LOCUS       NM_001078476            3171 bp    mRNA    linear   INV 04-MAY-2019
DEFINITION  Ciona intestinalis Smad4 protein (smad4), mRNA.
ACCESSION   NM_001078476
VERSION     NM_001078476.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 3171)
  AUTHORS   Imai KS, Hino K, Yagi K, Satoh N and Satou Y.
  TITLE     Gene expression profiles of transcription factors and signaling
            molecules in the ascidian embryo: towards a comprehensive
            understanding of gene networks
  JOURNAL   Development 131 (16), 4047-4058 (2004)
   PUBMED   15269171
REFERENCE   2  (bases 1 to 3171)
  AUTHORS   Satou Y and Satoh N.
  TITLE     Genomewide surveys of developmentally relevant genes in Ciona
            intestinalis
  JOURNAL   Dev. Genes Evol. 213 (5-6), 211-212 (2003)
   PUBMED   12736827
REFERENCE   3  (bases 1 to 3171)
  AUTHORS   Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A,
            Hamaguchi M, Awazu S, Yagi K, Sasakura Y, Nakayama A, Ishikawa H,
            Inaba K and Satoh N.
  TITLE     A cDNA resource from the basal chordate Ciona intestinalis
  JOURNAL   Genesis 33 (4), 153-154 (2002)
   PUBMED   12203911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB210688.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB210688.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00013799, SAMD00028078
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3171
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="6"
                     /map="6"
     gene            1..3171
                     /gene="smad4"
                     /note="Smad4 protein"
                     /db_xref="GeneID:778905"
     misc_feature    25..27
                     /gene="smad4"
                     /note="upstream in-frame stop codon"
     CDS             58..1641
                     /gene="smad4"
                     /codon_start=1
                     /product="Smad4 protein"
                     /protein_id="NP_001071944.1"
                     /db_xref="GeneID:778905"
                     /translation="

MQNPTTSNDACLSIVHSLMCHRQGGESESFAKRAIESLVKKLKEKKDELESLITAITTSGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHLKVCKFAFDLKCDSVCINPYHYDRVVSPGIDLSGLTLQHTPAAAPLVSNDYQDLKITDVQGNWMNQGKAEAMPLGPVQHQASEEYTSTSKAGTSNGISNGPVSGTMQYTPGASSFSTPSSSAPVNPNQAIGSASQQLIQYSQRNQHMSWQAGSTAKYTPEMSTPMTAPYYSPNDVPYLPVSTHPGPEFWCSITAYEMDVQVGETFKVPSSCPAVTVDGYVDPSGGNRFCLGQLSNVHRTEASEKARLHIGKGVQLVCHGEGDVWVKCLSDHAVFVQSYYLDREAGRSPGDAVHKIYPNAYIKVFDLRQCHRQMQQQANTASAAANAQAAAVSGNIPGPGSVGGIAPAIGLPGLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQDIKQTPCWIEIQLHRALQLLDEVLHTMPIGEPHSHD"

     misc_feature    82..456
                     /gene="smad4"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD4;
                     Region: MH1_SMAD_4; cd10492"
                     /db_xref="CDD:199816"
     misc_feature    order(154..156,166..168,175..177,271..276,283..297,
                     304..306,358..363)
                     /gene="smad4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199816"
     misc_feature    order(253..255,385..387,421..423,436..438)
                     /gene="smad4"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:199816"
     misc_feature    931..1605
                     /gene="smad4"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD4;
                     Region: MH2_SMAD_4; cd10498"
                     /db_xref="CDD:199823"
     misc_feature    order(958..960,967..969,982..987,1030..1044,1054..1056,
                     1066..1077,1081..1089,1102..1104,1114..1119,1123..1125,
                     1441..1449,1459..1461,1468..1470,1537..1539,1558..1560,
                     1564..1566,1570..1572,1579..1581,1588..1593,1603..1605)
                     /gene="smad4"
                     /note="trimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:199823"
ORIGIN      

atttgactgtgtgtggttttagaataaactgcctggatatccagaccagcaaatacaatgcagaaccctacgacgtcaaatgatgcgtgtttaagcattgtacatagtcttatgtgccaccgacaaggtggggagagtgaatcttttgcgaagcgagcaatcgaaagtttggtgaaaaaattaaaagagaaaaaagacgaattagaaagtttaataaccgccattacaactagtggtgcccacccttctaaatgtgtcactatacaaagaaccctggatggaaggctgcaggtagccggtcgcaaaggtttcccccatgttatatatgcccgtttatggcgatggccagatcttcacaaaaacgagcttaaacacctaaaagtctgcaaattcgcgtttgatttgaaatgcgactcggtgtgtattaacccctaccactatgatagagtggtctcgccaggaattgatttatctggactcactttacagcatacacctgctgcagctcccttggtatccaacgattaccaagatttaaagataactgacgtgcaagggaactggatgaaccaaggcaaggctgaagctatgccattgggacctgtacaacatcaagcctcagaagaatacactagtacctctaaagcaggtacctcgaatggcattagcaatggccctgtctctggtacgatgcaatatactcctggagcttccagtttttctacacctagctcaagcgcgccagtgaaccctaatcaagctattggcagtgcctcgcaacagcttatacaatacagtcagagaaatcaacacatgagttggcaagctggcagcactgcgaaatacacaccagaaatgagcacgcccatgactgcaccttattattcaccaaatgatgttccttacctaccagtatccacacatccaggccccgagttctggtgttcaatcactgcatatgagatggacgtccaagttggtgagacatttaaagttccatcttcgtgtccagctgttactgtggatggttatgttgacccttctggtggcaacagattttgtcttggtcagctatcaaacgtacatagaactgaagcatcagaaaaagcaaggttacacatcggcaaaggtgtccagctagtgtgccatggagagggggacgtttgggtgaagtgtttaagtgatcatgcagtatttgtacaaagctactaccttgatagggaagcaggcaggtcaccaggggatgcagttcataaaatctacccaaatgcttatataaaggtttttgatttgcggcagtgccatagacagatgcagcaacaagctaacacagcttcagcagcagcaaacgcacaagctgctgctgtatcagggaatatacctggacctggttctgtaggtggaatagcccctgctataggtctgccaggtttatcagcagccgcaggcataggagtggatgatctccgtagactttgtattcttagaatgagttttgtaaaaggctgggggcctgactaccctcgacaagatataaaacaaacgccttgttggatagaaatacaactgcatagagccctccaattacttgatgaagttttacacacaatgccaataggggaacctcattctcatgactgatgatatacagctaagtgtaaacatatatagatcattgccttcaaaatatgtatgttagtaacaacataacaataccaaactgttcctcattttgtccaagtgaaaatcttgtttcaattattggttgagtgttttatatgaattttttttgaatatttaataacttttcaagtttctatgctgtaacaatttgggttatatcacattataaactgtatttgcaaaagcctatttttttaggtatgaatttttatttaaaaagggttagttgaattttaaccaaaaaaaaacagttaacatctcttttttgtcacaactcacaagagcctttttctttttgatcatgtgacttctcttctattttgttcagtgttttgcactactaattgaatgtggtctctcttattttttaacttttttcgttaatgagtacaacttaatacaactacactctttcatttctgtatctgaatacccatttttccatgtcggaccaaccacttgaactgtataagcatgtaacattaaattagtattttactactaatacactattagcataggcgtcgcacttttgaatttttaacaaaacaggggttgacatttttttccaaatgcagttgggttcatagcgaaaaacatagggaacttcattgattaatgtgtcaaatgcaatatactttgtctatgtttgtttgtatagacacataacagcaaggtaaaatgtatattaaaatataaaaaaatgggttataaaacacattatattacatctgttttaaaacttggagtgacatgccaccccaggcacccctaaagtggcgtctatgactactagtagcaaatcacctttagcctaaactgaacaaatacatttttgagtaaaaatcgttacttttaattatctgtcctaaaattgtaatatgtttggctatgggttgttatttgcctttcatacagcattatattagcatatgatgtgtatttaaatcgtgtgccatcattttatgaactataacgttaccattgccactacagcatgccaattacgttacatactatagtaccagtgcggaactttgttttattgtacataccgtatttaccgcttgcagtatgctaccccatgagtttactttttcttttttccttatatctctcttttaagaagataaaaatggaaaaagccaaaaatcgctctttaaacatgtggctttctacccaatgagtttactttttttcttttttcctaacctctcttttaagaagagaaatggaaaaaaagcatatcaccttttgaacttggggtcccaatatttttactccagtattaaacgcactgccttgtaactcaaaactaatttgaccccagtttttgccagttctttttcaatacaaatgcggttgtgtatttcagtcttgttaaacattcactatgtattttgaaagtcggaccttatattttatgcacgcatgaaattctcgttttgaaaattaaaccccactctgaacaaaaaaaaaaaaaaaaaa

//