LOCUS       NM_001386714            1952 bp    mRNA    linear   VRT 28-DEC-2020
DEFINITION  Danio rerio claudin 23.1 (cldn23.1), mRNA.
ACCESSION   NM_001386714 XM_001337411
VERSION     NM_001386714.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Mathiyalagan N, Miles LB, Anderson PJ, Wilanowski T, Grills BL,
            McDonald SJ, Keightley MC, Charzynska A, Dabrowski M and Dworkin S.
  TITLE     Meta-Analysis of Grainyhead-Like Dependent Transcriptional
            Networks: A Roadmap for Identifying Novel Conserved Genetic
            Pathways
  JOURNAL   Genes (Basel) 10 (11), E876 (2019)
   PUBMED   31683705
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Cheung CT, Nguyen TV, Le Cam A, Patinote A, Journot L, Reynes C and
            Bobe J.
  TITLE     What makes a bad egg? Egg transcriptome reveals dysregulation of
            translational machinery and novel fertility genes important for
            fertilization
  JOURNAL   BMC Genomics 20 (1), 584 (2019)
   PUBMED   31307377
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT027832.10 and CR536613.20.
            
            On Aug 31, 2020 this sequence version replaced XM_001337411.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC081659.1, EL646214.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1782              CT027832.10        10500-12281         c
            1783-1952           CR536613.20        174631-174800       c
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1952
                     /gene="cldn23.1"
                     /gene_synonym="cldn23a; cldn23a2; si:ch211-95j8.2"
                     /note="claudin 23.1"
                     /db_xref="GeneID:553515"
                     /db_xref="ZFIN:ZDB-GENE-091204-28"
     exon            1..1952
                     /gene="cldn23.1"
                     /gene_synonym="cldn23a; cldn23a2; si:ch211-95j8.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..880
                     /gene="cldn23.1"
                     /gene_synonym="cldn23a; cldn23a2; si:ch211-95j8.2"
                     /note="claudin 23; claudin 23a"
                     /codon_start=1
                     /product="claudin 23a precursor"
                     /protein_id="NP_001373643.1"
                     /db_xref="GeneID:553515"
                     /db_xref="ZFIN:ZDB-GENE-091204-28"
                     /translation="

MRTPGILIFGMVMAPCGWVLDLTSTVATNWRTVNNVPGYSTDMVVGQGIWDSCLTYSSTRTQTCNQQGNDQIYFKNQIIPIAQGMMVASLIVTALGLVVATPGVRCWREKPRWILAALGGLLIFCSGVLTIIPIAWYTHILTSINSTMVIRSSTTTPDIRVGYCIILGYIGGIMEVLGGFVMFIGICSCCGGRNRGEKPQPKTTERPVPRPTAQTRSYRPRNESPSNSSSVPYSQKSLDDDLDFPRAKTRERDRGRGTDRGRDLASVNASYTGRPYDADL"

     sig_peptide     38..94
                     /gene="cldn23.1"
                     /gene_synonym="cldn23a; cldn23a2; si:ch211-95j8.2"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    50..574
                     /gene="cldn23.1"
                     /gene_synonym="cldn23a; cldn23a2; si:ch211-95j8.2"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
ORIGIN      

ctcacctcagacacagacagcagctcaaccctcaaccatgcggactccggggatcctgatattcgggatggtcatggcgccctgcggctgggtcctggacctgaccagcactgttgcaacaaattggcgcactgtcaacaacgtgccaggctactctacagatatggtggtgggccagggaatctgggacagctgcttgacctactcatcaactagaacccaaacatgcaaccaacaaggcaacgaccaaatctacttcaaaaaccaaatcattccgattgctcaaggaatgatggtcgcatccttgatcgtaactgctctcggcttggtggtggcaactcctggggttcgatgctggagggaaaaacccagatggatactggctgcgctgggtggcctacttattttctgttccggtgtcctgaccatcattccaattgcgtggtacactcacatattgacaagcatcaattccacaatggtcataagaagctcaacgacgacccctgacatccgtgtaggatactgcataattttgggctacatcggaggcatcatggaggttctcggtggttttgtgatgttcatcgggatttgctcctgctgcgggggacggaatcgtggagaaaagcctcaacccaaaacaacagaaaggcctgtgcccagaccaacggctcaaacgaggagctacagaccaagaaatgagagtccaagcaattccagcagcgtaccgtactcgcagaagtctctggacgatgacctggacttcccaagagccaaaaccagagagagagacagaggtagaggaacagacagagggagagatttggcatcagtcaacgcatcctacactggaaggccgtatgatgctgatctctagaggtattaacttggttaagacatactgtgaatattcctttacaattttgtgagtgttgatgacgaagctgtttgaacaactggagtgtaaattcctggaattgttgttacaccagtttttttttttttacaatgtataagtacacatatttttggaagtatgtttcatgagaatactagcctttctgcttctgtgtttaactgcaattcaatgtcttgtttgatgtatatttgtatgtatgaattgtgaattttctacagcatttttttacaagtatacaagtgtactttaaatgtttacagcagttactgtttgtgctttccatttgcaccctgaagctaaaaaactctgaatttgtacaatagcaaaaaatgtaggtttaaaatcagctcttgcaccttaatgaacatataatcggtatcacattaatatcgcaaggttcgattttatacccaatgtcctttgaaagcattgaatgtgcaatattttccatagctgcggaaatacagtacaagctaaagttagtcatcatggtttctgtaatgcagtaaaactagtaatactggttgtttcagtttgatctccacacaagattatgggtcatgtttgaattgtcaggtgattcatgagtcaagtgaacgatgaaatgatagcaatgaagaagtaaacgtctatgttgtgttattttcctgtttttttatttgaagaaaatgagcgagaagctgttgtagaacaatgagctgagtttgtaccttcagtcagcatcaaaacaaacttgtacccgttacataaattgacctgcagcacaaaacatgaaatatattacggcaataaattaggctaattaattattaactgtaaaacagttgcatgtgacagcaacaaggtgtaaatgaggtaaaaagctttcaggaagtaggtgtaagactttttttgctgactttatttttcctgtaacctaccagattatgttgtattttacactgggctcaagatttgtgaggtttcttaacaatccaactttgtgtaaatgttcttttcttgtattaaagtactatttatttaaaacaaa

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