LOCUS       NM_213337               2667 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio transmembrane protein 59-like (tmem59l), mRNA.
ACCESSION   NM_213337
VERSION     NM_213337.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Aoki M, Segawa H, Naito M and Okamoto H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU463178.10 and BC154612.1.
            
            On Aug 9, 2013 this sequence version replaced NM_213337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC154612.1, GFIL01041252.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476754, SAMEA4476792
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                CU463178.10        125445-125500
            57-2667             BC154612.1         1-2611
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="22"
                     /map="22"
     gene            1..2667
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /note="transmembrane protein 59-like"
                     /db_xref="GeneID:406646"
                     /db_xref="ZFIN:ZDB-GENE-040426-2651"
     exon            1..309
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /note="upstream in-frame stop codon"
     CDS             145..1164
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /codon_start=1
                     /product="transmembrane protein 59-like precursor"
                     /protein_id="NP_998502.2"
                     /db_xref="GeneID:406646"
                     /db_xref="ZFIN:ZDB-GENE-040426-2651"
                     /translation="

MLQFGGRVRGVPALVSLILVALAAASSDLFDNQLGDINYCKKQCQMSIKNKSPAKDSIMNACHRGCRLYSICQFVNGNTGINTSKEECQGACQEAYSKLLEQEACSTGCASQPAEPEIKRRKLKALTNRPKPISVMEAVSSWCNDIVSSAQSFISSTWTFYLQADDGKVVVFQSQPEIEYSLPELQAPRSNVVDKPWPQVNSHTQRPHTGGRSHRERNAAKPGVKGKNVSQHAEDPAAEHDFLGCMSRRSGLPRWILAACLFLSIMVMLWLSCASLVTAPEQHIKTQLSINGDKEFMDDAQKVNPYHLTPVIAMTIAQSEESKEAGPLPVKVDLSKTSL"

     sig_peptide     145..219
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    334..957
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /note="Brain specific membrane anchored protein; Region:
                     BSMAP; pfam12280"
                     /db_xref="CDD:432450"
     exon            310..415
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            416..510
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            511..663
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            664..772
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            773..887
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1005
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..2643
                     /gene="tmem59l"
                     /gene_synonym="wu:fi68e12; zgc:63977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgaggagtgacgacacggcgcatcaaaggcacgagatcaccgaggctgatagagcccgaaccgaagcagcagcagcggcaggaacaggtcgagaagcaccgaaccccgcagacgcgccagtgcaccgaatcctgaggaaaaaagatgctccagttcggcggcagggtgcgcggagttcccgcactcgtctctctgattctggtggcgttggcggcggcatcatctgatctgtttgacaaccaactgggcgatatcaattactgcaaaaagcaatgccagatgtccatcaaaaacaaaagccccgccaaagactccatcatgaatgcctgtcaccgcggctgccggctctactccatctgccagtttgtgaacggaaatacaggcatcaataccagcaaggaagagtgccagggagcctgccaggaggcctacagtaaactgctggagcaggaggcgtgcagcacggggtgtgccagccagcccgctgagccggagatcaaacggagaaagctcaaggctcttaccaaccgtcccaagcccatctccgtaatggaggccgtgtctagctggtgcaatgacatcgtcagctccgcccagagttttatttcttccacctggaccttctacttgcaggccgatgatgggaaggttgttgtgtttcagagccagccagagattgagtactccttgcctgagctacaagccccgcgctccaacgtggttgacaaaccctggcctcaagtcaactcccacacacagcggccacatactggtgggcggtcacatagggagaggaatgcagcaaaacctggggtgaaaggaaagaacgtcagccaacatgccgaggacccagctgctgagcatgacttcctgggatgcatgtcaaggcgctcaggtctgccacgttggattttagccgcctgcctcttcctgtctatcatggtgatgctgtggcttagctgtgccagtcttgtcacggcacccgaacagcacatcaagactcagctcagcatcaatggggataaagagttcatggatgacgctcaaaaggtcaacccttaccacctgacgccagtgatcgcgatgacaatcgcccaatcagaagagagcaaggaggcggggccacttccagtcaaggtcgacctcagcaaaacatctctttaaaagcaccgaagagatcgacacttttgacaaatagggttaaactcatctccagagctatttctcgcaatttaagaggaagtgacatcatttttctaaataaaaataatacaactgcatgacgccatttattatatcggttacgacgtatgtcctgtctgaatactagtcttctcactgaatttgcagaaagaactgtagtataggtgcttgttcacataatatactaacacgttttcgactataatatatacatacactagttaacgtcatgagcaacgttgcaatgtttcttatcgctaagtgcactgtataaacacgggcttagatgttaagtcatgccacaacctcaaaagaatggttatttgtcaagctttagggcctttaatactatgagaaacgtttagtttggcgatgaatgctttcaaagcgcccctccttgttattaattagcgtcgcaatataagctttgaaggtgatctgtcgcactcgtagattctcgcttttgatgtgaaacgagcaacaggaaaattaaatgaagccaattagcgtaagatctggtttcataacgacgtttacaaaacacgaatgcgtcctttgaactgatatgtaatcaaactgacaaggactcttaattgctttacagattgtgaatgcagtagtttgctggattttgttcagttgtacagttaaataaagaaaaaactgtggttttgtacacaggcaggtattgaggcaaatttctttttttcatatgcataattacgcatccatactaagcctgactaaaccactcacattcatgtcaaggaagcatgatgtgtatttattgaattatttatttatgtatttattcaaaagaataaagcagcgcctgtagtcttttagctctcgtttagatagcccattgatttgtatgttacataatcataatcctttatagacaggaaaatgcttgctgttcagaccgaatgtgaattgttgtattattccaatgcctttctcccccccttaaatattctccatctctgcccggtttattgtgggtggagtttggggcgggttttgaatgcccagccaccaggctttgacaaatatctttttgtaactagactgtaggattgaggagctttcatggcactatttgtcttgtgctgctattcgccccatttaagcccagccacagtgcatgctagtacgctatgagacattgaatatatcgtcccatctattttggaaacaaactgctgtacgctcgtgatctttgtgtttttgcttaatgttctgtaggcattgtaattatgaccatagattactaagaagaggtgagattccttacttataagccatttaatatctactggtacatcgttactgtatgaaatacaagttggtaatatctttttatttctttcttttgaatagtttcccaaaagaaactccataatatcggacaaataaagtgttttcatgttgtaattaaaaaaaaaaaaaaaaaaaaaaaaa

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