LOCUS       NM_170766               2281 bp    mRNA    linear   VRT 02-AUG-2023
DEFINITION  Danio rerio T cell leukemia homeobox 3b (tlx3b), mRNA.
ACCESSION   NM_170766
VERSION     NM_170766.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2281)
  AUTHORS   Schwarzer S, Spiess S, Brand M and Hans S.
  TITLE     Dlx3b/4b is required for early-born but not later-forming sensory
            hair cells during zebrafish inner ear development
  JOURNAL   Biol Open 6 (9), 1270-1278 (2017)
   PUBMED   28751305
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2281)
  AUTHORS   Takeuchi M, Yamaguchi S, Sakakibara Y, Hayashi T, Matsuda K, Hara
            Y, Tanegashima C, Shimizu T, Kuraku S and Hibi M.
  TITLE     Gene expression profiling of granule cells and Purkinje cells in
            the zebrafish cerebellum
  JOURNAL   J Comp Neurol 525 (7), 1558-1585 (2017)
   PUBMED   27615194
  REMARK    Erratum:[J Comp Neurol. 2021 Aug 1;529(11):3127. PMID: 34050936]
REFERENCE   3  (bases 1 to 2281)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2281)
  AUTHORS   Aoki M, Segawa H, Naito M and Okamoto H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   5  (bases 1 to 2281)
  AUTHORS   Regadas I, Matos MR, Monteiro FA, Gomez-Skarmeta JL, Lima D, Bessa
            J, Casares F and Reguenga C.
  TITLE     Several cis-regulatory elements control mRNA stability, translation
            efficiency, and expression pattern of Prrxl1 (paired related
            homeobox protein-like 1)
  JOURNAL   J Biol Chem 288 (51), 36285-36301 (2013)
   PUBMED   24214975
REFERENCE   6  (bases 1 to 2281)
  AUTHORS   Wotton KR, Weierud FK, Dietrich S and Lewis KE.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2281)
  AUTHORS   Chen J, Jette C, Kanki JP, Aster JC, Look AT and Griffin JD.
  TITLE     NOTCH1-induced T-cell leukemia in transgenic zebrafish
  JOURNAL   Leukemia 21 (3), 462-471 (2007)
   PUBMED   17252014
REFERENCE   8  (bases 1 to 2281)
  AUTHORS   Takamiya M and Campos-Ortega JA.
  TITLE     Hedgehog signalling controls zebrafish neural keel morphogenesis
            via its level-dependent effects on neurogenesis
  JOURNAL   Dev Dyn 235 (4), 978-997 (2006)
   PUBMED   16502420
REFERENCE   9  (bases 1 to 2281)
  AUTHORS   Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL and Look AT.
  TITLE     Cre/lox-regulated transgenic zebrafish model with conditional
            myc-induced T cell acute lymphoblastic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 6068-6073 (2005)
   PUBMED   15827121
REFERENCE   10 (bases 1 to 2281)
  AUTHORS   Nguyen VH, Trout J, Connors SA, Andermann P, Weinberg E and Mullins
            MC.
  TITLE     Dorsal and intermediate neuronal cell types of the spinal cord are
            established by a BMP signaling pathway
  JOURNAL   Development 127 (6), 1209-1220 (2000)
   PUBMED   10683174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005027.13.
            
            On Aug 2, 2023 this sequence version replaced NM_170766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF398519.1, BC162334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA898401, SAMEA898403
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               BX005027.13        145148-145663
            517-754             BX005027.13        147763-148000
            755-2281            BX005027.13        149468-150994
FEATURES             Location/Qualifiers
     source          1..2281
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..2281
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="T cell leukemia homeobox 3b"
                     /db_xref="GeneID:266965"
                     /db_xref="ZFIN:ZDB-GENE-021021-1"
     exon            1..516
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..968
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="tlx3"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 3b"
                     /protein_id="NP_739572.2"
                     /db_xref="GeneID:266965"
                     /db_xref="ZFIN:ZDB-GENE-021021-1"
                     /translation="

MDRAPSSSPSGTSQTSQPTQHEPISFGIDQILSGTDQESQQNSTRNSSESSSGSSSASGGCYHLGSPTGASATPYTTLTGTFHGIAAPYEESSPYGMNLTLAPGGVIRVPAHRPLAAAVPPPMASAVPGLGSLSFPWMESSQRFAKDRFAAALTPFTVARRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKTLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMIQLQHDAFQKSLTDSVPTDPLCIHNSSLFALQNLQPWASEESSKLGGVTALV"

     misc_feature    order(588..602,606..608,657..659,675..677,714..716,
                     720..725,732..737,741..749,753..758)
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    594..755
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(594..596,603..605,723..725,732..737,744..746)
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            517..754
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2281
                     /gene="tlx3b"
                     /gene_synonym="Tlx-3b; ztlx-3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcaaatccaggactgttcgaaattgtctgtggaataaaaccgctggaaaggttcgggtggtgaggatggaccgagctccaagctccagcccaagtggcaccagtcaaacatcacaaccaacccaacatgaacccatcagcttcggcattgaccagattctcagcggaaccgatcaagaatcacagcagaactcgaccaggaatagttcggagagcagcagtggcagtagcagtgcgagcggaggctgttaccatctcggcagcccaacgggagcgagcgcaacgccgtacacgacgcttaccggcacatttcatggtatcgcggctccttatgaggagtccagtccatacggaatgaacttgacccttgcgcccggaggagtgattagggtcccggcgcacaggccccttgccgcggccgttcctccacctatggccagcgcggtacccggacttgggagcctcagttttccctggatggagagcagccagcgctttgcaaaagacaggtttgcagcagccttgacgccttttactgtggctcgacgtattggtcacccgtaccagaaccgcacaccaccaaagagaaagaagcctcgcacgtccttctccagagtgcagatctgtgagctggagaagcgctttcacagacaaaaatacctggccagcgctgaacgggcagctttggccaaaactctaaagatgacagacgcacaggtcaaaacatggtttcagaaccgcaggactaaatggagacggcaaacggcggaggaaagggaagcagagcgtcagcaggccaaccggctaatgattcagcttcagcatgatgccttccagaaatctttgactgattcagttccaacagatccgctctgcatccacaactcatccctgtttgccctgcagaacctacagccttgggctagtgaagagagcagcaagcttggaggagtgacggcgctcgtatgagtatcgcaactcaaaggaaaagacattctttgttttgatggactaggatgttggttgactttatccccatcccaaatgactatttcattcaaccacaaaaaaggcgaggaactaatttcggcagtctacaaatgagcaaacccatataaataaaaaggcctttccaaaataaatgaaggccgttttctgtggtgtgtctgtgagtacagagacttttatccccatcagggtcaatttcattgacaaactgacccaaaggaaggacagggcatctcagctgacccttttacagagctactaatctcctcttccatcctttcatttgcccttctgccctaaacccccccctcccccctgtgtaatttctccaccactcagagctgtgcaatacaggattaatgcagaagagggaagtaacaatgaattaattatttataatgcaagttgcacgacctaaaatgcccccaatatgtccatgtaagaaaaaaaggacaaaaaagtatttttaaagagtagtacagtcttcaacacatataatttcatttctttctcaagttgggtataatagcaaaatgtatcatttcagattttaacccacacaaaaataattcagagttggtttaaatccaatttgcattaaatatggacaaactttacatttgaattattattaatatttatttaatcattattttaagtttttttttttttttaccttttattgggataggatagtggaggacagacaggaaaacattgggagcagagagaagggaagggtcggcataggacctcgagccaggaatcgaacttgggtcgccatgagccctatggtgctatatgtcatcgctcttaaccactaggctattggcgcagaccattttaattatttttcaattaacgttttaattcagtggttaggtttgtcaatattttcacccaaattcttgagtgaaggaacaataacactctcctatttgtgtttttatttatatttatgaaacggcatcccaacaatttgaggaataggatgaagtgtcctgaagaaaggggtaattttgtattttgcagtggttgcaattttcatcacccgcgtttcattcagtagtatcttcaaatgcagctcaaaaactttttcgaaacagtccagtggctgagcgttgtgtgtcagtgggaaatgaacaatttaaagggtttgtgagatgaccctgtgatgtaggtgtgctgttgcatcccaaaatctgtattatactttgtatttgataaatatgtaaatagcaaacaaaaaggaataaacattgttttggcattaa

//