LOCUS       NM_001163312            1499 bp    mRNA    linear   VRT 29-MAY-2023
DEFINITION  Danio rerio ladybird homeobox 1b (lbx1b), mRNA.
ACCESSION   NM_001163312 XM_001333611
VERSION     NM_001163312.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Juarez-Morales JL, Weierud F, England SJ, Demby C, Santos N, Grieb
            G, Mazan S and Lewis KE.
  TITLE     Evolution of lbx spinal cord expression and function
  JOURNAL   Evol Dev 23 (5), 404-422 (2021)
   PUBMED   34411410
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Boswell CW and Ciruna B.
  TITLE     Understanding Idiopathic Scoliosis: A New Zebrafish School of
            Thought
  JOURNAL   Trends Genet 33 (3), 183-196 (2017)
   PUBMED   28174019
  REMARK    Review article
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Guo L, Yamashita H, Kou I, Takimoto A, Meguro-Horike M, Horike S,
            Sakuma T, Miura S, Adachi T, Yamamoto T, Ikegawa S, Hiraki Y and
            Shukunami C.
  TITLE     Functional Investigation of a Non-coding Variant Associated with
            Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression
            of the Ladybird Homeobox Gene Causes Body Axis Deformation
  JOURNAL   PLoS Genet 12 (1), e1005802 (2016)
   PUBMED   26820155
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   Lukowski CM, Drummond DL and Waskiewicz AJ.
  TITLE     Pbx-dependent regulation of lbx gene expression in developing
            zebrafish embryos
  JOURNAL   Genome 54 (12), 973-985 (2011)
   PUBMED   22077099
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Lyons PJ, Ma LH, Baker R and Fricker LD.
  TITLE     Carboxypeptidase A6 in zebrafish development and implications for
            VIth cranial nerve pathfinding
  JOURNAL   PLoS One 5 (9), e12967 (2010)
   PUBMED   20885977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1499)
  AUTHORS   Jovelin R, Yan YL, He X, Catchen J, Amores A, Canestro C, Yokoi H
            and Postlethwait JH.
  TITLE     Evolution of developmental regulation in the vertebrate FgfD
            subfamily
  JOURNAL   J Exp Zool B Mol Dev Evol 314 (1), 33-56 (2010)
   PUBMED   19562753
REFERENCE   7  (bases 1 to 1499)
  AUTHORS   Wotton KR, Weierud FK, Juarez-Morales JL, Alvares LE, Dietrich S
            and Lewis KE.
  TITLE     Conservation of gene linkage in dispersed vertebrate NK homeobox
            clusters
  JOURNAL   Dev Genes Evol 219 (9-10), 481-496 (2009)
   PUBMED   20112453
REFERENCE   8  (bases 1 to 1499)
  AUTHORS   Ochi H and Westerfield M.
  TITLE     Lbx2 regulates formation of myofibrils
  JOURNAL   BMC Dev Biol 9, 13 (2009)
   PUBMED   19216761
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1499)
  AUTHORS   Wotton KR, Weierud FK, Dietrich S and Lewis KE.
  TITLE     Comparative genomics of Lbx loci reveals conservation of identical
            Lbx ohnologs in bony vertebrates
  JOURNAL   BMC Evol Biol 8, 171 (2008)
   PUBMED   18541024
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR855357.16
            and CT573247.8.
            
            On Jul 16, 2009 this sequence version replaced XM_001333611.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FP122478.1, BC090687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-564               CR855357.16        2902-3465           c
            565-984             CR855357.16        2001-2420           c
            985-1499            CT573247.8         104446-104960       c
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..1499
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="ladybird homeobox 1b"
                     /db_xref="GeneID:793810"
                     /db_xref="ZFIN:ZDB-GENE-050309-27"
     exon            1..564
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    237..239
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="upstream in-frame stop codon"
     CDS             252..1049
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="lbx1; ladybird homeobox 1a"
                     /codon_start=1
                     /product="transcription factor LBX1b"
                     /protein_id="NP_001156784.1"
                     /db_xref="GeneID:793810"
                     /db_xref="ZFIN:ZDB-GENE-050309-27"
                     /translation="

MTTIKVVKICGAMESRGLNPLDHLPPPASSNKPLTPFSITDILSKPTVKRFHRIHRLPASDRVRQSITVSRQTLITQASPLCALQELASKTFKGLELGVLQAAEGKDGLKLFGQRDSPKKRRKSRTAFTNHQLYELEKRFLHQKYLSPADRDQIAHQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESVRSTGLVPLDKLAKLADLERCAAAGATGNPGPQCSPRLGHEYKTVHKLCLSPMSSLSDHTSQDCSEDEEVEIDVDV"

     misc_feature    order(615..629,633..635,684..686,702..704,741..743,
                     747..752,759..764,768..776,780..785)
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    621..782
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(621..623,630..632,750..752,759..764,771..773)
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            565..1499
                     /gene="lbx1b"
                     /gene_synonym="im:7139117; lbx1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agaactgcagagctgtcaaagcacaaggataactgctcatttgctgttgcctgttgggtgctgatggtgagagaagactaactcgttaaatgttgccattgttgttaggcagtttttcggagaactgcaaggacatttttagatttttaaattagaattaggctacaagttggaagcattacaagtttcttccaaaacaaattatagaaccacataatttgtaaccaaagctgctatagacaaaggctggaatgacaaccatcaaagtcgtcaaaatctgtggtgctatggagagccgtgggctaaaccccctggaccaccttccaccacccgcgagctccaacaagcccttaacgccattcagcatcacagacatcctcagcaaaccgactgtcaaacgatttcacaggattcaccgacttccagcatcagacagagtccgacagagcatcaccgtttccaggcagactctcatcactcaagcctcgcctctgtgcgctctgcaggaactggcgagcaaaaccttcaagggtctcgaattaggtgttctccaagcagcagaaggaaaggatgggctaaaattatttggtcaaagggacagtcctaaaaaacgccgaaaatccagaacggccttcacaaaccatcagttatatgaactagagaaaaggtttctccatcaaaaatacttgtcacctgccgacagagaccaaattgcccatcagctgggacttacaaacgcgcaggtcataacctggttccagaatcgacgggcgaaattaaaacgagacctcgaggagatgaaagcggacgtggagtccgttagatccacaggtttagtccctctggataaactcgctaaactggctgatctggagaggtgtgcggccgctggagccacggggaacccggggccccagtgctcaccacggctgggtcacgagtacaagactgtgcacaaattatgtctgtcccccatgtcgtctctctcagaccacacaagtcaagactgctccgaagacgaagaagtggaaatagacgtcgatgtctgatttaaaaccactgtgtagcctgaaattgtgacgcatatcttcagacgttgtaataataatatgaacgcatgcacataaccgtctttagagaagctgatttagtttaatttatagtcagactatgcaagtctatctcctttatagttcgacattgactgaactagcagctgtatattttatatttataatatattgtacataatgtggctttaatgatgtaaagaatattgaacatgaaccagggcatcaaacagagcaatacaaccttttattgaagataactatttttacaggtgtatttattacatatacgtttcatttatgcagttttttttatataaagttgttgttctgtttacttggagtgccttttaacattgtggcattgtaccagttacagtgtgtcatttaatgtaaattgaatttgaaaataaaacatttataccgttt

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