LOCUS       NM_001032661            1914 bp    mRNA    linear   INV 04-MAY-2019
DEFINITION  Ciona intestinalis aldo-keto reductase 1a (akr1a), mRNA.
ACCESSION   NM_001032661
VERSION     NM_001032661.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 1914)
  AUTHORS   Tokuoka M, Imai KS, Satou Y and Satoh N.
  TITLE     Three distinct lineages of mesenchymal cells in Ciona intestinalis
            embryos demonstrated by specific gene expression
  JOURNAL   Dev. Biol. 274 (1), 211-224 (2004)
   PUBMED   15355799
REFERENCE   2  (bases 1 to 1914)
  AUTHORS   Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A,
            Hamaguchi M, Awazu S, Yagi K, Sasakura Y, Nakayama A, Ishikawa H,
            Inaba K and Satoh N.
  TITLE     A cDNA resource from the basal chordate Ciona intestinalis
  JOURNAL   Genesis 33 (4), 153-154 (2002)
   PUBMED   12203911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB178231.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB178231.1, AK113086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06445495, SAMN06445655
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1914
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="1"
                     /map="1"
     gene            1..1914
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /note="aldo-keto reductase 1a"
                     /db_xref="GeneID:494429"
     exon            1..1078
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /note="upstream in-frame stop codon"
     CDS             20..1774
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /codon_start=1
                     /product="aldo-keto reductase 1a precursor"
                     /protein_id="NP_001027833.1"
                     /db_xref="GeneID:494429"
                     /translation="

MKFVVICLVVVALCCTTAEGDNDDVTILPYEVSAEDLIANFIIPKRPLIVKDACKNWPLYKMLHNSKKLEAIKDVKLNTSMVHHSNYAPLESTFGDFVKVDLHGTSFIYDVLNGDPAISKSLKMPWMISSCSDLQEEFKTHGDIVLTGSKTKRKSSAALDCTNANTITAILSGRSTVRKMGKKHLYELVRGDMLFTPKGVCLNVMNVGTFVSASFSWTLESDELPVMAKKCARPSLRSVVDETWVWQDGNKKYISEIPDVKLNSGYMMPPIGLGTARLFSKTYETVKTALKLGYRMLDTAQIYTGEDKINNFKVSSEEEIGRAIADSDVPRSELFIVTKLAPESMEKENAIAKVEESLKKLRTDYIDLLLIHDFYMSTACGPDDTDLPECKNNPFLAWKTMEEMQAKGLVRSIGVSNIYIEDLQYLVKMAKTPISAVQNWFDPLHQEREIRALCAKNNIRFMGYSALGFTWIDKEQGLGRDVNPVLTNQNIVAIGNNHDLPTTLVVLRWAMEMNVTVMPCTTNVDHLEQNLNSRLFPLDNKSFPLIDQLDNLLGDPFQDEELPEEEPQKEEKPETAEMPSKDEL"

     sig_peptide     20..79
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    821..1660
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /note="AKR1/2/3/4/5 family of aldo-keto reductase (AKR)
                     and similar proteins; Region: AKR_AKR1-5-like; cd19071"
                     /db_xref="CDD:381297"
     misc_feature    order(839..847,911..913,926..928,1034..1036,1133..1135,
                     1160..1162,1265..1270,1331..1333,1409..1429,1526..1528,
                     1571..1582,1595..1597,1604..1609)
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /note="active site"
                     /db_xref="CDD:381297"
     misc_feature    order(911..913,926..928,1034..1036,1133..1135)
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381297"
     exon            1079..1413
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1895
                     /gene="akr1a"
                     /gene_synonym="Ci-AKR1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggcgataaaattcaaatatgaagtttgtggttatttgcctggtcgttgtggccctgtgctgcacgaccgctgaaggagacaatgatgacgtaacaatacttccttatgaagtcagtgccgaggaccttatcgccaactttattatcccgaagaggccgcttatcgtaaaggacgcttgtaagaattggccactgtataagatgcttcataattcaaagaaattagaagctattaaagatgtcaaactaaacacgtctatggttcaccattcaaactacgcgccccttgagtcaacgtttggcgatttcgtgaaagtagacctgcacggtacttccttcatatacgatgtccttaacggcgacccggctatctcaaaatcccttaaaatgccatggatgatttcttcgtgtagtgaccttcaagaagagttcaaaacacacggtgacattgtattgaccggtagcaaaacgaaaagaaaaagttctgccgccctggattgcactaacgcgaatacaataacagctattttatctgggagatcgacagttagaaagatggggaagaagcacttgtacgaactcgtcagaggtgacatgctgttcacgccaaagggagtctgtcttaatgttatgaatgttggtacattcgtgagcgcgtccttctcgtggacgcttgaatccgatgaattaccagtcatggcaaagaaatgtgctcggccgtcactgcggtctgtcgttgatgaaacatgggtctggcaagacggcaataagaaatacattagcgaaatccccgatgtcaagctcaactctgggtatatgatgccaccaatcggactgggaactgctcgtctttttagtaaaacatacgagaccgttaaaaccgcattgaagcttggctacagaatgttagacactgctcaaatatacactggagaagataaaataaataactttaaagtgtcttccgaagaggagattggtcgtgccattgcggacagcgacgtaccacgctcagagttgttcatcgtcacaaaactcgctcctgagagcatggaaaaagagaacgcaatcgcaaaggtggaagagtcgctaaagaagttgagaacagattatattgatcttctcctaatccatgacttctacatgagcaccgcgtgtggtccggatgatactgaccttccagaatgcaagaacaatccttttcttgcatggaaaacaatggaagaaatgcaagcaaagggtttggttcggagcattggtgttagcaacatttacattgaggatcttcaataccttgtgaaaatggccaagacaccaataagcgctgtgcagaactggttcgacccacttcaccaggaaagagaaatcagggcgctttgcgcaaagaacaacattcgttttatgggatacagtgccctcggcttcacatggattgacaaagagcaaggactaggacgcgatgttaacccggttcttacaaaccagaacattgtcgctattggaaataaccacgacctcccaacaaccttggtggtcttgcgctgggcaatggaaatgaatgtgaccgtaatgccttgcacaacaaacgtggatcatctggagcagaatctaaacagcaggttgttcccgctggacaacaagagcttcccattgattgaccaactggacaatcttttaggcgatccgtttcaggacgaagaactaccagaggaagaaccgcaaaaggaggaaaagccagagacagcagaaatgccatccaaagacgagctgtgattggatctcacatattgtcgttggtttcttaatgtttctctttgttgttatgttggatttagcgcctttcgggcgactttgtggcgtcttgtcttcttgaaatacagttacaaagttcgaggaaaaaaaaaaaaaaaaaa

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