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2024-11-01 07:49:30, GGRNA.v2 : RefSeq release 226 (Sep, 2024)

LOCUS       NM_131856               2180 bp    mRNA    linear   VRT 08-SEP-2024
DEFINITION  Danio rerio Kruppel like factor 2a (klf2a), mRNA.
ACCESSION   NM_131856
VERSION     NM_131856.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Greysson-Wong,J., Rode,R., Ryu,J.R., Chan,J.L., Davari,P.,
            Rinker,K.D. and Childs,S.J.
  TITLE     rasa1-related arteriovenous malformation is driven by aberrant
            venous signalling
  JOURNAL   Development 150 (18) (2023)
   PUBMED   37708300
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Paolini,A., Sharipova,D., Lange,T. and Abdelilah-Seyfried,S.
  TITLE     Wnt9 directs zebrafish heart tube assembly via a combination of
            canonical and non-canonical pathway signaling
  JOURNAL   Development 150 (18) (2023)
   PUBMED   37680191
  REMARK    Erratum:[Development. 2023 Nov 1;150(21):dev202439. doi:
            10.1242/dev.202439. PMID: 37922126]
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   Li,H., Luo,Q., Cai,S., Tie,R., Meng,Y., Shan,W., Xu,Y., Zeng,X.,
            Qian,P. and Huang,H.
  TITLE     Glia maturation factor-gamma is required for initiation and
            maintenance of hematopoietic stem and progenitor cells
  JOURNAL   Stem Cell Res Ther 14 (1), 117 (2023)
   PUBMED   37122014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Grdseloff,N., Boulday,G., Rodel,C.J., Otten,C., Vannier,D.R.,
            Cardoso,C., Faurobert,E., Dogra,D., Tournier-Lasserve,E. and
            Abdelilah-Seyfried,S.
  TITLE     Impaired retinoic acid signaling in cerebral cavernous
            malformations
  JOURNAL   Sci Rep 13 (1), 5572 (2023)
   PUBMED   37019926
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Juan,T., Ribeiro da Silva,A., Cardoso,B., Lim,S., Charteau,V. and
            Stainier,D.Y.R.
  TITLE     Multiple pkd and piezo gene family members are required for
            atrioventricular valve formation
  JOURNAL   Nat Commun 14 (1), 214 (2023)
   PUBMED   36639367
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Corti,P., Young,S., Chen,C.Y., Patrick,M.J., Rochon,E.R., Pekkan,K.
            and Roman,B.L.
  TITLE     Interaction between alk1 and blood flow in the development of
            arteriovenous malformations
  JOURNAL   Development 138 (8), 1573-1582 (2011)
   PUBMED   21389051
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Nicoli,S., Standley,C., Walker,P., Hurlstone,A., Fogarty,K.E. and
            Lawson,N.D.
  TITLE     MicroRNA-mediated integration of haemodynamics and Vegf signalling
            during angiogenesis
  JOURNAL   Nature 464 (7292), 1196-1200 (2010)
   PUBMED   20364122
  REMARK    Erratum:[Nature. 2010 Sep 16;467(7313):356]
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Vermot,J., Forouhar,A.S., Liebling,M., Wu,D., Plummer,D., Gharib,M.
            and Fraser,S.E.
  TITLE     Reversing blood flows act through klf2a to ensure normal
            valvulogenesis in the developing heart
  JOURNAL   PLoS Biol 7 (11), e1000246 (2009)
   PUBMED   19924233
  REMARK    GeneRIF: klf2a expression appears to be necessary for normal valve
            formation.
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Henry,T.B., Menn,F.M., Fleming,J.T., Wilgus,J., Compton,R.N. and
            Sayler,G.S.
  TITLE     Attributing effects of aqueous C60 nano-aggregates to
            tetrahydrofuran decomposition products in larval zebrafish by
            assessment of gene expression
  JOURNAL   Environ Health Perspect 115 (7), 1059-1065 (2007)
   PUBMED   17637923
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Yergeau,D.A., Cornell,C.N., Parker,S.K., Zhou,Y. and Detrich,H.W.
            3rd.
  TITLE     bloodthirsty, an RBCC/TRIM gene required for erythropoiesis in
            zebrafish
  JOURNAL   Dev Biol 283 (1), 97-112 (2005)
   PUBMED   15890331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX323550.13 and BX908392.13.
            
            On Sep 21, 2011 this sequence version replaced NM_131856.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063933.1, AF392992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               BX323550.13        2009-2399           c
            392-1286            BX323550.13        700-1594            c
            1287-1880           BX323550.13        1-594               c
            1881-2180           BX908392.13        177265-177564       c
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="22"
                     /map="22"
     gene            1..2180
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="Kruppel like factor 2a"
                     /db_xref="GeneID:117508"
                     /db_xref="ZFIN:ZDB-GENE-011109-1"
     exon            1..391
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    302..304
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="upstream in-frame stop codon"
     CDS             320..1462
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /codon_start=1
                     /product="Krueppel-like factor 2a"
                     /protein_id="NP_571931.2"
                     /db_xref="GeneID:117508"
                     /db_xref="ZFIN:ZDB-GENE-011109-1"
                     /translation="
MALSGTILPSISTFSAQKEKCWENRWKDELDRSMHLSCIADLSNMDNLNRITDDEDLDKYLDLEFILANTAGSDNLGLGMAGDYRMQESRNMYNPTTYSVPEINPSPPPPYTTSLMAELLQSDIDTYCQPSLQGRFLVRPAFPTQDISECIKVEPCMDSYGPVRGMVPKVKQEGNGACMRSYEQPRLANSPQGAGSMTPPQSPAELINTDCQSHSQMCHALTFSQSYQGNTGFPHAAPPQMQLPYQSTHHFSMCDDGLAMPNANQRVLLTPPSSPLELDAKPKRGRRTWPRKRTATHTCTFSGCGKTYTKSSHLKAHHRTHTGEKPYHCSWEGCGWKFARSDELTRHFRKHTGHRPFQCHLCERAFSRSDHLALHMKRHM"
     misc_feature    329..1210
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="N-terminal domain of Kruppel-like factor 2; Region:
                     KLF2_N; cd21583"
                     /db_xref="CDD:409229"
     misc_feature    1223..1282
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1229..>1375
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="FOG: Zn-finger [General function prediction only];
                     Region: COG5048"
                     /db_xref="CDD:227381"
     misc_feature    order(1235..1237,1241..1243,1247..1249,1253..1258,
                     1265..1270,1277..1279,1325..1327,1331..1333,1343..1348,
                     1355..1360,1367..1369,1409..1411,1415..1417,1421..1423,
                     1427..1432,1439..1444,1451..1453)
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:275368"
     misc_feature    1304..1372
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     misc_feature    1346..1423
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:463886"
     misc_feature    1394..1456
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /note="C2H2 Zn finger [structural motif]; Region: C2H2 Zn
                     finger"
                     /db_xref="CDD:275368"
     exon            392..1286
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..2180
                     /gene="klf2a"
                     /gene_synonym="etID35223.22; fb08e06; wu:fb08e06"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
gtgatttaaagaagagcccgtgcgctctcaacatccaagacgaaaggcgcacacgccggagagcagcagctatataccggggctaaaattagggacggatagtgcgtatttcctccgcttcttataattggtccagcttgcgctgccgtgatatttataagataaaggtcttccaccactcatactttctgcatgagtgttaaacatagtgtaaagagcagagcagagttgtagtgcactacaaccaaagtttctccgagggattgcaacaaatccccgatctttaaagtttgttttaccttaactgggacgactggaaatggctttgagtggaacgattttaccgtctatttccacattttcggcgcagaaggaaaaatgctgggagaacaggtggaaggatgaactggacaggtccatgcatctcagctgcatagctgacctatctaacatggacaacctcaacagaataacagacgacgaagatcttgacaagtacctggatctggagtttatactggccaacactgcaggttctgacaatctcggactcggcatggcaggcgactacagaatgcaagagtccagaaacatgtacaacccgactacatactcggtgcctgagatcaacccatcaccacctccaccgtacaccaccagcctcatggcagagcttctgcagtctgacattgacacctactgccaaccgtctctccagggaagattcctagtcaggcctgctttccccactcaggacatttcggagtgtatcaaagtggagccctgcatggatagttacggacctgtacgaggaatggttcccaaagtcaaacaagagggcaacggtgcatgcatgagatcctatgagcagccaagactagccaactctccccagggagcaggcagcatgactcccccacagagccctgcggagctcatcaacacagactgtcagtcacactcgcagatgtgccatgccttaacgttcagccagagctatcaaggcaacacaggatttccccacgcagcacctccacagatgcagctgccttaccaaagcacacatcacttcagcatgtgcgacgatgggcttgcaatgcccaacgccaaccaaagagtacttctgacaccaccctcatctcctctagagctggacgccaaaccaaagagggggcgccgcacgtggccgaggaaacgcacggcgactcacacttgcactttttctggatgtggcaaaacttacacaaaaagttctcacttgaaggctcatcacagaacacacacaggcgagaagccctatcattgcagttgggaaggctgtgggtggaagttcgcccgttctgatgaattgacccgtcacttccgcaagcacaccggacaccgacccttccagtgccacctgtgcgaacgtgccttctccaggtccgaccatctcgcccttcatatgaaacgtcatatgtaggaacggactctggaaaatgtggactaaacgcactgaacagtgaacattgtctgtacccccccccccccccccccccccccccccccccctcttatttaaagtatggtgaaggggaaacatgaactgacttgacctattgcttgtagctggttctacacttcaattctttacagaatttacagaaacaaactatatttttcgtttccaaagagcaagttcaactcatactataggctggacctaaacctcaagacggaactggaatcagacagtataatgtgctttaagttaacatgatgtgctgcggacatcacgacagtgccttttaatatgcgtatacatctcacgagtgccacgaatactggcgttttttttaacgacaaatgtatgctattgtgtcaagaaactaaataagctttgtaagacaatgttttcctctttcaaaactgccttaaaagttaacaaaaggggcgttaactgaatgttttaagtaatttgtgcatttatcgacataaacgtttttatttttaaaaatcagggtcttatggtttcgttttttttaaacgcaatttgtatgctgttaacgttgaattgcagactgtcccatgtttggatgacatgataagggctatgtgagttgttctggaccaaagcattttatgtacataatttatacactgtatatattgtacatattaaacttaaattgcgatataaa
//

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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]