LOCUS       NM_131721               7896 bp    mRNA    linear   VRT 21-OCT-2023
DEFINITION  Danio rerio mitogen-activated protein kinase 8b (mapk8b), mRNA.
ACCESSION   NM_131721
VERSION     NM_131721.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 7896)
  AUTHORS   Shao GJ, Wang XL, Wei ML, Ren DL and Hu B.
  TITLE     DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal
            regeneration at the early stage of zebrafish
  JOURNAL   Neural Regen Res 18 (3), 577-581 (2023)
   PUBMED   36018180
REFERENCE   2  (bases 1 to 7896)
  AUTHORS   Derrick CJ, Santos-Ledo A, Eley L, Paramita IA, Henderson DJ and
            Chaudhry B.
  TITLE     Sequential action of JNK genes establishes the embryonic left-right
            axis
  JOURNAL   Development 149 (9) (2022)
   PUBMED   35352808
REFERENCE   3  (bases 1 to 7896)
  AUTHORS   Wohlfart DP, Lou B, Middel CS, Morgenstern J, Fleming T, Sticht C,
            Hausser I, Hell R, Hammes HP, Szendrodi J, Nawroth PP and Kroll J.
  TITLE     Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes
            increased retinal angiogenesis and impaired glucose metabolism
  JOURNAL   Redox Biol 50, 102249 (2022)
   PUBMED   35114580
REFERENCE   4  (bases 1 to 7896)
  AUTHORS   Kuil LE, MacKenzie KC, Tang CS, Windster JD, Le TL, Karim A, de
            Graaf BM, van der Helm R, van Bever Y, Sloots CEJ, Meeussen C,
            Tibboel D, de Klein A, Wijnen RMH, Amiel J, Lyonnet S,
            Garcia-Barcelo MM, Tam PKH, Alves MM, Brooks AS, Hofstra RMW and
            Brosens E.
  TITLE     Size matters: Large copy number losses in Hirschsprung disease
            patients reveal genes involved in enteric nervous system
            development
  JOURNAL   PLoS Genet 17 (8), e1009698 (2021)
   PUBMED   34358225
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7896)
  AUTHORS   Zhang Y, Cai Y, Zhang SR, Li CY, Jiang LL, Wei P and He MF.
  TITLE     Mechanism of hepatotoxicity of first-line tyrosine kinase
            inhibitors: Gefitinib and afatinib
  JOURNAL   Toxicol Lett 343, 1-10 (2021)
   PUBMED   33571620
REFERENCE   6  (bases 1 to 7896)
  AUTHORS   Hendricks M and Jesuthasan S.
  TITLE     PHR regulates growth cone pausing at intermediate targets through
            microtubule disassembly
  JOURNAL   J Neurosci 29 (20), 6593-6598 (2009)
   PUBMED   19458229
REFERENCE   7  (bases 1 to 7896)
  AUTHORS   Zhang Y, Bai XT, Zhu KY, Jin Y, Deng M, Le HY, Fu YF, Chen Y, Zhu
            J, Look AT, Kanki J, Chen Z, Chen SJ and Liu TX.
  TITLE     In vivo interstitial migration of primitive macrophages mediated by
            JNK-matrix metalloproteinase 13 signaling in response to acute
            injury
  JOURNAL   J Immunol 181 (3), 2155-2164 (2008)
   PUBMED   18641354
  REMARK    GeneRIF: JNK-Mmp13 signaling pathway plays an essential role in
            regulating the innate immune cell migration in response to severe
            injury in vivo
REFERENCE   8  (bases 1 to 7896)
  AUTHORS   Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, Chan SC, Luo W, Han Y,
            Lu Z, Ye Z, Zhou HM, Han J, Meng A and Lin SC.
  TITLE     A beta-catenin-independent dorsalization pathway activated by
            Axin/JNK signaling and antagonized by aida
  JOURNAL   Dev Cell 13 (2), 268-282 (2007)
   PUBMED   17681137
  REMARK    GeneRIF: A dorsalization pathway that is exerted by Axin/JNK
            signaling and its inhibitor Aida during vertebrate embryogenesis,
            is defined.
REFERENCE   9  (bases 1 to 7896)
  AUTHORS   Krens SF, He S, Spaink HP and Snaar-Jagalska BE.
  TITLE     Characterization and expression patterns of the MAPK family in
            zebrafish
  JOURNAL   Gene Expr Patterns 6 (8), 1019-1026 (2006)
   PUBMED   16774848
REFERENCE   10 (bases 1 to 7896)
  AUTHORS   Amali AA, Rekha RD, Lin CJ, Wang WL, Gong HY, Her GM and Wu JL.
  TITLE     Thioacetamide induced liver damage in zebrafish embryo as a disease
            model for steatohepatitis
  JOURNAL   J Biomed Sci 13 (2), 225-232 (2006)
   PUBMED   16456712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR774192.15.
            
            On Feb 26, 2016 this sequence version replaced NM_131721.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference genome strain
            was available for the full length of the gene. The extent of this
            transcript is supported by partial transcript alignments and
            orthologous alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030900.1, GFIL01025906.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CR774192.15        96501-96618         c
            119-298             CR774192.15        92172-92351         c
            299-428             CR774192.15        90209-90338         c
            429-487             CR774192.15        89366-89424         c
            488-626             CR774192.15        89082-89220         c
            627-792             CR774192.15        88453-88618         c
            793-864             CR774192.15        86175-86246         c
            865-1047            CR774192.15        83818-84000         c
            1048-1172           CR774192.15        82088-82212         c
            1173-1236           CR774192.15        81639-81702         c
            1237-1314           CR774192.15        81343-81420         c
            1315-7896           CR774192.15        73813-80394         c
FEATURES             Location/Qualifiers
     source          1..7896
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..7896
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="mitogen-activated protein kinase 8b"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
     exon            1..118
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            119..298
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1331
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /EC_number="2.7.11.24"
                     /note="c-Jun N-terminal kinase 1; stress-activated protein
                     kinase JNK1; MAPK 8; MAP kinase 8"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8"
                     /protein_id="NP_571796.1"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
                     /translation="

MNRNKREKEYYSIDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDHVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWSIGCIMAEMVRGSVLFPGTDHIDQWNKVIEQLGTPSQEFMMKLNQSVRTYVENRPRYAGYSFEKLFPDVLFPADSDHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEVEAPPPAITDKQLDEREHSVEEWKELIYKEVLEWEERTKNGVIRGQPASLAQVQQ"

     misc_feature    249..1256
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850"
                     /db_xref="CDD:270840"
     misc_feature    order(270..290,294..296,333..335,339..341,390..392,
                     432..434,498..518,522..527,627..629,633..635,639..644,
                     648..650,678..683,690..692,723..725,729..740,744..746,
                     855..857)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="active site"
                     /db_xref="CDD:270840"
     misc_feature    order(270..290,294..296,333..335,339..341,432..434,
                     498..518,648..650,678..680)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(390..392,522..524,627..629,633..635,690..692,
                     723..725,729..740,744..746,855..857)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(510..512,528..530,555..557,564..566,651..665,
                     1143..1148,1152..1154,1161..1163)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(678..710,720..746)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270840"
     misc_feature    723..731
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DGD9.1);
                     Region: TXY"
     misc_feature    723..725
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="Phosphothreonine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9DGD9.1); phosphorylation
                     site"
     misc_feature    729..731
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="Phosphotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9DGD9.1); phosphorylation
                     site"
     exon            299..428
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            429..487
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            488..626
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            627..792
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            793..864
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1047
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1172
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1236
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1314
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..7896
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtggacggaaacgcagtgcttgtgtcttgtgtggaaagacaaatacaacaacccgctgagaagaccccagtgtttttatgattctacacttgaattgtctgttcatcttttaggaggatttttgaaggtgaagctcttcttgaatgcccaggatacagtcagtacggttttcatcatgaacaggaataagcgcgagaaagaatattacagcatagatgtaggagattcaacgttcaccgttttgaagcgctatcagaatttaagaccaatcgggtccggagcacaaggcatcgtctgctcagcgtatgaccacgtcctcgatcgaaatgtggcaattaagaaactcagccgaccctttcaaaaccaaactcatgccaaacgggcctacagagaactggtcctgatgaaatgcgtcaaccacaaaaatataattggcttactaaacgtgttcacaccacagaagacacttgaagagttccaggatgtttatctggtgatggagctgatggatgcaaacctgtgtcaggtgattcagatggagctggaccacgagaggctgtcctacctgctctatcagatgctctgcggcattaaacacctgcacgctgctggcatcatacacagggatctgaaacccagtaatatagtagtgaaatcggactgcacgctgaagatcctggatttcggtctggcccgaacggctgcaaccggcctcctcatgactccttatgtcgtgacacgctattatcgggccccagaggtcatcctgggcatgggttatcaagctaacgttgatgtctggtctattggctgcatcatggctgaaatggtcagaggtagtgtgttgtttcctggcacagaccatattgaccagtggaataaagtgatcgagcagctgggcacgccgtcacaggagttcatgatgaagctgaatcagtctgtgaggacgtatgtggagaaccggcctcggtatgcgggatacagctttgagaagctcttcccagacgtgctcttccccgcagactcggaccacaacaaactcaaggcgagtcaggcacgagacttgttatccaaaatgctggtaatagatgcatccaagcggatctctgtagacgaggcgcttcagcacccctacatcaacgtttggtacgacccatcagaagtggaggcgccgccaccagcgatcacggataaacagctcgatgagagagaacactcagtggaagagtggaaagagctcatatacaaggaagtgctggaatgggaggagcgaacaaaaaatggagtgatcagaggacagccggcctcgctagcacaggtgcagcagtgagcagtgactcccatgagccctcgacgtcgtcctcctccataaacgatgtgtcgtccatgtccaccgaggtcacgctgacctcagacaccgacagcagtcaggagacgtccaacggagcgctgcactgctgcagatgaccatccttcttcaacctccgtcaccctctgaaatccttcatcaccttccattgtcttctgtcatgattcttcatcctccaaaatgcttcatcaccttccaaaatcatctattgttctctgtcatggttcttcatcctccaaaatcctcccattggccttttaaaatcctccatcctcccctgtcaccttccaaaatcctctagccccctcaaatatgctctgttaccctctaaaatcctccatccttctttgtttaccatccaaaatcctcaatcgccctccaaattcctccattctcctcagttaccttccaaaatcctccattgtcttcattcaccctccaaaatcctccactaccccgtaaatcctccattaccctccaaaatccctcattgtgtttgtcaggattcttcatcctctgtcgccctccaaaatccttcattttcctccaaaatcctctgtcaccggcaaaatcctcctacattatccttcaaaatccttaattgccctccattttcctccagagtcctctgtcacctccaaaatctcttcattcacccttcaaaatactcagttgccctctaaaatcctctattttcctctagaatcctctgtcacctcccaaatcctcctcaatcgccctccaaaatcctctatcaccctctaaaatcctccatcacccttcaaaattctccatcacgctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcctccataacccttcaaaatctcccattaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcaccctccaaaattctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccattaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccattaccttccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccataacccttcaaaatctcccatcaccctccaaaatcatatatcaccctccaaaatcctccattaccctccaaaattctccatcatcctccaaaattctccatcatcctccaacattctccattaccctccaaaattctccatcaccctccagaatcgtccatcaccctccaaaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaatcctcaaactttcaagctcttgtcaattcaaaagtgtaagagtggcggggatagtttttttgagggcatctcaaaggcttttacaccaaaccagcattactttcactgctttcctgtttttattttgaactttgcatcaaattgaagctactgctacgtcgtcttgccattcggaagtggaatgattcaagtttatttgtaaagataaatggtgaatatatttttttcgagatgttttatttttttgagagtcattttaatcactaatgagtggaggttcattaaatggcacgtccattttttttggacaagtgagtatttccacactgttactactgctttggagtataaaaggcatctgtatgtttgttttggtctgataagtggtttaatttatggcctgtgtaactaaatcacgattagttgaacgtttaattcggttgtcttacagaatcacattttaaagtgctttttcgggatctgtaagctgatttttcctctaatttccacacacaagatttacttcacataatattctctctgtaaaaacacgtttgggttttcagaattcacattatgtaatctagcctgtacatatttcatctacaaacacagaaaacatcccagcttaattccgcttcaactgtacagtcacagctcttcatgtctgaacacttcaatatatgatctgaagcccatgccaggtttttggcccatgcatacaaaatgctttcgatttttccagtactgattttgaatttataaccaatatgcatacagctttgttgtcttattgagtatgcgttaagacaccgaactgatttactggatgcagcactcttgctaaatgaatatagaatgaatattaatgaaacccaaaggagcatgaaaaatgaacgcaacgtttctcatttcttgtttgctttaagtggaaatgtgtaaacattgcttaaatgtgatggttttctacagtagcgttcaaaataatagcaggacaacatgactaaccagaataatccagattttcataataatttttattgctacatggcaaacaagttaccaggtgcagtaaattctcaaaaaacaaacacgagcatttatgatatgcacgctcttaaggatgtgcaattgggcaattagttgaagggggtgtgtttaaaaaaatagcagtgtggtatttcgatcagtgaggtcatcaattttgggataaaacaggtgtgaaccaggtgggcccctatttaaggacatgtttgttgaacatgcatttgaaaaaagcctcatggtgcgtttacaccgttgaaccttttgtgttttctcgcttcatccgcacgtcaaattcgactcatattcaaatagagtcaaattcgtgactctagtttcgatgctaaatggctaacatggattttattgaggtagtagctgtgctttatgaaggctgaaaaacagcgtagatttgtttggcgccattagtccactagatcctttcagaggtgcacccagaggttcatcaactccaccagaatctatatccggatgatggacgcttttagcagtgcatccgactgagccaagcccagtttgaggagctgttgtccggtgtcggcaagaggatttccccttgcaacaccaacaacattgccgcttcatttaaacgcgtcaagcctcattcacactactagtgactcacaccggcaaagcgagagagaagcgaccactcatttcaacggagaacaagctacttccggcaaccaccatctacgtccacatacagccacattttctccctctgtacctggatattgcctgcctgctgcacctaaggactctgaaagcgatgtttgtcttgccccagcagcgcctgtgcctcttctttcctcctcttctgaccacctagtcatattctgtcttgtgatttatatgtaggcgtttgaataggtttgtggtattaccacagtacctcattgttttgttacacgtgtcacaaaccgcattgtttgattttatggaagtgaagtagctccacacaaaacttcgcttgcggtcacccatatccaatgacagcacaactgaacaacatgtgccagcggactgactgagcggctagctagcgtgctctgcagttgtacagtgccatattatgcacatgactcggcaagcggaagaacaagtagttccgactaagttggcattattccgataaactagggtaattgtggttactttccactgtatttctatttccaataaatgacatatttgctccaaattactgaaatatcaatattttgataagataatcgattctagaacacacaaagctagcatcggagatatcgatattttagtattgatccgcacatcactactgtgaggttgtgatgggaagttcagatcattttactgactcggatctttgagtcttgttcatcaagatgagcgaatcttttttcgagtcatttcgctcatttggttcaatttgccaaaatattattaaaatgttacaaattgcttccaaacacatctacaactagcccaaaaggttgatcacatgacaattacgtcataaatagatcactataagaaggagaaaataataattcaatgttgacctgctcttttgtcaatgaaggtattgtcgtctctttgctcagctcacctcttcatgtcttcgaaagtcagtgtttcgttcaatgtacacacacagtctaaaccaatcttctggttcttgagtcgttcgttcatcacatgacaaaatgactcaatcccgaggagtcgagagatgaacagttcaattctttttccggctctaaacgcatatgattggcccgtgatgaacgaatgactccgacccgatagaggactcgagagatgaacagatcaattctttctccggctataaacgcatatgattggcccgtgaggaacgaatgactccgacccgatagaggactcgagagatgaacggttcaattcttttttttccgggtctaaacgcatatgattggcatctgcctttccgctatgaacgactccaaagactttaaatgaacgataccacctacacaaatgtgcgcacgcggatgaacgaatcactccctgagaagactcgtagttccagagtcatattgaagattcgttcaaaatgaacaaatcgttcatgaacgacccatcactactgtgaggagctaccaagcacatgccagatgaagcgaatctattttcaagaatgaatcattgtttgaacacacccctttcaattaattgccaattgcacagcctgaagagcgtgcatatcatgaatgctgggtcctgtttttattctaagaatctgctgcacctacttgtgacttgcttgccatgaagcaataaacaaaatatgctaaaaacgtattctggttagccatgttgtactgctattattttcagaaataggcaaaattgcttgaggtatttcgagaaagtcaatgttttcatatttcactggcaaatgagacacaaatactatcaagacaaatgtaattggctacagtttttccattgtaatattaagaggaaaaaaatgcctatgtaatgtttggaatgtaataatatgtgtacatagctggtgtatgtagtgtaatctatgctcatcctactgtacacttgatgtgaagcgtacatcatgaccttaatgtgttaaatccatcgctaaatgttcaaaaacgccattcatcattgggttatctttgctttttgatttgctttctaaatggagaaagtgcctcgagagtccagcatcgatttctgaacgatcagaaaggagaaatttgggtgaggttttccaaagtattcctgttcttgtcaagttggagtgtctatttttgtattgttccggatgtagcttgaaggtttttggggtatgttgagaatgtgattggacgtttttctcaagcaaggtctttcatcaaagtaaattggaactttttttgtcgtgtttggttcgcggctttattttctatatggaaatatgcatcaaatgctgtaaagtgggaattacatttcccatgaggcaatgctatcgaatgtatgtgtatggcgatcgaaggaaatggaaggtttgcgtaacgattggcagacattttgttttagtcgcatcccgttcatgtttgttttccattttaagtgctcttaagttctttctttgctctctttaggcacgtcaaggaattttaatactctttgttttcctcagttgtgttcgctttcacttcaactctcaaacacgttatgattcagatcaaagtaggctttgatgaactacctcactctaaatttctacagattttccttttttttttgcgacatagctgaccgtaagatagatgttaatacagatttcattatttatttatttctaaagtgaactattgtcaatataaggcgacgtgtagttttgtacattatgtatacttcacctagaagtaaaagaactgaaatgtaaatttgatctctttgtttaatttccttctttgtactcatttttttacagttcatgtgcaatacccactgctgtcatgctagttgtaatcgctagatctagacttattagttttacgtacccagaggtagagagatgttttggtactgtccgagaaattaatgttttgtctttttaaacctggattttgttttgttttgtcaatgttacatgacctgttttaccaaaaatgaaaatctgtggctgatgttagcaaggtgttcagtttagctcctggactttgagtcctgttcaaaagcatctgtaaattatccagcgtgttaagatttggtgctggtatgtaatatttgctagcaatgccagccctacagttagttatccaattgctagctctgtgtgcactaaacagcatacagacgatgagaagtgcactactacaaagaatgcactgggatcttatgatgccaattgtacatgtactgcaaataaacaccagtttgaatcagaactaattctcca

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