LOCUS       NM_001030111            1442 bp    mRNA    linear   VRT 17-OCT-2021
DEFINITION  Danio rerio follistatin-like 3 (secreted glycoprotein) (fstl3),
            mRNA.
ACCESSION   NM_001030111
VERSION     NM_001030111.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Gu L, Tian L, Gao G, Peng S, Zhang J, Wu D, Huang J, Hua Q, Lu T,
            Zhong L, Fu Z, Pan X, Qian H and Sun L.
  TITLE     Inhibitory effects of polystyrene microplastics on caudal fin
            regeneration in zebrafish larvae
  JOURNAL   Environ Pollut 266 (Pt 3), 114664 (2020)
   PUBMED   32768670
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Giffen KP, Liu H, Kramer KL and He DZ.
  TITLE     Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse
            Inner Ear Non-sensory Supporting Cells
  JOURNAL   Front Neurosci 13, 1117 (2019)
   PUBMED   31680844
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS,
            Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C and Parichy DM.
  TITLE     Thyroid hormone regulates distinct paths to maturation in pigment
            cell lineages
  JOURNAL   Elife 8, e45181 (2019)
   PUBMED   31140974
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Wagner DE, Weinreb C, Collins ZM, Briggs JA, Megason SG and Klein
            AM.
  TITLE     Single-cell mapping of gene expression landscapes and lineage in
            the zebrafish embryo
  JOURNAL   Science 360 (6392), 981-987 (2018)
   PUBMED   29700229
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC134879.1.
            
            On Apr 1, 2007 this sequence version replaced NM_001030111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC134879.1, BC097220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="22"
                     /map="22"
     gene            1..1442
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="follistatin-like 3 (secreted glycoprotein)"
                     /db_xref="GeneID:557352"
                     /db_xref="ZFIN:ZDB-GENE-050913-111"
     exon            1..175
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..840
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /codon_start=1
                     /product="follistatin-related protein 3 precursor"
                     /protein_id="NP_001025282.2"
                     /db_xref="GeneID:557352"
                     /db_xref="ZFIN:ZDB-GENE-050913-111"
                     /translation="

MNVLAVLHCVILISVCEILGEHRTSAGMCWLQQGPEHRCDMVLMRGVSREECCAAGRLDTAWSNASLPINEVSLLGFLGIVSCKPCKENCEGVNCGLGKVCRMKSGRPQCVCSPDCSNISTKHAVCGSDGNSYKDECALLMARCKGHPDLEIMYQGECKKSCSNVVCPGTHTCVTDQTNSAHCVMCRTAPCPMPMITEQTICGNDNITYQSACHLRRATCFLGRSIGVRHYGHCRSNEASEENSLF"

     sig_peptide     100..159
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    430..573
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="Kazal type serine protease inhibitors; Region:
                     KAZAL; smart00280"
                     /db_xref="CDD:197624"
     misc_feature    700..801
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /note="Kazal type serine protease inhibitors and
                     follistatin-like domains. Kazal inhibitors inhibit serine
                     proteases, such as, trypsin, chyomotrypsin, avian
                     ovomucoids, and elastases. The inhibitory domain has one
                     reactive site peptide bond, which serves the...; Region:
                     KAZAL_FS; cd00104"
                     /db_xref="CDD:238052"
     exon            176..361
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            362..577
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            578..805
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1417
                     /gene="fstl3"
                     /gene_synonym="si:dkey-28h18.3; zgc:114170"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccacgtcccagtctgcagacttcttatcagtacaagtacttcagaggaaagccgctggttccttcaaacatctgtgttaaagaagctttcggcagcatcatgaacgttttggctgtcctgcactgtgtgatacttatttcagtttgtgaaatacttggagaacatcgaacgagcgctggcatgtgctggttgcagcagggtccggagcaccgctgtgacatggtgctcatgaggggtgtgagcagggaagagtgctgtgctgctggccgtctggacactgcctggtccaatgctagtctgcccatcaatgaagtcagcctgctgggattcctgggaatagtttcctgtaagccgtgtaaagagaactgtgaaggagtgaactgtggccttggaaaggtgtgtagaatgaagtcaggacgcccacagtgcgtttgctctccagactgttccaacatctccactaaacacgcagtgtgtgggagcgatgggaattcctacaaagacgagtgcgcgctcctgatggctcgctgcaaaggtcatcctgacctggagataatgtaccagggggaatgcaaaaagtcctgctcaaatgtggtatgtcctggtactcatacctgtgtgacggaccagactaacagtgcccactgtgtcatgtgccgcactgcaccttgtccgatgcccatgatcaccgagcaaaccatctgcggcaatgataacatcacttaccaaagtgcttgccacctgcgtagggcaacctgctttttgggtcgatccataggagttcgccactatggacactgcagaagtaatgaagcaagtgaggaaaattcactcttctgaggatgtcaagacagatcctctccttgtatatattatgatggcacataagacgtgagagaacctgtttgaaaccatatcacaacacggtcctctgtaccaaagaaccactagtattttataggcatgcaattcaatacttaaaggaaacgtgtggtttttaacaggagaattgaactgatgaattgacagtgtgcatattgtaaatatactacaagctactatttattggagaaaagttaggaagtcggtgttatttatgtgttaacacgtttgagacaccatatattcgtacatcagctgcctttctctatgtatttattgtgggttttgcttcagttttcatgtatttgtcagaactgaataatgtaaacgtgcacgacagggtttccgtacctttgaatcctcataattactgaacagaaatgactaaaacattttttttgttttcacaaagagctatttcttgccaaataaatgtttttttacattacattttatggtatttatattatttttgtactaaatgtattatattattttatgtttttatttaaatgataataaataataattcacaaaaaaaaaaaaaaaaaaaaaaaaaa

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