LOCUS       NM_001327784            1341 bp    mRNA    linear   VRT 09-DEC-2023
DEFINITION  Danio rerio nicotinamide riboside kinase 2 (nmrk2), transcript
            variant 1, mRNA.
ACCESSION   NM_001327784
VERSION     NM_001327784.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Horzmann KA, Lin LF, Taslakjian B, Yuan C and Freeman JL.
  TITLE     Anxiety-related behavior and associated brain transcriptome and
            epigenome alterations in adult female zebrafish exposed to atrazine
            during embryogenesis
  JOURNAL   Chemosphere 308 (Pt 3), 136431 (2022)
   PUBMED   36126741
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Sullivan C, Lage CR, Yoder JA, Postlethwait JH and Kim CH.
  TITLE     Evolutionary divergence of the vertebrate TNFAIP8 gene family:
            Applying the spotted gar orthology bridge to understand ohnolog
            loss in teleosts
  JOURNAL   PLoS One 12 (6), e0179517 (2017)
   PUBMED   28658311
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EH432193.1, EH594583.1, CU013534.11 and EH485974.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01028370.1, EH432193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               EH432193.1         10-223
            215-814             EH594583.1         217-816
            815-935             CU013534.11        60296-60416         c
            936-1341            EH485974.1         12-417
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1341
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="nicotinamide riboside kinase 2"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
     exon            1..155
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..726
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integrin beta 1 binding protein 3"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 2 isoform 1"
                     /protein_id="NP_001314713.1"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
                     /translation="

MKFIIGIGGVTNGGKTTLTGRLIKNLPNCCVVHQDDFFKPQDQIELGEDGFRQWDVITALDMDAMVNTVKGWMENPVKFARSHGVSVSTTSDPDSDIHILIVEGFLLYNYKPLIDVYNKCFYVTIPYEECKRRRSTRTYTVPDPPGLFDGHVWPMYLKHRTEMENSSLDIQYLDGMSSKDELYNQLYEDIQNSLLNIL"

     misc_feature    139..630
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="Nicotinamide riboside kinase (NRK) is an enzyme
                     involved in the metabolism of nicotinamide adenine
                     dinucleotide (NAD+). This enzyme catalyzes the
                     phosphorylation of nicotinamide riboside (NR) to form
                     nicotinamide mononucleotide (NMN). It defines the NR...;
                     Region: NRK1; cd02024"
                     /db_xref="CDD:238982"
     misc_feature    order(154..156,169..180)
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="active site"
                     /db_xref="CDD:238982"
     exon            156..246
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            247..295
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            296..461
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            462..533
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            534..640
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            641..726
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1326
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aatgaaatagtaaaaagagggagattctgggagaaaggaaaggagagagaggctgaaagcattcccaaggaagcgattcctttgctagtgtcctatcgcgaagaccaagaacaaacaaagaggatcagaatgaagtttattattggaatagggggtgtgaccaatggaggaaagacaactttgactggaagactcataaagaacctaccaaactgttgtgtggttcatcaagatgattttttcaagccccaagatcaaatagagctcggggaggacggctttagacaatgggatgtcattaccgccttagacatggacgccatggtgaacactgttaaaggatggatggagaacccggtgaagtttgcacgatcccatggcgtgagcgtttccaccacatctgaccctgatagtgacatccacatactcattgtggagggatttctgctttataactacaagcctttaattgacgtctataacaagtgcttctacgtcaccattccatatgaagagtgcaaaaggagaagaagtacgagaacgtacaccgttcctgacccacccggtctgtttgacggccatgtttggccaatgtacttgaaacacaggacagaaatggagaacagcagcttggatatccaatatctggacggcatgagctctaaggacgagctctataaccaactttatgaagacattcagaactctctgttgaacatcttatagcatctccaatcggattgaagatgtgtttgtgtatagaactgtaaataggatcttaagtagattcggcttctgccactggatgaactttgtaaatacgatgaagtactaacttatttgaaaacttgtggctagtgcctttgattttatattgctctgtgtaacttttgttttatttaaaatcacgcctcactctctgggctgatcagagatgtacagttttcatgtatactgtaattgaagaacttcaatcaaaacacacatttgaactctttatctgttgtgttttcattcttagcattgagacgtgcatgcatttaaaccatcttgtgcatgtttatggattatgatgaaggaatataataaaaatataaaataaataacacataactcaagaaataaatatgaatgtattgggcaagatataacatatatacattttaattaaaacatttcacagagtttaagtaaatactgtaaaattccagggcttttaatgtaaagattgttcatttacatgaaaatgcattagatattatgtatgcgctttcattctcagcattaaaacatgcatgttattttaaaaaacatgcaaatatttccaaaaaaaaaaaaaaa

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