LOCUS       NM_001004559            1873 bp    mRNA    linear   VRT 01-NOV-2020
DEFINITION  Danio rerio claudin 2 (cldn2), mRNA.
ACCESSION   NM_001004559 XM_685901
VERSION     NM_001004559.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   van den Bos R, Cromwijk S, Tschigg K, Althuizen J, Zethof J, Whelan
            R, Flik G and Schaaf M.
  TITLE     Early Life Glucocorticoid Exposure Modulates Immune Function in
            Zebrafish (Danio rerio) Larvae
  JOURNAL   Front Immunol 11, 727 (2020)
   PUBMED   32411141
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Hsu AY, Gurol T, Sobreira TJP, Zhang S, Moore N, Cai C, Zhang ZY
            and Deng Q.
  TITLE     Development and Characterization of an Endotoxemia Model in Zebra
            Fish
  JOURNAL   Front Immunol 9, 607 (2018)
   PUBMED   29651289
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Philip AM, Wang Y, Mauro A, El-Rass S, Marshall JC, Lee WL, Slutsky
            AS, dosSantos CC and Wen XY.
  TITLE     Development of a zebrafish sepsis model for high-throughput drug
            discovery
  JOURNAL   Mol Med 23, 134-148 (2017)
   PUBMED   28598490
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Shu Y, Lou Q, Dai Z, Dai X, He J, Hu W and Yin Z.
  TITLE     The basal function of teleost prolactin as a key regulator on ion
            uptake identified with zebrafish knockout models
  JOURNAL   Sci Rep 6, 18597 (2016)
   PUBMED   26726070
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   McKee R, Gerlach GF, Jou J, Cheng CN and Wingert RA.
  TITLE     Temporal and spatial expression of tight junction genes during
            zebrafish pronephros development
  JOURNAL   Gene Expr Patterns 16 (2), 104-113 (2014)
   PUBMED   25460834
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Baltzegar DA, Reading BJ, Brune ES and Borski RJ.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Kumai Y, Bahubeshi A, Steele S and Perry SF.
  TITLE     Strategies for maintaining Na(+) balance in zebrafish (Danio rerio)
            during prolonged exposure to acidic water
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 160 (1), 52-62 (2011)
   PUBMED   21600298
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX530030.12.
            
            On or before Aug 5, 2009 this sequence version replaced
            XM_685901.2, NM_001004559.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081634.1, EH492234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BX530030.12        58105-58254
            151-1873            BX530030.12        63011-64733
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..1873
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="claudin 2"
                     /db_xref="GeneID:562525"
                     /db_xref="ZFIN:ZDB-GENE-040912-26"
     exon            1..150
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    110..112
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="upstream in-frame stop codon"
     exon            151..1873
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1006
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /codon_start=1
                     /product="claudin-2"
                     /protein_id="NP_001004559.2"
                     /db_xref="GeneID:562525"
                     /db_xref="ZFIN:ZDB-GENE-040912-26"
                     /translation="

MAILALELMGFFFGLIGMLGTLVATLLPYWATSAHVGPNIVTAVVSMKGLWMECVYQSTGAFQCETYNTLLGLTVDLQAARAMMVMSSIFSVMACAVSTVGMQCTVCMDGSSVKTKVAGVGGSMFLLAGLLSLIPVAWKTHEVVQTFYMPNMPASLKFEIGDCLYVGLASSLLSMLGGGLLSASCCDDIDGNRGSRRHYPYPERNALRGPSHSMTYQPAALHSTTNPNITNKTQTLNSHTSSGTHSIQAQDSRKMTRQNTAAGYDVTGYV"

     misc_feature    206..694
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
ORIGIN      

cagaggtgcttgtgtgttcatggacggggcagatcctcatatctacagatcaacagagatggcaggatcacaaacagaaggactgtgggaaaacacaggcacatatgagtgaattaagagctgctggcaacacctcactgctgaacatagcaatccagcaaaacttcatcaaacacttcctccagcacacaacatggcgattctagcactggagttgatgggtttcttttttggcctcatcggcatgcttgggaccctggtagccactcttctcccctactgggcaacatctgcacacgttggccccaatattgtgaccgcagttgtcagcatgaagggtctttggatggagtgcgtttaccagagcactggcgccttccaatgcgagacttacaacaccctcctgggactaaccgtcgacctgcaagcggcccgggccatgatggtcatgtcctccatcttctccgtcatggcctgcgccgtttccaccgttggcatgcagtgcaccgtctgcatggacggatcttcagtcaagaccaaagtagctggagttggcggctccatgttcctcctggctgggcttttatcgttgattcccgtcgcctggaagacccacgaagtggtgcagaccttctacatgcccaacatgccagccagtcttaaatttgagattggcgattgtctgtatgtaggtttagcttcctctcttttgtccatgcttggtggcggactattgagtgcatcctgttgcgatgacatagatggaaacaggggatccagacggcattatccctatccagagcggaatgccttgcgtgggccgtcccattcaatgacctaccagccagccgctctacattcaaccacaaaccccaacattaccaataagacgcagactcttaatagtcacacaagctccggtacccactccattcaagcccaggattcaaggaaaatgactcggcaaaacactgcggctggctatgatgtcactggctatgtttgaagatttgtgtcggccagtgcagttgagttttacataaagtgattaatacttggattgctgaaaggctcagagaatgtagacgctggtagagcatgaggaagggtgtgtgtgtgtgaaggtctatgaggtgtgtttggcttcttttttgcataattgtcttttttaggagtttcaaaatgaaaacaaaatagcaaaatgatttaatgattgtatggattgaaggtggtttgtaaacacgcaagttaatattttagttgtcgtataagaagaaccgtgtcaattagccttcttaaagggatagttggcccaaaagagaaatttagcagctaatttaccctacctttaggtgtagtttttgttgattttgaaagaaatactgttcgtaaaaaaagcatggttctcgctgattcataaatggcaagtcgagttgcacttttagagtaaaaatatacttataggcaaagcaaaattaatacctgaggtactaaataaataagtagcctgtgctacctgttaatatctgatacagtaatgtctcgtgaagtgaaattatcagtctgtgcagcaaactgaacgttatttataccctagttttggctaaaaattttatttaacgtgctgctgaagaaaaatgtctcccactatattgtcctaaaggtgagtaaattaccggcaagagcgaactatccctttaagaacattttttatattcaaatgcttgttttttatgacatttaaatacattggttttatttgtttctaatagcagtcttcacttttcactgtttctaagcacctatatgcactcggttgagcacttaaggaacatattaaccttgtaaataaaattttgagttgtttactagt

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