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2024-11-01 08:35:38, GGRNA.v2 : RefSeq release 226 (Sep, 2024)

LOCUS       NM_200656               2915 bp    mRNA    linear   VRT 29-JUL-2024
DEFINITION  Danio rerio guanylate cyclase activator 1Ab.1 (guca1ab.1), mRNA.
ACCESSION   NM_200656 XM_697225
VERSION     NM_200656.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Cudia,D.L., Ahoulou,E.O., Bej,A., Janssen,A.N., Scholten,A.,
            Koch,K.W. and Ames,J.B.
  TITLE     NMR Structure of Retinal Guanylate Cyclase Activating Protein 5
            (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances
            Cyclase Activation
  JOURNAL   Biochemistry 63 (10), 1246-1256 (2024)
   PUBMED   38662574
  REMARK    GeneRIF: NMR Structure of Retinal Guanylate Cyclase Activating
            Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization
            and Enhances Cyclase Activation.
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Cudia,D., Roseman,G.P., Assafa,T.E., Shahu,M.K., Scholten,A.,
            Menke-Sell,S.K., Yamada,H., Koch,K.W., Milhauser,G. and Ames,J.B.
  TITLE     NMR and EPR-DEER Structure of a Dimeric Guanylate Cyclase Activator
            Protein-5 from Zebrafish Photoreceptors
  JOURNAL   Biochemistry 60 (41), 3058-3070 (2021)
   PUBMED   34609135
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Ogawa,Y. and Corbo,J.C.
  TITLE     Partitioning of gene expression among zebrafish photoreceptor
            subtypes
  JOURNAL   Sci Rep 11 (1), 17340 (2021)
   PUBMED   34462505
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Ames,J.B.
  TITLE     Structural Insights into Retinal Guanylate Cyclase Activator
            Proteins (GCAPs)
  JOURNAL   Int J Mol Sci 22 (16), 8731 (2021)
   PUBMED   34445435
  REMARK    GeneRIF: Structural Insights into Retinal Guanylate Cyclase
            Activator Proteins (GCAPs).
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Lim,S., Scholten,A., Manchala,G., Cudia,D., Zlomke-Sell,S.K.,
            Koch,K.W. and Ames,J.B.
  TITLE     Structural Characterization of Ferrous Ion Binding to Retinal
            Guanylate Cyclase Activator Protein 5 from Zebrafish Photoreceptors
  JOURNAL   Biochemistry 56 (51), 6652-6661 (2017)
   PUBMED   29172459
  REMARK    GeneRIF: these results indicate a strong Fe(2+)-induced inhibition
            of guanylate cyclase by GCAP5 and suggest that GCAP5 may serve as a
            redox sensor in visual phototransduction.
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Sulmann,S., Vocke,F., Scholten,A. and Koch,K.W.
  TITLE     Retina specific GCAPs in zebrafish acquire functional selectivity
            in Ca2+-sensing by myristoylation and Mg2+-binding
  JOURNAL   Sci Rep 5, 11228 (2015)
   PUBMED   26061947
  REMARK    Erratum:[Sci Rep. 2015 Sep 02;5:13508. doi: 10.1038/srep13508.
            PMID: 26329014]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Fries,R., Scholten,A., Saftel,W. and Koch,K.W.
  TITLE     Zebrafish guanylate cyclase type 3 signaling in cone photoreceptors
  JOURNAL   PLoS One 8 (8), e69656 (2013)
   PUBMED   23940527
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Scholten,A. and Koch,K.W.
  TITLE     Differential calcium signaling by cone specific guanylate
            cyclase-activating proteins from the zebrafish retina
  JOURNAL   PLoS One 6 (8), e23117 (2011)
   PUBMED   21829700
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Imanishi,Y., Yang,L., Sokal,I., Filipek,S., Palczewski,K. and
            Baehr,W.
  TITLE     Diversity of guanylate cyclase-activating proteins (GCAPs) in
            teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5,
            GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs
            (GCAP1-8) in pufferfish (Fugu rubripes)
  JOURNAL   J Mol Evol 59 (2), 204-217 (2004)
   PUBMED   15486694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057493.1.
            
            On Jul 6, 2005 this sequence version replaced XM_697225.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057493.1, DN856622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="AB"
                     /db_xref="taxon:7955"
                     /chromosome="22"
                     /map="22"
     gene            1..2915
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /note="guanylate cyclase activator 1Ab.1"
                     /db_xref="GeneID:393629"
                     /db_xref="ZFIN:ZDB-GENE-040426-1577"
     exon            1..223
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..622
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /note="guanylate cyclase activator 1e"
                     /codon_start=1
                     /product="guanylate cyclase activator 1Ab.1"
                     /protein_id="NP_956950.1"
                     /db_xref="GeneID:393629"
                     /db_xref="ZFIN:ZDB-GENE-040426-1577"
                     /translation="
MGDSSSMSATELSACKCHQWYRKFMTECPSGQLTFYEFKKFFGLKNLSEKSNAYVNTMFKTFDIDDDGCIDFMEYVAALSLVLKGGVQQKLRWYFKLFDMDGSGCIDKDELLLIFKAVQAINGAEPEISAEDLADMVFNKIDVNGDGELSLEEFMEGISADEKISEMLTQSLDLTRIVSNIYNDSYIEQEAEIIEDQA"
     misc_feature    113..499
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; Region: FRQ1; COG5126"
                     /db_xref="CDD:444056"
     exon            224..373
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /inference="alignment:Splign:2.1.0"
     exon            374..464
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /inference="alignment:Splign:2.1.0"
     exon            465..2902
                     /gene="guca1ab.1"
                     /gene_synonym="gcap5; guca1e; zgc:66243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
gtgcaccgtcctgacgctcctcagcatgggggactcctccagcatgtccgccaccgagctcagcgcctgcaaatgccaccagtggtaccgcaagttcatgaccgagtgtccgtccggccagctcaccttctacgagttcaagaagttcttcggcctcaagaatctgtccgagaaatcgaacgcatacgtcaataccatgttcaagaccttcgacattgacgacgatggctgtattgatttcatggagtatgtggcagctctgagtctggtcctgaaaggcggtgttcagcagaagctgcgctggtatttcaagctcttcgatatggacggcagcggctgtatcgacaaggacgaactgctgctcatcttcaaggcggttcaagccattaatggagccgagccggagatctctgcagaggacttggctgatatggtgtttaacaagattgatgttaatggagacggcgagttgtctctggaagagttcatggagggcatctcggcggatgagaagatctcagagatgctgacccagagtttggatctgacccggatcgtgagcaacatctacaacgactcctacatcgagcaggaggccgagatcatcgaggatcaagcatgacaacactgagagtctggagcggacgcttttattggctccttcccagagtagcgagtgccgagtgtaaaacatagatcggccaaagctctgggtctgtgcactagattatatcatctgaacgcacaaaatgctccagtactgtgagtgtgtagttcagcctgagggtggcgctctaacactgacacacaggctgtaagtacacaccacacatgcgtagaacgcttctagaaatgccttaatgtagagtttaatgcctctgaatgctgatttagagttttgaacaagcgtaggaaatcttggtcgcactttattttaatgtacaattcacgctaacaacaaaccattcactaagaatatagctcaatacactactgattagctgcttaataatagttagtaggttagtagttgggtattgggttggattagagatgtaggatatgatcaaacatgctaatatctcctaataatgctaagccagtcataaatgctgtgaattgttacttaaacttagtgttactaaatacttatttgcattatatgtgagcatatgtaaagatgtatatatttttattaatctactacgttgttaaggaagtagcaattactgaagaagatgacgaatcgagtcagagcggtttacgaggtaatgtgaagaaagcagagcagtctgcagttccgtttttcgccaccgatttacactgtagttttatgggggcgctgttgagctcagtgcttagcctcacttaaagggccagttcacccaaaaatgataatattctcatcatttcttcactctttacaggtttaaacctgtttaactttatttattctgttaaactcaaaggaacatatactgaaaaagctggaaacctttaaccattgacattcatagtattttatttcggttttcctactactaagtgcttttcactttcctcaaaaaacaaaactgaagaaagaaactcacacattttttaaacaaaatcacagcagttttctgaacatatgaaccgaattttccaatatatatttcttttattgcttaaatcaggggtgcccaaacttcttcgtatgaagggccaaaaaccgaatatcattgagagtcgcgggctgaagatggccattgggaatttcctaatttatttcagaatatttcaaaataaatagaaaacattacataaaatcatattaaataatgctggataacattttaaatgataaattatttcaataaaaacaatcagatttataacagggctgctgcagtgaatcgattaaattgataaaaatcgattactaaaagcgttggcaatgaatttcataatcgatttgttgtgtcgcgtgacacgggtatggttgattattaaaaagcacttcagttgaaaggagttcaacagcaggagcctacttttgttctgttttgaagtgagggccgtaaagtccctggtgctgatgtttcactcgttatccagcttgtcaagcatgacaagttagcattaactcatttacttttagagcggaaataaaaaaaatgaacctgagtttggcgcggtgtctggcgctgggcagagctctcagtaagggaccgtctgaaaagtgcttctttatttttttttttcccccaaaaacaaaaccaacttaaccccgctgagaaagacgtgtcatattatcacaattatgcagcgttttaaccgcctaatgcttattttatgttttagacatgtaaactcacagacttactagtaaaacaaaacatttagagtttgtaaaacacacaaggaagtctaacaatccattcaaatataatttgctgatgtgatttattcatatcagatacacattacacatagtgaacgtaactttaaagctgaatctactcttctctaaggtcaccagccacttacttgcatgtgtttaggcggtaactggtgaatttaccgccgtattctgcttttatgaatgaggagaactggtatgtgaactggtaaaacttctgcttttgtcttttcggttagaaattaatgctttttttattcgattcatcgaaaaaaaatctagattaatcaattataaaaataatgattagttgcagccctaatttataacacagcggagttcagtgctgaatacactagtcaagcagaatctgcctttgacttaatttgctcaccaaactctctgcattgtcgggtgacggtatttgcatttaaactaaatctgatttacttacaccatttaattgacactggtaatttcagctagcttttaacaataaaaaaaaaaaaaaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]