2024-05-06 12:02:32, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001122973 1176 bp mRNA linear VRT 09-OCT-2022 DEFINITION Danio rerio LIM homeobox 4 (lhx4), mRNA. ACCESSION NM_001122973 XM_695590 VERSION NM_001122973.1 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. REFERENCE 1 (bases 1 to 1176) AUTHORS Guo R, Ge K, Wang Y, Lu M, Li F, Tian L, Gan L and Sheng D. TITLE LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish JOURNAL Sci Rep 11 (1), 1977 (2021) PUBMED 33479361 REMARK GeneRIF: LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and visual function in zebrafish. Publication Status: Online-Only REFERENCE 2 (bases 1 to 1176) AUTHORS Postlethwait,J.H., Farnsworth,D.R. and Miller,A.C. TITLE An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities JOURNAL bioRxiv (2020) PUBMED 32908984 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1176) AUTHORS Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD and Grant SG. TITLE Evolution of complexity in the zebrafish synapse proteome JOURNAL Nat Commun 8, 14613 (2017) PUBMED 28252024 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 1176) AUTHORS Weger BD, Weger M, Gorling B, Schink A, Gobet C, Keime C, Poschet G, Jost B, Krone N, Hell R, Gachon F, Luy B and Dickmeis T. TITLE Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids JOURNAL PLoS Genet 12 (12), e1006512 (2016) PUBMED 27941970 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 1176) AUTHORS Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and Bobe J. TITLE Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database JOURNAL BMC Genomics 17, 368 (2016) PUBMED 27189481 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 1176) AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and Hertzano R. TITLE RFX transcription factors are essential for hearing in mice JOURNAL Nat Commun 6, 8549 (2015) PUBMED 26469318 REMARK Publication Status: Online-Only REFERENCE 7 (bases 1 to 1176) AUTHORS Diotel N, Rodriguez Viales R, Armant O, Marz M, Ferg M, Rastegar S and Strahle U. TITLE Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches JOURNAL J Comp Neurol 523 (8), 1202-1221 (2015) PUBMED 25556858 REFERENCE 8 (bases 1 to 1176) AUTHORS Seredick S, Hutchinson SA, Van Ryswyk L, Talbot JC and Eisen JS. TITLE Lhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons JOURNAL Development 141 (20), 3900-3909 (2014) PUBMED 25231761 REMARK GeneRIF: Lhx3 and Lhx4 have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons REFERENCE 9 (bases 1 to 1176) AUTHORS Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H and Yoshihara Y. TITLE From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish JOURNAL J Neurosci 29 (15), 4756-4767 (2009) PUBMED 19369545 REFERENCE 10 (bases 1 to 1176) AUTHORS Hutchinson SA and Eisen JS. TITLE Islet1 and Islet2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity JOURNAL Development 133 (11), 2137-2147 (2006) PUBMED 16672347 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CR381643.18, CT025732.9 and BX294388.5. On Apr 4, 2008 this sequence version replaced XM_695590.2. ##Evidence-Data-START## Transcript exon combination :: GFIL01014454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476810 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-85 CR381643.18 6943-7027 c 86-257 CT025732.9 18621-18792 c 258-460 CT025732.9 13699-13901 c 461-615 CT025732.9 7162-7316 c 616-787 CT025732.9 4856-5027 c 788-1176 BX294388.5 106170-106558 c FEATURES Location/Qualifiers source 1..1176 /organism="Danio rerio" /mol_type="mRNA" /strain="Tuebingen" /db_xref="taxon:7955" /chromosome="8" /map="8" gene 1..1176 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="LIM homeobox 4" /db_xref="GeneID:571943" /db_xref="ZFIN:ZDB-GENE-060728-1" CDS 1..1176 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /codon_start=1 /product="LIM/homeobox protein Lhx4" /protein_id="NP_001116445.1" /db_xref="GeneID:571943" /db_xref="ZFIN:ZDB-GENE-060728-1" /translation="
MKMMQSAAVLPGESAVKGLPDILGVPLQQIPQCAGCSQHILDKFILKVLDRHWHSKCLKCADCHALLADKCFSRAGNVYCKEDFFKRFGTKCASCQQGIPPTQVVRKAQDFVYHLHCFACVMCSRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSETGAKRPRTTITAKQLETLKSAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRNRGSSKTEKESSADDAGLSDSELSFRDDQILSDLGHANGLYGSVGDVSNGNMLNGSFSLDGGGQPYHDLRAGSPYGLPQSPSSITSLPGHTPLLNNLGFSMDGLMGQAGQPSVGQALRAMAGGPTSDLSTGSSTGYPDFPTSPASWLDEMDHSQF"
misc_feature 97..252 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="The first LIM domain of Lhx4; Region: LIM1_Lhx4; cd09468" /db_xref="CDD:188852" misc_feature order(97..99,106..108,160..162,169..171,178..180,187..189, 238..240,247..249) /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="Zn binding site [ion binding]; other site" /db_xref="CDD:188852" misc_feature 274..441 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="The second LIM domain of Lhx3-Lhx4 family; Region: LIM2_Lhx3_Lhx4; cd09376" /db_xref="CDD:188762" misc_feature order(274..276,283..285,340..342,349..351,358..360, 367..369,427..429,436..438) /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="Zn binding site [ion binding]; other site" /db_xref="CDD:188762" misc_feature order(310..312,385..387) /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="Isl binding site; other site" /db_xref="CDD:188762" misc_feature order(481..495,499..501,550..552,568..570,607..609, 613..618,625..630,634..642,646..651) /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature 487..648 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="Homeobox domain; Region: Homeobox; pfam00046" /db_xref="CDD:425441" misc_feature order(487..489,496..498,616..618,625..630,637..639) /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" exon 1..85 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" exon 86..257 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" exon 258..460 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" exon 461..615 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" exon 616..787 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" exon 788..1176 /gene="lhx4" /gene_synonym="si:dkeyp-35f11.3" /inference="alignment:Splign:2.1.0" ORIGIN
atgaaaatgatgcaaagtgcggctgtgctgcccggcgagagcgcggtgaagggtctgccggacatcctcggagtgccactgcaacaaatccctcagtgcgcaggctgcagtcaacacatcctggataagttcatcctaaaggttctggatcggcactggcactcaaaatgcctgaagtgcgccgactgccacgcgctcctggcggacaaatgtttctctcgcgccgggaatgtctactgcaaagaggacttcttcaagcgtttcgggacaaagtgtgcatcgtgccagcaggggattcctcctacacaggtggtccggaaagctcaggactttgtgtaccatcttcactgttttgcatgtgtgatgtgcagcagacagttggccactggagatgagttctacctcatggaggacggcagactcgtgtgcaaagaggactacgaaacagccaagcagaacgatgattcagaaacaggagcaaaacgtccacgcaccaccatcacagccaaacagctggaaactctcaaaagcgcctataagaactcgccaaaaccagcaagacacgtgcgagagcaactttcctcagaaacgggcctggacatgagagtggtgcaggtgtggtttcagaacagacgggcaaaagaaaaacggctgaagaaagacgcgggccggcatcggtggggtcagttctacaaaagcgtcaaacgcaacagaggctccagtaaaacagagaaggaaagctcagccgacgatgcaggactcagtgacagtgagctcagtttcagagatgatcagatcctgtcagacttgggtcatgctaacggcctgtacggaagtgtcggcgacgtctctaatggtaacatgctcaacgggagcttctctttggatggaggcgggcagccttaccatgacctgcgggcagggagtccctatggcctgcctcagtcgccctcgtccatcacttccctgccaggccacactcctctactcaacaacttaggcttcagcatggacggcctcatgggtcaggccggtcagcccagtgtgggtcaagctctgagagccatggccggaggccccacctctgacctatccacaggaagcagcacgggatacccagacttccccaccagcccggcctcatggctcgatgaaatggaccactctcagttctga
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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