LOCUS       NM_001002518            1114 bp    mRNA    linear   VRT 08-OCT-2023
DEFINITION  Danio rerio mitochondrial ribosomal protein L46 (mrpl46), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001002518
VERSION     NM_001002518.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1114)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1114)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076280.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076280.1, EH546969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1114
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..1114
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /note="mitochondrial ribosomal protein L46"
                     /db_xref="GeneID:436791"
                     /db_xref="ZFIN:ZDB-GENE-040718-224"
     exon            1..271
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    14..16
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /note="upstream in-frame stop codon"
     CDS             32..892
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /codon_start=1
                     /product="39S ribosomal protein L46, mitochondrial"
                     /protein_id="NP_001002518.1"
                     /db_xref="GeneID:436791"
                     /db_xref="ZFIN:ZDB-GENE-040718-224"
                     /translation="

MAAPFARVCQPLWRKITTAILSKGVRNVSSTRQQWAKLNVKTAGAASPWALHGAVCLQRLPVVSQDRSPIEEDFMELMRQIEFEKSLLADHEVKVLEDTARMSRKQDEDYDSDEEDDYRNKKIVTAQDLEDVWEQNLKQFQPAPRLQGDGETDMSSLERCLADSLVLLVQKDVGSQKIWLLPQIEWQTGETLRQTAERALASLPGADLKATFLGNAPCGFYKYKYPKDVQKEGLVGAKVFFFKAVMSSQKHLPLEKNTFAWVKKDELQEFLKPEYLKQVRRFIMTL"

     misc_feature    176..508
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /note="39S mitochondrial ribosomal protein L46; Region:
                     MRP-L46; pfam11788"
                     /db_xref="CDD:432074"
     misc_feature    485..877
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /note="Mitochondrial ribosomal protein L46 (MRP L46) is a
                     component of the large subunit (39S) of the mammalian
                     mitochondrial ribosome and a member of the Nudix hydrolase
                     superfamily. MRPs are thought to be involved in the
                     maintenance of the mitochondrial DNA; Region: MRP_L46;
                     cd04661"
                     /db_xref="CDD:240019"
     misc_feature    581..649
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /note="modified nudix motif [active]"
                     /db_xref="CDD:240019"
     exon            272..473
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /inference="alignment:Splign:2.1.0"
     exon            474..644
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1096
                     /gene="mrpl46"
                     /gene_synonym="fk88g07; wu:fk88g07; zgc:92810"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcaatgcactgcgtgagcacgtgtgggcaacatggctgcgcccttcgctagagtttgtcaacctttatggaggaaaataactacagctatattaagcaaaggggtgagaaatgtatcgtccactaggcaacagtgggcaaagcttaatgttaaaactgcgggagctgcatctccgtgggcgctgcatggagctgtgtgtctgcagagactgcctgtagtctctcaggacaggagccccatagaggaggacttcatggagctgatgcgtcagatcgagtttgagaaaagtctgctagcggaccatgaggtgaaggtcctggaagatactgctcgaatgagccggaaacaagatgaagattacgattcggatgaggaggacgattacagaaacaaaaagattgttacagcgcaggatctggaggatgtttgggaacagaatctgaagcagtttcaaccagctccgagattacaaggtgacggtgagacagacatgagctccttagagcgttgtttagcagatagtctcgtcctgctggtacagaaggatgttggcagtcaaaagatttggcttctgcctcagattgagtggcagacgggagaaacacttcgacagacggccgaacgtgcccttgcgagtcttccaggtgctgatctgaaggccactttccttggcaatgcaccttgtggattttacaagtataaatacccaaaagacgttcagaaagagggcctcgtcggagccaaggttttcttcttcaaagctgtgatgtccagccagaagcacttgcccctagagaagaatacatttgcctgggtgaaaaaagatgaactccaggagtttttgaagccagagtacctaaaacaagtcaggcgcttcattatgactttgtaatattgcgggggaaaaggacaaaataaagaatatgttggtggaaaatgcctacttttggatcagaggatgacaacaaatagtataaatgatgttcagatgtcttttataacaattcggtgtgtttattaataatgctcttatctgtttttgcccgacacttaagttgcaatttgtcatgtaaatgtattaaaattaataatgtttaaaaaaaaaaaaaaaaaa

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