LOCUS       NM_001002475            2045 bp    mRNA    linear   VRT 20-FEB-2022
DEFINITION  Danio rerio NK6 homeobox 1 (nkx6.1), mRNA.
ACCESSION   NM_001002475
VERSION     NM_001002475.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JC, Miller AL
            and Ma RC.
  TITLE     Investigating the role of dachshund b in the development of the
            pancreatic islet in zebrafish
  JOURNAL   J Diabetes Investig 12 (5), 710-727 (2021)
   PUBMED   33449448
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Tschaikner PM, Regele D, Rock R, Salvenmoser W, Meyer D, Bouvier M,
            Geley S, Stefan E and Aanstad P.
  TITLE     Feedback control of the Gpr161-Galphas-PKA axis contributes to
            basal Hedgehog repression in zebrafish
  JOURNAL   Development 148 (4) (2021)
   PUBMED   33531430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Mi P, Gao Q, Feng ZY, Zhang JW, Zhao X, Chen DY and Feng XZ.
  TITLE     Melatonin attenuates 17beta-trenbolone induced insomnia-like
            phenotype and movement deficiency in zebrafish
  JOURNAL   Chemosphere 253, 126762 (2020)
   PUBMED   32302915
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Ma P, Song NN, Cheng X, Zhu L, Zhang Q, Zhang LL, Yang X, Wang H,
            Kong Q, Shi D, Ding YQ and Mao B.
  TITLE     ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through
            modulating Shh/Gli signaling
  JOURNAL   J Mol Cell Biol 12 (5), 337-344 (2020)
   PUBMED   31336385
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Arribat Y, Mysiak KS, Lescouzeres L, Boizot A, Ruiz M, Rossel M and
            Bomont P.
  TITLE     Sonic Hedgehog repression underlies gigaxonin mutation-induced
            motor deficits in giant axonal neuropathy
  JOURNAL   J Clin Invest 129 (12), 5312-5326 (2019)
   PUBMED   31503551
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Hutchinson SA, Cheesman SE, Hale LA, Boone JQ and Eisen JS.
  TITLE     Nkx6 proteins specify one zebrafish primary motoneuron subtype by
            regulating late islet1 expression
  JOURNAL   Development 134 (9), 1671-1677 (2007)
   PUBMED   17376808
  REMARK    GeneRIF: Study shows that zebrafish primary motoneurons express two
            related transcription factors Nkx6.1 and Nkx6.2; in their absence,
            the CaP motoneuron subtype develops normally, whereas the MiP
            motoneuron subtype develops a interneuron-like morphology.
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Guner B and Karlstrom RO.
  TITLE     Cloning of zebrafish nkx6.2 and a comprehensive analysis of the
            conserved transcriptional response to Hedgehog/Gli signaling in the
            zebrafish neural tube
  JOURNAL   Gene Expr Patterns 7 (5), 596-605 (2007)
   PUBMED   17307034
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Kimura Y, Okamura Y and Higashijima S.
  TITLE     alx, a zebrafish homolog of Chx10, marks ipsilateral descending
            excitatory interneurons that participate in the regulation of
            spinal locomotor circuits
  JOURNAL   J Neurosci 26 (21), 5684-5697 (2006)
   PUBMED   16723525
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Cheesman SE and Eisen JS.
  TITLE     gsh1 demarcates hypothalamus and intermediate spinal cord in
            zebrafish
  JOURNAL   Gene Expr Patterns 5 (1), 107-112 (2004)
   PUBMED   15533825
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Cheesman SE, Layden MJ, Von Ohlen T, Doe CQ and Eisen JS.
  TITLE     Zebrafish and fly Nkx6 proteins have similar CNS expression
            patterns and regulate motoneuron formation
  JOURNAL   Development 131 (21), 5221-5232 (2004)
   PUBMED   15456722
  REMARK    GeneRIF: In zebrafish, Nkx6.1 is expressed in early-born primary
            and later-born secondary motoneurons
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076337.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076337.1, BC164096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168448, SAMEA3505370
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..2045
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="NK6 homeobox 1"
                     /db_xref="GeneID:436748"
                     /db_xref="ZFIN:ZDB-GENE-040718-178"
     misc_feature    255..257
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="upstream in-frame stop codon"
     CDS             345..1283
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="NK6 transcription factor related, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.1"
                     /protein_id="NP_001002475.1"
                     /db_xref="GeneID:436748"
                     /db_xref="ZFIN:ZDB-GENE-040718-178"
                     /translation="

MLAVGQMDGSRQSAFLLNTPPLAALHSMTEMKTPLYPAYPLSSTGPASSTSPTATSPNPGGIPVSSPGIKTSSGLSALASAQQCAIATPHGINDILSRPSVACSPAGILSGLPRFSSLSPPPPPGLYFSPSAAAVAVARYPKPLTELPGRTPIFWPGVMQSPHWRDARFACSPHQNSVLLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETERLKGASENEDDDDDYNKPLDPNSDDEKITQLLKKHKPNSALIIHTSENESS"

     misc_feature    order(903..917,921..923,972..974,990..992,1029..1031,
                     1035..1040,1047..1052,1056..1064,1068..1073)
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    909..1070
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(909..911,918..920,1038..1040,1047..1052,1059..1061)
                     /gene="nkx6.1"
                     /gene_synonym="zgc:92879"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
ORIGIN      

aattatctcccagatcttcatgtgaactacccagaaagactctctttttatttatagatttcaaaaacactctcttttgaaaggacgacgctctgttgtatcatgcaagatctaaaagaacagaatggatattggccagaggagatgagtatgaagctccagtacaactgattgggatttttttagagaaattactttttttggctccatatcgcaaggtgtcttttgtttatttttcgtttctcctcttcatttagtattctgcgtttgttttcacgttttcccgggtcactgtccttcttcttgcgcgatatttagttaaagttgtagtttgtgtcttggttatgttagcggtggggcaaatggacgggtctcgccaaagcgctttcctactcaataccccacctttagctgctttacacagtatgaccgagatgaagacgccgctttacccagcctacccgttatcttccactggaccagcatcctccacttcaccgacagctacctctccgaatccaggtgggatcccggtctcgtccccggggatcaaaacctccagtggactttcagctctcgcatcagcccagcagtgcgcgatcgccacacctcacggaataaacgacatcctcagccgaccctcggtggcttgttcccccgcaggaatcttgtctggactgccccgtttcagcagcctgagtcccccaccgcctccagggctttatttcagccctagtgccgcggctgtagcggtggctcgctatcccaaacccctgacagagcttcccggcagaaccccgatattctggcctggagttatgcaaagcccacactggagagatgccagatttgcgtgctcaccacatcaaaactcagttctgctcgacaaagatgggaaaaggaaacacacgcgaccgacgttttccgggcagcaaatttttgcactggaaaaaacatttgagcaaacgaaatatttagccggccctgaaagagcccgactagcctactctttaggaatgacagagagtcaagtcaaggtgtggtttcaaaaccgaagaacaaaatggagaaaacggcacgcggctgaaatggcctcggcgaagaaaaaacaagattcagaaaccgagaggctgaaaggagcttcggaaaatgaagacgacgacgacgactacaataaacctttagacccaaactcggacgatgaaaaaattacacagttactgaaaaaacacaaaccgaactcagctcttatcattcacacgtcggaaaacgagagctcgtaaaaaggaaacgggaaatgggttgtcagattcttcaagaagtgtcaaaattaatataggctacttttcccccaccaagtttgagctctggtttgagaggaaggatgcagatcagaggaatatgcactattggtggaactgaacgtgcatcagtgtctgctatagacacgtttcaacataaagacaacggtacttttttgtaaattaacagcgtgagttgtatcgcataggaattatattactgtgaatatttatgtgtaaaatattttgaatagtaaacatgacagaattcgttcacttcgcttcagtttaatttttggttaaggctttgtgatttgcatttttttcatatcattaatttgtgtaggtgcttatcaccacgagttattttattttttctctgagtgtaagttccctcaaccatttgatctttaaaaataaacaacaatagaaatatataacacctttcagaatttaccacactaatggcaaaagacatatgagcgacagctcaaattgaggctcagtcaaaagatttatctggctttgccaagtgtaaatacaaacacctaaccgtatatttgtaatataatgcatagtgttcgtctcccaatgttaggatgtttcttttattttcccccatgattaatttatgatattttaagtttgtaacggtgttttggatcctgcaaaatgcgccatgcaggttcgtgtgtattgcacttttatttaataaaatgttaaacgtaaaaaaaaaaaaaaaaa

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