LOCUS       NM_001114715            1542 bp    mRNA    linear   VRT 11-NOV-2023
DEFINITION  Danio rerio leucine zipper protein 2 (luzp2), transcript variant 1,
            mRNA.
ACCESSION   NM_001114715
VERSION     NM_001114715.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C,
            Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood
            J, McCarroll SA and Schier AF.
  TITLE     Phenotypic Landscape of Schizophrenia-Associated Genes Defines
            Candidates and Their Shared Functions
  JOURNAL   Cell 177 (2), 478-491 (2019)
   PUBMED   30929901
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC154442.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC154442.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     gene            1..1542
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="leucine zipper protein 2"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
     exon            1..309
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    230..232
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="upstream in-frame stop codon"
     CDS             248..1288
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="leucine zipper protein 2 isoform 1 precursor"
                     /protein_id="NP_001108187.1"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
                     /translation="

MKFIGAVYLLFLLPALSFNSSYEGLEKKLKEVFTERTGILRHLSKTSKELDSIKGNLQSLKNEDAVPKKDVQRILELSHKQRDEMKSLQAALQKQLDDAAERAEKQQATIKFLKMEMEKKTKIIKDLQQENKSLKNKLLSGNKLCDIHAEESKKIQAQLKELRYGKKDLIFKGQQLMDLENKLKVAKDELEKAALDKESQLKALKDTVHICFSSVLHSQTASLHRFPATPTNLLRYSALVNNSRVTFQQPHMKDIPKVPRITTTSKLPVSSAVMRRESTGPKDCQMVKVGSDCSHNQTESSSVMKKTFGHSQSKTPEQNGQGQARTAEESVKTDGELKKTQSDKHN"

     sig_peptide     248..298
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     299..1285
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /product="Leucine zipper protein 2. /id=PRO_0000315277"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2)"
     misc_feature    302..304
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    <314..>862
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="Chromosome segregation ATPase [Cell cycle control,
                     cell division, chromosome partitioning]; Region: Smc;
                     COG1196"
                     /db_xref="CDD:224117"
     misc_feature    638..640
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    731..817
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2);
                     Region: Leucine-zipper"
     misc_feature    968..970
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     misc_feature    1058..1285
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="propagated from UniProtKB/Swiss-Prot (A5D8S1.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1133..1135
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A5D8S1.2); glycosylation site"
     exon            310..421
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..492
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..574
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..637
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..700
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..763
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..838
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1006
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1111
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1183
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1531
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tatttgaagccggagtgcctcgcactttcacatacacagaccgctcgcagcgttgcatctgtctgccgcggcgtgtgtgcctgcattaacgcgcgtgtgcaccacagacagagagagcgagagagagagagagagagagagagagagtggcgagccaaccaggagctaaagggagaagggaaaagcgagcgatcgagagaaaaagggggaaagagaaacgccgagtgcatgagagcaagacaaagcaatgaaattcatcggagccgtttacctcctgttcctcctccctgctttaagcttcaacagcagctatgaggggctggaaaagaagctgaaggaggttttcacagagaggacaggaattttacgacatctctccaaaacatcaaaggaactggacagcataaaaggaaacctgcagtcactgaagaatgaggatgctgtgcccaagaaggatgtgcagaggatcctggagctcagtcacaagcaaagggatgagatgaagtcactccaggcagctctgcagaaacaactggatgatgcagctgagcgtgcagagaaacagcaggccactataaagttcttaaagatggagatggaaaagaaaacgaaaatcatcaaagaccttcagcaagagaataaaagccttaagaacaaacttctgtccgggaacaagctctgtgacattcatgcagaagagtccaaaaaaatccaagcccaactgaaagagctgaggtatggcaaaaaggatttaatttttaagggtcaacagctgatggacttggagaacaaactcaaagtagccaaagatgaactggagaaggcagcgctggataaggagtcacagctaaaagccctgaaggacacagtgcatatctgcttctcgtctgttctacacagccagacagcaagtttacacagatttccagccacaccaaccaacctgttgaggtattcagccttggtcaacaactccagagtcacctttcagcagccacacatgaaggacatcccgaaagttccccggatcacaacaacaagtaaattgcctgtgagcagtgcggtaatgaggagagagagcacggggcccaaagactgccagatggtgaaggtgggatcagactgttcccacaatcagactgaaagctcatctgtgatgaaaaagacatttggacacagtcagtcgaagaccccagagcagaacggacaaggccaggcaaggacagcagaggaaagtgtgaaaacagatggggagctaaaaaagacacaatcggacaaacacaactgaagggacagtggaagacttggcagattttctgcatggtaaaaaaatgatgtcagatctgtttaagcccctcttcgttcactgagcttataagcacacacacacagatacatatgcacacaaacacgcgcacacacacacacactgtagccaaacacaatctacatacactaaatactcattctaacactgctaatgtagaaaagaaattcccaaaattaaattttgaacttttttaataaaaaaaaaaaaaaaaa

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