LOCUS       NM_001007187            1740 bp    mRNA    linear   VRT 20-DEC-2022
DEFINITION  Danio rerio family with sequence similarity 53 member B (fam53b),
            mRNA.
ACCESSION   NM_001007187
VERSION     NM_001007187.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Bhattacharya S, Gargiulo D and Iovine MK.
  TITLE     Simplet-dependent regulation of beta-catenin signaling influences
            skeletal patterning downstream of Cx43
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30377172
  REMARK    GeneRIF: both Smp and beta-catenin function in a common molecular
            pathway with cx43 to influence both evx1 expression and joint
            location.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Kizil C, Kuchler B, Yan JJ, Ozhan G, Moro E, Argenton F, Brand M,
            Weidinger G and Antos CL.
  TITLE     Simplet/Fam53b is required for Wnt signal transduction by
            regulating beta-catenin nuclear localization
  JOURNAL   Development 141 (18), 3529-3539 (2014)
   PUBMED   25183871
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Aoki M, Segawa H, Naito M and Okamoto H.
  TITLE     Identification of possible downstream genes required for the
            extension of peripheral axons in primary sensory neurons
  JOURNAL   Biochem Biophys Res Commun 445 (2), 357-362 (2014)
   PUBMED   24513284
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Aanes H, Winata CL, Lin CH, Chen JP, Srinivasan KG, Lee SG, Lim AY,
            Hajan HS, Collas P, Bourque G, Gong Z, Korzh V, Alestrom P and
            Mathavan S.
  TITLE     Zebrafish mRNA sequencing deciphers novelties in transcriptome
            dynamics during maternal to zygotic transition
  JOURNAL   Genome Res 21 (8), 1328-1338 (2011)
   PUBMED   21555364
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Kizil C, Otto GW, Geisler R, Nusslein-Volhard C and Antos CL.
  TITLE     Simplet controls cell proliferation and gene transcription during
            zebrafish caudal fin regeneration
  JOURNAL   Dev Biol 325 (2), 329-340 (2009)
   PUBMED   19014929
  REMARK    GeneRIF: smp is required in fin regeneration through control of
            cell proliferation, the regulation of specific genes and proper
            bone patterning.
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly
            PD, Chu F, Postlethwait JH and Talbot WS.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC066405.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..1740
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="family with sequence similarity 53 member B"
                     /db_xref="GeneID:406586"
                     /db_xref="ZFIN:ZDB-GENE-040426-2495"
     exon            1..104
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /inference="alignment:Splign:2.1.0"
     exon            105..270
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    121..123
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="upstream in-frame stop codon"
     CDS             184..1323
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="smp; simplet; protein simplet"
                     /codon_start=1
                     /product="protein FAM53B"
                     /protein_id="NP_001007188.1"
                     /db_xref="GeneID:406586"
                     /db_xref="ZFIN:ZDB-GENE-040426-2495"
                     /translation="

MCVAMVIIHTKTLEKKAVDDVTSEASLQPQEPLTMSQGTALFSCGIMDSGRWADVGSVCGVQQRPVGSSLESLWDSMREAGATGGISGLLRDLSLSEASPASAAPPSKRQCRSLSCSDELGCRSSWRPQGSRVWTAVEKRRCHSGGSVQRGVFNPSGFPAMQRSSSFSLPAHSSHLEPFTHGFPFQAFSECPQTPQTLYRSHEQICPAEASSPESTPELQRRSGQTGLARSRSQPCVHNHQKIGVKRRRPADSHKQRPSLDLLKMTQKLQDFHSLSCPGFSGDDKTLPSSSPALLNDTCERAQNDSSADAPIHQSESSSEDALIHQSDSSSADALIHQSESSRPAGKERECLWAGLCSRRGRDLFQLGGELDIEQIERN"

     misc_feature    196..984
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="Family of FAM53; Region: FAM53; pfam15242"
                     /db_xref="CDD:434564"
     misc_feature    799..954
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="propagated from UniProtKB/Swiss-Prot (F1QN48.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    919..930
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="propagated from UniProtKB/Swiss-Prot (F1QN48.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:25183871"
     misc_feature    1087..1227
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /note="propagated from UniProtKB/Swiss-Prot (F1QN48.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            271..325
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /inference="alignment:Splign:2.1.0"
     exon            326..984
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1699
                     /gene="fam53b"
                     /gene_synonym="wu:fo86c04; zgc:55329; zgc:77156"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcgctcgtgcggcggcggtagcgggagatgagcggtggacgcgcgcggggatgaggatgatctgaacggtcgtgtttaccggagacccgccggccgctgttccgtgaaggggttcggtgtgatgtcggatcggctatgagcttctctacaactgtcctgcactggaatggaccgtggcaaagatgtgtgttgccatggtaattattcacactaaaacactggaaaagaaggcagttgacgatgtaacatccgaagcgtctctgcagccgcaggagccgctgaccatgagccaggggacagctctgttctcctgtggaatcatggactctgggcgctgggcagatgttggcagtgtgtgtggcgtccagcagcggcctgtgggctccagtctggagagcctgtgggacagcatgcgtgaggcgggcgccactggcggcatcagtgggttactgcgggatctgagtctgagcgaagcgtctcctgccagtgctgcgccgcccagcaaacgccagtgccgctcgctgtcctgctcggatgagctgggctgccgctcatcctggcgtccgcagggttcgcgcgtctggacagcggtggaaaagcggcgctgccacagcggagggagcgtccagagaggagtcttcaatccatcaggctttcctgcaatgcagcgcagctccagcttcagtctgccggcgcacagcagtcatctggagcccttcactcacggtttcccattccaggcattctccgagtgtccgcagacgccgcagacgctgtaccgttcacatgagcagatctgcccggcggaggccagctcccctgaatccaccccagagctccagcgccgcagcgggcagactggactcgcacgcagccgatcacagccctgcgtacacaaccatcagaagatcggcgtcaagcgcaggagaccggccgactcgcacaaacagaggccctcgctggacctgctcaagatgacacagaagctgcaggattttcacagtctcagctgtccaggattcagcggcgacgacaaaactctgccgtccagcagcccggcactcctcaacgacacatgcgagcgtgctcagaatgacagctcagcggatgcccccatccaccaatcagagagcagctcagaggacgccctcatccaccaatcagatagcagctcagcggacgccctcatccaccaatcagaaagcagcaggcccgcaggaaaggagcgcgaatgcttgtgggcggggctttgtagcagaaggggccgggacttattccagctgggcggagaactggatatcgagcagattgagaggaactgagaagcatttcttgttggattattatgggatgtacgcttcagtaagtgatgcaggacacatgtaatcgactcagggtgaagcacatggaggacgtgatccgagctccgtgtggcgcaagagaacacgcacacgtttagattagcagagccatttgacattataaaaaaaagagatacgactctgacgttcacacacacagacatacacacacgttaaagggcttcagatgtgtaaccgtagtaatatcaggtaattcagttcctcactggtgaaaacaaagctattagatctatttttgtctttttacattgaataactacagaagtaaatgtacttatttctctacaataaacagcattgtaatgtgtttgtaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//