LOCUS       NM_001004618            1277 bp    mRNA    linear   VRT 09-DEC-2023
DEFINITION  Danio rerio nicotinamide riboside kinase 2 (nmrk2), transcript
            variant 2, mRNA.
ACCESSION   NM_001004618
VERSION     NM_001004618.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Horzmann KA, Lin LF, Taslakjian B, Yuan C and Freeman JL.
  TITLE     Anxiety-related behavior and associated brain transcriptome and
            epigenome alterations in adult female zebrafish exposed to atrazine
            during embryogenesis
  JOURNAL   Chemosphere 308 (Pt 3), 136431 (2022)
   PUBMED   36126741
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Sullivan C, Lage CR, Yoder JA, Postlethwait JH and Kim CH.
  TITLE     Evolutionary divergence of the vertebrate TNFAIP8 gene family:
            Applying the spotted gar orthology bridge to understand ohnolog
            loss in teleosts
  JOURNAL   PLoS One 12 (6), e0179517 (2017)
   PUBMED   28658311
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU013534.11.
            
            On May 25, 2016 this sequence version replaced NM_001004618.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081471.1, GW711368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168447, SAMEA3505370
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               CU013534.11        67466-67620         c
            156-246             CU013534.11        67302-67392         c
            247-412             CU013534.11        65629-65794         c
            413-484             CU013534.11        62576-62647         c
            485-591             CU013534.11        62389-62495         c
            592-677             CU013534.11        60878-60963         c
            678-1277            CU013534.11        59905-60504         c
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1277
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="nicotinamide riboside kinase 2"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
     exon            1..155
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            156..246
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    234..236
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="upstream in-frame stop codon"
     exon            247..412
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..677
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="isoform 2 is encoded by transcript variant 2;
                     integrin beta 1 binding protein 3"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 2 isoform 2"
                     /protein_id="NP_001004618.2"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
                     /translation="

MDAMVNTVKGWMENPVKFARSHGVSVSTTSDPDSDIHILIVEGFLLYNYKPLIDVYNKCFYVTIPYEECKRRRSTRTYTVPDPPGLFDGHVWPMYLKHRTEMENSSLDIQYLDGMSSKDELYNQLYEDIQNSLLNIL"

     misc_feature    <264..581
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="Nucleoside/nucleotide kinase (NK) is a protein
                     superfamily consisting of multiple families of enzymes
                     that share structural similarity and are functionally
                     related to the catalysis of the reversible phosphate group
                     transfer from nucleoside triphosphates...; Region: NK;
                     cl17190"
                     /db_xref="CDD:450170"
     exon            413..484
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            485..591
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            592..677
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1277
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aatgaaatagtaaaaagagggagattctgggagaaaggaaaggagagagaggctgaaagcattcccaaggaagcgattcctttgctagtgtcctatcgcgaagaccaagaacaaacaaagaggatcagaatgaagtttattattggaatagggggtgtgaccaatggaggaaagacaactttgactggaagactcataaagaacctaccaaactgttgtgtggttcatcaagatgattttttcaagtcattaccgccttagacatggacgccatggtgaacactgttaaaggatggatggagaacccggtgaagtttgcacgatcccatggcgtgagcgtttccaccacatctgaccctgatagtgacatccacatactcattgtggagggatttctgctttataactacaagcctttaattgacgtctataacaagtgcttctacgtcaccattccatatgaagagtgcaaaaggagaagaagtacgagaacgtacaccgttcctgacccacccggtctgtttgacggccatgtttggccaatgtacttgaaacacaggacagaaatggagaacagcagcttggatatccaatatctggacggcatgagctctaaggacgagctctataaccaactttatgaagacattcagaactctctgttgaacatcttatagcatctccaatcggattgaagatgtgtttgtgtatagaactgtaaataggatcttaagtagattcggcttctgccactggatgaactttgtaaatacgatgaagtactaacttatttgaaaacttgtggctagtgcctttgattttatattgctctgtgtaacttttgttttatttaaaatcacgcctcactctctgggctgatcagagatgtacagttttcatgtatactgtaattgaagaacttcaatcaaaacacacatttgaactctttatctgttgtgttttcattcttagcattgagacgtgcatgcatttaaaccatcttgtgcatgtttatggattatgatgaaggaatataataaaaatataaaataaataacacataactcaagaaataaatatgaatgtattgggcaagatataacatatatacattttaattaaaacatttcacagagtttaagtaaatactgtaaaattccagggcttttaatgtaaagattgttcatttacatgaaaatgcattagatattatgtatgcgctttcattctcagcattaaaacatgcatgttattttaaaaaacatgcaaatatttcc

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