGGVNNILLPQGRPLVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQQHRQDIIQDLATMVRELLIQFYKSTRFKPTRIIYYRDGISEGQFNQVLQHELLAIREACIKLEKDYQPGITFVVVQKRHHTRLFCMDRNERVGKSGNIPAGTTVDTKITHPFEFDFYLCSHAGIQGTSRPSHYHVLWDDNHFTSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDQQALAKAVQIHQDTLRTMYFA"

     misc_feature    681..905
                     /gene="ago2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    933..1085
                     /gene="ago2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    1086..1448
                     /gene="ago2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1242..1244,1287..1289,1329..1331,1341..1343,
                     1395..1397,1416..1418,1422..1424)
                     /gene="ago2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1581..2933
                     /gene="ago2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2067..2069,2079..2081,2115..2126,2133..2135,
                     2157..2159,2166..2168,2178..2180,2190..2192)
                     /gene="ago2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2271..2273,2277..2279,2487..2489,2901..2903)
                     /gene="ago2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ttagacattattaatttaaataacggaggttttctaagtacacaacgctaactcgaactaaatagttaaaataaaactaaatgcgacgctcagacaattgttgtaacgtgtttttgtgtagtttttggagagtctggtaaatcaggcgcttgagcggcgacggggggaagggacggacggacgggccactcggagctctcgtgctccagcaactctgcgcgctcactttaatcttacttttcacctctgtatcgatgctgttttgaaagaaaacccagctcttccgttaccgcatgtgttacgtggcatcagaagacccaaaagtgtcggcccgggattgaattttgctgcagaaagcgattaaaatgtatcccattggagcagctggtgctactgagctgtttcagggacgtccgtcttcagggtcagatgtttctgctcccgcgtctcctccagcaccacaagaatatgtcttcaaaccacctcagcggccagactttggcacaatgggtaggacaatcaagcttcaggccaacttctttgaaatggaaattcccaagttggaggtttatcattatgaaatagacatcaagcctgagaaatgcccacggagagttaaccgtgaaatagttgagcacatggtccagcactttaaaacgcagatctttggagatcgaaagcctgtgtatgatgggaggaagaatctctacactgccatgcctttacccattggaagagacaaagtggagctggaggtcacgattcctggggagggaaaagacaggagctttaaagtcgctataaagtggatgtcctgtgtcagtctgcaagctttgcatgaagcactctctggacggctaccaaacatccctttcgagaccattcaggctctggatgttgtcatgagacatttgccctctatgaggtacaccccagtcggacgttcattcttcactccatcggagggctgctctaaccctcttggtggaggaagagaagtttggtttggttttcatcagtctgttcggccatcactctggaagatgatgctcaacattgatgtgtctgccactgcgttctacaaagctcaacccgtcattgaattcatgtgtgaggttttggattttaaaagcatcgaagagcagcaaaagcccttaacagattcccaaagagtgaagtttaccaaggagatcaagggtttgaaggttgaaattactcactgtggacaaatgaagaggaagtacagagtgtgtaatgtgacgagaagaccagccagccatcaaacgtttcctttgcagcaagagaatggtcagaccattgaatgcactgtcgcccagtacttcaaggataagtacaaactggtgcttcgatacccacatctcccatgtttacaagttggtcaggagcagaaacacacctaccttccgttggaggtctgcaacattgtagccgggcagcgatgcatcaagaaactgacagacaatcagacctccactatgatacgtgccacagccaggtctgcgcccgaccgtcaggacgagatcagcaaactgatgagaagtgccaacttcaatacagatccttatgtgcgtgagtttggagtcatggtaagagacgatatgactgaagtcaatggtcgggttcttcaagcaccgtcgattctctatggtggaagggtaagaatctcctctgctcaactcagcatttggttgaatccctgtctaatttggtcatgtctttggctgtttcagaacaaagcaatagcaaccccagtccagggcgtgtgggacatgaggaacaagcagttccacacagggattgaaatcaaagtttgggccattgcctgctttgccccacagaggcagtgcacagaactcctgctgaaggccttcactgaccagcttcgtaagatctcacgtgatgctgggatgcccattcagggccagccgtgcttttgcaaatatgcccagggagcagacagtgtggagcccatgttcaaacacctcaagtacacttatcaagggttacagttggtggtggtcatcttacccggcaagactcctgtttatgctgaggtgaagcgtgttggagacactgttctcggcatggccacgcagtgtgtccaggtgaagaatgtgcagaagaccacacctcaaaccctttctaacctctgcctcaagattaacgtcaaactgggtggagtcaacaacattcttcttccacagggcaggcccttggtgttccagcaaccagttatctttttgggtgcagatgtgactcatccaccagctggagatggcaagaaaccctcaattgctgctgtcgttggcagtatggatgcccacccaagcagatactgtgccacagtgcgggtgcagcagcaccggcaggacatcattcaggatctggcaaccatggtcagagagttactcatccagttctacaaatccacacgcttcaaaccaacacgcatcatctactacagagacggcatctctgaaggccagtttaaccaggttctacagcatgagctgctggctattcgtgaggcctgcatcaagctggagaaagattatcagccgggtatcaccttcgttgtagtacagaagagacaccacaccagactcttctgcatggacaggaacgaacgggttggaaagagtggaaacatccctgctggcaccactgtcgacaccaaaattactcatccattcgagtttgacttttatctttgcagtcatgctggaattcagggaaccagtaggccgtcccactatcatgtgctgtgggacgacaaccatttcacctctgacgagctgcaggtcctcacctaccagctgtgccacacctatgttcgctgcacccgctcggtctccattcctgcaccagcctattacgcccacttggtggcgtttcgcgcccgctaccacttggttgacaaagaacatgacagtgctgaaggcagtcacacatcaggtcagagtaacggcagagatcaacaagccctggccaaagctgtgcagatccaccaggacacactgcgcaccatgtacttcgcctgaacaaagccagaaccaagccccacaatcctgaaaacagcacggtgtgtgtgtatatgtgtgtgtgtgtgtgcgtgtgtgtaattttaagtgttatacaaacgagacccttcaaatggagacaaaatgaggaccgccatgctgttcgacttttaactgccccttaattcggtttccaaacatatttaatatccaagctgatatgtgaatttttattcatttatcttttaattttgttcctcgtttggttcagtgggcatggttgtgtatctcttgtgcatgtcagattagaggttaacgcgtttacatagtcaatcccaaaaaattctgactttttttacactgaaagttacatttgcatccaagcgggcttgatttagtactattgccaaggcaggtgatggagactgttgaacattagtttttacaaactcatcaaaccaatggattcgggtcagtttaggacttcacggatcaggtttagggcttgtggcgatgcagtttccacagctaaattatttatcagcgaacgcaagtgcactgaccagaaggggacttcaggacaaaagtacttatcctgttttatttcatctatttgtgctaatatgatttattttcttcttctagtggtgtgatttcttgttcagtccagggctcagtcgacctactgtgtacctgtccgccaatgatcatgtgtcagtacagaatcatgaacgcatttggatgtaggaattgttttgacaatcagttttctgccgctcatatgagactggttctcattcgtttttcctgtgccgggttctcagtgcggaaacgactctgtactgtggatagatgtcctgaaaagtactattatcttgcattaagatgagattatctttcaattgtactgccattttcgctggtttatccgccgtgattgtaacaacctcaagtttcggtcgtttgtgacatcaaaatttaatcacatttcactttaagcacctattcgttgttcataatgttccccaaattgaaacttgaggtgacttttgtcagtaatattagggaaagtggagccctgtgatttttgcttggttctttgtgctgttttcagtggtgaagtttgactgtgttttgctgacagggtcgtcgtcgcactccagcaggcaatcaaaacttttaaagaacgataccaatatcagaatttttcacacaacgaagtcagaatgaaaatttcaaatgcaccttagattgtttgtttttttccctaactcgcgtgttcccatgatgagaatttttcgtatctctttccaacactcaagatagtttctaaatatttaatctttctttcatagacctttcatagagtcatgaggcgagcgctgaggcgtttataatgaatcgaaaacatttatttagtgtaaatcagtccaaatggagcttgaattgaagcgcaatacgttgtttgtttttgtgtgtgtgtgtgtgtgtcggtgaactgatttcttgtaaacagccttctcaagcatatcatgatgtgtagtggtcgatctatcgagtctcgttagcgaattaaccgtaagatcacttccccaaataatgcttcaattctgaacttgaaattcttgggaatatttttaaccatctttttttctaactatgcattcttaaccaagagattctagtggtatgtttgtgtatatgaattatgaatttagaacgtttgtaatgtagtccttttcatgccgggtacttttagtagtgtaaatagttccagccctgtacccgctgtagcagtattagcttacaaaatactctatttttattaacaattggatgttctttatatggctctcaattattcctgttagccaaacaagattactatgtacttgtagtcggtgtcctaccataactgaagcacaataggacattataattgtaggtgctagagtttattcttgagactaccatttgttttttttatcgtcaccttttaaacgagaagcatggagtgcttgtttgttttgtttattttattatttttatctatgacatttaacccaacccaacagactgtgtataaggggcattttaatttatcttccaatacttgactagagttctgttattatttggcgctgatcttgtaactcgtgaaatttagatgcactttttttttttttttttttttttttttttgagagcaatggatacatccctagtttaccttcggtggctaaatggattttgagtatgctaactgtgtgcagttgtgtggaaatgactagatgtcctacctcttgttacctgttacttgcattatggtaacattaccgcactggtcatttcctcataattgcattaagtggaagttgatgatcttgctctaaagtggcgtctttgttaattcatgttttgtttcagaggccatacctgctgccatttagcctagacgcttattgttttattggtagttttaagctatgtattcaaagctacgattgagtgctgcgagtttcaaatgtcgtacgtttgatgttttgaagtcagacgtgaatccaaaaagaatattaaatgcttgggtgtgcaccatcagatgttcctaaaatgtgtagtgtggattcaagttgattgctttctgccctttataattcgcagcgcgttgttgctttatccatgtactcgtttaaatgtgtcacgtagttttcctgtatctttttttttttaaggtttgaataatattatttatcttttagcatcagaaacatgagatgaaatcatcgctcaaactactttttacatcgatttttctcttgaacaatcagatttttatttcttcgaaaccattatatttcattctcatgaactgctctgtttagttgttttcagaagttactgagtttttagtatttgaacctgtttgaaatcagcaccttagtcaaaaggtctacaacatatgcaatttctcaagtatgaaatatgagatgtttttgcactatatcagaagaggtgttaataatttgtggaaggttagagaggagaagaaccatcaagtttagactagtcttggcctcgtttctttgttcatgtacaatcatattggcactaacctattcaaagttgacacattagaaggtcttgagttcttacgctatgcaaaaactcatttccatttagagccgtcgctctttttatacatggtgttcttgcagaacaagttgcgtttaccaaattgagtttgggaatttgagtaaactcaaatcccattttatatgttttccaaacctgttttctgtttaatgaggacatgagtctgatgcaaattttttatcgaaataattccgttaaatgcaaatggccaaggacagagggagaagaatgaagtaaggtgctggttttgtagagaccgtcacgataatctatgctgcagcatctctgtttcagatcttaacaggcacatatagtgttaactgaaaattgaattggtgcctctgaaagctttgaattgtttatccgtcaatgttacgccattaacattttatggatcgctctttcatcatcatttctagattgctgcttgagtgaagcttgtatattgctttggcgaggttctgtgtggggttacagtgtccacatgcttctttgttttacactttattgtttgaataaaactagttgattgccccaataaatattatttaaaaaccataaacgccagtctcatcaaaggttagagcccctaatcttaaaagatatatttgctaatgtattggcattagaactttgcactagtgttctgaagcagaaatgtacgcctctcttcacataccgtgatcgttttgtaattcctaaggtggcaagtttcaaagatgccagccttatgacctgctacaaccatacggatacaagcgaacagtttgaatgtacttcatacgcctgcatactggttaagaacctccattattttaatccgtttgcttgttttgttttatgcatgcacattgaaagcagctttgagtcgttgaactttttatccatgcatactttgaactgtatctcaaaactcatcgttgctttaaattaatagtggcaacatttggacggatggttcagaatacacactggcacaaagatctgatgtttgtggtgctgtactgtaaaaagtgtacataaggcagcgttttctgtgtgtttttttgcctattactgctcttgtttgacagattagaagtttcatctaaagggtttttgagctatacaacaatacccatgtacccaacaagccaaattcacactcgtatgaagcccttttgctttaccagctctgtggtggtcctgtaatcatggcagtggtacttgtgcacaaactaaaccacagatcagttgccatttagctagttgtctgattggggaatgatggtttccgaacatgtcccctttactatttttaaaatgaatctaaatgaccaaaatttttgcaagggattaatttttttttccaaaacgagcacagttccattaattcattataaatcatgctaaaatggtatttattcgaatataagcatcacagttgggtcttgtgactgattcatctgaataactgagagcttcatcatgacctggctttttaaaccaacttggagaagaaaaaagaaaaaaaaaactacctcaatagtgtcgggtgctaatgttaaaatatcccttatatgtatatgtgctcatgacaaagaacaataatcgtgaccaaacaacacaagcctatactgtgtattacgtgtttagtttttattatttgtgtatgatggatcaacatgagggatgtaacaaaactgcggtggaccaaaataaatcgtttccctttttaaaatgtagttttcaatatgcatcagttttattcgaattaaatggagctgttctcagatcctctggagaacaaatggtcaagaatgagcgttcaggccaagattgttgccaaaacacggtttcgttttgtcagacgtcgtgttgagttggttgatctagaattgtgccatattatggagaacatacaggacagtaaacgtccaatgaccactgctctgtgtctaaagcgtgttcctattaagcggcttgtcaacctgtgtcagcttttggagtgctagcgttatacttgattcttctacttgatttgtatccagtattgcaataaaaacttcgcactcatccgatccggaactgttcgatgaaagctccacggcgttttttttgtttttgtttttaagctatctgtatttaaactgtcatgtgacgtcgctacattttatgaagggaatttttaatttgacttctctcaaactctgattaaggacgcgttggggcgtcctgatacactggcatttgagtttctcgagggagagcataataaggtacaaaaggttgtgtggaaatcagttacgattctcgtttctcattggtgagctcaataacgtccagcgtgtttttatgtcgtgtttgtgtgcctttggaaatctctcccgaccctgatcaagggactgtcctttattcatttgatgctcggcgccacatcatttatcatgcaaccttgagtgaatgctgcatagaatgatcagtatttgtattttgcactttctaagcagttttaaaggacgccctgttgtaattggggcgcacagactatttaagacgaggtattttctgctacaataggaattttaaggaaccatatgactcgttggttgaaaaaaaataaagtgtatagatgtgaagtacctcataagcctgataaatgctgcataaactcttcatttattgttcttttgtgaatctattttcccctattggaaggtttgatgtgcacaacagcgcaaagcaccttcatttatgacattgaggcgctctaaaaccagttatgcaagtcaaatgcgaggttttcggtcatattcactgacattataagacattagcaagcctctagcttcagctttgcatcacagctattggatacgtagtgacgtttgcagtcaaaagttacagttgactcaggtatcgccattaagggctgtatctgcttttgcctcccattttccctcacctgtgtcttaacgtagccttagaactgcattcatggatggatagatcatagtgaagaatatctggccttaaaaatatgcactatcaaccacaacatgcaagtcactacagatcagatctttcgttttctgccataaaactacctccgagaatgtaggagtgtcctggaactgacacatcaaggtttattttcatttttaaggttataatctgtaatcgacaatcatcttttagtttattaaattcgcagtatgagttacagttcattctgggacgctctagttttgtttctttatgaaaagcgtgtccatgttagtcatggaagagccaagcgaccaacgtttctagctgaaggttttcttgcactgctttgtgacgtcaaaccttcctctttttttttttttacatcagcaaattatctttcatttaacctcgtgttttgctcctttataacatgccaaattaaatttgctgtcattcctgtcatggtaaagtctttaatttctgattcatgtgtttgcattcactgctaagctctatgttgttgtttcttggtaatgtaaagtgagtttatttcttttttttttttttttttttaacaagtaagattacaaccaagatatgctgtaaaccctgctaagacataatgtgaaaacgtatcatttaatatagctcacttttgcttgactgtgtattgcatcatttaataaagttaatttcctcttaa

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