LOCUS       NM_001020614            1640 bp    mRNA    linear   VRT 03-JUL-2021
DEFINITION  Danio rerio exoribonuclease 1 (eri1), mRNA.
ACCESSION   NM_001020614 XM_696796
VERSION     NM_001020614.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Wang S, Ji D, Yang Q, Li M, Ma Z, Zhang S and Li H.
  TITLE     NEFLb impairs early nervous system development via regulation of
            neuron apoptosis in zebrafish
  JOURNAL   J Cell Physiol 234 (7), 11208-11218 (2019)
   PUBMED   30569449
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Zhao XF, Fjose A, Larsen N, Helvik JV and Drivenes O.
  TITLE     Treatment with small interfering RNA affects the microRNA pathway
            and causes unspecific defects in zebrafish embryos
  JOURNAL   FEBS J 275 (9), 2177-2184 (2008)
   PUBMED   18384379
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Eckfeldt CE, Mendenhall EM, Flynn CM, Wang TF, Pickart MA, Grindle
            SM, Ekker SC and Verfaillie CM.
  TITLE     Functional analysis of human hematopoietic stem cell gene
            expression using zebrafish
  JOURNAL   PLoS Biol 3 (8), e254 (2005)
   PUBMED   16089502
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Kennedy S, Wang D and Ruvkun G.
  TITLE     A conserved siRNA-degrading RNase negatively regulates RNA
            interference in C. elegans
  JOURNAL   Nature 427 (6975), 645-649 (2004)
   PUBMED   14961122
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC095343.1.
            
            On Jul 6, 2005 this sequence version replaced XM_696796.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095343.1, BC164140.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..1640
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="exoribonuclease 1"
                     /db_xref="GeneID:553641"
                     /db_xref="ZFIN:ZDB-GENE-050522-39"
     exon            1..353
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    240..242
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="upstream in-frame stop codon"
     CDS             270..1283
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="three prime histone mRNA exonuclease 1"
                     /codon_start=1
                     /product="3'-5' exoribonuclease 1"
                     /protein_id="NP_001018450.1"
                     /db_xref="GeneID:553641"
                     /db_xref="ZFIN:ZDB-GENE-050522-39"
                     /translation="

METKEKSRKPPNKTPQSEGDQEDQPCPDTSCEKNEDQEPSSPKQGEFSDPVYKEIALANGAINRMNREELRAKCTELKLDTRGVNDVLRKRLKSYYKKQKLMHSPAAEGNSDMYFDYICVVDFEATCEENNPPDYLHEIIEFPMVLIDTHTLEIVDSFQEYVKPVLHPQLSEFCVKLTGITQEMVDEAKTFHQVLKRAISWLQEKELGTKYKYMFLTDGSWDMGKFLHTQCKLSRIRYPQFARKWINIRKSYGNFYKVPRTQTKLICMLENLGMEYDGRPHCGLDDSRNIARIAIHMLKDGCQLRVNECLHSGEPRSVPISAPIEGAPAPQPPKKRD"

     misc_feature    453..557
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="SAP domain; Region: SAP; pfam02037"
                     /db_xref="CDD:426575"
     misc_feature    621..1163
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="DEDDh 3'-5' exonuclease domain of Caenorhabditis
                     elegans ERI-1, human 3' exonuclease, and similar proteins;
                     Region: ERI-1_3'hExo_like; cd06133"
                     /db_xref="CDD:99836"
     misc_feature    order(633..644,648..650,786..788,921..935,945..947,
                     1110..1112,1125..1127)
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="active site"
                     /db_xref="CDD:99836"
     misc_feature    order(633..644,648..650,786..788,921..935,945..947,
                     1110..1112,1125..1127)
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99836"
     misc_feature    order(633..635,639..641,933..935,1110..1112,1125..1127)
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99836"
     exon            354..514
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     exon            515..731
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     exon            732..815
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     exon            816..925
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1040
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1610
                     /gene="eri1"
                     /gene_synonym="thex1; zgc:110635"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggaagttgaaacgtcagtgagtgtcagcggcagcgtgattcacgtttgagaaactaactgcacgcaaccagaagttttactatcaggcacctatttatatcaaaatgtacatgcagcaaactgaagacatcgagacgagcatttagtgttgaaatattttaaagtggattaagtacatgtaacgttagagacaccgcgacgcttaacgcgcgaaaccagatgtgagtgtttctgaaatgatctaacgttactagactttcagatctgatggagacgaaggaaaagagccgtaaacctccaaataagactccacagtctgaaggagatcaggaggatcaaccctgtcctgatacttcctgtgaaaaaaatgaagatcaggagccttcctcaccaaaacagggagagttcagtgatccggtgtataaagagattgcattggcaaatggtgccatcaaccgaatgaacagagaagagttgcgtgcgaaatgcacagagctgaaacttgacacacgtggagttaatgatgtcctaaggaagcgcctcaaaagctactacaaaaagcagaagttgatgcattcacctgctgcagaagggaacagtgacatgtactttgactacatctgtgtggtggattttgaagcaacatgcgaagagaataacccaccagattacctccatgaaatcattgagttccccatggtgttgatcgacacacacacactggagattgtagactcgtttcaggagtatgtgaagccagtgctgcacccacagctctctgagttttgtgtaaaacttaccggaataacgcaggaaatggtggatgaggcaaaaacattccatcaagttttaaagcgagcaatttcttggcttcaggaaaaagaactgggcacaaaatacaaatatatgtttttgacagacgggtcttgggacatggggaaatttcttcatacacagtgcaaactgagtcgcatcagatacccacagtttgccagaaaatggatcaatatcagaaagtcttatgggaatttttataaggttcctcgtactcagacgaagctgatctgcatgctggagaatctggggatggagtatgatggacgtccgcactgtggtctagatgactcacgcaacattgccagaatcgccatccacatgctgaaggacggctgtcagctgagggtgaatgagtgcttgcattcaggagaaccgcggagcgtgcctatctctgcccctattgaaggagcaccagcacctcagccccccaaaaaacgagactagaaagactctttgccaaaaaaataacaacaaatatgaaaacctgccatgttgtggaaaaatgatctagattaataaatattgaaatatttgctgagagaattgtacatcataacagatgatgaagcttcaccattacagcaaattggtttcatgtactgtatttggaacttgctcctgagaaacatacactgcaggaagtgtttatttccagcctgatgggtaattagtaattgttgtattttttaaaatccctattgcacatacattttgcagctctgctctacatgtattattttgccaataaactttttagtgatggtgagattgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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