LOCUS       NM_001123280            2713 bp    mRNA    linear   VRT 18-NOV-2023
DEFINITION  Danio rerio neurofilament medium chain b (nefmb), mRNA.
ACCESSION   NM_001123280 NM_001083033 XM_689365
VERSION     NM_001123280.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V and
            Bunick CG.
  TITLE     Update of the keratin gene family: evolution, tissue-specific
            expression patterns, and relevance to clinical disorders
  JOURNAL   Hum Genomics 16 (1), 1 (2022)
   PUBMED   34991727
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Faria M, Prats E, Gomez-Canela C, Hsu CY, Arick MA 2nd,
            Bedrossiantz J, Orozco M, Garcia-Reyero N, Ziv T, Ben-Lulu S, Admon
            A, Gomez-Olivan LM and Raldua D.
  TITLE     Therapeutic potential of N-acetylcysteine in acrylamide acute
            neurotoxicity in adult zebrafish
  JOURNAL   Sci Rep 9 (1), 16467 (2019)
   PUBMED   31712630
  REMARK    Erratum:[Sci Rep. 2020 Feb 5;10(1):2247. PMID: 32024938]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Wang S, Ji D, Yang Q, Li M, Ma Z, Zhang S and Li H.
  TITLE     NEFLb impairs early nervous system development via regulation of
            neuron apoptosis in zebrafish
  JOURNAL   J Cell Physiol 234 (7), 11208-11218 (2019)
   PUBMED   30569449
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Fan Z, Liu L, Huang X, Zhao Y, Zhou L, Wang D and Wei J.
  TITLE     Establishment and growth responses of Nile tilapia embryonic
            stem-like cell lines under feeder-free condition
  JOURNAL   Dev Growth Differ 59 (2), 83-93 (2017)
   PUBMED   28230233
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Fuller-Carter PI, Carter KW, Anderson D, Harvey AR, Giles KM and
            Rodger J.
  TITLE     Integrated analyses of zebrafish miRNA and mRNA expression profiles
            identify miR-29b and miR-223 as potential regulators of optic nerve
            regeneration
  JOURNAL   BMC Genomics 16 (1), 591 (2015)
   PUBMED   26265132
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2713)
  AUTHORS   Aoki M, Segawa H, Naito M and Okamoto H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   8  (bases 1 to 2713)
  AUTHORS   Dee CT, Hirst CS, Shih YH, Tripathi VB, Patient RK and Scotting PJ.
  TITLE     Sox3 regulates both neural fate and differentiation in the
            zebrafish ectoderm
  JOURNAL   Dev Biol 320 (1), 289-301 (2008)
   PUBMED   18572157
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX005158.8.
            
            On or before Mar 21, 2009 this sequence version replaced
            NM_001083033.1, XM_689365.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EE717930.1, DY568874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     gene            1..2713
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /note="neurofilament medium chain b"
                     /db_xref="GeneID:100033387"
                     /db_xref="ZFIN:ZDB-GENE-070103-4"
     exon            1..1027
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2179
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /note="neurofilament, medium polypeptide b"
                     /codon_start=1
                     /product="neurofilament medium chain b"
                     /protein_id="NP_001116752.1"
                     /db_xref="GeneID:100033387"
                     /db_xref="ZFIN:ZDB-GENE-070103-4"
                     /translation="

MDMMSSSRRRALETRSIRPPTSTVRSWAKSSPLSFKRTTNVSSSRAAYSPAVLASPDGFELSAALNGDPVRNNEKEQLQGLNDRFASYIDKVRFLEEQNKQLEAEIQALKQQKLSQSLQTDAYDRELQDLRCALEQLHKEKAQILLDTDHMDEDLQRIRERYEDESRLREHMDAAIRGMKKDKDDSVLMKMDLERKVQALVDEMDFLRQNHEEEISELLAQLQAAQVPVVEMRDLQKTDITSALRDIRAQLDGLSSKNLQQAEEVFKCRYAMLTDAAEQNKDAIKSIRDEIGDYRRQIQGKSVELEALRGTKDSLERQLHDIEDRHNTDVSSYQEMIHQLENDLKGTKWEMARHLREYQDLLNVKMALDAEIAAYRKLLEGEETRFCAAVTAFAYSQPKTSKVKHKIVEEIIEETKGESDIDDDLAEVAKEVAEEAEEEEKEEEEETVAASQAKVSSAAPEGEEEEEEEGGDEEEEAEEGEAAAEEEEEEDEEGEEEEEPQVEVIEETELCGEKSPTSEKEGSEKEEEEDEGKGEEKEDEDEKEDTKSEGEGEKKEESGGEEEKKEESGGEEEKKEESGGEEEKKEESGGEEEKKEESAGEEAKADSEKDDKKSDTEEDEKKSPVSEEKAESPAEEKKQDEKQVDKVVVANNKEEASPKEEVQTRTVETITNGDKETKAEPEKEEKKPEEKPQEKKKVAKKVEKVAPQVKKEIKGKD"

     misc_feature    32..229
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /note="Intermediate filament head (DNA binding) region;
                     Region: Filament_head; pfam04732"
                     /db_xref="CDD:428095"
     misc_feature    242..1180
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:425436"
     exon            1028..1152
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..2713
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2713
                     /gene="nefmb"
                     /gene_synonym="nefm; zgc:158491"
ORIGIN      

caccaattcacaagcaccattcaccatggacatgatgagctcctcccgccgaagggctctggagacacggagtatacgcccgccgacatccaccgtgcgctcgtgggctaaaagcagccctctgtcgttcaaaagaaccacgaatgtgtcttcctccagagccgcgtacagccccgccgtgctcgcgtctcctgacgggttcgagctgagcgcggcactcaatggagatccggtgcgcaataacgagaaggagcagctccaggggctcaacgaccgcttcgccagctacatcgacaaggttcgcttcctcgaggagcaaaacaagcagcttgaggcggagattcaagcgctaaagcagcagaaactgtcgcagtctctgcagaccgatgcgtacgaccgcgagctccaagacctgcgctgcgccctggagcagctccacaaggagaaggcgcagatcctgctggacaccgaccatatggacgaggatctccagcggatccgagagcgctacgaagatgaatcccggctcagagagcacatggatgctgcgatccgaggcatgaagaaagacaaagacgactcggttctcatgaagatggacctggagaggaaagttcaggcgctcgtggacgaaatggacttcttgcggcagaaccacgaggaggagatcagcgagcttctagctcagcttcaagccgcgcaggtgccggtggtggagatgagggacctccagaagaccgacatcacctctgcgctccgggatatccgcgcgcagctggacgggctgtcctccaagaacctccagcaggctgaagaagtgttcaagtgccgctacgccatgctgacggacgccgcggaacagaacaaggatgctataaagtccatacgggacgagatcggggactaccgccgtcagatccaaggcaagagcgtcgaactggaggctcttcgaggcaccaaagattcactggagaggcagctgcatgacatcgaggaccgccataacaccgacgtgtccagttatcaggaaatgattcaccaattggaaaacgatctaaaaggaacgaaatgggaaatggctcgtcatctccgggaatatcaggatctgctcaacgtcaagatggcactggatgcagaaatagccgcttacaggaaactgctggaaggtgaggagactcgcttctgcgccgccgtaaccgcatttgcctacagccagccaaaaacctcaaaggtcaagcataaaatagtggaggagatcatcgaggagaccaaaggagaaagcgacatcgatgatgatctggcagaggtggcaaaagaggtggcagaagaggcggaagaggaagagaaggaggaagaggaggagactgttgctgccagtcaggccaaagtgagttcagccgctcccgaaggagaagaagaggaagaagaagaaggaggagatgaggaagaagaagcagaagaaggagaagctgctgctgaggaggaagaagaggaagacgaggaaggagaggaggaagaggagccacaagtggaagtgatcgaagagaccgagctgtgcggtgagaaatctccaacatcagagaaagagggcagcgaaaaagaagaagaggaagatgaaggtaaaggagaggagaaggaagatgaggatgagaaagaagacaccaaatctgaaggagaaggagagaagaaagaggaatcaggaggagaagaagagaagaaagaagaatcaggaggagaagaagagaagaaagaggaatcaggaggagaagaagagaagaaagaggaatcaggaggagaagaagagaagaaagaggaatcagctggagaagaagctaaggctgattcagagaaggacgacaagaaaagcgacacagaagaagatgaaaagaaatcacctgtaagtgaggagaaagctgaaagtccagcggaggaaaagaagcaggacgaaaagcaagtcgacaaggtagtcgtagccaacaataaagaagaagccagtccaaaagaagaagtccaaaccagaacggtggaaaccatcaccaacggagacaaagaaaccaaagcagaaccagagaaggaggagaagaagcctgaagaaaagcctcaggagaaaaagaaagtggccaaaaaggtggagaaagtggctccgcaggtgaagaaggagatcaagggaaaagactgacgcgagtgactctgccagggaattagttataatcaattgttaggcataattctatttgatgcaaaatgtgaacaaacccccaacccgagcggcgtttgatgcagctagccaatataattgcatgcgtgttgaatgactgacttgcatgtgtggttttggtggtgacgtagccacgctgagccgctgcgtctgaaacagaattaaagcgcatttgcattaaagtgcgagtacattaggctgctaatgaaggcgagaggttttacagcgatgccagttcatcggcggttctcttggcaataatggtgctacttcaatatcatcattcgcaggcacactttgagcagaaactccagttatatatgatgtctttctaatatacttcttgccttaagacgtaatgcactgaatcaacgagaagagtcgggttgttaacacacaaacagctgttaacagagatactgtgaaagctactgtaaagttgctgctctttgcaatatcacctcaatcaataaaagctcatcaagtccttacaaa

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