LOCUS       NM_170765               2223 bp    mRNA    linear   VRT 24-JUL-2022
DEFINITION  Danio rerio T cell leukemia homeobox 1 (tlx1), mRNA.
ACCESSION   NM_170765
VERSION     NM_170765.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Xie L, Chen Z, Guo H, Tao Y, Miao X, Wu R and Li Y.
  TITLE     Congenital Asplenia Interrupts Immune Homeostasis and Leads to
            Excessive Systemic Inflammation in Zebrafish
  JOURNAL   Front Cell Infect Microbiol 11, 668859 (2021)
   PUBMED   34262881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Lin Z, Luo M, Zhou B, Liu Y and Sun H.
  TITLE     CFTR regulates embryonic T lymphopoiesis via Wnt signaling in
            zebrafish
  JOURNAL   Immunol Lett 234, 47-53 (2021)
   PUBMED   33951474
REFERENCE   3  (bases 1 to 2223)
  AUTHORS   Loontiens S, Vanhauwaert S, Depestel L, Dewyn G, Van Loocke W,
            Moore FE, Garcia EG, Batchelor L, Borga C, Squiban B, Malone-Perez
            M, Volders PJ, Olexiouk V, Van Vlierberghe P, Langenau DM, Frazer
            JK, Durinck K and Speleman F.
  TITLE     A novel TLX1-driven T-ALL zebrafish model: comparative genomic
            analysis with other leukemia models
  JOURNAL   Leukemia 34 (12), 3398-3403 (2020)
   PUBMED   32591643
REFERENCE   4  (bases 1 to 2223)
  AUTHORS   Xie L, Tao Y, Wu R, Ye Q, Xu H and Li Y.
  TITLE     Congenital asplenia due to a tlx1 mutation reduces resistance to
            Aeromonas hydrophila infection in zebrafish
  JOURNAL   Fish Shellfish Immunol 95, 538-545 (2019)
   PUBMED   31678534
  REMARK    GeneRIF: Our data suggest that tlx1 is a crucial regulator of
            spleen development in fish, as it is in mammals.
REFERENCE   5  (bases 1 to 2223)
  AUTHORS   Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS,
            Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe
            G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah
            K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM,
            Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G
            and Langenau DM.
  TITLE     TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell
            Acute Lymphoblastic Leukemia
  JOURNAL   Cancer Discov 7 (11), 1336-1353 (2017)
   PUBMED   28974511
REFERENCE   6  (bases 1 to 2223)
  AUTHORS   Zweier-Renn LA, Hawley TS, Burkett S, Ramezani A, Riz I, Adler RL,
            Hickstein DD and Hawley RG.
  TITLE     Hematopoietic immortalizing function of the NKL-subclass homeobox
            gene TLX1
  JOURNAL   Genes Chromosomes Cancer 49 (2), 119-131 (2010)
   PUBMED   19862821
  REMARK    GeneRIF: Detrmination site by nested polymerase chain reaction the
            integration sites in TLX1-immortalized hematopoietic cell lines.
REFERENCE   7  (bases 1 to 2223)
  AUTHORS   Jovelin R, Yan YL, He X, Catchen J, Amores A, Canestro C, Yokoi H
            and Postlethwait JH.
  TITLE     Evolution of developmental regulation in the vertebrate FgfD
            subfamily
  JOURNAL   J Exp Zool B Mol Dev Evol 314 (1), 33-56 (2010)
   PUBMED   19562753
REFERENCE   8  (bases 1 to 2223)
  AUTHORS   Wotton KR, Weierud FK, Dietrich S and Lewis KE.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2223)
  AUTHORS   Chen J, Jette C, Kanki JP, Aster JC, Look AT and Griffin JD.
  TITLE     NOTCH1-induced T-cell leukemia in transgenic zebrafish
  JOURNAL   Leukemia 21 (3), 462-471 (2007)
   PUBMED   17252014
REFERENCE   10 (bases 1 to 2223)
  AUTHORS   Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL and Look AT.
  TITLE     Cre/lox-regulated transgenic zebrafish model with conditional
            myc-induced T cell acute lymphoblastic leukemia
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 6068-6073 (2005)
   PUBMED   15827121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF398517.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF398517.1, BC162115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505377, SAMEA3505393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..2223
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /note="T cell leukemia homeobox 1"
                     /db_xref="GeneID:266964"
                     /db_xref="ZFIN:ZDB-GENE-021021-2"
     exon            1..569
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    74..76
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /note="upstream in-frame stop codon"
     CDS             113..1018
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 1"
                     /protein_id="NP_739571.1"
                     /db_xref="GeneID:266964"
                     /db_xref="ZFIN:ZDB-GENE-021021-2"
                     /translation="

MDHMGAHLHQTHADTISFGIDQILNNADQGSCMITNPRMQDLDYGLGCIVSTAYNTMTGNYNVNNSSGYNGNSCSVGSYNMNLGANVNGNCLNSSGVIRVPAHRPLGSVHSSIPTSAATVPSMGSMGTINNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQKTINQPVTPDPICLHNSSLFALQNLQPWTENTAKISSVPNTD"

     misc_feature    order(641..655,659..661,710..712,728..730,767..769,
                     773..778,785..790,794..802,806..811)
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    647..808
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(647..649,656..658,776..778,785..790,797..799)
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            570..807
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..2223
                     /gene="tlx1"
                     /gene_synonym="hox11; SI:dZ46P4.1; Tlx-1; ztlx-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

catgcagtcaatgcagttagataacgacaagtctggactaaactgcgttttagttgctgtatgataactcgggtgacgtgggggatcgcaggagcgcgcgcctctccacaccatggatcatatgggagcgcatctccaccagacgcacgcagacaccatcagttttgggatcgatcagattctcaacaatgcagaccaggggagctgcatgatcaccaaccccagaatgcaggacctggactacggtttgggctgcatagtcagcacagcatacaataccatgactggtaactacaacgtcaataactcctctggatacaatggaaactcttgcagcgtcgggtcctacaacatgaacttgggcgcgaatgttaacggaaattgccttaattcgtcgggagtgatccgggttcctgcacaccggccgctgggcagcgttcactcgtccattcccacaagcgctgccacggtgccaagtatgggaagcatgggcactattaacaatctcacgggattaacgtttccgtggatggagagtaacaggagatataccaaagacaggtttacagtggccctctcaccgttcactgtaacacgccgtataggtcacccgtaccagaaccgaacacctccgaagaagaagaagccccggacgtcgttcacgcgccttcagatatgtgagctggagaaacgctttcaccgtcagaagtatctggcgtcagccgagagagcagccttagcgaaagcacttaaaatgactgatgcgcaggtcaaaacatggttccagaacagaagaacgaaatggaggcggcagacagcggaggagagagaagccgagcgacaacaagccaaccgaattctaatgcagcttcagcaagaagcttttcaaaagactataaaccagcctgttactccagacccaatctgtctacacaacagctctctattcgcacttcagaacctgcagccctggactgagaacacggcaaaaatcagcagcgttcccaacactgactgatggagacttgtggacgcgcggtgtacagaggaacagcaacagcacattacttcttttaactaaattactattttatttgtaacatgcaacttgtttaaagtaactttaataattgcctttctcgtgcagaataatcagttttgaaattgatttttataggtttgatcatttccattttaaaatgcaacgaacaaattgttattgcgcatttggtttgtctcttgcgcattcattttatttggtatataccatacctacttctaagatctgacgcgtgtgataacactttataataccttaaattaaacatcacaacattttacaaatgaaatatagataacaaacgtacgagccttagttaaattaggggcttttctaaaagcataataatttaatttaattgatattaggtcagaaatcgccacagaactaattgtgcatgggctatgttaaattagaacacctaaatggataaataaaattgccatagcacacatcttcctccgtcactagaaaaaggctctctgttctaatacttttttgtggagaaaaaggagcattactgcttgtttggtgaagctaaaacgaatagtgaacgccacctttctgatgtagcctatgaaatatacggtaagcgtcgttataattaaaatcctttttattgaaagaatatgcacacgcagggtgaaaggttgcacttcttaacccacaatcgagcgaaaactaaagtttctcttttactgtcttacgacggtctctttcacttctgacagtttacagtcgcgataccctctgtcagtagaatgtgaattgaaaaattaagctattaaaatcgtttgattgggtgtactttgaatataaaggaattaaaaagtaaatgtatccaagttcaaagtactaaatagtcgatttgttcaatatttaatagcctatatgcacctttttaacttgttcctacactgaaagaaaatggataatattacagttattataaactgttatcacaaaattaatattattattattattaggcttaccaatttggcttttgttactattttttttataatcacagagggaccgaatttttgcacgtttgttaacctaagtgggctaacatttttaaaaatcgacacgatttaaaagtagtctacaagggtctacataatggaatttcatttgttatgcaactatggtgaagacgg

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