LOCUS       NM_001006044            1661 bp    mRNA    linear   VRT 06-MAY-2023
DEFINITION  Danio rerio claudin 5b (cldn5b), mRNA.
ACCESSION   NM_001006044
VERSION     NM_001006044.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Paulissen E and Martin BL.
  TITLE     Myogenic regulatory factors Myod and Myf5 are required for dorsal
            aorta formation and angiogenic sprouting
  JOURNAL   Dev Biol 490, 134-143 (2022)
   PUBMED   35917935
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Gurung S, Restrepo NK, Chestnut B, Klimkaite L and Sumanas S.
  TITLE     Single-cell transcriptomic analysis of vascular endothelial cells
            in zebrafish embryos
  JOURNAL   Sci Rep 12 (1), 13065 (2022)
   PUBMED   35906287
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Mu X, Qi S, Wang H, Yuan L, Wang C, Li Y and Qiu J.
  TITLE     Bisphenol analogues induced metabolic effects through eliciting
            intestinal cell heterogeneous response
  JOURNAL   Environ Int 165, 107287 (2022)
   PUBMED   35598417
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Li Y, Wang C, Zhang L, Chen B, Mo Y and Zhang J.
  TITLE     Claudin-5a is essential for the functional formation of both
            zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier
  JOURNAL   Fluids Barriers CNS 19 (1), 40 (2022)
   PUBMED   35658877
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Tsaryk R, Yucel N, Leonard EV, Diaz N, Bondareva O,
            Odenthal-Schnittler M, Arany Z, Vaquerizas JM, Schnittler H and
            Siekmann AF.
  TITLE     Shear stress switches the association of endothelial enhancers from
            ETV/ETS to KLF transcription factor binding sites
  JOURNAL   Sci Rep 12 (1), 4795 (2022)
   PUBMED   35314737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Wang Y, Pan L, Moens CB and Appel B.
  TITLE     Notch3 establishes brain vascular integrity by regulating pericyte
            number
  JOURNAL   Development 141 (2), 307-317 (2014)
   PUBMED   24306108
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Gomez G, Lee JH, Veldman MB, Lu J, Xiao X and Lin S.
  TITLE     Identification of vascular and hematopoietic genes downstream of
            etsrp by deep sequencing in zebrafish
  JOURNAL   PLoS One 7 (3), e31658 (2012)
   PUBMED   22438865
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Xie J, Farage E, Sugimoto M and Anand-Apte B.
  TITLE     A novel transgenic zebrafish model for blood-brain and
            blood-retinal barrier development
  JOURNAL   BMC Dev Biol 10, 76 (2010)
   PUBMED   20653957
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Zhang J, Piontek J, Wolburg H, Piehl C, Liss M, Otten C, Christ A,
            Willnow TE, Blasig IE and Abdelilah-Seyfried S.
  TITLE     Establishment of a neuroepithelial barrier by Claudin5a is
            essential for zebrafish brain ventricular lumen expansion
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1425-1430 (2010)
   PUBMED   20080584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083368.1.
            
            On Sep 30, 2011 this sequence version replaced NM_001006044.1.
            
            Sequence Note: This RefSeq record was created from a transcript of
            a different strain than the reference genome strain because no
            single transcript from the reference strain was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC083368.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1661              BC083368.1         1-1661
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1661
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="claudin 5b"
                     /db_xref="GeneID:450023"
                     /db_xref="ZFIN:ZDB-GENE-041010-140"
     exon            1..1646
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    82..84
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="upstream in-frame stop codon"
     CDS             88..750
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /codon_start=1
                     /product="claudin-5b"
                     /protein_id="NP_001006044.2"
                     /db_xref="GeneID:450023"
                     /db_xref="ZFIN:ZDB-GENE-041010-140"
                     /translation="

MANMISACLEIVGLCLTVTGTLLVMVACGLPMWKVSAFIEGNIVVAQNIWDGLWMSCVVQSTGQMQCKMHDSVLALTTDLQTARALTVISAVLGVLALMITIAGAQCTNCINTESIKSKVVNAGGVMYIVAGLFVLIPLCWMANNIISDFYDPQVPYAKKREIGAALYIGWAASAMLLVGGAILCFSRPHDEKSTYPLKYIPPPTKGTSINGDYDKRNYV"

     misc_feature    139..639
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
ORIGIN      

agaaactcctcaagcacttcatctgagcgatgtagagacacttctgctgcttctgacagatttagactttggagaaaaaaataaacaatggcaaatatgatttctgcatgtctggagattgttggactctgcttgaccgtcaccgggactcttttggtgatggtagcctgtgggttgcccatgtggaaagtgtccgccttcattgaaggcaacattgtggtggcgcaaaacatctgggacgggctgtggatgtcctgtgttgttcaaagcacaggtcagatgcaatgcaaaatgcacgactctgtcctggcgctgaccactgacctccagacagctcgggctctgactgtcatctctgcggttttgggggtcctggctctcatgataaccatcgccggtgctcaatgcaccaattgcatcaacacggagtctatcaaatccaaagtggtcaacgccggaggcgtgatgtacatcgtcgcaggcttgtttgttctgattcctctgtgctggatggccaataacatcatctcagacttctacgatcctcaagttccctacgccaaaaagagagaaatcggagctgcgctgtacatcggatgggcagcatctgcaatgcttctggtcggaggagcgattctgtgtttctcccgtccacatgatgagaaatccacatatccacttaaatatatccctccgccgacaaaaggcacatcgatcaatggggactatgataaacgaaactacgtctgatcaagaggctaactatatggacttttgcaggtgcaaatggacttttaaaacgataatgctgatgatacaccgtggacctactttgggaaatgatcccataggcaactaggtgttactaattaggtgcaatgggatccagatacaatattgttgcctattcttaatggaaaagcaactttacaacattgcaaaatcactcaaaaagtcgccctgtgtatcatcagcataagggtagcttaccgataagcatgttttttatgttttgtacacatttgtactgatcttcaattcttttatatgactgtacagtgtaagaattatttttaaagtgcaaatgttgcaggtcatattgataaaaatgccattttttttacatgcaacaagtcttgtattgaactagtcaacatttaaagtggatcaagagtgacccaagacaagagtgggtattgttctgaagtttttcctagtttttttaatccaattcaaatgtactgtagattcatttcagtgaaacagcattgcatacttgcatttgaaagctatttaaaatgctctattaaccgaaggtcgcggtaataacgaattaaatgcacacgggtatttttggtcttcgttaatgatattagggtcagcgacccacttgtttgtgttcgatttttatcactgtggctcaaggggggtgaagggagggtccatatttcttgtttttgttctgctttactaattagacacggtctgtgcttcaacgagacactgaataatgtctattgttctgcctgtaaacgtgcaggcaggctggtttgatcatctaaacctcctgattgtacataattgtatgaaactttttagtaaatttgtgcatatacaaagtaataaataaaatgtttttttgttaaaaaaaaaaaaaaaaa

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