LOCUS       NM_131773               3544 bp    mRNA    linear   VRT 29-JUL-2023
DEFINITION  Danio rerio claudin 12 (cldn12), mRNA.
ACCESSION   NM_131773
VERSION     NM_131773.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Zhang FL, Yang YL, Zhang Z, Yao YY, Xia R, Gao CC, Du DD, Hu J, Ran
            C, Liu Z and Zhou ZG.
  TITLE     Surface-Displayed Amuc_1100 From Akkermansia muciniphila on
            Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal
            Health in High-Fat-Fed Zebrafish
  JOURNAL   Front Nutr 8, 726108 (2021)
   PUBMED   34722607
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Wu N, Xu X, Wang B, Li XM, Cheng YY, Li M, Xia XQ and Zhang YA.
  TITLE     Anti-foodborne enteritis effect of galantamine potentially via
            acetylcholine anti-inflammatory pathway in fish
  JOURNAL   Fish Shellfish Immunol 97, 204-215 (2020)
   PUBMED   31843701
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Guo X, Li J, Ran C, Wang A, Xie M, Xie Y, Ding Q, Zhang Z, Yang Y,
            Duan M and Zhou Z.
  TITLE     Dietary nucleotides can directly stimulate the immunity of
            zebrafish independent of the intestinal microbiota
  JOURNAL   Fish Shellfish Immunol 86, 1064-1071 (2019)
   PUBMED   30590163
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Shu Y, Lou Q, Dai Z, Dai X, He J, Hu W and Yin Z.
  TITLE     The basal function of teleost prolactin as a key regulator on ion
            uptake identified with zebrafish knockout models
  JOURNAL   Sci Rep 6, 18597 (2016)
   PUBMED   26726070
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3544)
  AUTHORS   Kumai Y, Bahubeshi A, Steele S and Perry SF.
  TITLE     Strategies for maintaining Na balance in zebrafish (Danio rerio)
            during prolonged exposure to acidic water
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 160 (1), 52-62 (2011)
   PUBMED   21600298
REFERENCE   7  (bases 1 to 3544)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Exogenous GDF9 but not Activin A, BMP15 or TGFbeta alters tight
            junction protein transcript abundance in zebrafish ovarian
            follicles
  JOURNAL   Gen Comp Endocrinol 171 (2), 211-217 (2011)
   PUBMED   21291886
REFERENCE   8  (bases 1 to 3544)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   9  (bases 1 to 3544)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   10 (bases 1 to 3544)
  AUTHORS   Loh YH, Christoffels A, Brenner S, Hunziker W and Venkatesh B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR848685.7 and EH545623.1.
            
            On Feb 18, 2016 this sequence version replaced NM_131773.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF359433.1, AF359431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CR848685.7         58383-58408
            27-193              EH545623.1         40-206
            194-194             CR848685.7         59462-59462
            195-902             EH545623.1         208-915
            903-3544            CR848685.7         61527-64168
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..3544
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /note="claudin 12"
                     /db_xref="GeneID:81593"
                     /db_xref="ZFIN:ZDB-GENE-010328-14"
     exon            1..163
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    132..134
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /note="upstream in-frame stop codon"
     exon            164..462
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1211
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /codon_start=1
                     /product="claudin-12"
                     /protein_id="NP_571848.1"
                     /db_xref="GeneID:81593"
                     /db_xref="ZFIN:ZDB-GENE-010328-14"
                     /translation="

MSCRDIHATNAFAFVIAMLSVGGLTVATLIPQWRTMRLLTFNRNAKNVTVYDGLWTKCVRRDGSSGCYYFDSDWYAKVDQLDLRLLQFCLPTGLLFSSLALLLCLTGMCKTACCSKTPDDIKNSRCLVNSSGCHLVAGMLLFLGGAIAMPPSVWFLFHTRHLNERYDHLFAVEFGVYVAIGSAGGLILAALLMFMWYCMCKKLPSPFWLPLPEVPTMTQSLSAQPLMTNGLPTPVTYAPQSFPPAVLDAPAFVPMQGYPQPASTQPMPPHVYMPQMSVPDGYGSEVGASQVYSYAPSQSYAPSQGYAPSQSYAPSQRYAGHRYSTRSRTSGIEIDIPVLTD"

     misc_feature    <813..>1136
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /note="Atrophin-1 family; Region: Atrophin-1; pfam03154"
                     /db_xref="CDD:427171"
     exon            463..3544
                     /gene="cldn12"
                     /gene_synonym="wu:fc27c11; wu:fc37h01; zgc:86588"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtgacgtactgccgcgcctgcggtcagtgtgttgtgcgcgctcccgaagaagaagagtgttcatacaacacggtggaacccaacgacagaaaaccaccgatttaagtgagaaaatgactgctacatcacctaaacattcattaaacgctcgacattaatcaggtatcatttgctgacttcagccatgtcttgtcgtgacattcacgccaccaatgcgttcgcctttgttattgcgatgctgtcggtcggtggtttgaccgttgctacactcattcctcagtggagaaccatgcgcctgcttaccttcaaccgtaatgccaaaaatgtgactgtatacgatggcctgtggaccaagtgtgtacggcgggatggctcttcaggctgctattactttgactcagactggtacgcaaaagtagaccagttggacctcagattgctgcaattctgtttacctactggtctgctgttttccagcttggctcttctgctctgtcttactggcatgtgtaaaactgcttgctgctccaaaacccctgacgacatcaagaactctcgctgcttggtcaacagctcaggctgccatctagtagctgggatgcttctgtttctaggtggagcgatcgccatgccaccctccgtctggttcctcttccacacccgtcacctaaatgagcgctacgatcatttatttgctgttgagtttggggtgtatgtggccatcggcagtgctggtggtttaatcctggctgctctgctgatgttcatgtggtattgtatgtgtaaaaaactgccttcgcctttctggctgcctcttcctgaagtgcccacaatgacccaaagcctctctgcgcagcctctcatgaccaacggtttgcctactcccgtgacgtacgcgccccagagcttccctccagccgttctggacgcccctgcttttgtcccaatgcagggttaccctcaacctgcatccacacagcctatgcccccccacgtctacatgccacaaatgtctgtgccagatggttatggctcagaagttggagcctcgcaggtttatagttatgccccctcacaaagctacgctccttctcagggatatgctccatcacaaagctacgcgccatcacagaggtacgccggacaccgatattcgacacgctcccgaacgtcagggattgagattgacattcctgtcctcacagattgagattggctgtctaaggatatttcaaattaaaaaggtcatatttagaaattagacaacaactctgatggtaaatttaaagtcatgtaaatggttaaatagaaagaacagccttcatttggttaatgtcgcctctaattcttaggactaaaatggccagaactatcagaaaagtgatttgagcagatagaaaggtgacattctcatataacctcgtattacaactaaagtctgcagtaaagcaactctgaacacatcaaaccttgaagcagatgagctactgcagaagaagagcaaactggtgacactcctgtctgctaagaaaactgaggttcccattgacatgagctcaacaaaactatgacagaaaattgtaggaaggttggctattctgatacatcttaggcccatttcagttctacctcttaaacccttccacttactcttacgcctccaagcaaaagagaatcagtaagcgaaagtgccgtttttattgaatcaaaaaggtcataattagaaattagagaacaactccgatggtaaatttgaagacatgtaaatggttaaattgaaagattagcctttattcagttgatgtcgccggtgcctcttaattattagtactgaaaatggccaaaaaaggaaaaatcgatcaaaaaaattatttgagcagataaaaaggtgacattttctcaaataacctcttattacgattaaagtctgcaggagagcaactctgaacacagcaaaccttgaagtagatgagctacagcagcagcagaagaagagcactctggtgacactcctgtctgctaggaaaactgatgctccaattgacatgaattcaacaaaactcgatatcagatcaggcaaccattttacaatcttctgttaacacttaggcccaatccagccttccactcactgattattttttgcttggaggcgcagtaaggcgaaatgccctccaaatacaaaggtcataattagaaattagagaacaactatgatggtaaatttgaagtcatgtaaattgtaaaattgaaaaataagcctttattcagttgatgtcaccaatgcctcttaattcttggcactgaaaatggccaaaaaaagggaaaaaaacaacccgaaaagcgatttgagcagatagaaaggtgatgttgtctcaaataacctcttactacaactaaagtcttcaggggagcaactctgaacacatcaaaccttgaagcagatgagctacagcagcagaagaagagcgcactagtgacattctggtctgctaagaaatctgatcataattagaaattagagtacaactctcatggtgaatttgaagttatgtaaatggttaaagatacgcctttattcagtggatgtcgcagatgcctcttaattcttagcactaaaatggccaaaaagggaaaaaaggtcatgaaagcagtaacactagctgaagttgtgcatctcgctttataatagtttcatttataaaacacaagcaaaacaaacttgttaataatttcactgagtatgtcaaggtgacttcacttaattcatactcatgtttcgtgttgttactctgcttttaaatgtcagtagaaacactgaatataaagttgattttaagcactgttttaacctttaagcaaatatttctgctaatatctaaatgtgactattacagtaaatattagaaagagatgtaacactgactgctgaaactgtattattctcagtgccatgaagttggacgttttcttttttaagcttagtgaatatgttggtttattgctctaatatctgtacatcatgttttcatggggttttatgcagatgtcacaatgttaaacgaacacctagtagaggttttttatatatacatggaagaatcatctctgcctgatgcctttgtgcagcttaactcttgtttccagaactgtacttccacttattaatttaatcctttataatgagccttacatcaacaagccattaactgaacactgcgttgcattccattgttttcttataaatgtaaatgttatcttattgttgttgttgtgttttaaaggtgtcaccagcgtattcatcattgtgcaactcagcatttgaataatgaatgctccattaatgtgtttgtttactgttagtttcttagctgaattgaggaaaacacgctaatgtcttaaacttgatcttcgcctattgaatgttgcacatatctatttcagtttgcctgtttctgcaaagctctgcagcacaatgttaattttaatcactgtgtagtttactaatgtctttgtttttttattaaagtgcagtttattgaa

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