LOCUS       NM_181495               3193 bp    mRNA    linear   VRT 20-DEC-2022
DEFINITION  Danio rerio NOTCH regulated ankyrin repeat protein a (nrarpa),
            mRNA.
ACCESSION   NM_181495
VERSION     NM_181495.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3193)
  AUTHORS   Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G and Gill
            PS.
  TITLE     Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch
            pathways
  JOURNAL   Biol Open 10 (2) (2021)
   PUBMED   32694189
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3193)
  AUTHORS   Nitzan M, Karaiskos N, Friedman N and Rajewsky N.
  TITLE     Gene expression cartography
  JOURNAL   Nature 576 (7785), 132-137 (2019)
   PUBMED   31748748
REFERENCE   3  (bases 1 to 3193)
  AUTHORS   You MS, Wang WP, Wang JY, Jiang YJ and Chi YH.
  TITLE     Sun1 Mediates Interkinetic Nuclear Migration and Notch Signaling in
            the Neurogenesis of Zebrafish
  JOURNAL   Stem Cells Dev 28 (16), 1116-1127 (2019)
   PUBMED   31140357
REFERENCE   4  (bases 1 to 3193)
  AUTHORS   Jagadeeshan S, Sagayaraj RV, Paneerselvan N, Ghouse SS and Malathi
            R.
  TITLE     Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3
            using zebrafish embryo model
  JOURNAL   Cell Biol Toxicol 33 (1), 41-56 (2017)
   PUBMED   27581547
REFERENCE   5  (bases 1 to 3193)
  AUTHORS   Katz S, Cussigh D, Urban N, Blomfield I, Guillemot F, Bally-Cuif L
            and Coolen M.
  TITLE     A Nuclear Role for miR-9 and Argonaute Proteins in Balancing
            Quiescent and Activated Neural Stem Cell States
  JOURNAL   Cell Rep 17 (5), 1383-1398 (2016)
   PUBMED   27783951
REFERENCE   6  (bases 1 to 3193)
  AUTHORS   Wright D, Ferjentsik Z, Chong SW, Qiu X, Yun-Jin J, Malapert P,
            Pourquie O, Van Hateren N, Wilson SA, Franco C, Gerhardt H, Dale JK
            and Maroto M.
  TITLE     Cyclic Nrarp mRNA expression is regulated by the somitic oscillator
            but Nrarp protein levels do not oscillate
  JOURNAL   Dev Dyn 238 (12), 3043-3055 (2009)
   PUBMED   19882724
REFERENCE   7  (bases 1 to 3193)
  AUTHORS   Baxendale S, Chen CK, Tang H, Davison C, Hateren LV, Croning MD,
            Humphray SJ, Hubbard SJ and Ingham PW.
  TITLE     Expression screening and annotation of a zebrafish myoblast cDNA
            library
  JOURNAL   Gene Expr Patterns 9 (2), 73-82 (2009)
   PUBMED   19007914
REFERENCE   8  (bases 1 to 3193)
  AUTHORS   Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, Ondr
            JK, Rao S, Lang RA, Thurston G and Gerhardt H.
  TITLE     Nrarp coordinates endothelial Notch and Wnt signaling to control
            vessel density in angiogenesis
  JOURNAL   Dev Cell 16 (1), 70-82 (2009)
   PUBMED   19154719
  REMARK    GeneRIF: Results show that the Notch-regulated ankyrin repeat
            protein (Nrarp) acts as a molecular link between Notch- and
            Lef1-dependent Wnt signaling in endothelial cells to control
            stability of new vessel connections in mouse and zebrafish.
REFERENCE   9  (bases 1 to 3193)
  AUTHORS   Ishitani T, Matsumoto K, Chitnis AB and Itoh M.
  TITLE     Nrarp functions to modulate neural-crest-cell differentiation by
            regulating LEF1 protein stability
  JOURNAL   Nat Cell Biol 7 (11), 1106-1112 (2005)
   PUBMED   16228014
REFERENCE   10 (bases 1 to 3193)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF509780.1.
            
            On Feb 11, 2007 this sequence version replaced NM_181495.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF509780.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3193
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..3193
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="NOTCH regulated ankyrin repeat protein a"
                     /db_xref="GeneID:353224"
                     /db_xref="ZFIN:ZDB-GENE-030515-6"
     exon            1..3178
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    167..169
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="upstream in-frame stop codon"
     CDS             176..514
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /codon_start=1
                     /product="notch-regulated ankyrin repeat-containing
                     protein A"
                     /protein_id="NP_852472.1"
                     /db_xref="GeneID:353224"
                     /db_xref="ZFIN:ZDB-GENE-030515-6"
                     /translation="

MSQADISTCSAPQRVFQEAVKKGNTKELHSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANREGWSALHIAAFGGHQDIVLYLITKAKYSSGAR"

     misc_feature    order(227..229,236..244,248..253,263..265,272..274,
                     311..313,317..319,323..325,335..340,347..355,359..364,
                     374..376,383..385,410..412,416..418,422..424,434..439,
                     446..454,458..463,473..475)
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    230..487
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:432791"
     misc_feature    317..412
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    317..406
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7T3Y0.1);
                     Region: ANK 1"
     misc_feature    416..505
                     /gene="nrarpa"
                     /gene_synonym="fc89b12; id:ibd2282; Nrarp-a; wu:fa14d10;
                     wu:fc89b12; zgc:100826"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7T3Y0.1);
                     Region: ANK 2"
ORIGIN      

cttgcgaaggattgaactttcttgctaggtcttttggatacaagactgcattttacacaccaagtgtgtcgtttacttgtcctttttgggatatactctcgtcttattcaagtctcacgcgcctaaactggttttagtccagttaagctgcgagtttctcccagtgtgaagcatcatgagccaggcggatatatcgacgtgctcggcgccgcagagagtcttccaggaggcggtaaaaaaaggcaacaccaaggagctccactcactgctgcagaacatgaccaactgcgagtttaacgtcaactccttcggccccgagggacagacggcgctgcaccagtcggtcatcgacgggaacctggagctcgtgaaactgctggttaaatttggagccgatattcggctcgccaaccgggagggctggagcgcgttgcacatcgccgctttcgggggacaccaagacatcgtgttatacctcatcaccaaggccaagtactcgtccggcgcgcggtgatccggtgcaacacgcggaaaagaccgggctcgtttcgttctagcattgatctgacagaccgcggagaagttcccttaaaaccaaatgagggctgtagcctttttctttcccgtgagtatgtatatcaatctgtctgtggtcagatctggcgacgagagagagactgaaacgcacgctgcgttggtactatagctttttattgaatgtttaagtcagcagatctggactgtgtgtggctttaccaggccgtgacctgttgacctgtccacctggagaaatcgagatggcacttgatgctgtggctgaatgctggaatagttgaaagaggtgaactccagaatgaaggccatcatcctctgttttggctaaacactgtcttttaatacgaaccgtgcaagtcgtttcatcaatcaaatcatgtggcattggtgaccagtgctcaaatatttcctcgaaataacaattgacttattcttaagtactgtacacatagctttaccgtgtctctctgtataagtagtctattgcgctctgccttcacctagcagacccgcagcttccacacagctttcaggccagtgcgacccatatggttaacgtgttactaaaaaaatcgctgctttcgcttttcttttatttcttaatttttgtttgtatcaaaacgtcaggaaagtcgcctttgggacacactttgtaatcttctttcagtattttgaattaacaccctggtcatcactgtgaatacaggctgggtttgtctttttatttatgaaggtacattgagatgatgcatttaaattatgttgtggttattttttaagactatagcctaagtgtaaaagtatgtagggtgacataaagctgcttcggactcgttacaggctaaactgtcccgcgtggagactccacgcctcggccccccacgtgtacacctagatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatttttttttttttttttctcccctgggaaaacgcgtgccctttttaacttttattctggttctctgcatcagctacctcgacttgaaagtattcaacaaaatcatatgctctctgtctcaagccttctctttaactcttctcagttacccactagtgctgtttttaatgtttatttttttggtcaacagtatcattaggccctatttgggttattttacttgatgtcatccccacatcttcactcgggacaaatatatctccatgaaccaaaataagatccattggtcattccgacttttcgttcaccaagcatggttgagacgttgtatgtggttttatttgcttaattttgcatacagctttttttgtttcaactgcagtgacaaaaagtgaaatgcattgcatgactattaaatgcagggagttttgttgcacataaacgtggagccttttacgccccctagtgcctggtcgggtaactgcaggagctgaggcttaccaatagttactactgagcaggactatacaagtgaacatttaaaaagactattccgttgcaggaaacatcgacagattcgcttaaaaagagactgcctgccgcttttaagagtcatggcacctgatgtttgtttcaatgctgcttttatgtaagtttttccttgatacaatggccaacagtgagagagtggacgaggacatctaatatatcagttagatttttctgcgagaagccccatgcagttgtgtgagcgtgtgtgattgtactcatcctgtcttgcacaaaccaacgctacaatattttaagtggcgttgctgatgtttccagcccctgacgctcaacctggtttgccggccaggagctcctggagaaagcaaccgatgtgaaaccattctcaagatcatctgttcgattggtataggcagaacaaatatgcatcgcttgtcttaaacttgatatttttactcttgttgaaaatattgcactgatgatgactgttgttaattcgttgacttcaggtcaacattttatttttttctaaatagaaaaaaggaacacaacaaaaatactattgtataaaaaaaagctccaggttatattgtctcttcttgttgtataacattacgtttgcaaagatgtttatctctgtgatcgggtgtatgtgtatacatatatagtatatatatggatatatagacgctgatatctcagagcactttcttatttgaagtgctctcctcctgatgttaataaaggggaataatacatgtgatggtaagatcattgtaacaaaagaaattgcacgatgtatagttgtttcaccccaaactttgtcataacatttatgacatggggttaaatgactggataggtgtatatgaatgagtaaaagtgctgtttttttctttctttgtctttttgtggaccaagttattttgtgtctccagcaaacaaaagttttatgagtgatgcgagtgttcgttgtgttgatttcagctttttgtttgtgcgtccgtttttgtttgtaatttttgaacatttgtaacactgtgattcgtgtgtggtgaggatatgagtgctgtaatgtgtgtttttttgttgttgttgttgtatgcgtgtatgtgttcaagccagtaaagaaataattaaaccttcaaaaaaaaaaaaaaa

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