LOCUS       NM_152940               2385 bp    mRNA    linear   VRT 29-JUL-2023
DEFINITION  Danio rerio cone-rod homeobox (crx), mRNA.
ACCESSION   NM_152940
VERSION     NM_152940.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Carstensen MB, Medvetzky A, Weinberger A, Driever W, Gothilf Y and
            Rath MF.
  TITLE     Genetic ablation of the Bsx homeodomain transcription factor in
            zebrafish: Impact on mature pineal gland morphology and circadian
            behavior
  JOURNAL   J Pineal Res 72 (4), e12795 (2022)
   PUBMED   35249239
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Itoh T, Inoue S, Sun X, Kusuda R, Hibi M and Shimizu T.
  TITLE     Cfdp1 controls the cell cycle and neural differentiation in the
            zebrafish cerebellum and retina
  JOURNAL   Dev Dyn 250 (11), 1618-1633 (2021)
   PUBMED   33987914
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Ogawa Y, Shiraki T, Fukada Y and Kojima D.
  TITLE     Foxq2 determines blue cone identity in zebrafish
  JOURNAL   Sci Adv 7 (41), eabi9784 (2021)
   PUBMED   34613771
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Dhakal S, Rotem-Bamberger S, Sejd JR, Sebbagh M, Ronin N, Frey RA,
            Beitsch M, Batty M, Taler K, Blackerby JF, Inbal A and Stenkamp DL.
  TITLE     Selective Requirements for Vascular Endothelial Cells and
            Circulating Factors in the Regulation of Retinal Neurogenesis
  JOURNAL   Front Cell Dev Biol 9, 628737 (2021)
   PUBMED   33898420
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Hao Q, Zheng M, Weng K, Hao Y, Zhou Y, Lin Y, Gao F, Kou Z,
            Kawamura S, Yao K, Xu P, Chen J and Zou J.
  TITLE     Crumbs proteins stabilize the cone mosaics of photoreceptors and
            improve vision in zebrafish
  JOURNAL   J Genet Genomics 48 (1), 52-62 (2021)
   PUBMED   33771456
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Babb SG, Kotradi SM, Shah B, Chiappini-Williamson C, Bell LN,
            Schmeiser G, Chen E, Liu Q and Marrs JA.
  TITLE     Zebrafish R-cadherin (Cdh4) controls visual system development and
            differentiation
  JOURNAL   Dev Dyn 233 (3), 930-945 (2005)
   PUBMED   15918170
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Perkins BD, Nicholas CS, Baye LM, Link BA and Dowling JE.
  TITLE     dazed gene is necessary for late cell type development and retinal
            cell maintenance in the zebrafish retina
  JOURNAL   Dev Dyn 233 (2), 680-694 (2005)
   PUBMED   15844196
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Shen YC and Raymond PA.
  TITLE     Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis
  JOURNAL   Dev Biol 269 (1), 237-251 (2004)
   PUBMED   15081370
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Stenkamp DL and Frey RA.
  TITLE     Extraretinal and retinal hedgehog signaling sequentially regulate
            retinal differentiation in zebrafish
  JOURNAL   Dev Biol 258 (2), 349-363 (2003)
   PUBMED   12798293
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   Stenkamp DL, Frey RA, Mallory DE and Shupe EE.
  TITLE     Embryonic retinal gene expression in sonic-you mutant zebrafish
  JOURNAL   Dev Dyn 225 (3), 344-350 (2002)
   PUBMED   12412019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF503443.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503443.1, CN510104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505372
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     gene            1..2385
                     /gene="crx"
                     /note="cone-rod homeobox"
                     /db_xref="GeneID:81881"
                     /db_xref="ZFIN:ZDB-GENE-010403-1"
     misc_feature    375..377
                     /gene="crx"
                     /note="upstream in-frame stop codon"
     CDS             411..1256
                     /gene="crx"
                     /codon_start=1
                     /product="cone-rod homeobox protein"
                     /protein_id="NP_694419.1"
                     /db_xref="GeneID:81881"
                     /db_xref="ZFIN:ZDB-GENE-010403-1"
                     /translation="

MMSYIKQPHYAVNGLTLSASGMDLLHTAVGYPATPRKQRRERTTFTRTQLDILEALFTKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQTSGQPKPRPPKKKSSPPPDLTSDPGTSSSVVAAPTPTVPPSVSAGTAPVSVWSPTSLSPLPDPLCGSGTPCVQRPAPYPMSYGQPSSYSQGYGSSPYFSGLDCSPYLSPMTTQLSASGGALSPLTVPSMGGSLSQSPSLSSQGYSTASLGFSSVDCLDYKDQQAWKLNFSTVDCLDHKFQVL"

     misc_feature    522..701
                     /gene="crx"
                     /note="Region: homeodomain"
     misc_feature    555..692
                     /gene="crx"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    864..1100
                     /gene="crx"
                     /note="Otx1 transcription factor; Region: TF_Otx;
                     pfam03529"
                     /db_xref="CDD:427350"
ORIGIN      

cggcacgaggctcatagtgtcccgctcctgtccggtcttacccaagggacacgcgcctttaccaacgccaaaactctgaccaagagccagcaacttttctcgcatatagacatttatttgttctttaactcacattagggtctattattggatatttagagcgatagtaatggtagattcctacttaaacttgggcaaaagtgtaagcttattgaagacagcgagtagcgcgcgcgcgagcatctacagctgtttgaggagcacagacacgcgccaggcgcgagcacagacacgcgacccccgacccgtaaaacagcgtcgcagagaaaaaagagagtgagagggggtgagagagggagggagagagagagcaatagagagagtgtgcgagagacgcggccgtcccaagaatgatgtcctacataaagcagccccattatgctgtgaacgggttaacactgtccgcctcaggaatggacctgctccacaccgccgtcggctacccagccactccgaggaagcagcgtcgagagcgcaccaccttcactcgcacccagctggacattctggaagctttgttcaccaaaacacgctatccagacatatttatgagagaagaggtagctctgaaaatcaaccttcccgagtccagagttcaggtgtggtttaagaaccgtcgtgctaaatgccgccagcagcagcagcagaccagcggtcagcccaagccccgtccccccaaaaagaagtcctcccctccccctgatctgacctctgaccctggcactagctcctcggtggtggctgccccgaccccgaccgtgccccctagtgtgagcgcaggcacagcaccagtttctgtatggagtcccacttctctttcccccctccctgatccactgtgtggttcaggcaccccctgcgtgcagcgtcctgctccatatcccatgagctacggtcagccctcttcctacagccagggctatggctcttctccttacttcagcggattggattgcagcccgtacctttctcccatgaccacccagctgtcagcaagtggaggcgccctctcccccctcaccgtgccctccatgggcggctcgctcagccagtcgccctctctctcctcccagggatacagcactgcgtcgttgggcttcagttcggtagactgccttgactacaaggaccagcaggcctggaagctcaacttcagcactgtggactgcctcgaccacaaattccaggtgctgtagaaaagaaagtgagagagagagagtgaagcgcaagagggaaggaaagatgcgtgaagaagaaatgatgcagaactattgccggagacattgtgatgatgaacaggactgaatcagcgtgattcatgtgatcttagaggtgaaaaaaggagcacccattttggaacaggtgaagactgttcctctgtaatccagatctgctctgtgattggctgagattgaagggactcttcaagtctactgatcagtcatcattattaaccatttacctcacacatgcacacaccattgactaactttcacaatgcatacacacaaacacacattggtattaatggtttataaggacatgccattggcattatgtattttatacagttaaaaccatttttatatgaccccacccctaaatctgacccttccaagaaatctgtggcacatttgaaatgtcaatttaagcattttgaattacaaggacataagaaatgtcctcataaaccacagcaatgttgtaattcctaggtcatacccatgtcattatacatttctgtccttgtaaaccacaaaaaccagtacacacagaaacaaagacatgcacataactggaggggaatctgtgtttgtttgtttttttgcagatacagttagcttattgttggacaaagttgttctttctacttttttcatgagtttggtttggtttgtctgtactgggagacattaggagttcttgtgtcgtgcttttagcttgctgttatttatgtatcgttaaattatgttaacttataacaaataatgttgttttctgttagtttgagttaatcgttactaattaaacttcatttaatggcatcgtatgcatgctatcgacatatgttttctatttgggtgaccttgtgtggaaaaatgttggtgtttacaaatgtcattatgttgctttgactgaacacgtacagaggggagctgaaggttttcatttttaattagtattactattccattaattgtggctttgtttaacaacgtctgtctaacaagagttgtctgaactcgcttcttgttgattatggcaagaataaagtatcactgtaattaactaaaaacagggctggaaaaaaaaaaaaaaaaaaaa

//