LOCUS       NM_001045138            1410 bp    mRNA    linear   VRT 09-FEB-2020
DEFINITION  Danio rerio programmed cell death 2 (pdcd2), mRNA.
ACCESSION   NM_001045138 NM_200399 XM_690925
VERSION     NM_001045138.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Witjes L, Van Troys M, Vandekerckhove J, Vandepoele K and Ampe C.
  TITLE     A new evolutionary model for the vertebrate actin family including
            two novel groups
  JOURNAL   Mol. Phylogenet. Evol. 141, 106632 (2019)
   PUBMED   31560986
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Kramer J, Granier CJ, Davis S, Piso K, Hand J, Rabson AB and
            Sabaawy HE.
  TITLE     PDCD2 controls hematopoietic stem cell differentiation during
            development
  JOURNAL   Stem Cells Dev. 22 (1), 58-72 (2013)
   PUBMED   22800338
  REMARK    GeneRIF: pdcd2 plays a critical role in regulating the
            transcriptional hierarchy controlling hematopoietic lineage
            determination.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Trachtulec Z, Vlcek C, Mihola O and Forejt J.
  TITLE     Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates
  JOURNAL   Gene 335, 151-157 (2004)
   PUBMED   15194198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL772388.35.
            
            On or before Apr 21, 2008 this sequence version replaced
            NM_200399.1, XM_690925.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054132.1, GDQH01007701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AL772388.35        118231-118647
            418-657             AL772388.35        119405-119644
            658-798             AL772388.35        120160-120300
            799-899             AL772388.35        120384-120484
            900-1013            AL772388.35        120579-120692
            1014-1410           AL772388.35        121508-121904
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..1410
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /note="programmed cell death 2"
                     /db_xref="GeneID:393370"
                     /db_xref="ZFIN:ZDB-GENE-040426-1236"
     exon            1..417
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    96..98
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /note="upstream in-frame stop codon"
     CDS             102..1178
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /codon_start=1
                     /product="programmed cell death protein 2"
                     /protein_id="NP_001038603.1"
                     /db_xref="GeneID:393370"
                     /db_xref="ZFIN:ZDB-GENE-040426-1236"
                     /translation="

MAANTLKESNTHSDVVLGFLEEAESWQLLSDQFPSKVGGRPAWLSQSDLPAVSELQCEECKLPAVFLLQVYAPVTEYDRCFHRTLFVFCCKTPACYTRNDSKCFKVFRSQLPRKNEFYPFNPPPDEKPEQPVHDAQVLGSGLKLCRLCGCLGQKACSRCHSVTYCCKEHQTTDWKQRHKKECLAEASQVSGELNSFLFPEWELVTEPEVIPAKDELQESPSLDQENIASLNSGLEDSELESMALHETLDSKVFQKFKQRIANEPQQVLRYCRGGSPLWVTAEHVPREEEVPECTCGAKRLFEFQIMPQLLNHLKVDSTDASIDWGTVAIYTCAESCDQGNKYSPEFIWKQDFSGDQAE"

     misc_feature    534..647
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /note="MYND finger; Region: zf-MYND; pfam01753"
                     /db_xref="CDD:426410"
     misc_feature    852..1154
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /note="Programmed cell death protein 2, C-terminal
                     putative domain; Region: PDCD2_C; pfam04194"
                     /db_xref="CDD:427776"
     exon            418..657
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
     exon            658..798
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
     exon            799..899
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1013
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1410
                     /gene="pdcd2"
                     /gene_synonym="zgc:63685"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtctgagatcttgtttaacccgagccttaatctcagttgaacaaacacccgcacatttttttttaaactctcagctctgaatgtatgtgagagtttgacagatggctgcaaatacattgaaagagtcaaatacacacagtgacgtcgtgctgggcttcttagaggaggcagaatcatggcagcttctgagtgaccagtttccaagtaaagtcggcgggcgaccagcgtggctgagccagtcggatttaccagccgtgtctgagttacagtgcgaggagtgcaaactgccggcggtgtttcttctgcaggtctatgcgccagtcactgaatatgatcgatgttttcacaggacactgtttgtgttctgctgcaagacaccagcctgctatactcgaaacgacagcaagtgttttaaagtgttcagaagtcagttaccaaggaaaaatgagttttacccttttaatcctcctcctgacgaaaagcctgaacagccagtacatgatgctcaggttttgggttcaggactcaaactgtgcaggctgtgtggttgtctgggacagaaagcctgctctcgatgtcactctgtcacatattgctgtaaggagcatcagaccacagactggaaacaaagacacaagaaagagtgcttagctgaggcttctcaagtttcaggggagctgaattcatttctgtttcctgagtgggagctggtcaccgaaccagaggtgattccggcaaaagatgaacttcaggaatcccccagtctggatcaggagaacattgcatctttaaatagcggtttggaggacagtgagctggagagtatggctcttcatgaaacgttagactccaaagtctttcaaaagttcaagcagcgcattgctaatgagccacaacaggttttgcggtattgtagagggggatctcctctttgggtgacagctgaacatgtgccacgtgaagaggaagttccagagtgtacatgtggcgcaaaacggctctttgaattccagataatgccccaattactaaatcacctgaaagtggacagtacagatgccagcatagactgggggacagtggccatctacacctgtgctgaaagctgtgatcaaggcaacaaatattcccctgagttcatctggaaacaagacttttcaggagatcaagcagagtagaactattcatttaaatgaactttgtattaaagatatgtggtgaatcaaaatgattgattccttcatagtttgggtcttaaacttccattaaaatatccattgtcatatgaagaaattccacagattttggtttggacatgctgccaataaaaagtttgggttaagactttaacctgagatacattcaattgatcaaaaattaaagtaaaacatttacattgttgcaaaaaaa

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