LOCUS       NM_001002550            1927 bp    mRNA    linear   VRT 20-FEB-2022
DEFINITION  Danio rerio pirin (pir), mRNA.
ACCESSION   NM_001002550
VERSION     NM_001002550.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Huang Y, Yu SH, Zhen WX, Cheng T, Wang D, Lin JB, Wu YH, Wang YF,
            Chen Y, Shu LP, Wang Y, Sun XJ, Zhou Y, Yang F, Hsu CH and Xu PF.
  TITLE     Tanshinone I, a new EZH2 inhibitor restricts normal and malignant
            hematopoiesis through upregulation of MMP9 and ABCG2
  JOURNAL   Theranostics 11 (14), 6891-6904 (2021)
   PUBMED   34093860
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Postlethwait JH, Massaquoi MS, Farnsworth DR, Yan YL, Guillemin K
            and Miller AC.
  TITLE     The SARS-CoV-2 receptor and other key components of the
            Renin-Angiotensin-Aldosterone System related to COVID-19 are
            expressed in enterocytes in larval zebrafish
  JOURNAL   Biol Open 10 (3) (2021)
   PUBMED   33757938
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Postlethwait,J.H., Farnsworth,D.R. and Miller,A.C.
  TITLE     An intestinal cell type in zebrafish is the nexus for the
            SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System
            that contributes to COVID-19 comorbidities
  JOURNAL   bioRxiv (2020)
   PUBMED   32908984
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN510778.1, EH498285.1, EH585218.1, CR450831.4, EH602648.1 and
            EH524565.1.
            
            On Dec 5, 2015 this sequence version replaced NM_001002550.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076253.1, GFIL01030411.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               CN510778.1         1-753
            754-974             EH498285.1         600-820
            975-1028            EH585218.1         811-864
            1029-1029           CR450831.4         26070-26070
            1030-1222           EH602648.1         690-882             c
            1223-1324           EH524565.1         604-705             c
            1325-1336           EH602648.1         576-587             c
            1337-1360           EH524565.1         568-591             c
            1361-1361           CR450831.4         28473-28473
            1362-1458           EH524565.1         470-566             c
            1459-1460           CR450831.4         28571-28572
            1461-1927           EH524565.1         1-467               c
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="11"
                     /map="11"
     gene            1..1927
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /note="pirin"
                     /db_xref="GeneID:436823"
                     /db_xref="ZFIN:ZDB-GENE-040718-288"
     exon            1..446
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    345..347
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /note="upstream in-frame stop codon"
     CDS             354..1226
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /EC_number="1.13.11.24"
                     /codon_start=1
                     /product="pirin"
                     /protein_id="NP_001002550.2"
                     /db_xref="GeneID:436823"
                     /db_xref="ZFIN:ZDB-GENE-040718-288"
                     /translation="

MMIRKVSKVVLSVEQSEGVGARVRRSIGRRELKNLDPFLMLDEFCIAKPAGFPDHPHRGFETVTYLLSGVTAHEDSCGHSGKLEPGDLQWMTAGRGVIHAEMPVSDGRIYGLQLWVNLKSTDKMVEPQYQELKSKEIPKPSKDGVTVTVISGEALGVKSKIYTRTPTMYLDFLLKKDAKHMQPVPKGWTAFIYTLAGSLCTGPDNDLRTIEPHHTVVLEGGDCVRMENKAAEDSHFVLIAGEPINEPVVQHGPFVMNTQEEIDKTISDYRSATNGFERAKVWRSKIGQQF"

     misc_feature    354..1163
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /note="Redox-sensitive bicupin YhaK, pirin superfamily
                     [General function prediction only]; Region: YhaK; COG1741"
                     /db_xref="CDD:224655"
     exon            447..539
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            540..620
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            621..827
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            828..912
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            913..957
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1040
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1107
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1916
                     /gene="pir"
                     /gene_synonym="zgc:92778"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agttttcttaaaaggctctcattttcttagcctcacatgtcatatgtaaatgcacagtcactcttttgtggctcacaatattgcatagtcattgtgacatgcactgcgcctttaaataatccgaatctgaagagatgtcatctgcaaaggaagtaagccatgacaaacccaaaacgtcaacacagtataaaaacacacctgtcgtagcatgaactactgtatatacaacagcgaataatagtgtagtgggcatttgtgtataaataagcgtcttgatcagtctgggtgtattggtggcgctcacaaactgagagctagctattgtgatagggagatatatacagtaggtgtttatgatgatcagaaaagtttctaaggtggttttgagcgtcgaacagtccgaaggagtcggggctcgagttcgcaggagtattggacggagagagctaaaaaatctagacccgttcttgatgttagatgaattctgcatcgccaaaccagctggctttcctgatcatcctcaccgtggatttgagacggtaacatacttgttgagtggagtaacggcccatgaagactcctgtggtcacagcgggaagctggaacctggagaccttcagtggatgactgcaggtcgtggggtgattcatgctgagatgcctgtgtcggatggacgcatttatggtcttcagctttgggtaaatctgaaaagcacagataagatggtggagcctcagtaccaggagctaaagagcaaggagattcctaaacctagcaaagatggagtcactgtgaccgtcatctctggtgaagctcttggagtaaagtcaaagatttacacgaggactccaaccatgtatcttgactttttgctgaagaaagatgcaaaacacatgcagcctgttccaaaaggttggacagctttcatctacaccctcgcaggttctttatgcactggcccagacaatgatttgcggacaatagagccacaccacacggtggttttggaaggtggtgactgcgtcagaatggaaaacaaggctgctgaggactctcactttgtgttaattgctggcgaacccattaatgagcctgtagttcagcatgggccctttgtcatgaacacacaagaagagattgacaagaccatctcagactacagatcagccactaatggatttgagagagcaaaagtctggcgatcaaagattggtcaacagttttaaagtgtcttcaagatccttctctgagggaatatatctactttggtgcctttaccttcagcttcagcagctccgaacatacattaggccagggatcactaaacttgttcctggtggtctggtgtcctggagattttagctccaaccctaatcaaacacacctgaacaagcgaatcaaggtcttactaggtatacttgaaacacccaggcaggtgtgtcgaggcaagttggagctaaaccctgcagggcaccagacctccaggaacgagattggtgacccctgcattaggatatttaaattgtacaactgacatttattttaaagcaagatagtatgtactgaaattttaaataaagtattagtcgtctttctagtatgtttattaatagatattgtgctcaaggacactttcatacatcagcttaaatcatctcagggctcagtgggtaaagtcaattgaatttgttgatgactgcatataatacaatgacactgatatattttatgtgtaacttaagggtccaaaatatgctttatatgtggaatgttactcaaaatattgctgaccattacataggccatttattctgatgtattgcttaaaatgtgtgtgactttcctatgtactatttctgtttttggtttgtactatgtctctgtatctgatcacaacatgattttcttacctaaaaaaaaaaaaaaa

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