LOCUS       NM_199428               1598 bp    mRNA    linear   VRT 15-OCT-2021
DEFINITION  Danio rerio nucleophosmin 1a (npm1a), mRNA.
ACCESSION   NM_199428
VERSION     NM_199428.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Xu B, Tang X, Jin M, Zhang H, Du L, Yu S and He J.
  TITLE     Unifying developmental programs for embryonic and postembryonic
            neurogenesis in the zebrafish retina
  JOURNAL   Development 147 (12) (2020)
   PUBMED   32467236
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Cheung CT, Pasquier J, Bouleau A, Nguyen T, Chesnel F, Guiguen Y
            and Bobe J.
  TITLE     Double maternal-effect: duplicated nucleoplasmin 2 genes, npm2a and
            npm2b, with essential but distinct functions are shared by fish and
            tetrapods
  JOURNAL   BMC Evol Biol 18 (1), 167 (2018)
   PUBMED   30419815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   Chakraborty A, Uechi T, Nakajima Y, Gazda HT, O'Donohue MF, Gleizes
            PE and Kenmochi N.
  TITLE     Cross talk between TP53 and c-Myc in the pathophysiology of
            Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and
            in vitro models
  JOURNAL   Biochem Biophys Res Commun 495 (2), 1839-1845 (2018)
   PUBMED   29225165
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH,
            Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S and
            Bouchier-Hayes L.
  TITLE     NPM1 directs PIDDosome-dependent caspase-2 activation in the
            nucleolus
  JOURNAL   J Cell Biol 216 (6), 1795-1810 (2017)
   PUBMED   28432080
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Liu Q, Klingler RH, Wimpee B, Dellinger M, King-Heiden T,
            Grzybowski J, Gerstenberger SL, Weber DN and Carvan MJ 3rd.
  TITLE     Maternal methylmercury from a wild-caught walleye diet induces
            developmental abnormalities in zebrafish
  JOURNAL   Reprod Toxicol 65, 272-282 (2016)
   PUBMED   27544571
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Mirbahai L, Williams TD, Zhan H, Gong Z and Chipman JK.
  TITLE     Comprehensive profiling of zebrafish hepatic proximal promoter CpG
            island methylation and its modification during chemical
            carcinogenesis
  JOURNAL   BMC Genomics 12, 3 (2011)
   PUBMED   21205313
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Bolli N, Payne EM, Grabher C, Lee JS, Johnston AB, Falini B, Kanki
            JP and Look AT.
  TITLE     Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the
            expansion of hematopoietic cells in zebrafish
  JOURNAL   Blood 115 (16), 3329-3340 (2010)
   PUBMED   20197555
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Jovelin R, Yan YL, He X, Catchen J, Amores A, Canestro C, Yokoi H
            and Postlethwait JH.
  TITLE     Evolution of developmental regulation in the vertebrate FgfD
            subfamily
  JOURNAL   J Exp Zool B Mol Dev Evol 314 (1), 33-56 (2010)
   PUBMED   19562753
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Skarie JM and Link BA.
  TITLE     The primary open-angle glaucoma gene WDR36 functions in ribosomal
            RNA processing and interacts with the p53 stress-response pathway
  JOURNAL   Hum Mol Genet 17 (16), 2474-2485 (2008)
   PUBMED   18469340
REFERENCE   10 (bases 1 to 1598)
  AUTHORS   Wotton KR, Weierud FK, Dietrich S and Lewis KE.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005027.13.
            
            On Aug 20, 2015 this sequence version replaced NM_199428.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053240.1, CN016602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476743, SAMEA4476768
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               BX005027.13        167382-167554       c
            174-253             BX005027.13        166395-166474       c
            254-373             BX005027.13        166170-166289       c
            374-467             BX005027.13        165987-166080       c
            468-574             BX005027.13        165801-165907       c
            575-612             BX005027.13        165682-165719       c
            613-679             BX005027.13        160799-160865       c
            680-757             BX005027.13        160632-160709       c
            758-856             BX005027.13        160441-160539       c
            857-931             BX005027.13        160276-160350       c
            932-1598            BX005027.13        156929-157595       c
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1598
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /note="nucleophosmin 1a"
                     /db_xref="GeneID:266985"
                     /db_xref="ZFIN:ZDB-GENE-021028-1"
     exon            1..173
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2..4
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /note="upstream in-frame stop codon"
     CDS             134..973
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /note="nucleophosmin 1; nucleophosmin 1a (nucleolar
                     phosphoprotein B23, numatrin)"
                     /codon_start=1
                     /product="nucleophosmin 1a"
                     /protein_id="NP_955460.2"
                     /db_xref="GeneID:266985"
                     /db_xref="ZFIN:ZDB-GENE-021028-1"
                     /translation="

MDLEQMGPQTFLYGCELKAGKDITFNPEDDDYDHQLSVRMACVDPSTKDELNVVEIEGQDSEGQKVKAVLATLKPSTLPSVCLGGFEITPPVVFRLRTGSGPVHISGQHLVIMGGDQSFDEEEEEEEEEETVMTSKKRPALSTPKPSKKMKMDEEDDDDDDEDDDDEDDDEEDESEEESPVKEKKAPAKPKTPTQNGKGPKPSTPAKQTPQKGKKEQTPKTPQTPRTLADIKSKMMESVAKGVSLPKVQLKFENYVNNCFKGTDPKVVEELWKWRQTVK"

     misc_feature    167..466
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /note="Nucleoplasmin/nucleophosmin domain; Region:
                     Nucleoplasmin; pfam03066"
                     /db_xref="CDD:427119"
     misc_feature    818..964
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /note="Nucleophosmin C-terminal domain; Region: NPM1-C;
                     pfam16276"
                     /db_xref="CDD:435252"
     exon            174..253
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            254..373
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            374..467
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            468..574
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            575..612
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            613..679
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            680..757
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            758..856
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            857..931
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1598
                     /gene="npm1a"
                     /gene_synonym="npm1; sb:cb487"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtgattggctggaccggaggaccgtcacagaagtgggcgtgatttactcgatgtgggtcagtgtgctcttcctgcactcgtgttcgctgactgcacatttcagccgacgtacagtcacacacagcctgcagacatggatctcgaacagatgggtccccaaaccttcctgtacggttgtgaactgaaagcaggcaaggatatcacgtttaatccagaggatgatgattatgatcatcaattatcggttagaatggcctgtgtggatccctcgacaaaagatgaattgaatgttgtggagattgaaggacaagattcagagggtcagaaggtcaaggcagttctagcaacactcaagccttcaactctcccaagtgtatgtttgggtgggtttgagatcacgccaccggttgttttccgtctgcgcactggttctggtccagttcacattagtggacagcatcttgttatcatgggaggagatcagtcttttgatgaagaggaggaggaggaggaagaagaggaaaccgtgatgacatccaagaagaggccagcgctgtcaactccaaagccttcaaaaaaaatgaagatggatgaggaagatgacgatgatgatgatgaggacgatgatgatgaagatgacgatgaggaagatgaaagtgaagaggagtcacctgtgaaagaaaagaaagcaccagcgaaaccaaagacccctacacagaatggaaaaggacccaaacccagtacacctgctaaacaaactccacaaaagggcaagaaggaacagacacccaaaacgccacaaacaccacggactttagccgatatcaagtccaagatgatggagagtgtagcaaagggtgtgtcattaccaaaagtacagctgaagtttgagaactatgtgaataactgcttcaaaggcacagatccaaaggttgttgaggagctctggaagtggagacagactgtcaaataaatgaactaaaacgccttttattttgcttaaattaagcccctttcccacacgattttacttttgttacctgcaattttatgtttgtttgtccccatacctttcagtttttatgttaaatccgtgccattcctcgaaatgacttgaaacaacttgaccttgttcagtctgccttgtcctcaccctcggtcatgtcatttgagtgtggggttaacttggctgcagtattgctcaattatgaagctctgatttatataaagatatgttggtggtgcccgtccatgttttctttaaactgacatggaaatgtctgcatagctatctggttagatctgtgatgcgataatgcaatgtatgaatagtgggtttcagaatggcctcaatgtttaattctggtatttcagcagcagttgatattattttgtaattttcattccctggaaagagttaaatgccattgtatgttcaggattgaatggtcttcagatgtcatcaatgtattgtaatgtcacagactttgcagccctgtctcaacagaatcaggactcaggacatttcagatgtggttctgttttttgactttctgaaatgtttaaatgcaaataaaggatatatttcacaactgaaa

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