LOCUS       NM_001014818            2164 bp    mRNA    linear   VRT 21-AUG-2023
DEFINITION  Danio rerio paired like homeobox 2Bb (phox2bb), mRNA.
ACCESSION   NM_001014818 XM_696677
VERSION     NM_001014818.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2164)
  AUTHORS   MacLean JE, Wertman JN, Prykhozhij SV, Chedrawe E, Langley S,
            Steele SL, Ban K, Blake K and Berman JN.
  TITLE     phox2ba: The Potential Genetic Link behind the Overlap in the
            Symptomatology between CHARGE and Central Congenital
            Hypoventilation Syndromes
  JOURNAL   Genes (Basel) 14 (5), 1086 (2023)
   PUBMED   37239446
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2164)
  AUTHORS   Feng G and Sun Y.
  TITLE     The Polycomb group gene rnf2 is essential for central and enteric
            neural system development in zebrafish
  JOURNAL   Front Neurosci 16, 960149 (2022)
   PUBMED   36117635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2164)
  AUTHORS   Rea V, Bell I, Ball T and Van Raay T.
  TITLE     Gut-derived metabolites influence neurodevelopmental gene
            expression and Wnt signaling events in a germ-free zebrafish model
  JOURNAL   Microbiome 10 (1), 132 (2022)
   PUBMED   35996200
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2164)
  AUTHORS   Alhashem Z, Feldner-Busztin D, Revell C, Alvarez-Garcillan Portillo
            M, Camargo-Sosa K, Richardson J, Rocha M, Gauert A, Corbeaux T,
            Milanetto M, Argenton F, Tiso N, Kelsh RN, Prince VE, Bentley K and
            Linker C.
  TITLE     Notch controls the cell cycle to define leader versus follower
            identities during collective cell migration
  JOURNAL   Elife 11, e73550 (2022)
   PUBMED   35438077
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2164)
  AUTHORS   Raby L, Volkel P, Hasanpour S, Cicero J, Toillon RA, Adriaenssens
            E, Van Seuningen I, Le Bourhis X and Angrand PO.
  TITLE     Loss of Polycomb Repressive Complex 2 Function Alters Digestive
            Organ Homeostasis and Neuronal Differentiation in Zebrafish
  JOURNAL   Cells 10 (11), 3142 (2021)
   PUBMED   34831364
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2164)
  AUTHORS   Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A,
            Bally-Cuif L and Schilling TF.
  TITLE     Requirements for endoderm and BMP signaling in sensory neurogenesis
            in zebrafish
  JOURNAL   Development 132 (16), 3731-3742 (2005)
   PUBMED   16077092
REFERENCE   7  (bases 1 to 2164)
  AUTHORS   Nechiporuk A, Linbo T and Raible DW.
  TITLE     Endoderm-derived Fgf3 is necessary and sufficient for inducing
            neurogenesis in the epibranchial placodes in zebrafish
  JOURNAL   Development 132 (16), 3717-3730 (2005)
   PUBMED   16077091
REFERENCE   8  (bases 1 to 2164)
  AUTHORS   Elworthy S, Pinto JP, Pettifer A, Cancela ML and Kelsh RN.
  TITLE     Phox2b function in the enteric nervous system is conserved in
            zebrafish and is sox10-dependent
  JOURNAL   Mech Dev 122 (5), 659-669 (2005)
   PUBMED   15817223
  REMARK    GeneRIF: Phox2b function is sox10-dependent in the developing
            enteric nervous system
REFERENCE   9  (bases 1 to 2164)
  AUTHORS   Shepherd IT, Pietsch J, Elworthy S, Kelsh RN and Raible DW.
  TITLE     Roles for GFRalpha1 receptors in zebrafish enteric nervous system
            development
  JOURNAL   Development 131 (1), 241-249 (2004)
   PUBMED   14660438
REFERENCE   10 (bases 1 to 2164)
  AUTHORS   Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC and
            Rosenthal A.
  TITLE     Development of noradrenergic neurons in the zebrafish hindbrain
            requires BMP, FGF8, and the homeodomain protein soulless/Phox2a
  JOURNAL   Neuron 24 (3), 555-566 (1999)
   PUBMED   10595509
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY846871.1.
            
            On Jul 6, 2005 this sequence version replaced XM_696677.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY846871.1, BC162881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505389, SAMEA3505390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2164
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="AB"
                     /db_xref="taxon:7955"
                     /chromosome="14"
                     /map="14"
     gene            1..2164
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="paired like homeobox 2Bb"
                     /db_xref="GeneID:544654"
                     /db_xref="ZFIN:ZDB-GENE-050407-3"
     misc_feature    215..217
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="upstream in-frame stop codon"
     CDS             227..1081
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="paired-like homeobox 2b"
                     /codon_start=1
                     /product="paired like homeobox 2Bb"
                     /protein_id="NP_001014818.1"
                     /db_xref="GeneID:544654"
                     /db_xref="ZFIN:ZDB-GENE-050407-3"
                     /translation="

MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGTGKKSDSREEDSKEAKATDPDSTGGPGPNPNPTSNCGGPSPTGGQVSATGNGPVEQVKTSVAGMGPTAPTQGWASAPGTITSIPDSLGGPFASVLSSLQRQNGAKATLVKTSMF"

     misc_feature    order(521..535,539..541,590..592,608..610,647..649,
                     653..658,665..670,674..682,686..691)
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(527..529,536..538,656..658,665..670,677..679)
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    530..688
                     /gene="phox2bb"
                     /gene_synonym="phox2b"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
ORIGIN      

acgcgggggggcagtttttgagcaggcgccgagcagtgcacatctacccacggcacgagcntcttttaaacctgtaaaaattcagccgtcacaagctccccatctccgtctgcgttttggcttgcttttttcatgtgctccttaccaatttaatccaatttgaatttgacgtttgtgtgtatttttccttgggagtgcagctttccttctccactgagccttttcaatgtataaaatggagtattcttacctcaattcctctgcctacgagtcctgtatggccgggatggacacttcgagcctggcgtcagcctatgcggacttcagctcctgcagccaagccagtggctttcagtacaatcccatcaggacgacgtttggggccacctccgggtgcccgtcgcttacaccgggctcctgtagtctaggcaccctgcgggaccaccagagcagtccgtacgccgcagttccctacaagcttttcaccgatcacggaggcttgaatgagaagcgaaagcagaggcgcattcggacaactttcaccagcgcgcagctcaaggagctggagcgcgtgttcgcggagactcactacccagacatttacacacgagaggagctcgcgcttaagattgatctcaccgaagctagggtgcaggtgtggtttcagaacaggcgcgccaaatttcgcaaacaagagcgcgcagccgccgcagcagctgctgcagcaaaaaacggcactgggaagaaatctgactcgcgagaagaggacagcaaagaggcaaaggctaccgatcctgacagcactggcgggccagggcctaacccgaaccctacctccaactgtggtggaccgagccccacagggggacaggtcagtgccacaggaaatggcccggttgaacaggtgaagacgtcagtggccggaatgggacccaccgcgccgactcaaggttgggcctcagccccgggcaccatcacctccattccggactctctgggcggaccgttcgctagcgttctgtcctcattacaaagacagaacggagccaaagccactttagtaaagaccagcatgttctgagttagtgcttgatgcagaaaagaagcgacgaccgcgagattcaacaaacaaacaagagtttactctagagactgattactgagacggaaaaaagagaatgccaaaagaaagagagagccctgtatctctattcactagtgaagaaagaatagaccatctacggtagccatccgactactttcaaatgccactggtttacaccacaagctggataatacatcacttacaccatgttaacactcggactgttttgttttggctttggtcgtcgacaaatctgactagtgcaagtaaactaaccgatagactgcgatgtgcgctcctgctgcaaagaacactcaacaaggactcatgaagatacaatgtcattattcagtgtcattatacttgtcattatatcttggcgccataattctttgtttacattgactttaaacataccaatagcgcaagttacacgtctgtgttacagaatactgccaaatgtggcactctgttatatatttttacttataaatttacaaagccttagagccaggagctctgcaaacattcatctacatatttactattaatcaaggcgaattgttcttcaaaatggcacaagtacatacttcattgttgacaggaatacgtaaatgttttgtgtgtctttctacagctgtgtttttgtggctcaaattgtatagtgttaaaaagtattgacgtcctagataaacatagaccacatcccccttgtagttcattaagtctttataatgttttacaagttacaactggcgcattctttggaggaaaagggaatggatgcaaaacattgtatttattttctatattatttgcatgttgtcttctccgtccaattttataatgatttcacctattttgtgagcataatgtaacatgttttttgtccaggatttgagaattatttatatgtaggtaatggatgcttatatttaagaaggaaatatttctacatgtgcacatagtttttcaggtgtaccattgacatggctgttgatgataaaaacaattatgatgctgaaaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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