LOCUS       NM_001326290            2460 bp    mRNA    linear   VRT 25-MAR-2023
DEFINITION  Danio rerio homer scaffold protein 1b (homer1b), transcript variant
            2, mRNA.
ACCESSION   NM_001326290 XM_005157295
VERSION     NM_001326290.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Ikeda A, Yamasaki C, Kubo Y, Doi Y, Komamizu M, Komatsu M and
            Shiozaki K.
  TITLE     Alteration of the neuronal and glial cell profiles in
            Neu1-deficient zebrafish
  JOURNAL   Glycoconj J 39 (4), 499-512 (2022)
   PUBMED   35877057
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Deng J, Wang Y, Hu M, Lin J, Li Q, Liu C and Xu X.
  TITLE     Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a
            Subtype of Autism
  JOURNAL   Front Mol Neurosci 15, 904935 (2022)
   PUBMED   35754711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Gao L, Penglee R, Huang Y, Yi X, Wang X, Liu L, Gong X and Bao B.
  TITLE     CRISPR/Cas9-induced nos2b mutant zebrafish display behavioral
            abnormalities
  JOURNAL   Genes Brain Behav 20 (5), e12716 (2021)
   PUBMED   33200539
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Frank DF, Miller GW, Connon RE, Geist J and Lein PJ.
  TITLE     Transcriptomic profiling of mTOR and ryanodine receptor signaling
            molecules in developing zebrafish in the absence and presence of
            PCB 95
  JOURNAL   PeerJ 5, e4106 (2017)
   PUBMED   29201571
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2460)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2460)
  AUTHORS   Lin CY, Chen JS, Loo MR, Hsiao CC, Chang WY and Tsai HJ.
  TITLE     MicroRNA-3906 regulates fast muscle differentiation through
            modulating the target gene homer-1b in zebrafish embryos
  JOURNAL   PLoS One 8 (7), e70187 (2013)
   PUBMED   23936160
  REMARK    GeneRIF: Results indicate that miR-3906 controls [Ca(2+)]i
            homeostasis in fast muscle through fine tuning homer-1b expression
            during differentiation
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2460)
  AUTHORS   Baraban SC, Dinday MT and Hortopan GA.
  TITLE     Drug screening in Scn1a zebrafish mutant identifies clemizole as a
            potential Dravet syndrome treatment
  JOURNAL   Nat Commun 4, 2410 (2013)
   PUBMED   24002024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033828.6 and EH491241.1.
            
            On May 13, 2016 this sequence version replaced XM_005157295.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA2168446,
                              SAMEA2168447 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CT033828.6         32678-32690
            14-429              EH491241.1         30-445
            430-430             CT033828.6         44976-44976
            431-836             EH491241.1         447-852
            837-837             CT033828.6         70714-70714
            838-985             EH491241.1         854-1001
            986-1056            CT033828.6         82158-82228
            1057-1167           CT033828.6         83956-84066
            1168-1248           CT033828.6         84167-84247
            1249-2460           CT033828.6         87491-88702
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     gene            1..2460
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="homer scaffold protein 1b"
                     /db_xref="GeneID:436769"
                     /db_xref="ZFIN:ZDB-GENE-040801-44"
     exon            1..359
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    253..255
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="upstream in-frame stop codon"
     CDS             355..1437
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="isoform 2 is encoded by transcript variant 2; homer
                     homolog 1; homer homolog 1b; homer scaffolding protein 1b"
                     /codon_start=1
                     /product="homer protein homolog 1b isoform 2"
                     /protein_id="NP_001313219.1"
                     /db_xref="GeneID:436769"
                     /db_xref="ZFIN:ZDB-GENE-040801-44"
                     /translation="

MGEQPIYSTRAHVFQIDPSTKKNWMPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMSFTKTSQKFGQWADSRANTVYGLGFSSEHHLAKFADKFAEYKEAARIAKEKSLEKMELASSPSQESPADIHSPLTPPVTADLCRINGTGDDVTLSDVSPNSMLQSDLSPTTPTLAHSPTTNKHWEAELAALKSNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVSELESQSSQTNVIKSQKTELNQTIEELECTLRAKEEEMMRLKEEVENAKQLQAQKDELTKKLEDTDMRNKELEEQLSDLEQRLESSQVDQENLRKNLKTLLEILDGKIFELTELRDNLAKLIEDS"

     misc_feature    361..687
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="Homer/Vesl family proteins EVH1 domain; Region:
                     EVH1_Homer_Vesl; cd01206"
                     /db_xref="CDD:269917"
     misc_feature    order(424..426,562..564,574..576,619..621)
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:269917"
     misc_feature    <922..>1428
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /note="Chromosome segregation ATPase [Cell cycle control,
                     cell division, chromosome partitioning]; Region: Smc;
                     COG1196"
                     /db_xref="CDD:224117"
     exon            360..516
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            517..648
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            649..741
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            742..899
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1056
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1167
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1248
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..2460
                     /gene="homer1b"
                     /gene_synonym="homer1; zgc:100854; zgc:92844"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tagattcatctttagagccacacgcccaccgagagagaggcagcggctcgttattcacccctgcgccaccgttacctcacgctcttcaacgaatacaatattcacaccgcagagatgcgaggtgagcccgtcgtgtgccaaagcagctgaaattgggcagtattagtgggcaattcgccgtgggatccattcagtgaatctgacagcctacatacagagcgcgtaacgagagacgcagaatgccgctgctcataatgtgaccgaccgcatccagagccgcttcattcagctggaagaacaaactcgctgatcaacaaatcctatctcgtctcaggagggaaaaacaacagcaacatgggggagcagcccatctacagcacccgggcacacgtcttccagatagaccccagcactaagaaaaactggatgcccaccagcaaacatgcggtcactgtatcttacttctacgacagtaccaggaacgtgtacagaatcatcagcttggatggatcgaaggcaataataaacagcactatcaccccgaacatgtccttcacaaagacatctcaaaagtttggccagtgggctgacagccgtgccaacacagtgtatgggctgggtttctcctccgagcatcatctggccaagttcgcagataaatttgcagagtacaaagaagcagccagaatagccaaggagaagtctctagaaaagatggagctggcaagttcgccctctcaggaatcgcctgctgacattcattcccctctgactccaccggtcactgcggacctctgccgaatcaacggcactggtgatgatgtcactctgtctgacgtgtcacccaactctatgcttcaatcagatctttctcccaccacgccgactcttgcacacagcccaactaccaacaaacactgggaggcagagctagcagcactaaagagcaacaatgctaagctcacagctgctctgctggagtccacagccaacgtcaaacaatggaaacagcagctcgccgcttatcaggaggaggctgaaaggctacacaaacgggtttcagaattggaaagtcaaagtagtcaaaccaacgtgatcaaatcccagaaaactgagctgaaccaaacaatagaggagctggaatgcactctgagggcaaaggaagaggaaatgatgcgattgaaagaagaagtagaaaacgccaagcagcttcaagctcaaaaagatgaactcaccaaaaaattagaggacacggatatgcggaacaaggagctagaggaacagttgtctgacctggagcagcgcctagagtccagtcaggtggaccaggagaacctgcgcaagaacctcaaaactctgctggagatcctggatggaaagatcttcgagctgaccgagctgagagacaacctagccaaactcatcgaagacagctagactcgcatctctactagacatttttacagaaaaattaaataaaaaccacacagtgtccaattcaggcccagagagagtctgactttcacagtcggactctccttcactcacttacatggaatgattaacctttggttgcacttgattttgtattttagttttttcgaggtacgtttattctcttcagtgccactgctaccgactgagttttattgtttcaaacactacattttctttcattcttgatgtttccttgaattcccctccccgaaataggcagcctgcaaagactacggctgcagataggctcctactctttaacggtgctggttttgtgtgcctggctgttggcgtaaaatggacgttacctatgctgctgaggacacttacatgaattacactgactggatcttcagtcgcattttaagactggatattcagagccatatgttgtagccaaacgttattggctcgcctcttccccttcatggaaactgcctcaatgttaagtaagtcaaagtttcaggatactcaaccgctgacctaaaaatctcttgacatttagcagacgctgagatgtagatgtggcgtaaacgctttaggcctgtaatatacactgagcaatattagtgtgagcgtctgtatggcagattagtgtgagccacctcaatgcatccgtcaggtactcaaacgctcgaaaggacgaatttacggtcatctttcggatttctccagcgatcagtgtattgcttttggatcgtattggccttattatatccactatctatacatttttcaggattttttcttgaagacgaggatcttccttttgtttgttaacttaccaaatgcaattatgtattcgattccttacgattttcaataacgctattattgtaatatttaaaaggtccatcctgctgatggctgttacggtacatagatcactgtcagtatgattgtatttatatgtggggaaaattctgtttttgatttcccaatgttaataaagactatttaaag

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