LOCUS       NM_131178               1429 bp    mRNA    linear   VRT 30-SEP-2023
DEFINITION  Danio rerio developing brain homeobox 1b (dbx1b), mRNA.
ACCESSION   NM_131178
VERSION     NM_131178.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1429)
  AUTHORS   Mukaigasa K, Sakuma C and Yaginuma H.
  TITLE     The developmental hourglass model is applicable to the spinal cord
            based on single-cell transcriptomes and non-conserved
            cis-regulatory elements
  JOURNAL   Dev Growth Differ 63 (7), 372-391 (2021)
   PUBMED   34473348
REFERENCE   2  (bases 1 to 1429)
  AUTHORS   Tsai TY, Sikora M, Xia P, Colak-Champollion T, Knaut H, Heisenberg
            CP and Megason SG.
  TITLE     An adhesion code ensures robust pattern formation during tissue
            morphogenesis
  JOURNAL   Science 370 (6512), 113-116 (2020)
   PUBMED   33004519
REFERENCE   3  (bases 1 to 1429)
  AUTHORS   Gerber V, Yang L, Takamiya M, Ribes V, Gourain V, Peravali R,
            Stegmaier J, Mikut R, Reischl M, Ferg M, Rastegar S and Strahle U.
  TITLE     The HMG box transcription factors Sox1a and Sox1b specify a new
            class of glycinergic interneuron in the spinal cord of zebrafish
            embryos
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30760481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1429)
  AUTHORS   Roberson S and Halpern ME.
  TITLE     Convergence of signaling pathways underlying habenular formation
            and axonal outgrowth in zebrafish
  JOURNAL   Development 144 (14), 2652-2662 (2017)
   PUBMED   28619821
REFERENCE   5  (bases 1 to 1429)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1429)
  AUTHORS   Wong L, Weadick CJ, Kuo C, Chang BS and Tropepe V.
  TITLE     Duplicate dmbx1 genes regulate progenitor cell cycle and
            differentiation during zebrafish midbrain and retinal development
  JOURNAL   BMC Dev Biol 10, 100 (2010)
   PUBMED   20860823
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1429)
  AUTHORS   Guner B, Ozacar AT, Thomas JE and Karlstrom RO.
  TITLE     Graded hedgehog and fibroblast growth factor signaling
            independently regulate pituitary cell fates and help establish the
            pars distalis and pars intermedia of the zebrafish adenohypophysis
  JOURNAL   Endocrinology 149 (9), 4435-4451 (2008)
   PUBMED   18499750
REFERENCE   8  (bases 1 to 1429)
  AUTHORS   Bonner J, Gribble SL, Veien ES, Nikolaus OB, Weidinger G and Dorsky
            RI.
  TITLE     Proliferation and patterning are mediated independently in the
            dorsal spinal cord downstream of canonical Wnt signaling
  JOURNAL   Dev Biol 313 (1), 398-407 (2008)
   PUBMED   18062957
REFERENCE   9  (bases 1 to 1429)
  AUTHORS   Gribble SL, Nikolaus OB and Dorsky RI.
  TITLE     Regulation and function of Dbx genes in the zebrafish spinal cord
  JOURNAL   Dev Dyn 236 (12), 3472-3483 (2007)
   PUBMED   17994542
REFERENCE   10 (bases 1 to 1429)
  AUTHORS   Seo HC, Nilsen F and Fjose A.
  TITLE     Three structurally and functionally conserved Hlx genes in
            zebrafish
  JOURNAL   Biochim Biophys Acta 1489 (2-3), 323-335 (1999)
   PUBMED   10673033
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF030285.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030285.1, BC162275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505372, SAMEA3505374
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1429
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="25"
                     /map="25"
     gene            1..1429
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="developing brain homeobox 1b"
                     /db_xref="GeneID:30416"
                     /db_xref="ZFIN:ZDB-GENE-000128-11"
     exon            1..446
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    50..52
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="upstream in-frame stop codon"
     CDS             86..1054
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="homeobox protein hlx2; developing brain homeobox
                     protein 1-B; H2.0-like homeobox 2"
                     /codon_start=1
                     /product="homeobox protein DBX1-B"
                     /protein_id="NP_571253.1"
                     /db_xref="GeneID:30416"
                     /db_xref="ZFIN:ZDB-GENE-000128-11"
                     /translation="

MMLPSVIAPPAMYPSFLRPSSALSLPPALQSAFTTHSSFLVEDLLRISRPAAFMHRSIPSPSASPPATGVTTLNTTSSAVHVAMSTALAKRSSSPQTSISSDPNYLKFGVNAILASTTRNASPPPPVQGMNAKTFPFPCFDGSFHPFIRASYFPASSSAVPIPGTFAWPLTARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLATKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKMNPNPDLSDVGKRFEHEAVLRESPRAPFCQSRGDHEFNADLHFKSPSISSKHSDFSESEDEEITVS"

     misc_feature    <602..973
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    order(629..637,641..643,692..694,710..712,749..751,
                     755..760,767..772,776..784,788..793)
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    629..790
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(629..631,638..640,758..760,767..772,779..781)
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    797..883
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9PTU0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    971..1051
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9PTU0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            447..548
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /inference="alignment:Splign:2.1.0"
     exon            549..751
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1397
                     /gene="dbx1b"
                     /gene_synonym="hlx2; sb:eu236"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

attctgccctcttggaccctaatctacgcaagtctctgcagtgagagagtgatttcctcgctgtcaatttctagaaaacggtgcaatgatgttgccaagtgttattgcgccacctgccatgtatccgagctttctgcggccctcgtcggctctttccttgcctccagcgttacaatcggcgttcaccacgcactcgagtttccttgtggaggacctgttgcggatcagcagacctgcagccttcatgcacagaagcatcccgtcgccaagtgcatctcctccagcaacaggtgtcacaactttgaacactacctcctccgcagtccacgtcgccatgtctactgctttggcaaaaagatcaagctccccgcaaacatcaatttccagcgatccaaattacctgaagtttggagtgaatgcgattctcgcgtcaacaacacgaaatgcttcaccaccacctcccgtgcaaggaatgaatgcaaaaacatttcctttcccttgttttgacggatcattccatccattcatcagagcatcatatttcccagcatcgtcatcagcagttccaattcccggaacttttgcttggccactcacagcacgagggaagccgaggagaggaatgcttcgacgggcagttttttctgacgtacagcgtaaagcgctggaaaagatgtttcaaaaacagaaatacatcagcaagccggacagaaagaaactggcgacgaaacttggtcttaaagattctcaggtgaaaatttggttccaaaaccgaaggatgaaatggcgaaattccaaagaaagagaacttctgtcgtctggcggctgcagggaacaaactttaccgacgaaaatgaaccctaatccagatttaagcgacgtcggaaaaaggtttgaacatgaggcggttctcagagaaagcccgcgcgcgcctttctgccaatcgcgcggtgatcacgagttcaatgcagatttacacttcaagtcgccctcgatctccagcaagcactcagacttctcagaatcagaagacgaggaaataaccgtgtcatagtctttaaataaactctgtaatttctattgacttgcacaaaactgaagaaaacgtggtgcttttgtttggcacggttgttttataggacacctttcagtcgaagagagaataaccgctgcgtttttagcagcttgtatagtgatttgtatgaatattttgtatggaattgtatttttataatctttcttaatgttttggaatatacttgtctataatcttaaaaacgtagatgcacatttctaacttaaaattttatattattatgtgtactgatgtttgttgtaaaaagtgtatatgtgtggaaaaaaatatttttacaaattaaaaatccaaagcaaaatactaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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