LOCUS       NM_001171587            3558 bp    mRNA    linear   VRT 06-MAR-2022
DEFINITION  Danio rerio prospero homeobox 3 (prox3), mRNA.
ACCESSION   NM_001171587 XM_687770
VERSION     NM_001171587.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3558)
  AUTHORS   Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins MM,
            Marin-Juez R, Guenther S, Maischein HM, Fukuda N, Canham MA,
            Brickman JM, Bogue CW, Jayaraman PS and Stainier DYR.
  TITLE     HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1
            signaling axis during vascular development
  JOURNAL   Nat Commun 9 (1), 2704 (2018)
   PUBMED   30006544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3558)
  AUTHORS   Yan H, Zhang C, Wang Z, Tu T, Duan H, Luo Y, Feng J, Liu F and Yan
            X.
  TITLE     CD146 is required for VEGF-C-induced lymphatic sprouting during
            lymphangiogenesis
  JOURNAL   Sci Rep 7 (1), 7442 (2017)
   PUBMED   28785085
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3558)
  AUTHORS   Venero Galanternik M, Castranova D, Gore AV, Blewett NH, Jung HM,
            Stratman AN, Kirby MR, Iben J, Miller MF, Kawakami K, Maraia RJ and
            Weinstein BM.
  TITLE     A novel perivascular cell population in the zebrafish brain
  JOURNAL   Elife 6, e24369 (2017)
   PUBMED   28395729
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3558)
  AUTHORS   Ernens I, Lumley AI, Zhang L, Devaux Y and Wagner DR.
  TITLE     Hypoxia inhibits lymphatic thoracic duct formation in zebrafish
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1129-1134 (2017)
   PUBMED   27916465
REFERENCE   5  (bases 1 to 3558)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3558)
  AUTHORS   Bussmann J and Schulte-Merker S.
  TITLE     Rapid BAC selection for tol2-mediated transgenesis in zebrafish
  JOURNAL   Development 138 (19), 4327-4332 (2011)
   PUBMED   21865323
REFERENCE   7  (bases 1 to 3558)
  AUTHORS   Aranguren XL, Beerens M, Vandevelde W, Dewerchin M, Carmeliet P and
            Luttun A.
  TITLE     Transcription factor COUP-TFII is indispensable for venous and
            lymphatic development in zebrafish and Xenopus laevis
  JOURNAL   Biochem Biophys Res Commun 410 (1), 121-126 (2011)
   PUBMED   21641336
REFERENCE   8  (bases 1 to 3558)
  AUTHORS   Tao S, Witte M, Bryson-Richardson RJ, Currie PD, Hogan BM and
            Schulte-Merker S.
  TITLE     Zebrafish prox1b mutants develop a lymphatic vasculature, and
            prox1b does not specifically mark lymphatic endothelial cells
  JOURNAL   PLoS One 6 (12), e28934 (2011)
   PUBMED   22216143
  REMARK    GeneRIF: conclude that Prox1b activity is not essential for
            embryonic lymphatic development in zebrafish
REFERENCE   9  (bases 1 to 3558)
  AUTHORS   Del Giacco L, Pistocchi A and Ghilardi A.
  TITLE     prox1b Activity is essential in zebrafish lymphangiogenesis
  JOURNAL   PLoS One 5 (10), e13170 (2010)
   PUBMED   20976189
  REMARK    GeneRIF: isolated a second ortholog, named prox1b, and analyzed its
            expression during development by whole mount in situ hybridization.
            We detected strong prox1b expression in the endothelium of
            posterior cardinal vein from where lymphatic precursors originate
            Erratum:[PLoS One. 2010;5(11). doi:
            10.1371/annotation/6c1f2c4a-7da6-43cd-a934-78b7550dfbaf]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3558)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FJ544314.1.
            
            On Apr 26, 2010 this sequence version replaced XM_687770.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ544314.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3558
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..3558
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /note="prospero homeobox 3"
                     /db_xref="GeneID:564431"
                     /db_xref="ZFIN:ZDB-GENE-050107-3"
     exon            1..274
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /inference="alignment:Splign:2.1.0"
     exon            275..1790
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    279..281
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /note="upstream in-frame stop codon"
     CDS             309..2288
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /note="prospero-related homeobox 3; prospero-related
                     homeobox gene 1b; prospero homeobox 1b"
                     /codon_start=1
                     /product="prospero homeobox 3"
                     /protein_id="NP_001165058.1"
                     /db_xref="GeneID:564431"
                     /db_xref="ZFIN:ZDB-GENE-050107-3"
                     /translation="

MDSPSDRFHQQPSQMCPFELYRSLPDSNPSGHRFPPGSLSSHPLFSPLMHPNSMSQKWGSFRQRQGLFPGLLVDDDVSEEDVFGKREFGATSSSQRGSGERGQAPEPSDWGQDFARVKRLRMDSAARSEDESIREGKRGRKSRSSFRMDEKKGMEQGNRRESREGRKRQRQELKLQLEETRGKLLELQRKVWRVYGGQADDEKDQENGGINLDEVADMFSDSDDPLVGNGFSPQRCSSKKNNETNGNGNAGIFPETSVDLDLELNGSQVWLGCSLIRGEWESAEGGQKFAQALKQELANVVAQVIDRVVRLYAESDPEAVSSAQEPSMTMDLNSDRRPRPQAVEQVEALPLVTKSPQDKRAPVAQSGHKDLLLPQANPSLAPLAQPPLPALLPPRGKEHFLPSYPPDNPVHLPLLHYTMQNLFARSLSSLPLHKDCLSESFMDFRSHNSAFPPLPLLGQLDPSPSDRAREVGMRAGGAGMVDGADAALYLAAGSSQEGLSPCHLKKAKLMFFYTRYPSSSTLKTYFPDVKFNRCVTSQLIKWFSNFREFFYIQMERFARQAAREVLTSARERALRLGRDTELYRILNMHYNKSNDYQVPERFVEISEVALREFFTAIQSGRDADPCWKKSIYKIICKLDSPVPDSFRLPGCPTDTYRMG"

     misc_feature    1800..2264
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /note="Homeo-prospero domain; Region: HPD; pfam05044"
                     /db_xref="CDD:428277"
     exon            1791..1898
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2099
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..3558
                     /gene="prox3"
                     /gene_synonym="prox1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaaagagagatagtaaaactgtgtgtgcgcgcgcacgggggcagcggacatccctccctcgcgcctcgacgcccactggctgatcaccacgcgatagagtgcgcgaggatgagagatggacagcagcgcgacacaggagacacagcaataacaggaaactcagtggcgctttcaacgctgatgctcccggtgaccagcggacacctcaaaaacaccgccatataacaccacaggaaagtgaccaagcgggggatgcgtgctgtctgactgttttatcctgaaagcagatcagaacagaaaaggaggctatggattccccttcggatcgatttcatcagcagccttcccagatgtgtcccttcgagctgtatcgcagcctgccagattccaacccctcaggccaccgatttccccccggcagcttgtcttctcatccgctcttctcccctctcatgcaccccaatagcatgtcccaaaagtggggcagtttccggcagcgtcagggcttgttccctgggcttctggtggatgatgatgtgagtgaggaggatgtctttgggaagagggagtttggggcgacctcatcatcacagcgtggttctggagaacggggacaagctcctgagccctctgactgggggcaggattttgcaagagttaagagactaagaatggactctgcagctagaagcgaagatgaatcaattagagaagggaagagagggagaaagagtagatcttcatttaggatggatgagaagaaaggaatggagcaaggcaacaggagggaaagcagggaaggaaggaagcggcagcggcaagaactaaagctccagctggaggaaaccagagggaaacttcttgaacttcagcgcaaggtgtggagggtgtacggagggcaggcggacgatgagaaggatcaagaaaacggaggaatcaatctggatgaggttgctgatatgttttctgacagcgacgatccacttgtaggcaatggattttctcctcaacgttgttcgtctaagaaaaacaatgaaaccaatggaaatggcaatgctggaatttttccagagacctctgtggacctggacctggagttaaacggcagtcaagtgtggctgggatgcagtttgatcaggggcgagtgggagagcgcagagggagggcagaagtttgctcaagcgttgaagcaggagcttgccaatgttgtcgctcaggttattgacagagttgttcgtctctatgctgaaagtgaccccgaggcagtctcatccgcccaggaacccagcatgacgatggatctaaactcagacaggaggccgagacctcaagctgtagagcaggtagaagctttgccactcgtcacaaagagtcctcaagacaagagggcccctgtcgctcaaagtgggcacaaggacctcctcctccctcaagccaatcctagcctcgctccgctagcccagccgcctctcccggcacttttaccccccaggggcaaggagcatttcctgccctcttatcccccagacaaccctgtccacctgccccttcttcactacaccatgcagaatctctttgcccgctccctctccagtctgcctcttcataaggactgcctgtctgaatctttcatggacttccgttcccacaactctgcgttcccacccctcccgctgctgggccagctcgacccctctccatcagatagagcaagggaagtgggcatgagggcaggtggtgcgggaatggtggatggtgcagatgcagcactctatcttgctgcaggttcatctcaggagggcctttctccgtgccacttgaagaaagccaagctcatgttcttctacacgcgctaccccagctccagcacactgaagacatatttccctgacgtcaagttcaatcgctgtgtcacttcccagctgattaagtggttcagtaacttccgggagttcttctatatccagatggagcgttttgcccggcaggcagccagagaggtgcttacatctgccagagaaagggctctccgcctgggcagagacaccgagctttaccgcattctcaacatgcactacaataagagcaatgattaccaggttccagagaggtttgtggagatatctgaagtggccctgagggagtttttcaccgccatccagagcggtcgggatgctgatccatgctggaagaagtccatctataagatcatctgtaaattagacagtccagtgcccgacagcttccggctgcccggatgccccacggatacttaccggatgggttaaagagagtttatctaccacacaggagggccagcagttaaaatagagggctttattgttgctcacttattgctggttctggaggtatttgtcctattaatttttcccaaacaaaagtctttgtcgaagggttataagtgattagttcactcaaaaacgacagtttactctccatttactccccctcaagtagttctaaaagctttatgagttttggttttattctgaacacaaaagaagatattttgaagaaagctgaaaacatcatttgacatccatagtagaaaaatcagatagtatgaaagtcaatggttaccagcttttttcaatatatcttcttataaacagatgtggaagaagtgaagggagaataaaggacgacagaattttcagttttgggtgaactttcactttaaccaaaccagcaatctgctagatgaatcgttgcacaacaataagcacttcaattagaagcgaagcgtacaaaaatcctagattgaatactatgaattaataagggaaagaactgcaaatatgcgaagcacagcaaattatacaatccaactgacaattaggagaaaactattgatttgaaggagaaaactattgatttgaatttggttgtatttatagcaactatatatttcaagtttgttgatgtgggcgaagatatatctgctttgcttcactttgctcgctgcaactctctgattggtggaactttttttgtacagcattataggtattgtagtttttctgccaggtattgccagttctgctatagaccatgatcgttttacagatgaattatgtattaattaatgtgaacagatgggttcagctaaagcacatacagtcagcgaacaacctcagagctcacaacaggtctgtcttaaaaggtttatcaattattgctagaaatcagtttccctatggagaaaatgaatggaattaaaactggtagaacttcaatattgcactctatcattgacagtggaggaaaatgtacaaaatagtgcagtgaatattatcatcatgatgctcaaaggtattactcattttagtccagttagcactgaaaacgcatctgattatatggaaaagagtttctcattttgtcagctgttacattaatgctcaataattgatctggaaatgcaggcctggttggctttcagactttttttatatatagatattacttgttaatcatgataatgttgctgagttttctgtgaacctgtggtatggtgtaataaaaatatgtaaaaca

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