LOCUS       NM_001099255            2669 bp    mRNA    linear   VRT 18-DEC-2022
DEFINITION  Danio rerio leucine zipper protein 2 (luzp2), transcript variant 2,
            mRNA.
ACCESSION   NM_001099255
VERSION     NM_001099255.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2669)
  AUTHORS   Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C,
            Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood
            J, McCarroll SA and Schier AF.
  TITLE     Phenotypic Landscape of Schizophrenia-Associated Genes Defines
            Candidates and Their Shared Functions
  JOURNAL   Cell 177 (2), 478-491 (2019)
   PUBMED   30929901
REFERENCE   2  (bases 1 to 2669)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC141788.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 3' coding
            region compared to variant 1. The resulting protein (isoform 2) is
            shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141788.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     gene            1..2669
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="leucine zipper protein 2"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
     exon            1..83
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    4..6
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="upstream in-frame stop codon"
     CDS             22..957
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="leucine zipper protein 2 isoform 2 precursor"
                     /protein_id="NP_001092725.1"
                     /db_xref="GeneID:100137118"
                     /db_xref="ZFIN:ZDB-GENE-060503-278"
                     /translation="

MKFIGAVYLLFLLPALSFNSSYEGLEKKLKEVFTERTGILRHLSKTSKELDSIKGNLQSLKNEDAVPKKDVQRILELSHKQRDEMKSLQAALQKQLDDAAERAEKQQATIKFLKMEMEKKTKIIKDLQQENKSLKNKLLSGNKLCDIHAEESKKIQAQLKELRYGKKDLIFKGQQLMDLENKLKVAKDELEKAALDKESQLKALRDTVHICFSSVLHSQTASLHRFPATPTNLLRYSALVNNSRVTFQQPHMKVGSDCSHNQTESSSVMKKTFGHSQSKTPEQNGQGQARTAEESVKTDGELKKTQSDKHN"

     sig_peptide     22..72
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    <88..>645
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /note="Chromosome segregation ATPase [Cell cycle control,
                     cell division, chromosome partitioning]; Region: Smc;
                     COG1196"
                     /db_xref="CDD:224117"
     exon            84..195
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..266
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..348
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..411
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..474
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..537
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..612
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..780
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..852
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..2641
                     /gene="luzp2"
                     /gene_synonym="si:ch211-243k12.1; si:dkey-239j7.1;
                     si:dkeyp-86e4.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcatgagagcaagacaaagcaatgaaattcatcggagccgtttacctcctgttcctcctccctgctttaagcttcaacagcagctatgaggggctggaaaagaagctgaaggaggttttcacagagaggacaggaattttacgacatctctccaaaacatcaaaggaactggacagcataaaaggaaacctgcagtcactgaagaatgaggatgctgtgcccaagaaggatgtgcagaggatcctggagctcagtcacaagcaaagggatgagatgaagtcactccaggcagctctgcagaaacaactggatgatgcagctgagcgtgcagagaaacagcaggccactataaagttcttaaagatggagatggaaaagaaaacgaaaatcatcaaagaccttcagcaagagaataaaagccttaagaacaaacttctgtccgggaacaagctctgtgacattcatgcagaagagtccaaaaaaatccaagcccaactgaaagagctgaggtatggcaaaaaggatttaatttttaagggtcaacagctgatggacttggagaacaaactcaaagtagccaaagatgaactggagaaggcagcgctggataaggagtcacagctaaaagccctgagggacacagtgcatatctgcttctcgtctgttctacacagccagacagcaagtttacacagatttccagccacaccaaccaacctgttgaggtattcagccttggtcaacaactccagagtcacctttcagcagccacacatgaaggtgggatcagattgttcccacaatcagactgaaagctcatctgtgatgaaaaagacatttggacacagtcagtcgaagaccccagagcagaacggacaaggccaggcaaggacagcagaggaaagtgtgaaaacagatggggagctaaaaaagacacaatcggacaaacacaactgaagggacagtggaagacttggcagattttctgcatggtaaaaaaaatgatgtcagatctgtttaagcccctcttcgttcactgagcttataagcacacacacacagatacatatgcacacaaacacgcgcacacacacacactgtagccaaacacaatctacatacactaaatactcattctaacactgctaatgtagaaaagaaattcccaaaattaaattttgaactttcttaataaaaaataaaaaatcccactgcatagtatggcatgcattatagagttttagatattgattttacaaggttacgatggtactggttgtttttaataactgttacttttttcactatctattttgttttgatttttttttctctcccagagtgaggacacacaacgttctttgatttgtgttgtttgtaattaaaaactttttctggcaccgcagaccagaattcagtgttaaaggtcacactgggggtcatttgagttctgtaaatttacacttgaggtcagattttaacttttgtcaaagcagcttctgaaaatatactgagccatgtactgaatgcaaaattgggctgcacgattttggggggaaaactgaactgtgatttttttttctagcacagactgatatttaacatgtatatatgttgtatatatttaattttattatcttctgttgagccgcacacctcatattgtggccttgaattaacatctgttctgtgacactaatatgtcagtgcttttaataattcattcccttgttttaactaaacagtgggcacaatgtaatactttgttgccccgtattcctaaattgtggccatgttgtaatgattagttgccttgttgtagttaaaacaatataactgaacatattattaaattgtgtgaatgaataaaatgagggaatactttattacatatttataatctattcacttatttttgcactggtcatgtgcaaacattaagcttttattatggtgggaaaagttcaagagaacttaatcttctcttgttgagtgcagctggtttaaagcacttctcttttcaaacttggagcatgctgtgttgtcaaatgcaagccaaattttaagcacatgttgacatgcgtaatcctgttataaagaatttactaggaaggaagcctctttgaggcacttaaaacactggatcaagatataactaaacacagaaccatgtttcattgaatacttttattcaacctaatcacaaagtttgtgatttgatattcaaacgaagccatgtcacagtttgtgttttattccgattaatcgtgcagccctaatggaaactgcatcaatcccacttctgctgaaatgacaaaaagaactgtttaatgctgttcaaggtacggtttgtctcgtgttgtagcaaagattaatttactcctcctactccatattacgaggctcaagttggctggccaactatcactgttgaatatttcggagcttttggtgccagaattaaagagaaaaactggactcacagtgagtcgtctccctaagaatgatgtgccatgcaccgagtacttaatctactgctacatctctctgtttctctaccttcttgtgtcctttacaataaaccgtgattttcgctaaatgtgtgaagaataaatggttatttgtggagtaaaacaactgaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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