2024-11-01 08:47:20, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_001252559 2729 bp mRNA linear VRT 08-OCT-2023 DEFINITION Danio rerio argonaute RISC component 4 (ago4), mRNA. ACCESSION NM_001252559 XM_003200646 VERSION NM_001252559.2 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. REFERENCE 1 (bases 1 to 2729) AUTHORS Raman R, Ryon M and Jagadeeswaran P. TITLE RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish JOURNAL Sci Rep 10 (1), 20187 (2020) PUBMED 33214638 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2729) AUTHORS Liu Y, Zhu Z, Ho IHT, Shi Y, Li J, Wang X, Chan MTV and Cheng CHK. TITLE Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan JOURNAL Front Genet 11, 853 (2020) PUBMED 32849832 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2729) AUTHORS Katz S, Cussigh D, Urban N, Blomfield I, Guillemot F, Bally-Cuif L and Coolen M. TITLE A Nuclear Role for miR-9 and Argonaute Proteins in Balancing Quiescent and Activated Neural Stem Cell States JOURNAL Cell Rep 17 (5), 1383-1398 (2016) PUBMED 27783951 REFERENCE 4 (bases 1 to 2729) AUTHORS McFarlane L, Svingen T, Braasch I, Koopman P, Schartl M and Wilhelm D. TITLE Expansion of the Ago gene family in the teleost clade JOURNAL Dev Genes Evol 221 (2), 95-104 (2011) PUBMED 21556854 REFERENCE 5 (bases 1 to 2729) AUTHORS Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson ND, Wolfe SA and Giraldez AJ. TITLE A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity JOURNAL Science 328 (5986), 1694-1698 (2010) PUBMED 20448148 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JX448395.1. On Dec 24, 2014 this sequence version replaced NM_001252559.1. ##Evidence-Data-START## Transcript exon combination :: JX448395.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2729 JX448395.1 1-2729 FEATURES Location/Qualifiers source 1..2729 /organism="Danio rerio" /mol_type="mRNA" /strain="AB" /db_xref="taxon:7955" /chromosome="19" /map="19" gene 1..2729 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="argonaute RISC component 4" /db_xref="GeneID:100535764" /db_xref="ZFIN:ZDB-GENE-030131-5357" exon 1..142 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" CDS 124..2715 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="argonaute 4; eukaryotic translation initiation factor 2C, 4; argonaute RISC catalytic component 4" /codon_start=1 /product="protein argonaute-4" /protein_id="NP_001239488.1" /db_xref="GeneID:100535764" /db_xref="ZFIN:ZDB-GENE-030131-5357" /translation="
MEALGPGPPAPTSLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDIDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVSLQWVSVVSLQMLLEALSGHLNEVPEDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPVIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNDMTEVTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMSYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQDLSQEQLFSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCSDKAERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHYDTQHTMYFA"
misc_feature 205..594 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:465134" misc_feature 625..777 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 778..1140 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(934..936,979..981,1021..1023,1033..1035,1087..1089, 1108..1110,1114..1116) /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_feature 1279..2586 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the...; Region: Piwi_ago-like; cd04657" /db_xref="CDD:240015" misc_feature order(1690..1692,1702..1704,1738..1749,1756..1758, 1780..1782,1789..1791,1801..1803,1813..1815) /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240015" misc_feature order(1894..1896,1900..1902,2140..2142,2554..2556) /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /note="active site" /db_xref="CDD:240015" exon 143..314 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 315..435 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 436..617 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 618..754 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 755..889 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 890..977 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 978..1125 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1126..1245 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1246..1374 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1375..1508 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1509..1693 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1694..1853 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 1854..2169 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 2170..2304 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 2305..2406 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 2407..2606 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" exon 2607..2729 /gene="ago4" /gene_synonym="eif2c4; fd14f04; wu:fd14f04" /inference="alignment:Splign:2.1.0" ORIGIN
cacatctacgcatcccttccatttcttaaattagccaccttaagcttcgagataccgcccccaatttcagtgtcggtacggagccgccaggccgggacagagacggagagagagccctcggccatggaagcgctcggacccggcccgcctgcccctacctccctcttccagccaccgcgccggcccggcttgggtacggtggggaagccgattcgcctgctggccaatcacttccaggtgcagatccccaagatcgacgtctaccattatgacatcgacatcaaacctgaaaaacggccccgcagggtcaacagagaggtggtggacacaatggttagacattttaagatgcagatctttggggaccggcagcctggatatgatggaaagaggaacatgtacacggcacatccgctacccatcgggagggacagggtggatctggaggtgacgctgccgggtgaagggaaggatcagacttttaaggtgtctctgcagtgggtgtcggtggtcagtctgcagatgctactggaagctctgtctggtcacctgaacgaggtgccggaggattcagttcaggctctggacgtcatcactcgtcacctgccttccatgcggtacactccagtaggccggtccttcttctctccaccagagggctactatcatccactgggaggagggagggaggtgtggttcggtttccatcagtctgtccgtcctgccatgtggaacatgatgctcaacatagatgtgtcagcaacagcgttttacagagctcagcctgtcatcgaattcatgtgtgaggttttggacatccagaacatcaacgagcagaccaaacccctcacagattcacaacgtgtcaagttcaccaaggagatccgaggactgaaagtggaggtcacacactgcggccagatgaagaggaagtaccgtgtgtgtaatgtcacgcgccgcccagccagtcatcagacgtttcctttgcagcttgagaatggacaagctatggagtgcaccgttgcccagtatttcaaacaaaagtacagcctgcagctcaaatacccccacctgccctgcctccaggtgggacaggagcagaagcacacgtaccttcccctggaggtttgtaatatagtggcaggacagcgctgcataaagaaactaacagataatcagacctccaccatgatcaaagctacggcccgctcagccccagacagacaggaggagatcagccgactggtcaaaagcaacagtatggttggcgggcccgacccttatctgaaagagtttggcattgtggtgcacaatgacatgaccgaggtgacagggcgggtcctcccagcgcccatgctgcagtatgggggccggaataagacggtggccacacccaaccagggcgtctgggacatgagggggaagcagttttatgccggaatagagatcaaggtttgggccgtggcctgcttcgcccctcagaaacaatgcagagaggacctgctcaagagtttcactgaccagctgcgcaagatttccaaggatgctgggatgccgatccaaggccagccgtgcttctgcaaatacgcccagggtgcagacagtgtggagcccatgttcaagcatctcaagatgtcttacgtgggcctgcagctcatcgtggtcatcctgcccggaaaaacacctgtctatgcggaggtgaagcgtgtgggagacactctcctgggaatggccactcagtgtgttcaggtgaagaacgtggtaaaaacgtctcctcagacgctctccaacctctgtctgaagatcaacgccaaactaggaggcatcaacaatgtgctggtgccacatcagaggccttctgtgttccagcagccggtgatcttcttgggtgcggatgtcactcaccctccagcgggcgatgggaagaagccgtccatcgctgcagtggtaggtagtatggacggacacccgagccgatactgcgccaccgtacgggtgcaaacgtcccgccaggatctgtcccaggagcagctcttcagccaggaggtcatccaggatctcaccaacatggtgcgcgagctgctcattcagttctacaaatccacccgattcaagcccacgcgcattatctactaccgcggaggagtttctgagggccagatgaagcaggtggcgtggccagagctgatcgccatcaggaaagcctgcatcagtctagaagaggattacaggccgggaatcacatacatcgtagtgcagaaacgccaccacactcgactcttctgctccgacaaagccgagagggttgggaagagtggcaacgtcccagcaggcactacggtggacagcaccatcacacacccctcagagtttgacttctacctgtgcagccatgctggcatccagggcaccagccgtccctctcactatcacgtgttgtgggacgacaactgtttcaccgctgacgagctccagcttttgacctatcagctctgccacacttatgtgcgctgcacccgctccgtctccatccccgcgccagcttactatgcccggctagtggccttccgtgcacgctatcatttagtggacaaagaccatgacagtgctgaaggcagtcacgtatcaggacagagcaacggtcgagacccgcaggcgctggcgaaagctgtgcagattcactacgacacacagcacaccatgtacttcgcctgaccacagccagcagg
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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