LOCUS       NM_199980               1823 bp    mRNA    linear   VRT 30-APR-2023
DEFINITION  Danio rerio integral membrane protein 2Cb (itm2cb), mRNA.
ACCESSION   NM_199980
VERSION     NM_199980.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Hu B, Lelek S, Spanjaard B, El-Sammak H, Simoes MG, Mintcheva J,
            Aliee H, Schafer R, Meyer AM, Theis F, Stainier DYR, Panakova D and
            Junker JP.
  TITLE     Origin and function of activated fibroblast states during zebrafish
            heart regeneration
  JOURNAL   Nat Genet 54 (8), 1227-1237 (2022)
   PUBMED   35864193
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Horzmann KA, Lin LF, Taslakjian B, Yuan C and Freeman JL.
  TITLE     Embryonic atrazine exposure and later in life behavioral and brain
            transcriptomic, epigenetic, and pathological alterations in adult
            male zebrafish
  JOURNAL   Cell Biol Toxicol 37 (3), 421-439 (2021)
   PUBMED   32737625
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Meyer DN, Crofts EJ, Akemann C, Gurdziel K, Farr R, Baker BB, Weber
            D and Baker TR.
  TITLE     Developmental exposure to Pb2+ induces transgenerational changes to
            zebrafish brain transcriptome
  JOURNAL   Chemosphere 244, 125527 (2020)
   PUBMED   31816550
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   Crespo B, Lan-Chow-Wing O, Rocha A, Zanuy S and Gomez A.
  TITLE     foxl2 and foxl3 are two ancient paralogs that remain fully
            functional in teleosts
  JOURNAL   Gen Comp Endocrinol 194, 81-93 (2013)
   PUBMED   24045113
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Garnett AT, Han TM, Gilchrist MJ, Smith JC, Eisen MB, Wardle FC and
            Amacher SL.
  TITLE     Identification of direct T-box target genes in the developing
            zebrafish mesoderm
  JOURNAL   Development 136 (5), 749-760 (2009)
   PUBMED   19158186
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   McPartland JM, Glass M, Matias I, Norris RW and Kilpatrick CW.
  TITLE     A shifted repertoire of endocannabinoid genes in the zebrafish
            (Danio rerio)
  JOURNAL   Mol Genet Genomics 277 (5), 555-570 (2007)
   PUBMED   17256142
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054689.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054689.1, EH496870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476797 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1823
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /note="integral membrane protein 2Cb"
                     /db_xref="GeneID:335863"
                     /db_xref="ZFIN:ZDB-GENE-030131-7806"
     exon            1..170
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..860
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /note="integral membrane protein 2C"
                     /codon_start=1
                     /product="integral membrane protein 2Cb"
                     /protein_id="NP_956274.1"
                     /db_xref="GeneID:335863"
                     /db_xref="ZFIN:ZDB-GENE-030131-7806"
                     /translation="

MVKISFQQVTVQKPEKENDGDKEEIQMPYSHKDELVLPVRSKKSPFSGLWCVVLGLVIFLSGLIMASVCLYRYYFNPQIPEDSFFHCRMMYEDPVFAPLLGRQELEEKVGIYLDDNYEQISVPVPDFGSGDPADIIHDFHRGLTAYYDIALDKCYVIELNTTIVMPPRNLWELLVNVKRGTYLPQTYMIQEEMVVTGRVRNLRQLGPFIHRLCYAKETYRLRRRSGQRRIDKRETKNCHTIRHFENTFAVETKICERLLL"

     misc_feature    456..734
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /note="The BRICHOS domain is found in a variety of
                     proteins implicated in dementia, respiratory distress and
                     cancer; Region: BRICHOS; smart01039"
                     /db_xref="CDD:198107"
     exon            171..311
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
     exon            312..500
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
     exon            501..611
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
     exon            612..762
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1804
                     /gene="itm2cb"
                     /gene_synonym="fj35c02; itm2c; wu:fj35c02; zgc:66349"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cacagctcagaagcgtccttggtggtacaatcaacactggacgtcctgaccgcagcagactagcaggagtcgacaaaatggtgaagatttccttccagcaagtgactgtgcagaagccagaaaaggagaacgatggagacaaagaggaaatccaaatgccgtactctcacaaggatgagttggtgctcccggtgagatctaagaagtctcccttcagtggcctttggtgtgtggtgctcggcctggtgatcttcctgtcaggcttgatcatggcctcagtgtgcctctacagatattacttcaaccctcagattccagaggacagtttcttccactgtcggatgatgtatgaagaccctgtgttcgcccctttactcggccgacaggagttagaagagaaagtgggcatctacctggacgataactatgagcagatcagcgttcccgtgccagatttcggtagcggcgacccggcagacatcattcatgactttcacaggggactcacagcttactacgacattgcgttggataagtgctacgtgatcgagctcaacaccacaattgtcatgccgcccagaaacctgtgggaactgcttgtcaatgtcaagcggggaacgtatttgccccagacctacatgattcaggaggagatggtggtaactggacgcgtcaggaacttgcgtcagctaggacccttcatccaccggctctgctacgcaaaagagacctacagactgcgacgccgtagcggacaaagacgcatcgataagagggagacgaaaaactgccacaccatccggcacttcgagaacacatttgctgtggagacgaagatctgtgaacgactcctgctgtagtttccctctcctatctcctccaatctactgagcaaaacccaaaccatctgtccagcttaacagcactttatcagcttgataaacctgtaaatgatgttagataaagccatgtctgttctctgtttgtcttttttttctaatgataaactgttacttttttcattatatatatatttttgtctttgttagtttttgatttgcactttgtctgtagtataacgttttatttcactctcaggttatgtgtgtgttgttgtttttcttcttgtggggaaagaagttgagattagcttcagacatttttagtctggcaatcgctgatgaatgatttgcattatttctgtttgtttgtttttgtgtcaagcctcggtttgtgtagactgacggctggttaagtggtttctttatctgtttgtttcctcttgtgttagcaaagaaatccagtattagaaaatcatcttcaatgccaaaagatgtatacctcatattttagaaatgacttcaagtcatagcgtaggtttgaacgtgatctaagcaatatacgttttcttatcttggatttcctatcttgaatttcatcggtttgtcgtcttgtttgtcaactgatgctccaagcattgctctttaatacttgtgaataaagtttgtagaaaaattttaaaaactgaaatggttccttatctttaaatgcagtgtgtgtgtgtgcgcatactgatcagaatggctgatttgaattgtcttttggcacagatgtgcgtaaatgtagtcctttctcttttttttatgttcatgcccaaggcagatccactagattcacttcatattgcttgcacttttttttctagtcgtaccatttatgtgtgtttgttcctcttccacataatggtgtagcaaagaactggttttgtctgaaataaatgaggcgtttaatttgatgcactctaaaaaaaaaaaaaaaaaaaa

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