LOCUS       NM_201306               2109 bp    mRNA    linear   VRT 30-OCT-2022
DEFINITION  Danio rerio low density lipoprotein receptor-related protein
            associated protein 1 (lrpap1), mRNA.
ACCESSION   NM_201306
VERSION     NM_201306.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   Liu S, Chen T, Chen B, Liu Y, Lu X and Li J.
  TITLE     Lrpap1 deficiency leads to myopia through TGF-beta-induced
            apoptosis in zebrafish
  JOURNAL   Cell Commun Signal 20 (1), 162 (2022)
   PUBMED   36261846
  REMARK    GeneRIF: Lrpap1 deficiency leads to myopia through TGF-beta-induced
            apoptosis in zebrafish.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2109)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2109)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2109)
  AUTHORS   Tseng LC, Zhang C, Cheng CM, Xu H, Hsu CH and Jiang YJ.
  TITLE     New classes of mind bomb-interacting proteins identified from yeast
            two-hybrid screens
  JOURNAL   PLoS One 9 (4), e93394 (2014)
   PUBMED   24714733
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2109)
  AUTHORS   Aanes H, Winata CL, Lin CH, Chen JP, Srinivasan KG, Lee SG, Lim AY,
            Hajan HS, Collas P, Bourque G, Gong Z, Korzh V, Alestrom P and
            Mathavan S.
  TITLE     Zebrafish mRNA sequencing deciphers novelties in transcriptome
            dynamics during maternal to zygotic transition
  JOURNAL   Genome Res 21 (8), 1328-1338 (2011)
   PUBMED   21555364
REFERENCE   6  (bases 1 to 2109)
  AUTHORS   Knoll-Gellida A, Andre M, Gattegno T, Forgue J, Admon A and Babin
            PJ.
  TITLE     Molecular phenotype of zebrafish ovarian follicle by serial
            analysis of gene expression and proteomic profiling, and comparison
            with the transcriptomes of other animals
  JOURNAL   BMC Genomics 7, 46 (2006)
   PUBMED   16526958
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2109)
  AUTHORS   Whitehead GG, Makino S, Lien CL and Keating MT.
  TITLE     fgf20 is essential for initiating zebrafish fin regeneration
  JOURNAL   Science 310 (5756), 1957-1960 (2005)
   PUBMED   16373575
REFERENCE   8  (bases 1 to 2109)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   9  (bases 1 to 2109)
  AUTHORS   Sharma MK, Denovan-Wright EM, Degrave A, Thisse C, Thisse B and
            Wright JM.
  TITLE     Sequence, linkage mapping and early developmental expression of the
            intestinal-type fatty acid-binding protein gene (fabp2) from
            zebrafish (Danio rerio)
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 138 (4), 391-398 (2004)
   PUBMED   15325340
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC049517.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..2109
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="low density lipoprotein receptor-related protein
                     associated protein 1"
                     /db_xref="GeneID:333939"
                     /db_xref="ZFIN:ZDB-GENE-030131-5871"
     exon            1..273
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    91..93
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="upstream in-frame stop codon"
     misc_feature    118..120
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MQLIILVSLFAVGA"
     CDS             160..1155
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /codon_start=1
                     /product="alpha-2-macroglobulin receptor-associated
                     protein"
                     /protein_id="NP_958463.1"
                     /db_xref="GeneID:333939"
                     /db_xref="ZFIN:ZDB-GENE-030131-5871"
                     /translation="

MAGKYSKEMNEKNASDKSNNQVEFRIAKLNQVWEKAIRMQLAPVRLSELHSDLKIQEKDELQWKKLKAEGMDEDGEREAKLRRNFNIILAKYGMDGKKDTRTLDSNRLKDHEVKIGDTFDDPKLDKLWNKARTSGKFSDEELQTLHREFQHHKDKIHEYNIVMDTVSRTEEIHKNVISPLEGDVKENVLHQKHTDLKQRMRDLNQGFERLRKITHEGYTDDSEFREPRVIELWEMAKRSNLSEDELDSLKEELRHFETKVEKHQHYQEQLELSHQKLKHVEALGDEDHIMRNKEKYNTLAEKAREMGYKMKKHLQDLTNKLSKNGLQHNEL"

     misc_feature    160..462
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="Alpha-2-macroglobulin RAP, N-terminal domain;
                     Region: Alpha-2-MRAP_N; pfam06400"
                     /db_xref="CDD:428920"
     misc_feature    241..270
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="3-helical coiled coil [structural motif]; Region:
                     3-helical coiled coil"
                     /db_xref="CDD:269813"
     misc_feature    292..357
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="3-helical coiled coil [structural motif]; Region:
                     3-helical coiled coil"
                     /db_xref="CDD:269813"
     misc_feature    388..429
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="3-helical coiled coil [structural motif]; Region:
                     3-helical coiled coil"
                     /db_xref="CDD:269813"
     misc_feature    514..1152
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /note="Alpha-2-macroglobulin RAP, C-terminal domain;
                     Region: Alpha-2-MRAP_C; pfam06401"
                     /db_xref="CDD:428921"
     exon            274..418
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            419..549
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            550..670
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            671..826
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            827..909
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1086
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..2084
                     /gene="lrpap1"
                     /gene_synonym="wu:fi20f07; wu:fi22c06"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ataggcatgtgaacgccgtatgattccagtagcgcttcctggatagcgctgcagatgctctacaaaacggtttatttaggtttttataactaatttgcttctgttgccacaattaaaatgcagcttataattttggtttcgttgttcgctgtcggtgcaatggcgggaaagtactcaaaagaaatgaatgaaaaaaatgcgtctgataaaagcaacaaccaggtggaatttaggattgccaaactaaatcaggtttgggaaaaggcgataaggatgcagcttgcaccggtccgtctgtcagaactacacagtgacttgaaaatccaagaaaaagatgaacttcaatggaaaaaactcaaagcagaagggatggacgaagatggagagagagaagccaagctcaggcgaaattttaatattattcttgcaaagtatggaatggatgggaaaaaagacacccgaacattggacagcaacagactgaaagatcatgaagttaaaatcggagacacatttgatgacccaaagttggacaagctgtggaataaggccagaacttctggaaaattctctgatgaggaactccagaccttacatagagaattccagcatcacaaagacaagatccatgagtataacattgtcatggacactgtcagccggactgaagagatccataagaatgtgatcagtcctctggagggggatgtgaaggagaacgttcttcatcagaaacacacagatctgaagcagagaatgagggatctaaaccagggctttgagcgtctccgcaagatcacccacgagggctacactgatgacagcgaatttagggagccacgagtcattgagctgtgggagatggcaaaaagatccaacctcagcgaagatgaacttgattctcttaaagaggaactccgacactttgaaacaaaggtggagaagcaccagcactatcaggagcagctggaactgtctcatcagaaactgaagcatgtggaggctctgggagatgaggatcacattatgagaaacaaagagaaatacaacactctggctgagaaagcacgggagatgggatacaagatgaagaagcacttgcaggatttaacgaacaagctttccaaaaatggattacaacacaatgaactctgagcactcttttcctcagcatggcagcactacagttagttatgatcacatatggagtgttattcctcactgattggctggggttatgaaggtaaggtgcacagcatttccactggaaagtcaaaccaattattaaataatgagatttttttttatggtacggagcagtgaacagttctgtgcattctgttcattatccatgttctatttgttgtggccaaatttgtatgaattttatgatacttgctaaaaaatgaactgaaacacgtgtagcttcccacaaacatgtgggtgcaatagaacttcacaacaaaaccacacgaaaaggctcgcaaagttttcaatgtaaacctttaagcttccatttgagcaatttcctaaagctgagcatcttaacatttaaagaaaggctcaattgaactctgccatgaaaaacggtgccatcccaatgcaggtttgatgttatatccagataacctctgttacgagctaaacctggcagattgaggacaatagatgtgctttaatggaaaaagctgcagtgaattggagaaccagaagctaaggccaggcacaaaagtaaagcaggtcttgaatcagccgttatatttaccaaacagcattgagtgcagatattatcaacatgattgacagctttgtccagagttagacttgaatcatcctgacttttagatatttaaagatttgttacaaaaattcaaactacaaactgattctattctatgacaatgtaattactcaatcaacagaattttgtgattttgtgtagaacacatgctataatccagtattgtaattcatgatcaggaatgtgttgtctgttgataatagaatctcttttgtataagtctatgttctgctcatgtcatgtcagtcgcacatttcataataaaacaaactaaccatttttttcaaaaaaaaaaaaaaaaaaaaaaa

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