LOCUS       NM_001040314            2208 bp    mRNA    linear   VRT 11-JUL-2020
DEFINITION  Danio rerio claudin 15b (cldn15b), mRNA.
ACCESSION   NM_001040314
VERSION     NM_001040314.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Bruch-Bertani JP, Uribe-Cruz C, Pasqualotto A, Longo L, Ayres R,
            Beskow CB, Barth AL, Lima-Morales D, Meurer F, Tayguara Silveira
            Guerreiro G, da Silveira TR, Alvares-da-Silva MR and Dall'Alba V.
  TITLE     Hepatoprotective Effect of Probiotic Lactobacillus rhamnosus GG
            Through the Modulation of Gut Permeability and Inflammasomes in a
            Model of Alcoholic Liver Disease in Zebrafish
  JOURNAL   J Am Coll Nutr 39 (2), 163-170 (2020)
   PUBMED   31241423
REFERENCE   2  (bases 1 to 2208)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2208)
  AUTHORS   McKee R, Gerlach GF, Jou J, Cheng CN and Wingert RA.
  TITLE     Temporal and spatial expression of tight junction genes during
            zebrafish pronephros development
  JOURNAL   Gene Expr. Patterns 16 (2), 104-113 (2014)
   PUBMED   25460834
REFERENCE   4  (bases 1 to 2208)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   5  (bases 1 to 2208)
  AUTHORS   Wilkins BJ and Pack M.
  TITLE     Zebrafish models of human liver development and disease
  JOURNAL   Compr Physiol 3 (3), 1213-1230 (2013)
   PUBMED   23897685
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC115253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505388, SAMEA4476765
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     gene            1..2208
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /note="claudin 15b"
                     /db_xref="GeneID:678556"
                     /db_xref="ZFIN:ZDB-GENE-060421-7652"
     exon            1..382
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    58..60
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /note="upstream in-frame stop codon"
     CDS             166..855
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /codon_start=1
                     /product="claudin-15b precursor"
                     /protein_id="NP_001035404.1"
                     /db_xref="GeneID:678556"
                     /db_xref="ZFIN:ZDB-GENE-060421-7652"
                     /translation="

MQNILQIFALLLGFLGCGSAVLSLYNHYWKVSTDDDSVIITSNIFENLWMSCADDSSGTFSCRDFQSLLALPGYIQACRALIITSIVLGTFGLVATLVGMQCFKIGGGNYIMKSRIAGAGGVFFILQGLCTMTAVSWYAFNITQEFFDPLYPGIKYEIGEGLYIGWSSATLALCSGSCLLCSCGLCTPMGKKSFRQSHLQDFRSSHQPQSINIVPTVSTTSHYLSRQYV"

     sig_peptide     166..225
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    193..693
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
     exon            383..547
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="alignment:Splign:2.1.0"
     exon            548..629
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="alignment:Splign:2.1.0"
     exon            630..752
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="alignment:Splign:2.1.0"
     exon            753..2172
                     /gene="cldn15b"
                     /gene_synonym="zgc:136755"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tttctgttgacttttgtcaaaactctcgacttctatattaaatctatatttcacaagtaaaacggcaagacaagcaatctatatcgcttggaatgtgcactatggacagcagaacatagactgatctctagccaccttggaaataccttagaaagatcaagaaaaatgcaaaatattctgcaaatatttgcacttttattgggttttttgggttgtgggtctgctgtattatcattatataatcactattggaaagtgtctacagatgatgatagtgtcattatcacctccaacatctttgagaacctctggatgtcctgtgcagatgactcttctggcactttcagttgtcgggattttcagtccttgcttgctttaccaggttacatccaagcatgtcgtgcactaataattacatccattgtgcttggcacatttgggctggtagcaactctggtaggtatgcagtgtttcaaaataggaggaggcaattacataatgaagagtagaatcgctggagctggaggtgtgttcttcatactgcaaggtctgtgcacaatgactgcagtgtcttggtatgctttcaatatcactcaggaattctttgacccgctttacccaggaataaagtatgaaattggagaagggctgtacattggttggagttcagccacgctggctttatgcagtggtagttgcttgctgtgttcctgtggattgtgcaccccgatggggaaaaagtcattccgtcaatcccatcttcaggacttcagatcttcacaccagcctcaatccattaatattgttccaacagtttctacaacatctcactatctttcaaggcaatatgtttagttaatgcaatgaattagtcagaccatcaaaatcgctagggcacttcagctcattttgaaagggcactttctatctaagactaaaaagggcatgtgcactgcacaggttgaaaactatgtgtgcatgtgcctgtggacaagaacggtcacttttttttatgttaacatgttctgaagttttctggataagttatgtaaatgtcttttgaaagaatttctttctttctttcttttttaacaattaatgctgaaaaggcatggccactatttttgtgcctgaaccttattgaatatacatttgtaggagttgcaagaatctgagagctcactgatcctccaaaggcaaatccagaaaggtaccaaaacattcctaaaaaagtggaagttaattttgagagcacgcaacttcatttctacgtttcgagtctggccaaactggatgaatgtgcacatgccaacatcattaggtacccaaaacagctgcctgatgttaagtcctataggtgtttttgttttgttttttttttactttgtgtacaaaatatttattgttgttcctcagactgtccgaagcttcttaggtaaattacttttaatggtatatgaagttttgcattcaagcagtcaattgtcttgaaaatataaaactcagcctaaattattcatttgcacaagtgtacttaaagcaaagattttcacgagtgccctaaaaactattccacaatttattcatcgcatacgtaaactagcaatttaaatcaattaataaatcacacacaaacatgttttgtcgtaagatgcccccttttgttaaaaataaaagctcgatgatagtacaaataataataccattataaatctagatcatgacaataatccagaaactagtcactgacaaagaatgctacaataagggttctgctttccacacttgccactatacgacaacttgtgctatgcttggtatatactgctttggtcggtacgcaaatgagattttatgtctgtgtatgcaaaatgtcagttaatcacctacagtgattttgcaattcccattttcatttagttaatctagtttttttttttatatatatatattcacagatcagttaataggctaagatcagtattgctgtaactagatctaacaaattcttactactcttttaacaaaggagtatatgccctgctgaaagatgattaccccagcaataaatacaaatgttatcaaagtaaagttcagtgaataaccactgcttctgatgggaccatgtaaatatattattaaagctaataataaagacaatccagaattgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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