LOCUS       NM_001177461             852 bp    mRNA    linear   VRT 08-AUG-2023
DEFINITION  Danio rerio PROP paired-like homeobox 1 (prop1), mRNA.
ACCESSION   NM_001177461 XM_001341349
VERSION     NM_001177461.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Fabian P, Tseng KC, Smeeton J, Lancman JJ, Dong PDS, Cerny R and
            Crump JG.
  TITLE     Lineage analysis reveals an endodermal contribution to the
            vertebrate pituitary
  JOURNAL   Science 370 (6515), 463-467 (2020)
   PUBMED   33093109
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Nakahara Y, Muto A, Hirabayashi R, Sakuma T, Yamamoto T, Kume S and
            Kikuchi Y.
  TITLE     Temporal effects of Notch signaling and potential cooperation with
            multiple downstream effectors on adenohypophysis cell specification
            in zebrafish
  JOURNAL   Genes Cells 21 (5), 492-504 (2016)
   PUBMED   27027936
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Angotzi AR, Mungpakdee S, Stefansson S, Male R and Chourrout D.
  TITLE     Involvement of Prop1 homeobox gene in the early development of fish
            pituitary gland
  JOURNAL   Gen Comp Endocrinol 171 (3), 332-340 (2011)
   PUBMED   21362424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX004962.10.
            
            On Jul 24, 2010 this sequence version replaced NM_001177461.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU848298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168448
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               BX004962.10        83676-83913         c
            239-471             BX004962.10        80258-80490         c
            472-852             BX004962.10        77527-77907         c
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..852
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="PROP paired-like homeobox 1"
                     /db_xref="GeneID:100001377"
                     /db_xref="ZFIN:ZDB-GENE-081107-40"
     exon            1..238
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="upstream in-frame stop codon"
     CDS             169..852
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="paired-like homeodomain transcription factor prop1"
                     /codon_start=1
                     /product="PROP paired-like homeobox 1"
                     /protein_id="NP_001170932.2"
                     /db_xref="GeneID:100001377"
                     /db_xref="ZFIN:ZDB-GENE-081107-40"
                     /translation="

MDIEKPQQQFPENYSEVTVSSSADIDVQIHPRKVSQKSESVRDGGARARPYPSPSRRRHRTTFSNEQLEHLELAFRQNHYPDIYYREELARVTKLNEARIQVWFQNRRAKQRKQDRITQKSLAVSMMPVRGPLFSTMCVSSSAMGRQCQCPHSLPHVPQFSPVLPPGGYPPHPSSGSQFSSPSGSLPSQANRQPNDWYNQLRNIGPSPTSVLSLASVPGLESTSHWN"

     misc_feature    order(337..351,355..357,406..408,424..426,463..465,
                     469..474,481..486,490..498,502..507)
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    343..504
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(343..345,352..354,472..474,481..486,493..495)
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            239..471
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..852
                     /gene="prop1"
                     /gene_synonym="si:ch211-93n23.5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acactgaccaaaacagacccaggttacaatattgtgggctccaccatcacattgaccaaacaggtgagaggtgtaaccgcactgtgatgtcacaactgtgaaggagtataatgtggtttgaacggaggtcaagagggaatcctgcttgcagcccagagagagtctgaaatggacatagagaaacctcagcaacagttccctgaaaattactctgaggtcacggttagctcaagcgcagatatagatgtccaaattcacccaagaaaagtttctcagaaatctgagagtgtcagggatggtggagcacgagcaagaccatacccttcaccatcccgccgcagacaccgaactaccttcagcaatgaacagctggagcacctggagttggctttcagacagaaccactatcctgatatctactacagagaggagcttgctagggtcaccaaacttaatgaggctcgcatacaggtgtggttccagaaccgtcgtgccaagcagcggaagcaggaccgtataacccaaaaatcgctggcagtaagcatgatgccagtgcgagggcctctctttagcaccatgtgcgtgtcttcctctgccatggggcggcagtgccagtgtcctcattccctgcctcacgtcccgcagttctctccagtgctgccccctggaggctacccaccccatccgtcttctggcagtcaattctccagcccttctggttctctcccatcacaagccaacagacagcctaatgactggtacaatcaattgcgcaacattgggccatcccccacctcagtgctctcactggcctctgtgccaggactggaaagtactagtcactggaactag

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