LOCUS       NM_001017571            2294 bp    mRNA    linear   VRT 04-NOV-2023
DEFINITION  Danio rerio carbonic anhydrase VIII (ca8), mRNA.
ACCESSION   NM_001017571
VERSION     NM_001017571.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Namikawa K, Dorigo A, Zagrebelsky M, Russo G, Kirmann T, Fahr W,
            Dubel S, Korte M and Koster RW.
  TITLE     Modeling Neurodegenerative Spinocerebellar Ataxia Type 13 in
            Zebrafish Using a Purkinje Neuron Specific Tunable Coexpression
            System
  JOURNAL   J Neurosci 39 (20), 3948-3969 (2019)
   PUBMED   30862666
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C,
            Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood
            J, McCarroll SA and Schier AF.
  TITLE     Phenotypic Landscape of Schizophrenia-Associated Genes Defines
            Candidates and Their Shared Functions
  JOURNAL   Cell 177 (2), 478-491 (2019)
   PUBMED   30929901
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Knogler LD, Kist AM and Portugues R.
  TITLE     Motor context dominates output from purkinje cell functional
            regions during reflexive visuomotor behaviours
  JOURNAL   Elife 8, e42138 (2019)
   PUBMED   30681408
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Matsumoto H, Fujiwara S, Miyagi H, Nakamura N, Shiga Y, Ohta T and
            Tsuzuki M.
  TITLE     Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During
            Zebrafish Embryogenesis, Especially in the Inner Ear
  JOURNAL   Mar Biotechnol (NY) 19 (5), 430-440 (2017)
   PUBMED   28695384
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Takeuchi M, Yamaguchi S, Sakakibara Y, Hayashi T, Matsuda K, Hara
            Y, Tanegashima C, Shimizu T, Kuraku S and Hibi M.
  TITLE     Gene expression profiling of granule cells and Purkinje cells in
            the zebrafish cerebellum
  JOURNAL   J Comp Neurol 525 (7), 1558-1585 (2017)
   PUBMED   27615194
  REMARK    Erratum:[J Comp Neurol. 2021 Aug 1;529(11):3127. PMID: 34050936]
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Ito Y, Kobayashi S, Nakamura N, Miyagi H, Esaki M, Hoshijima K and
            Hirose S.
  TITLE     Close Association of Carbonic Anhydrase (CA2a and CA15a),
            Na(+)/H(+) Exchanger (Nhe3b), and Ammonia Transporter Rhcg1 in
            Zebrafish Ionocytes Responsible for Na(+) Uptake
  JOURNAL   Front Physiol 4, 59 (2013)
   PUBMED   23565095
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Aspatwar A, Tolvanen ME, Jokitalo E, Parikka M, Ortutay C, Harjula
            SK, Ramet M, Vihinen M and Parkkila S.
  TITLE     Abnormal cerebellar development and ataxia in CARP VIII morphant
            zebrafish
  JOURNAL   Hum Mol Genet 22 (3), 417-432 (2013)
   PUBMED   23087022
  REMARK    GeneRIF: We provide evidence that the CA8 gene product is
            indispensable in early embryonic development in zebra fi sh,
            particularly in the brain and eye.
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   Tiefenbach J, Moll PR, Nelson MR, Hu C, Baev L, Kislinger T and
            Krause HM.
  TITLE     A live zebrafish-based screening system for human nuclear receptor
            ligand and cofactor discovery
  JOURNAL   PLoS One 5 (3), e9797 (2010)
   PUBMED   20339547
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Bae YK, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y,
            Higashijima S and Hibi M.
  TITLE     Anatomy of zebrafish cerebellum and screen for mutations affecting
            its development
  JOURNAL   Dev Biol 330 (2), 406-426 (2009)
   PUBMED   19371731
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   Lin TY, Liao BK, Horng JL, Yan JJ, Hsiao CD and Hwang PP.
  TITLE     Carbonic anhydrase 2-like a and 15a are involved in acid-base
            regulation and Na+ uptake in zebrafish H+-ATPase-rich cells
  JOURNAL   Am J Physiol Cell Physiol 294 (5), C1250-C1260 (2008)
   PUBMED   18322140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR847864.6.
            
            On Apr 20, 2018 this sequence version replaced NM_001017571.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               CR847864.6         24756-25241
            487-678             CR847864.6         29120-29311
            679-803             CR847864.6         31568-31692
            804-899             CR847864.6         32313-32408
            900-962             CR847864.6         35106-35168
            963-1011            CR847864.6         35242-35290
            1012-1124           CR847864.6         35429-35541
            1125-1294           CR847864.6         38759-38928
            1295-2294           CR847864.6         47368-48367
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..2294
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /note="carbonic anhydrase VIII"
                     /db_xref="GeneID:550233"
                     /db_xref="ZFIN:ZDB-GENE-050417-26"
     exon            1..486
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    405..407
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /note="upstream in-frame stop codon"
     CDS             414..1259
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /EC_number="4.2.1.1"
                     /note="CARP VIII"
                     /codon_start=1
                     /product="carbonic anhydrase-related protein"
                     /protein_id="NP_001017571.2"
                     /db_xref="GeneID:550233"
                     /db_xref="ZFIN:ZDB-GENE-050417-26"
                     /translation="

MADNVIEESGNYPGKDELDWGYEEGVEWGLLFPEANGEYQSPINLNSREARYDPQLLDVGLNPNYVVCRDCEVINDGHTVRIMLKSKSVVTGGPLPSDHEYELSEVRFHWGKENQRGSEHTVNFKAFPMELHLIHWNSTLFNSVEEAMGKKRGILIIALFVQVGKEHLGLKAITDVLQDLQYKGKTKIIPCFNPNTLLPDPLLRDYWVYEGSLTTPPCSENVTWILYRYPLTISQMQIEEFRRLRSHVKGAELPEGNDGMLGDNFRPTQPLSDRVVRAAFQ"

     misc_feature    486..1253
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /note="Carbonic anhydrase alpha related protein, group
                     VIII. Carbonic anhydrase related proteins (CARPs) are
                     sequence similar to carbonic anhydrases. Carbonic
                     anhydrases are zinc-containing enzymes that catalyze the
                     reversible hydration of carbon dioxide in a...; Region:
                     alpha_CARP_VIII; cd03120"
                     /db_xref="CDD:239394"
     exon            487..678
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            679..803
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            804..899
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            900..962
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1011
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1124
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1294
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..2294
                     /gene="ca8"
                     /gene_synonym="zgc:110118"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cccgtggccagactgcaaaccacaactgtttctatggtgctacatcagaggccaaagagcagccaatcagacggctcgtgtgggagcatgtgggttgagagagtgagttgctgaacttacttttggtttgctgtggagctgctgcagggaggaggacagagagctcttcactcagacaagaggagaggagaactcattattttcaatggaatgacgactagtttctgtcctgagtcagtgtggttggtgtgcctttgaagctattgagatcaatcacttccatttgtattgtgatacatcagtttcttcatgttttatgggtgggaggtgagcaaacgaggaggaagggtcagaaagaattagtttttgacatctggacagaacgtgagccgtggagagaagattgagttgccatggctgataatgttattgaagagagcggtaattaccctggaaaggatgagctggactggggatatgaagaaggtgttgaatggggtcttctgtttcctgaggccaatggagagtaccagtcccctataaacctcaactcacgcgaggctcgctatgacccgcagctgctggacgtggggctcaacccaaactatgtggtctgccgcgactgtgaagtcattaatgatggtcacactgtgaggatcatgctgaaatccaaatctgttgttactggaggtcctctccccagtgaccatgagtatgagctgagcgaggtgcgctttcactggggcaaagaaaaccagagaggatctgaacacactgtcaacttcaaggcttttccaatggagcttcatctaatacactggaactctacattattcaacagcgtggaggaggccatgggcaagaaaagaggcattctcatcatcgccctgtttgtgcaggttgggaaggaacatcttggtctgaaggccatcacagacgtcctgcaggacctgcagtataaggggaagactaaaataattccatgttttaatcccaacacattactccctgatcctctattaagagattactgggtgtatgagggctctttaaccaccccgccctgtagtgagaacgtcacctggattctgtaccgttaccctttgaccatctctcagatgcagattgaagagtttcgtcgccttaggtcccatgttaaaggagcagagcttccagaaggcaatgatgggatgctgggggacaactttagaccgacccaaccactgagtgacagggtggtcagggcagccttccagtaacacccccgcagcgggaccattttaatctgccatggctattagacatgacaaagaaatcaagataaaggctgaacaacatcctggctatgtgaaagttcatcacttcctgtagagctgggcatccttttctatttcagtgtcctgagtgcggcccgatgtgtgcagaagctacagtgagcatgaagaaacactctgtaatacgtttgtatgaagaaggactaacgcttgaagaatattcagcagttatgaattttaacaatatgtagcacgtgtgtaatcctataaatgctgctttataggaatctcatacaatattcataactgatgtgtgatgtagacattactgacaaacttaatattacatgagcagataccatttattgatgttttcatgtctgtgcattgattgcgttcaaatgttataattgaaattaattattgttgtttaatttactgattgactaaagctccaaacattgttttgatgagtttcttttctttacctgtgctatgatgaacagagtatgaaggaccatgtatgtagtagactctgttagtgttagctttagatctgtgttgatggtctgtacttgttattatgctcacatctgcatatttaagaaggtggcatacagcatttcaactggtcttttgctctgtcattatcttgctttacgcaactttttagcaaggttacccatttgtagagctgcaaaaaggaaacatgattcactgagagatatgtgtgtctgtatgtcattttttaaaaaacatgacgagccacagattgtgcagttctcatgggaaaccacgttcagataaaaagaactgctgttgcgtaccttgaaatcccctttgcatgataatgattgacatctaagagcaaggatctgcagcctggcatttataacagaaatcacagcgtcattgctcactgggatttccactgtacattttgtgcagcagtacttacgttgtcatgtgcttaggcttgtgttttaaataaagttaaagattttaaggcattttatgtta

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