LOCUS       NM_001190307            1176 bp    mRNA    linear   VRT 16-OCT-2021
DEFINITION  Danio rerio potassium channel, subfamily K, member 18 (kcnk18),
            mRNA.
ACCESSION   NM_001190307 XR_084393
VERSION     NM_001190307.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1176)
  AUTHORS   Rahm AK, Wiedmann F, Gierten J, Schmidt C, Schweizer PA, Becker R,
            Katus HA and Thomas D.
  TITLE     Functional characterization of zebrafish K2P18.1 (TRESK)
            two-pore-domain K+ channels
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 387 (3), 291-300 (2014)
   PUBMED   24311292
REFERENCE   2  (bases 1 to 1176)
  AUTHORS   Gierten J, Hassel D, Schweizer PA, Becker R, Katus HA and Thomas D.
  TITLE     Identification and functional characterization of zebrafish
            K(2P)10.1 (TREK2) two-pore-domain K(+) channels
  JOURNAL   Biochim Biophys Acta 1818 (1), 33-41 (2012)
   PUBMED   21963410
REFERENCE   3  (bases 1 to 1176)
  AUTHORS   Enyedi P and Czirjak G.
  TITLE     Molecular background of leak K+ currents: two-pore domain potassium
            channels
  JOURNAL   Physiol Rev 90 (2), 559-605 (2010)
   PUBMED   20393194
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from GQ304739.2.
            
            On Nov 14, 2011 this sequence version replaced NM_001190307.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ304739.2, CK687289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168447, SAMEA2168448
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="17"
                     /map="17"
     gene            1..1176
                     /gene="kcnk18"
                     /note="potassium channel, subfamily K, member 18"
                     /db_xref="GeneID:561821"
                     /db_xref="ZFIN:ZDB-GENE-100405-2"
     CDS             1..1176
                     /gene="kcnk18"
                     /note="two-pore-domain potassium channel TRESK; K2P18.1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 18"
                     /protein_id="NP_001177236.2"
                     /db_xref="GeneID:561821"
                     /db_xref="ZFIN:ZDB-GENE-100405-2"
                     /translation="

MSVSQKRQFTGRCSTLFWRLFPHVFLILSLVLYAVLGALVFRAIEYTNPRNESEEILSIVQKVMEIVQNHTDASEQKHLINKAKYILDDYCYEKERDHGWTFFASLFFCCTVFTTVGYGRIYPLTSKGKVACVLYAMVGIPLMLLVISDVGDLLAVLLSKAYTRLNLFFRRWIGHQSWRLQSHEKTSALPQAQADTDGTYKFNQDVVVLETTNNQQVIQTRSSIRRGSFQLRNNKEIFDRIIVRESFRIKGTLSKSCSCPELDRVPTPKDELFNDIGQEMEQLDVPLLVILLMVFAYMVICSQILKCWEKQMDHSDAFYFTFITLTTIGFGDIVPEHPKFFMVTFLFIITGMAIMSMAFKLGQSQIVCFYRRCIKSLSMGKVRIHNDLNNN"

     misc_feature    289..462
                     /gene="kcnk18"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:429715"
     misc_feature    868..1077
                     /gene="kcnk18"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:429715"
     exon            1..214
                     /gene="kcnk18"
                     /inference="alignment:Splign:2.1.0"
     exon            215..349
                     /gene="kcnk18"
                     /inference="alignment:Splign:2.1.0"
     exon            350..1176
                     /gene="kcnk18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgtccgtgtcacaaaagagacagtttacggggagatgctcgacactcttctggcgtttgtttcctcatgttttcctaattttatcactcgttttatacgcggttttaggagcgcttgtcttcagagcgattgagtacacgaatcctcgaaatgagtcggaggagatcctgtccattgtgcaaaaagtgatggagatcgttcagaatcacacagacgcctcagagcagaagcacctaatcaataaagcaaaatacattttggatgattactgttatgagaaggaacgtgatcacggatggaccttctttgcttcacttttcttctgctgtacagtgttcactactgtaggttatggacgaatttatccgttgacaagtaaagggaaagtggcatgtgtcctgtatgcgatggtgggcatccctctgatgctgctggtcatctcggatgtgggtgatctcttagctgttctcctctccaaagcatatactcgccttaacctgttcttcagacgatggataggacatcagtcatggagacttcagagccacgaaaagacatcagctcttccacaagctcaagctgatactgacggcacctataagttcaatcaggatgtcgtggtgctcgagacaacaaacaatcaacaggtgatacaaactaggtcttccatcaggcgcgggtcctttcagctccgtaacaacaaagagatctttgaccgcattattgtaagggagagcttcaggatcaaaggaactctctcaaaatcctgttcatgcccagaactggaccgtgtgccaaccccaaaagatgagttattcaacgacatcggacaggagatggagcagttggacgtccctctgctggtcatcttgctgatggtgtttgcctacatggtgatctgcagtcagattctgaaatgctgggagaagcagatggaccattctgatgccttttatttcaccttcatcaccctaaccaccattggctttggcgacattgtgcccgaacacccaaaattcttcatggttacttttttgttcatcatcacaggcatggccattatgagtatggcctttaaacttggccaatcgcaaattgtttgcttttacaggcggtgtataaagagtctaagcatgggcaaggtaagaattcacaatgacttaaacaacaactga

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