LOCUS       NM_200705               1478 bp    mRNA    linear   VRT 05-AUG-2023
DEFINITION  Danio rerio retinaldehyde binding protein 1a (rlbp1a), mRNA.
ACCESSION   NM_200705 XM_689709
VERSION     NM_200705.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Chen DD, Liu B, Wang Y, Jiang M, Shang G, Xue M, Jia X, Lang Y,
            Zhou G, Zhang F, Peng X and Hu Y.
  TITLE     The downregulation of HSP90-controlled CRALBP expression is
            associated with age-related vision attenuation
  JOURNAL   FASEB J 37 (3), e22832 (2023)
   PUBMED   36826429
  REMARK    GeneRIF: The downregulation of HSP90-controlled CRALBP expression
            is associated with age-related vision attenuation.
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Schlegel DK, Ramkumar S, von Lintig J and Neuhauss SC.
  TITLE     Disturbed retinoid metabolism upon loss of rlbp1a impairs cone
            function and leads to subretinal lipid deposits and photoreceptor
            degeneration in the zebrafish retina
  JOURNAL   Elife 10, e71473 (2021)
   PUBMED   34668483
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Raj B, Farrell JA, Liu J, El Kholtei J, Carte AN, Navajas Acedo J,
            Du LY, McKenna A, Relic D, Leslie JM and Schier AF.
  TITLE     Emergence of Neuronal Diversity during Vertebrate Brain Development
  JOURNAL   Neuron 108 (6), 1058-1074 (2020)
   PUBMED   33068532
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Hoang T, Wang J, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne
            M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N,
            Campbell WA, Rajaii F, Parayil T, Trinh V, Kim DW, Wang G, Campbell
            LJ, Ash J, Fischer AJ, Hyde DR, Qian J and Blackshaw S.
  TITLE     Gene regulatory networks controlling vertebrate retinal
            regeneration
  JOURNAL   Science 370 (6519) (2020)
   PUBMED   33004674
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Xu B, Tang X, Jin M, Zhang H, Du L, Yu S and He J.
  TITLE     Unifying developmental programs for embryonic and postembryonic
            neurogenesis in the zebrafish retina
  JOURNAL   Development 147 (12) (2020)
   PUBMED   32467236
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Lupo G, Gestri G, O'Brien M, Denton RM, Chandraratna RA, Ley SV,
            Harris WA and Wilson SW.
  TITLE     Retinoic acid receptor signaling regulates choroid fissure closure
            through independent mechanisms in the ventral optic cup and
            periocular mesenchyme
  JOURNAL   Proc Natl Acad Sci U S A 108 (21), 8698-8703 (2011)
   PUBMED   21555593
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC
            and Kennedy BN.
  TITLE     Duplication and divergence of zebrafish CRALBP genes uncovers novel
            role for RPE- and Muller-CRALBP in cone vision
  JOURNAL   Invest Ophthalmol Vis Sci 49 (9), 3812-3820 (2008)
   PUBMED   18502992
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Fleisch VC, Schonthaler HB, von Lintig J and Neuhauss SC.
  TITLE     Subfunctionalization of a retinoid-binding protein provides
            evidence for two parallel visual cycles in the cone-dominant
            zebrafish retina
  JOURNAL   J Neurosci 28 (33), 8208-8216 (2008)
   PUBMED   18701683
  REMARK    GeneRIF: Cralbp a expression in retinal pigment epithelial cells is
            essential for cone vision and provides evidence that both the
            canonical and the alternative visual cycle depend on the same type
            of retinoid-binding protein.
REFERENCE   9  (bases 1 to 1478)
  AUTHORS   Bernardos RL, Barthel LK, Meyers JR and Raymond PA.
  TITLE     Late-stage neuronal progenitors in the retina are radial Muller
            glia that function as retinal stem cells
  JOURNAL   J Neurosci 27 (26), 7028-7040 (2007)
   PUBMED   17596452
REFERENCE   10 (bases 1 to 1478)
  AUTHORS   Leung YF and Dowling JE.
  TITLE     Gene expression profiling of zebrafish embryonic retina
  JOURNAL   Zebrafish 2 (4), 269-283 (2005)
   PUBMED   18248185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059449.1.
            
            On Jul 6, 2005 this sequence version replaced XM_689709.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU348853.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="wild-type"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..1478
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="retinaldehyde binding protein 1a"
                     /db_xref="GeneID:393678"
                     /db_xref="ZFIN:ZDB-GENE-040426-1662"
     exon            1..11
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="upstream in-frame stop codon"
     exon            12..52
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..982
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="cralbpb; rlbp1b"
                     /codon_start=1
                     /product="retinaldehyde-binding protein 1a"
                     /protein_id="NP_956999.1"
                     /db_xref="GeneID:393678"
                     /db_xref="ZFIN:ZDB-GENE-040426-1662"
                     /translation="

MAATGSFRMVSEEEQALRAKLEHLTVKDHGPVYGPCMKLPDHTKQKAKDELNETDEKRASAIKELRAMIKDKAGQGDEVAKTVQDKFGKEPDSLLLRFIRARKFDVARAHELMKGYVRFRRDYPELFENLTPEAVRSTIEAGYPRILSTRDKNGRVVLLFNIDNWDLEEVTFDETLRAYCVILEKLLENEETQINGFVLIENFKGFTMQHASGIKHTELKKMVDMLQDSFPARFKAVHVIHQPWYFTTTYNVVKPFMKSKLLERVFVHGDELDGYLRDFGAEILPPDFDGTGPACDGRETAIKLFGSEDTAL"

     misc_feature    218..391
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="CRAL/TRIO, N-terminal domain; Region: CRAL_TRIO_N;
                     smart01100"
                     /db_xref="CDD:215024"
     misc_feature    479..916
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="Sec14p-like lipid-binding domain. Found in
                     secretory proteins, such as S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p), and in
                     lipid regulated proteins such as RhoGAPs, RhoGEFs and
                     neurofibromin (NF1). SEC14 domain of Dbl is known to...;
                     Region: SEC14; cd00170"
                     /db_xref="CDD:238099"
     misc_feature    order(509..511,515..517,521..523,599..601,644..646,
                     650..652,698..700,710..712,722..724,734..736,743..745,
                     752..754,758..760,779..781,800..802,836..838)
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="phospholipid binding pocket [chemical binding];
                     other site"
                     /db_xref="CDD:238099"
     misc_feature    order(737..739,833..835)
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /note="salt bridge; other site"
                     /db_xref="CDD:238099"
     exon            53..181
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     exon            182..386
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     exon            387..565
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     exon            566..724
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     exon            725..835
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1459
                     /gene="rlbp1a"
                     /gene_synonym="CRALBPa; rlbp1l; zgc:73076"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cttcggctgagtttccattcagcccgtggagaatctgagcactatggctgctactggaagttttcgtatggtgtccgaggaggagcaggcattacgggctaagcttgaacatctgactgtgaaagaccacgggccagtgtatggaccctgtatgaaactgccggatcatacaaaacagaaggctaaagatgagctgaacgaaacagatgagaagagagcgtctgctataaaggaactcagagccatgattaaagacaaggcaggccaaggagatgaggtggccaaaactgtgcaagacaaattcggcaaggagcctgattctctactcctgagattcatacgtgcgcgcaagtttgacgtggccagagcacacgagctcatgaaaggatatgtgcgttttcggcgagactatccggagctgtttgagaacttaaccccggaggccgtacgcagcactattgaagccggttacccacgaatcctctccaccagagacaagaacggccgagtggtgctgctcttcaacatcgacaactgggacctggaggaggtcacctttgatgagaccctgcgtgcctactgtgtaatccttgagaaacttctagaaaacgaagagacccaaatcaacggcttcgtcctcattgagaacttcaagggcttcacgatgcagcacgcatctggaatcaaacacaccgagctgaagaagatggtggacatgttacaggactcttttcctgcccggtttaaggctgtgcacgtgatccaccagccctggtacttcacgaccacctacaacgtggtgaagcccttcatgaagagcaaactgctggagagggtttttgttcatggagacgagctagatggctacttgcgggacttcggagctgaaatccttcctccagatttcgatggaacgggtcccgcttgtgacggcagagaaacagccatcaaactgttcggatctgaagacacagccctttaaatgacccacacaacacaagtattttgatgaacgtatgattcagacgtttaatagaaaatatatggatgaaagccttacagatgtttagtttaacatttttaactgccttattaccatgaaagtattatgagcagatcgcagaacagtatcgtagagatgaaatattgcacatttcacttgccgatacctacaattcttactgttattgttttttaaaagaaactttgctgaagagtttttcattctctgccttgaaaatggtggtcgagtttatatagtgttttgtactagtcatgtgttcaaaataagtgtagtagagaattaaatgcataaacttgattacaagccttaaccaaggaaaaagttttagactgaatgttgtgtgaagtagatgttgtggacgtcgttttaacccatattggttttccagcctgtcgagtctaattgacattttcaataaaatggccaaatggttcaaaaaaaaaaaaaaaaaaaa

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