LOCUS       NM_001002194            1253 bp    mRNA    linear   VRT 20-DEC-2022
DEFINITION  Danio rerio centrosomal protein 41 (cep41), mRNA.
ACCESSION   NM_001002194
VERSION     NM_001002194.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Ki SM, Kim JH, Won SY, Oh SJ, Lee IY, Bae YK, Chung KW, Choi BO,
            Park B, Choi EJ and Lee JE.
  TITLE     CEP41-mediated ciliary tubulin glutamylation drives angiogenesis
            through AURKA-dependent deciliation
  JOURNAL   EMBO Rep 21 (2), e48290 (2020)
   PUBMED   31885126
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Patowary A, Won SY, Oh SJ, Nesbitt RR, Archer M, Nickerson D,
            Raskind WH, Bernier R, Lee JE and Brkanac Z.
  TITLE     Family-based exome sequencing and case-control analysis implicate
            CEP41 as an ASD gene
  JOURNAL   Transl Psychiatry 9 (1), 4 (2019)
   PUBMED   30664616
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, Marsh SE, Olvera
            J, Brancati F, Iannicelli M, Ikegami K, Schlossman AM, Merriman B,
            Attie-Bitach T, Logan CV, Glass IA, Cluckey A, Louie CM, Lee JH,
            Raynes HR, Rapin I, Castroviejo IP, Setou M, Barbot C, Boltshauser
            E, Nelson SF, Hildebrandt F, Johnson CA, Doherty DA, Valente EM and
            Gleeson JG.
  TITLE     CEP41 is mutated in Joubert syndrome and is required for tubulin
            glutamylation at the cilium
  JOURNAL   Nat Genet 44 (2), 193-199 (2012)
   PUBMED   22246503
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072712.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="25"
                     /map="25"
     gene            1..1253
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="centrosomal protein 41"
                     /db_xref="GeneID:431741"
                     /db_xref="ZFIN:ZDB-GENE-040704-35"
     exon            1..72
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    13..15
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="upstream in-frame stop codon"
     CDS             40..1164
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="testis specific, 14; testis-specific gene A14
                     protein"
                     /codon_start=1
                     /product="centrosomal protein of 41 kDa"
                     /protein_id="NP_001002194.1"
                     /db_xref="GeneID:431741"
                     /db_xref="ZFIN:ZDB-GENE-040704-35"
                     /translation="

MSVKRGIGDSAFLKKKIPQNPKYQHVKTRLDTGSSLTKYMERLEEARKNYRYRKDELFKRLKVTTFAQLVIQVASVSDQNDNIKDEMAGLEDDVSIFSASPGLDCLSDQTNGSPQPNLPPPQTINIDESGDNGFSPRSTLQSVISGVGELDLDKNGQKTIRLSPVSTSNTTECPYPDCPYLLLDVRDRELYDQCHIVSAYSYPIATLSRTMNPYTKEVLDYKNASGKIIIVYDEDERIASQAATTMCERGFENLFMLSGGLKVVAQKFPEGMTTGSVPISCLPSPTGPAGRKRSAQHQTSQLAEKKWRFTAEDLDKIQHYLEEVFIPSETSSRLSSRMSTSSARSKASTVGSSRQGSSIAGSESARSRSSRPWK"

     misc_feature    568..825
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="Rhodanese-like domain; Region: Rhodanese;
                     pfam00581"
                     /db_xref="CDD:425764"
     misc_feature    736..738
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="active site residue [active]"
                     /db_xref="CDD:238089"
     misc_feature    874..942
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GQN0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1024..1161
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6GQN0.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            73..136
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            137..184
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            185..246
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            247..313
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            314..464
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            465..634
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            635..702
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            703..817
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1033
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1229
                     /gene="cep41"
                     /gene_synonym="tsga14; zgc:91859"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggtagctaacattagccgccgaagctctgctgctggaagatgtcggtgaagagggggattggcgattcagcgtttttaaagaagaagattcctcagaacccaaaatatcagcatgtaaaaacaaggcttgatacaggctccagcctgacaaaatacatggagagactagaggaggcaagaaaaaactacagatataggaaggacgagttgtttaagagactgaaagtgaccacatttgcacagctggtaatccaagttgcttcggtatcagatcagaatgacaacattaaagatgaaatggcgggattagaagatgatgtttcgatattctctgcatcaccgggcctcgactgtctctccgatcagactaatggctccccacaaccaaaccttcctcctccacagaccatcaacattgacgaatccggcgacaatggcttttctcccagatctacacttcaaagtgtcatcagtggcgtgggagaattagatctggacaagaacggacagaagaccatccggctgtctccggtttctacctccaacaccacagagtgtccctatcccgactgcccatatctgttgctggatgtgcgggacagagagctgtatgaccagtgccatattgtcagtgcgtatagctaccctattgcaaccttatcaaggacgatgaacccgtacacaaaagaagtgcttgactacaaaaatgcatctggaaagatcatcatcgtgtatgacgaggatgagaggatagcaagtcaagcagccactaccatgtgtgaaagaggcttcgagaatcttttcatgctgtcgggggggttaaaagtggttgctcagaagtttccagaaggaatgacgaccggctcagttcccatctcctgtttgccatcaccaacaggccctgcaggacgcaagcgatcagcacagcaccagacatcacagttggcagagaaaaagtggcggttcacagcagaagatcttgacaaaatccagcattaccttgaggaggtgttcatacccagtgaaaccagcagtcgcctcagcagcagaatgtccactagcagcgctcgctccaaagcgtctacagtcggtagcagtcgacaaggttcatccatagcaggatcagaaagtgctcgttcaagaagtagtcgaccctggaaataaccctcgctttcacctggtcacagcttcacttcaatgcataaataaatccatgctgttttactttaaaaaaaaaaaaaaaaaaaaaaaaa

//