LOCUS       NM_001076668            1858 bp    mRNA    linear   VRT 12-APR-2020
DEFINITION  Danio rerio ring finger protein 183 (rnf183), mRNA.
ACCESSION   NM_001076668
VERSION     NM_001076668.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Putiri E and Pelegri F.
  TITLE     The zebrafish maternal-effect gene mission impossible encodes the
            DEAH-box helicase Dhx16 and is essential for the expression of
            downstream endodermal genes
  JOURNAL   Dev. Biol. 353 (2), 275-289 (2011)
   PUBMED   21396359
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            BC124313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC124313.1, EH115180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1858
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /note="ring finger protein 183"
                     /db_xref="GeneID:767730"
                     /db_xref="ZFIN:ZDB-GENE-060929-1090"
     exon            1..123
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    109..111
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /note="upstream in-frame stop codon"
     exon            124..1843
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1128
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF183"
                     /protein_id="NP_001070136.1"
                     /db_xref="GeneID:767730"
                     /db_xref="ZFIN:ZDB-GENE-060929-1090"
                     /translation="

MGDGREKPQSSRKGSNAKPKLDSKGSLNLGSSEQRQRADKPVRRSRSNDTENRRREASRGRERDRRDEGRPQRGRSEEGRRRGHNHEPGNRAWDKEPPKDELQDTECIVCFCNFDNVFKTPKLLSCGHTFCLECLARINVNSPEIKTLTCPICREVTEIRHGRDLPHLLNNEAIFRQLPSEMQRALSVRFKRSKGKLVLKNPPTNNSIKTTLNLPVSKKKEEQAGNNAIGAIEEGLGQATMINVGRPPNRMRGRMRRVMYSSQCYYAVVAVIISITVALMMVGIFTFVVMPNLQRPITKPLQNQTGSSAVQADSSP"

     misc_feature    490..654
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; Region: RING_Ubox; cl17238"
                     /db_xref="CDD:450175"
     misc_feature    order(496..498,505..507,553..555,559..561,568..570,
                     577..579,625..627,634..636)
                     /gene="rnf183"
                     /gene_synonym="zgc:153310"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:438111"
ORIGIN      

agcgaatggattgaggaagtcagaatgaagagcaggttgaacacatttcacatctttattggatgaacagcgggaaaaatgagcgaccccaaaacatcagggctcaactgatcttcagctcaggcatctctgcacagcacttccactttactgttaatcagctcctacacctctataatgggcgacgggagggagaaaccacagagcagcagaaaagggtctaacgccaagccgaagcttgatagcaaaggcagcttaaacctgggatcttcagagcagcgacagagggctgacaagcctgtcaggagaagccggagcaatgacacggagaaccggcggcgtgaagccagccgaggcagagaacgggaccggagagatgaaggaagaccacagcgggggcgcagcgaggaggggcggaggcgaggccacaaccatgagcctggaaacagagcctgggacaaagagcctcccaaagatgaactgcaagacacagagtgcatcgtatgcttctgcaacttcgacaacgtcttcaaaaccccaaagttactgtcttgtggacacacgttctgtctggaatgtctggctcggataaatgtaaactctccggagatcaaaactctgacttgtccaatttgcagagaggtgacagaaatccgacatggccgagaccttccacatttgttaaataatgaagccatttttcggcaacttccaagtgaaatgcaaagggcgctttctgtgcgcttcaagcgcagcaagggcaaactcgtcctcaagaatcctccaacaaacaactccattaagaccactttaaatctgccggtgtcaaagaagaaagaggagcaagctggaaataatgctattggagctatagaggaaggtctcggccaggcgactatgatcaacgtgggaaggcctccaaacaggatgaggggtcgcatgaggagggtaatgtactccagtcagtgctattacgccgtagtggcagtcattatctccatcactgtggctctaatgatggtgggtatcttcacctttgtggtgatgcctaacttgcaaagaccaattaccaagccattacagaaccaaactggaagcagtgcggttcaagctgactcttcgccttgagggatgaggaaactcaaaacgcttgggtaggatgacttgcatagcaaaacaagattcttggaagcttttgcattgtatccagcactgccctttttgtttgcttttgtctgagatgcttcaggcgggctcgataggaattaactggaaaaacttgaacgtgatgcacactgttgtttgttgagcacagatatatgcagacagttgttttaagagcaagagggaacaatgcaatgatgacatctactctgacctacaatgaattgtattgtaaaagtatgaatcaatgggtattgttttgttaaggctggaaaatgctgtactttattcttataaacgaactatatttttcatgtacctgaatgtgctactccactatggtttgcggtattaagatcgaaggataaaaatgtgacacctcatcaatgcaaaaaaatatgcttctaatactgtatgtaacaacgcaaatgtaagctcataaattttcttcctcatgttggaaaaacatttaatagatgcgtataagtctttgaattgtgttgcacatgatgtattttcatagttttttattcacatgcacaaacagagaaatgtcacaatgaaaagtggaaactaatatgcattttggtgcattttctgtttcagtgactttgaagtataatgcacacaaaaataaatgttcttccgtggctaaaaggaaaatgatacaaccagtaaaaaaaaaaaaaaaaaa

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