2024-11-01 07:49:30, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_131856 2180 bp mRNA linear VRT 08-SEP-2024 DEFINITION Danio rerio Kruppel like factor 2a (klf2a), mRNA. ACCESSION NM_131856 VERSION NM_131856.3 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. REFERENCE 1 (bases 1 to 2180) AUTHORS Greysson-Wong,J., Rode,R., Ryu,J.R., Chan,J.L., Davari,P., Rinker,K.D. and Childs,S.J. TITLE rasa1-related arteriovenous malformation is driven by aberrant venous signalling JOURNAL Development 150 (18) (2023) PUBMED 37708300 REFERENCE 2 (bases 1 to 2180) AUTHORS Paolini,A., Sharipova,D., Lange,T. and Abdelilah-Seyfried,S. TITLE Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling JOURNAL Development 150 (18) (2023) PUBMED 37680191 REMARK Erratum:[Development. 2023 Nov 1;150(21):dev202439. doi: 10.1242/dev.202439. PMID: 37922126] REFERENCE 3 (bases 1 to 2180) AUTHORS Li,H., Luo,Q., Cai,S., Tie,R., Meng,Y., Shan,W., Xu,Y., Zeng,X., Qian,P. and Huang,H. TITLE Glia maturation factor-gamma is required for initiation and maintenance of hematopoietic stem and progenitor cells JOURNAL Stem Cell Res Ther 14 (1), 117 (2023) PUBMED 37122014 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 2180) AUTHORS Grdseloff,N., Boulday,G., Rodel,C.J., Otten,C., Vannier,D.R., Cardoso,C., Faurobert,E., Dogra,D., Tournier-Lasserve,E. and Abdelilah-Seyfried,S. TITLE Impaired retinoic acid signaling in cerebral cavernous malformations JOURNAL Sci Rep 13 (1), 5572 (2023) PUBMED 37019926 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2180) AUTHORS Juan,T., Ribeiro da Silva,A., Cardoso,B., Lim,S., Charteau,V. and Stainier,D.Y.R. TITLE Multiple pkd and piezo gene family members are required for atrioventricular valve formation JOURNAL Nat Commun 14 (1), 214 (2023) PUBMED 36639367 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 2180) AUTHORS Corti,P., Young,S., Chen,C.Y., Patrick,M.J., Rochon,E.R., Pekkan,K. and Roman,B.L. TITLE Interaction between alk1 and blood flow in the development of arteriovenous malformations JOURNAL Development 138 (8), 1573-1582 (2011) PUBMED 21389051 REFERENCE 7 (bases 1 to 2180) AUTHORS Nicoli,S., Standley,C., Walker,P., Hurlstone,A., Fogarty,K.E. and Lawson,N.D. TITLE MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis JOURNAL Nature 464 (7292), 1196-1200 (2010) PUBMED 20364122 REMARK Erratum:[Nature. 2010 Sep 16;467(7313):356] REFERENCE 8 (bases 1 to 2180) AUTHORS Vermot,J., Forouhar,A.S., Liebling,M., Wu,D., Plummer,D., Gharib,M. and Fraser,S.E. TITLE Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart JOURNAL PLoS Biol 7 (11), e1000246 (2009) PUBMED 19924233 REMARK GeneRIF: klf2a expression appears to be necessary for normal valve formation. REFERENCE 9 (bases 1 to 2180) AUTHORS Henry,T.B., Menn,F.M., Fleming,J.T., Wilgus,J., Compton,R.N. and Sayler,G.S. TITLE Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression JOURNAL Environ Health Perspect 115 (7), 1059-1065 (2007) PUBMED 17637923 REFERENCE 10 (bases 1 to 2180) AUTHORS Yergeau,D.A., Cornell,C.N., Parker,S.K., Zhou,Y. and Detrich,H.W. 3rd. TITLE bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in zebrafish JOURNAL Dev Biol 283 (1), 97-112 (2005) PUBMED 15890331 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX323550.13 and BX908392.13. On Sep 21, 2011 this sequence version replaced NM_131856.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063933.1, AF392992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-391 BX323550.13 2009-2399 c 392-1286 BX323550.13 700-1594 c 1287-1880 BX323550.13 1-594 c 1881-2180 BX908392.13 177265-177564 c FEATURES Location/Qualifiers source 1..2180 /organism="Danio rerio" /mol_type="mRNA" /strain="Tuebingen" /db_xref="taxon:7955" /chromosome="22" /map="22" gene 1..2180 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="Kruppel like factor 2a" /db_xref="GeneID:117508" /db_xref="ZFIN:ZDB-GENE-011109-1" exon 1..391 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /inference="alignment:Splign:2.1.0" misc_feature 302..304 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="upstream in-frame stop codon" CDS 320..1462 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /codon_start=1 /product="Krueppel-like factor 2a" /protein_id="NP_571931.2" /db_xref="GeneID:117508" /db_xref="ZFIN:ZDB-GENE-011109-1" /translation="
MALSGTILPSISTFSAQKEKCWENRWKDELDRSMHLSCIADLSNMDNLNRITDDEDLDKYLDLEFILANTAGSDNLGLGMAGDYRMQESRNMYNPTTYSVPEINPSPPPPYTTSLMAELLQSDIDTYCQPSLQGRFLVRPAFPTQDISECIKVEPCMDSYGPVRGMVPKVKQEGNGACMRSYEQPRLANSPQGAGSMTPPQSPAELINTDCQSHSQMCHALTFSQSYQGNTGFPHAAPPQMQLPYQSTHHFSMCDDGLAMPNANQRVLLTPPSSPLELDAKPKRGRRTWPRKRTATHTCTFSGCGKTYTKSSHLKAHHRTHTGEKPYHCSWEGCGWKFARSDELTRHFRKHTGHRPFQCHLCERAFSRSDHLALHMKRHM"
misc_feature 329..1210 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="N-terminal domain of Kruppel-like factor 2; Region: KLF2_N; cd21583" /db_xref="CDD:409229" misc_feature 1223..1282 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn finger" /db_xref="CDD:275368" misc_feature 1229..>1375 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="FOG: Zn-finger [General function prediction only]; Region: COG5048" /db_xref="CDD:227381" misc_feature order(1235..1237,1241..1243,1247..1249,1253..1258, 1265..1270,1277..1279,1325..1327,1331..1333,1343..1348, 1355..1360,1367..1369,1409..1411,1415..1417,1421..1423, 1427..1432,1439..1444,1451..1453) /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="putative nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:275368" misc_feature 1304..1372 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn finger" /db_xref="CDD:275368" misc_feature 1346..1423 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="Zinc-finger double domain; Region: zf-H2C2_2; pfam13465" /db_xref="CDD:463886" misc_feature 1394..1456 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn finger" /db_xref="CDD:275368" exon 392..1286 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /inference="alignment:Splign:2.1.0" exon 1287..2180 /gene="klf2a" /gene_synonym="etID35223.22; fb08e06; wu:fb08e06" /inference="alignment:Splign:2.1.0" ORIGIN
gtgatttaaagaagagcccgtgcgctctcaacatccaagacgaaaggcgcacacgccggagagcagcagctatataccggggctaaaattagggacggatagtgcgtatttcctccgcttcttataattggtccagcttgcgctgccgtgatatttataagataaaggtcttccaccactcatactttctgcatgagtgttaaacatagtgtaaagagcagagcagagttgtagtgcactacaaccaaagtttctccgagggattgcaacaaatccccgatctttaaagtttgttttaccttaactgggacgactggaaatggctttgagtggaacgattttaccgtctatttccacattttcggcgcagaaggaaaaatgctgggagaacaggtggaaggatgaactggacaggtccatgcatctcagctgcatagctgacctatctaacatggacaacctcaacagaataacagacgacgaagatcttgacaagtacctggatctggagtttatactggccaacactgcaggttctgacaatctcggactcggcatggcaggcgactacagaatgcaagagtccagaaacatgtacaacccgactacatactcggtgcctgagatcaacccatcaccacctccaccgtacaccaccagcctcatggcagagcttctgcagtctgacattgacacctactgccaaccgtctctccagggaagattcctagtcaggcctgctttccccactcaggacatttcggagtgtatcaaagtggagccctgcatggatagttacggacctgtacgaggaatggttcccaaagtcaaacaagagggcaacggtgcatgcatgagatcctatgagcagccaagactagccaactctccccagggagcaggcagcatgactcccccacagagccctgcggagctcatcaacacagactgtcagtcacactcgcagatgtgccatgccttaacgttcagccagagctatcaaggcaacacaggatttccccacgcagcacctccacagatgcagctgccttaccaaagcacacatcacttcagcatgtgcgacgatgggcttgcaatgcccaacgccaaccaaagagtacttctgacaccaccctcatctcctctagagctggacgccaaaccaaagagggggcgccgcacgtggccgaggaaacgcacggcgactcacacttgcactttttctggatgtggcaaaacttacacaaaaagttctcacttgaaggctcatcacagaacacacacaggcgagaagccctatcattgcagttgggaaggctgtgggtggaagttcgcccgttctgatgaattgacccgtcacttccgcaagcacaccggacaccgacccttccagtgccacctgtgcgaacgtgccttctccaggtccgaccatctcgcccttcatatgaaacgtcatatgtaggaacggactctggaaaatgtggactaaacgcactgaacagtgaacattgtctgtacccccccccccccccccccccccccccccccccctcttatttaaagtatggtgaaggggaaacatgaactgacttgacctattgcttgtagctggttctacacttcaattctttacagaatttacagaaacaaactatatttttcgtttccaaagagcaagttcaactcatactataggctggacctaaacctcaagacggaactggaatcagacagtataatgtgctttaagttaacatgatgtgctgcggacatcacgacagtgccttttaatatgcgtatacatctcacgagtgccacgaatactggcgttttttttaacgacaaatgtatgctattgtgtcaagaaactaaataagctttgtaagacaatgttttcctctttcaaaactgccttaaaagttaacaaaaggggcgttaactgaatgttttaagtaatttgtgcatttatcgacataaacgtttttatttttaaaaatcagggtcttatggtttcgttttttttaaacgcaatttgtatgctgttaacgttgaattgcagactgtcccatgtttggatgacatgataagggctatgtgagttgttctggaccaaagcattttatgtacataatttatacactgtatatattgtacatattaaacttaaattgcgatataaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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